R Douglas Fields

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Myelination: an overlooked mechanism of synaptic plasticity?
    R Douglas Fields
    Nervous System Development and Plasticity Section, NICHD, National Institutes of Health, Bethesda, MD 20892, USA
    Neuroscientist 11:528-31. 2005
  2. pmc CaMKII inactivation by extracellular Ca(2+) depletion in dorsal root ganglion neurons
    Jonathan E Cohen
    Nervous System Development and Plasticity Section, National Institutes of Health, NICHD, Bldg 35, Room 2A211, MSC 3713, 35 Lincoln Drive, Bethesda, MD 20892, USA
    Cell Calcium 39:445-54. 2006
  3. ncbi request reprint Nerve impulses regulate myelination through purinergic signalling
    R Douglas Fields
    Nervous System Development and Plasticity Section, National Institutes of Health, NICHD, Bethesda, MD 20892, USA
    Novartis Found Symp 276:148-58; discussion 158-61, 233-7, 275-81. 2006
  4. ncbi request reprint Volume transmission in activity-dependent regulation of myelinating glia
    R Douglas Fields
    Nervous System Development and Plasticity Section, National Institutes of Health, NICHD, Bldg 49, Room 5A78, Bethesda, MD 20892, USA
    Neurochem Int 45:503-9. 2004
  5. pmc New insights into neuron-glia communication
    R Douglas Fields
    Neurocytology and Physiology Section, National Institute of Child Health and Human Development, Bethesda, MD 20892, USA
    Science 298:556-62. 2002
  6. pmc Astrocytes promote myelination in response to electrical impulses
    Tomoko Ishibashi
    Nervous System Development and Plasticity Section, National Institute of Child Health and Human Development, Bethesda, Maryland 20892, USA
    Neuron 49:823-32. 2006
  7. pmc Control of local protein synthesis and initial events in myelination by action potentials
    Hiroaki Wake
    Nervous System Development and Plasticity Section, the Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD 20892, USA
    Science 333:1647-51. 2011
  8. pmc Leukemia inhibitory factor regulates the timing of oligodendrocyte development and myelination in the postnatal optic nerve
    Tomoko Ishibashi
    Nervous System Development and Plasticity Section, National Institutes of Health, Bethesda, Maryland, USA
    J Neurosci Res 87:3343-55. 2009
  9. pmc Activity-dependent neuron-glial signaling by ATP and leukemia-inhibitory factor promotes hippocampal glial cell development
    Jonathan E Cohen
    Nervous System Development and Plasticity Section, National Institutes of Health, Bethesda, MD 20892, USA
    Neuron Glia Biol 4:43-55. 2008
  10. pmc Adenosine: a neuron-glial transmitter promoting myelination in the CNS in response to action potentials
    Beth Stevens
    Laboratory of Cellular and Synaptic Neurophysiology, National Institutes of Health, NICHD, Bethesda, MD 20892, USA
    Neuron 36:855-68. 2002

Collaborators

Detail Information

Publications38

  1. pmc Myelination: an overlooked mechanism of synaptic plasticity?
    R Douglas Fields
    Nervous System Development and Plasticity Section, NICHD, National Institutes of Health, Bethesda, MD 20892, USA
    Neuroscientist 11:528-31. 2005
    ..These new findings raise a larger question: How did the oligodendrocytes know they were practicing the piano or that their environment was socially complex?..
  2. pmc CaMKII inactivation by extracellular Ca(2+) depletion in dorsal root ganglion neurons
    Jonathan E Cohen
    Nervous System Development and Plasticity Section, National Institutes of Health, NICHD, Bldg 35, Room 2A211, MSC 3713, 35 Lincoln Drive, Bethesda, MD 20892, USA
    Cell Calcium 39:445-54. 2006
    ....
  3. ncbi request reprint Nerve impulses regulate myelination through purinergic signalling
    R Douglas Fields
    Nervous System Development and Plasticity Section, National Institutes of Health, NICHD, Bethesda, MD 20892, USA
    Novartis Found Symp 276:148-58; discussion 158-61, 233-7, 275-81. 2006
    ..Purinergic signalling interacts with growth factor and cytokine signalling, and these responses are developmentally regulated...
