Research Topics
Species | R Douglas FieldsSummaryAffiliation: National Institutes of Health Country: USA Publications
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Publications
Myelination: an overlooked mechanism of synaptic plasticity?R Douglas Fields
Nervous System Development and Plasticity Section, NICHD, National Institutes of Health, Bethesda, MD 20892, USA
Neuroscientist 11:528-31. 2005..These new findings raise a larger question: How did the oligodendrocytes know they were practicing the piano or that their environment was socially complex?..- CaMKII inactivation by extracellular Ca(2+) depletion in dorsal root ganglion neuronsJonathan E Cohen
Nervous System Development and Plasticity Section, National Institutes of Health, NICHD, Bldg 35, Room 2A211, MSC 3713, 35 Lincoln Drive, Bethesda, MD 20892, USA
Cell Calcium 39:445-54. 2006.... 
Nerve impulses regulate myelination through purinergic signallingR Douglas Fields
Nervous System Development and Plasticity Section, National Institutes of Health, NICHD, Bethesda, MD 20892, USA
Novartis Found Symp 276:148-58; discussion 158-61, 233-7, 275-81. 2006..Purinergic signalling interacts with growth factor and cytokine signalling, and these responses are developmentally regulated...- New insights into neuron-glia communicationR Douglas Fields
Neurocytology and Physiology Section, National Institute of Child Health and Human Development, Bethesda, MD 20892, USA
Science 298:556-62. 2002..By releasing neurotransmitters and other extracellular signaling molecules, glia can affect neuronal excitability and synaptic transmission and perhaps coordinate activity across networks of neurons... - Volume transmission in activity-dependent regulation of myelinating gliaR Douglas Fields
Nervous System Development and Plasticity Section, National Institutes of Health, NICHD, Bldg 49, Room 5A78, Bethesda, MD 20892, USA
Neurochem Int 45:503-9. 2004..ATP and adenosine have opposite effects on differentiation of Schwann cells and oligodendrocytes, providing a possible explanation for the opposite effects of impulse activity reported on myelination in the CNS and PNS... - Astrocytes promote myelination in response to electrical impulsesTomoko Ishibashi
Nervous System Development and Plasticity Section, National Institute of Child Health and Human Development, Bethesda, Maryland 20892, USA
Neuron 49:823-32. 2006..This activity-dependent mechanism promoting myelination could regulate myelination according to functional activity or environmental experience and may offer new approaches to treating demyelinating diseases... - Control of local protein synthesis and initial events in myelination by action potentialsHiroaki Wake
Nervous System Development and Plasticity Section, the Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD 20892, USA
Science 333:1647-51. 2011..This axon-oligodendrocyte signaling would promote myelination of electrically active axons to regulate neural development and function according to environmental experience... - Leukemia inhibitory factor regulates the timing of oligodendrocyte development and myelination in the postnatal optic nerveTomoko Ishibashi
Nervous System Development and Plasticity Section, National Institutes of Health, Bethesda, Maryland, USA
J Neurosci Res 87:3343-55. 2009..Myelination seems to recover by postnatal day 14, so LIF is not necessary for the completion of myelination during postnatal development... - Activity-dependent neuron-glial signaling by ATP and leukemia-inhibitory factor promotes hippocampal glial cell developmentJonathan E Cohen
Nervous System Development and Plasticity Section, National Institutes of Health, Bethesda, MD 20892, USA
Neuron Glia Biol 4:43-55. 2008..The results show that endogenous LIF is required for normal development of hippocampal astrocytes, and this process is regulated by spontaneous neural impulse activity through the release of ATP... - Extracellular ATP in activity-dependent remodeling of the neuromuscular junctionMin Jia
National Institute of Child Health and Human Development, The National Institutes of Health, Bethesda, Maryland 20892, USA
Dev Neurobiol 67:924-32. 2007..We conclude that extracellular ATP promotes stabilization of the neuromuscular junction and may play a role in activity-dependent synaptic modification during development... - Gene expression in the conversion of early-phase to late-phase long-term potentiationPhilip R Lee
Nervous System Development and Plasticity Section, National Institutes of Health, Bethesda, MD 20892, USA
Ann N Y Acad Sci 1048:259-71. 2005..Natl. Acad. Sci. USA 99: 3962-3967) showing that this conversion can be induced by antidromic stimulation of CA1 neurons in the absence of excitatory synaptic activity... - Making memories stickR Douglas Fields
Nervous System Development and Plasticity Section, National Institute of Child Health and Human Development, USA
Sci Am 292:75-81. 2005 - Adenosine: a neuron-glial transmitter promoting myelination in the CNS in response to action potentialsBeth Stevens
Laboratory of Cellular and Synaptic Neurophysiology, National Institutes of Health, NICHD, Bethesda, MD 20892, USA
Neuron 36:855-68. 2002.... 