  4. ncbi request reprint Volume transmission in activity-dependent regulation of myelinating glia
    R Douglas Fields
    Nervous System Development and Plasticity Section, National Institutes of Health, NICHD, Bldg 49, Room 5A78, Bethesda, MD 20892, USA
    Neurochem Int 45:503-9. 2004
    ..ATP and adenosine have opposite effects on differentiation of Schwann cells and oligodendrocytes, providing a possible explanation for the opposite effects of impulse activity reported on myelination in the CNS and PNS...
  5. pmc New insights into neuron-glia communication
    R Douglas Fields
    Neurocytology and Physiology Section, National Institute of Child Health and Human Development, Bethesda, MD 20892, USA
    Science 298:556-62. 2002
    ..By releasing neurotransmitters and other extracellular signaling molecules, glia can affect neuronal excitability and synaptic transmission and perhaps coordinate activity across networks of neurons...
  6. pmc Astrocytes promote myelination in response to electrical impulses
    Tomoko Ishibashi
    Nervous System Development and Plasticity Section, National Institute of Child Health and Human Development, Bethesda, Maryland 20892, USA
    Neuron 49:823-32. 2006
    ..This activity-dependent mechanism promoting myelination could regulate myelination according to functional activity or environmental experience and may offer new approaches to treating demyelinating diseases...
  7. pmc Control of local protein synthesis and initial events in myelination by action potentials
    Hiroaki Wake
    Nervous System Development and Plasticity Section, the Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD 20892, USA
    Science 333:1647-51. 2011
    ..This axon-oligodendrocyte signaling would promote myelination of electrically active axons to regulate neural development and function according to environmental experience...
  8. pmc Leukemia inhibitory factor regulates the timing of oligodendrocyte development and myelination in the postnatal optic nerve
    Tomoko Ishibashi
    Nervous System Development and Plasticity Section, National Institutes of Health, Bethesda, Maryland, USA
    J Neurosci Res 87:3343-55. 2009
    ..Myelination seems to recover by postnatal day 14, so LIF is not necessary for the completion of myelination during postnatal development...
  9. pmc Activity-dependent neuron-glial signaling by ATP and leukemia-inhibitory factor promotes hippocampal glial cell development
    Jonathan E Cohen
    Nervous System Development and Plasticity Section, National Institutes of Health, Bethesda, MD 20892, USA
    Neuron Glia Biol 4:43-55. 2008
    ..The results show that endogenous LIF is required for normal development of hippocampal astrocytes, and this process is regulated by spontaneous neural impulse activity through the release of ATP...
  10. pmc Adenosine: a neuron-glial transmitter promoting myelination in the CNS in response to action potentials
    Beth Stevens
    Laboratory of Cellular and Synaptic Neurophysiology, National Institutes of Health, NICHD, Bethesda, MD 20892, USA
    Neuron 36:855-68. 2002
    ....
  11. ncbi request reprint Making memories stick
    R Douglas Fields
    Nervous System Development and Plasticity Section, National Institute of Child Health and Human Development, USA
    Sci Am 292:75-81. 2005
  12. ncbi request reprint Extracellular ATP in activity-dependent remodeling of the neuromuscular junction
    Min Jia
    National Institute of Child Health and Human Development, The National Institutes of Health, Bethesda, Maryland 20892, USA
    Dev Neurobiol 67:924-32. 2007
    ..We conclude that extracellular ATP promotes stabilization of the neuromuscular junction and may play a role in activity-dependent synaptic modification during development...
  13. ncbi request reprint Gene expression in the conversion of early-phase to late-phase long-term potentiation
    Philip R Lee
    Nervous System Development and Plasticity Section, National Institutes of Health, Bethesda, MD 20892, USA
    Ann N Y Acad Sci 1048:259-71. 2005
    ..Natl. Acad. Sci. USA 99: 3962-3967) showing that this conversion can be induced by antidromic stimulation of CA1 neurons in the absence of excitatory synaptic activity...
  14. doi request reprint Nonsynaptic communication through ATP release from volume-activated anion channels in axons
    R Douglas Fields
    Nervous Systems Development and Plasticity Section, National Institute of Child Health and Human Development, National Institutes of Health, 35 Lincoln Drive, Bethesda, MD 20892, USA
    Sci Signal 3:ra73. 2010
    ..This nonvesicular, nonsynaptic communication could mediate various activity-dependent interactions between axons and nervous system cells in normal conditions, development, and disease...