Nonsynaptic communication through ATP release from volume-activated anion channels in axonsR Douglas Fields
Nervous Systems Development and Plasticity Section, National Institute of Child Health and Human Development, National Institutes of Health, 35 Lincoln Drive, Bethesda, MD 20892, USA
Sci Signal 3:ra73. 2010..This nonvesicular, nonsynaptic communication could mediate various activity-dependent interactions between axons and nervous system cells in normal conditions, development, and disease...- Imaging learning: the search for a memory traceR Douglas Fields
Nervous System Development and Plasticity Section, National Institutes of Health, NICHD, Bethesda, MD, USA
Neuroscientist 17:185-96. 2011.... - Signaling by neuronal swellingR Douglas Fields
National Institute of Child Health and Human Development, NIH, Building 35, Room 2A211, MSC3713, Bethesda, MD 20892, USA
Sci Signal 4:tr1. 2011.... - Purinergic signalling in neuron-glia interactionsR Douglas Fields
National Institute of Child Health and Human Development, National Institutes of Health, Building 35, Room 2A211, MSC 3713, 35 Lincoln Drive, Bethesda, Maryland 20892, USA
Nat Rev Neurosci 7:423-36. 2006..We review the involvement of ATP and adenosine receptors in neuron-glia signalling, including the release and hydrolysis of ATP, how the receptors signal, the pharmacological tools used to study them, and their functional significance... - MicroRNA regulation of homeostatic synaptic plasticityJonathan E Cohen
Section on Nervous System Development and Plasticity, The Eunice Kennedy Shriver National Institute of Child and Human Development, National Institutes of Health, Bethesda, MD 20892 3714, USA
Proc Natl Acad Sci U S A 108:11650-5. 2011..g., Huntington and Alzheimer's disease), where miR-485 has been found to be dysregulated... - White matter in learning, cognition and psychiatric disordersR Douglas Fields
Nervous System Development and Plasticity Section, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
Trends Neurosci 31:361-70. 2008..Cell-culture studies have identified molecular mechanisms regulating myelination by electrical activity, and myelin also limits the critical period for learning through inhibitory proteins that suppress axon sprouting and synaptogenesis... - Temporal integration of intracellular Ca2+ signaling networks in regulating gene expression by action potentialsR Douglas Fields
Nervous System Development and Plasticity Section, National Institutes of Health, NICHD, Bldg 35, Room 2A211, MSC 3713, 35 Lincoln Drive, Bethesda, MD 20892, USA
Cell Calcium 37:433-42. 2005.... - Oligodendrocytes changing the rules: action potentials in glia and oligodendrocytes controlling action potentialsR Douglas Fields
Nervous System Development and Plasticity Section, National Institutes of Health, Bethesda, MD 20892, USA
Neuroscientist 14:540-3. 2008..This unprecedented finding suggests a dynamic role for myelin in regulating impulse transmission through axons, promoting neural synchrony among the multiple axons under the domain of an individual oligodendrocyte... - White matter mattersR Douglas Fields
Nervous System Development and Plasticity Section, National Institute of Child Health and Human Development, USA
Sci Am 298:42-9. 2008 - Immune system evasion by peripheral nerve sheath tumorPhilip R Lee
Nervous System Development and Plasticity Section, National Institutes of Health, NICHD, Bldg. 35, Room 2A211, MSC 3713, 35 Lincoln Drive, Bethesda, MD 20892, USA
Neurosci Lett 397:126-9. 2006..Acquiring a "silent" immune signature may be a critical step in the progress towards malignancy in MPNSTs... - Semiconductor gel in shark sense organs?R Douglas Fields
Nervous System Development and Plasticity Section, NICHD, National Institutes of Health, Bethesda, MD, USA