  15. pmc Purinergic signalling in neuron-glia interactions
    R Douglas Fields
    National Institute of Child Health and Human Development, National Institutes of Health, Building 35, Room 2A211, MSC 3713, 35 Lincoln Drive, Bethesda, Maryland 20892, USA
    Nat Rev Neurosci 7:423-36. 2006
    ..We review the involvement of ATP and adenosine receptors in neuron-glia signalling, including the release and hydrolysis of ATP, how the receptors signal, the pharmacological tools used to study them, and their functional significance...
  16. pmc Imaging learning: the search for a memory trace
    R Douglas Fields
    Nervous System Development and Plasticity Section, National Institutes of Health, NICHD, Bethesda, MD, USA
    Neuroscientist 17:185-96. 2011
    ....
  17. pmc Signaling by neuronal swelling
    R Douglas Fields
    National Institute of Child Health and Human Development, NIH, Building 35, Room 2A211, MSC3713, Bethesda, MD 20892, USA
    Sci Signal 4:tr1. 2011
    ....
  18. pmc MicroRNA regulation of homeostatic synaptic plasticity
    Jonathan E Cohen
    Section on Nervous System Development and Plasticity, The Eunice Kennedy Shriver National Institute of Child and Human Development, National Institutes of Health, Bethesda, MD 20892 3714, USA
    Proc Natl Acad Sci U S A 108:11650-5. 2011
    ..g., Huntington and Alzheimer's disease), where miR-485 has been found to be dysregulated...
  19. pmc Immune system evasion by peripheral nerve sheath tumor
    Philip R Lee
    Nervous System Development and Plasticity Section, National Institutes of Health, NICHD, Bldg 35, Room 2A211, MSC 3713, 35 Lincoln Drive, Bethesda, MD 20892, USA
    Neurosci Lett 397:126-9. 2006
    ..Acquiring a "silent" immune signature may be a critical step in the progress towards malignancy in MPNSTs...
  20. pmc Oligodendrocytes changing the rules: action potentials in glia and oligodendrocytes controlling action potentials
    R Douglas Fields
    Nervous System Development and Plasticity Section, National Institutes of Health, Bethesda, MD 20892, USA
    Neuroscientist 14:540-3. 2008
    ..This unprecedented finding suggests a dynamic role for myelin in regulating impulse transmission through axons, promoting neural synchrony among the multiple axons under the domain of an individual oligodendrocyte...
  21. ncbi request reprint Temporal integration of intracellular Ca2+ signaling networks in regulating gene expression by action potentials
    R Douglas Fields
    Nervous System Development and Plasticity Section, National Institutes of Health, NICHD, Bldg 35, Room 2A211, MSC 3713, 35 Lincoln Drive, Bethesda, MD 20892, USA
    Cell Calcium 37:433-42. 2005
    ....
  22. ncbi request reprint White matter matters
    R Douglas Fields
    Nervous System Development and Plasticity Section, National Institute of Child Health and Human Development, USA
    Sci Am 298:42-9. 2008
  23. pmc White matter in learning, cognition and psychiatric disorders
    R Douglas Fields
    Nervous System Development and Plasticity Section, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Trends Neurosci 31:361-70. 2008
    ..Cell-culture studies have identified molecular mechanisms regulating myelination by electrical activity, and myelin also limits the critical period for learning through inhibitory proteins that suppress axon sprouting and synaptogenesis...
  24. ncbi request reprint Advances in understanding neuron-glia interactions
    R Douglas Fields
    Nervous Systems Development and Plasticity Section, National Institutes of Health, NICHD, Bldg 35, Room 2A211, MSC 3713, 35 Lincoln Drive, Bethesda, MD 20892, USA
    Neuron Glia Biol 2:23-6. 2006
    ....
  25. pmc Semiconductor gel in shark sense organs?
    R Douglas Fields
    Nervous System Development and Plasticity Section, NICHD, National Institutes of Health, Bethesda, MD, USA
    Neurosci Lett 426:166-70. 2007
    ..This new evidence, together with the anatomy of the organs and behavioral studies in the literature, best support the conclusion that the biological function of these sense organs is to detect electric fields...