Neurosci Lett 426:166-70. 2007..This new evidence, together with the anatomy of the organs and behavioral studies in the literature, best support the conclusion that the biological function of these sense organs is to detect electric fields... - Advances in understanding neuron-glia interactionsR Douglas Fields
Nervous Systems Development and Plasticity Section, National Institutes of Health, NICHD, Bldg 35, Room 2A211, MSC 3713, 35 Lincoln Drive, Bethesda, MD 20892, USA
Neuron Glia Biol 2:23-6. 2006.... - Nonsynaptic and nonvesicular ATP release from neurons and relevance to neuron-glia signalingR Douglas Fields
Nervous Systems Development and Plasticity Section, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, United States
Semin Cell Dev Biol 22:214-9. 2011..This has identified volume-activated anion channels as an important mechanism in activity-dependent ATP release from axons, and renewed interest in micromechanical changes in axons that accompany action potential firing... - Visualizing calcium signaling in astrocytesR Douglas Fields
National Institute of Child Health and Human Development, National Institutes of Health, Building 35, Room 2A211, MSC3713, Bethesda, MD 20892, USA
Sci Signal 3:tr5. 2010..This allows astrocytes to respond to neural impulse activity, communicate among other astrocytes, and influence neuronal communication by taking up or releasing neurotransmitters from synapses... - Physiological function of microgliaHiroaki Wake
Nervous System Development and Plasticity Section, the Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD 20892, USA
Neuron Glia Biol 7:1-3. 2011.... - Extracellular calcium depletion in synaptic transmissionJonathan E Cohen
National Institutes of Health, National Institute for Child and Human Development, Section on Nervous System Development and Plasticity, Bethesda, MD 20892, USA
Neuroscientist 10:12-7. 2004..Depletion of [Ca]o(2+) may function as an activity-dependent extracellular messenger that regulates nervous system function during development, learning, and disease... - Regulation of myelin genes implicated in psychiatric disorders by functional activity in axonsPhilip R Lee
National Institutes of Health, NICHD Bethesda, MD, USA
Front Neuroanat 3:4. 2009..This review examines evidence showing that genes and gene networks important for myelination can be regulated by functional activity in axons... - Regulation of the cell cycle in normal and pathological gliaBeth Stevens
Laboratory of Cellular and Synaptic Neurophysiology, National Institutes of Health, NICHD, Bethesda, Maryland 20895-4495, USA
Neuroscientist 8:93-7. 2002.... - Somatic action potentials are sufficient for late-phase LTP-related cell signalingSerena M Dudek
Laboratory of Cellular and Synaptic Neurophysiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 99:3962-7. 2002..These results show that a synapse-to-nucleus signal is not necessary for late-phase LTP-associated signaling cascades in the regulation of gene expression... - The shark's electric senseR Douglas Fields
National Institutes of Health, USA
Sci Am 297:74-80. 2007 - Neuroscience. The neuron doctrine, reduxTheodore H Bullock
Scripps Institution of Oceanography and Department of Neuroscience, University of California, San Diego, La Jolla, CA 92093, USA
Science 310:791-3. 2005 - The other half of the brainR Douglas Fields
University of Maryland, USA
Sci Am 290:54-61. 2004 - Patterned electrical activity modulates sodium channel expression in sensory neuronsJoshua P Klein
Department of Neurology and PVA EPVA Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, Connecticut 06510, USA
J Neurosci Res 74:192-8. 2003..These results show that a change in neuronal activity can alter the expression of sodium channel genes in a subtype-specific manner, via a mechanism independent of NGF withdrawal...