  26. pmc Synaptic plasticity by antidromic firing during hippocampal network oscillations
    Olena Bukalo
    Nervous System Development and Plasticity Section, Program in Development Neuroscience, the Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 110:5175-80. 2013
    ..Rescaling synaptic weights in subsets of neurons firing antidromically during SPW-Rs might contribute to memory consolidation by sharpening specificity of subsequent synaptic input and promoting incorporation of novel information...
  27. pmc Nonsynaptic and nonvesicular ATP release from neurons and relevance to neuron-glia signaling
    R Douglas Fields
    Nervous Systems Development and Plasticity Section, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, United States
    Semin Cell Dev Biol 22:214-9. 2011
    ..This has identified volume-activated anion channels as an important mechanism in activity-dependent ATP release from axons, and renewed interest in micromechanical changes in axons that accompany action potential firing...
  28. doi request reprint Visualizing calcium signaling in astrocytes
    R Douglas Fields
    National Institute of Child Health and Human Development, National Institutes of Health, Building 35, Room 2A211, MSC3713, Bethesda, MD 20892, USA
    Sci Signal 3:tr5. 2010
    ..This allows astrocytes to respond to neural impulse activity, communicate among other astrocytes, and influence neuronal communication by taking up or releasing neurotransmitters from synapses...
  29. doi request reprint Changes in brain structure during learning: fact or artifact? Reply to Thomas and Baker
    R Douglas Fields
    Nervous System Development and Plasticity Section, the Eunice Kennedy Shriver National Institute of Child Health and Human Development, 35 Lincoln Drive, Bldg 35, Room 2A211, Bethesda, MD 20892, USA
    Neuroimage 73:260-4; discussion 265-7. 2013
    ..This commentary identifies problems with some of the arguments raised in their review and suggests that there is strong evidence, from both animal and human studies, that experience can alter brain structure...
  30. doi request reprint Physiological function of microglia
    Hiroaki Wake
    Nervous System Development and Plasticity Section, the Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD 20892, USA
    Neuron Glia Biol 7:1-3. 2011
    ....
  31. ncbi request reprint Extracellular calcium depletion in synaptic transmission
    Jonathan E Cohen
    National Institutes of Health, National Institute for Child and Human Development, Section on Nervous System Development and Plasticity, Bethesda, MD 20892, USA
    Neuroscientist 10:12-7. 2004
    ..Depletion of [Ca]o(2+) may function as an activity-dependent extracellular messenger that regulates nervous system function during development, learning, and disease...
  32. pmc Regulation of myelin genes implicated in psychiatric disorders by functional activity in axons
    Philip R Lee
    National Institutes of Health, NICHD Bethesda, MD, USA
    Front Neuroanat 3:4. 2009
    ..This review examines evidence showing that genes and gene networks important for myelination can be regulated by functional activity in axons...
  33. pmc Somatic action potentials are sufficient for late-phase LTP-related cell signaling
    Serena M Dudek
    Laboratory of Cellular and Synaptic Neurophysiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 99:3962-7. 2002
    ..These results show that a synapse-to-nucleus signal is not necessary for late-phase LTP-associated signaling cascades in the regulation of gene expression...
  34. ncbi request reprint Regulation of the cell cycle in normal and pathological glia
    Beth Stevens
    Laboratory of Cellular and Synaptic Neurophysiology, National Institutes of Health, NICHD, Bethesda, Maryland 20895 4495, USA
    Neuroscientist 8:93-7. 2002
    ....
  35. ncbi request reprint The shark's electric sense
    R Douglas Fields
    National Institutes of Health, USA
    Sci Am 297:74-80. 2007
  36. ncbi request reprint Neuroscience. The neuron doctrine, redux
    Theodore H Bullock
    Scripps Institution of Oceanography and Department of Neuroscience, University of California, San Diego, La Jolla, CA 92093, USA
    Science 310:791-3. 2005
  37. ncbi request reprint The other half of the brain
    R Douglas Fields
    University of Maryland, USA
    Sci Am 290:54-61. 2004
  38. ncbi request reprint Patterned electrical activity modulates sodium channel expression in sensory neurons
    Joshua P Klein
    Department of Neurology and PVA EPVA Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Neurosci Res 74:192-8. 2003
    ..These results show that a change in neuronal activity can alter the expression of sodium channel genes in a subtype-specific manner, via a mechanism independent of NGF withdrawal...