M B Fessler

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Intracellular lipid flux and membrane microdomains as organizing principles in inflammatory cell signaling
    Michael B Fessler
    Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    J Immunol 187:1529-35. 2011
  2. doi request reprint Relationship of serum cholesterol levels to atopy in the US population
    M B Fessler
    Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
    Allergy 65:859-64. 2010
  3. doi request reprint Novel relationship of serum cholesterol with asthma and wheeze in the United States
    Michael B Fessler
    Department of Health and Human Services, Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    J Allergy Clin Immunol 124:967-74.e1-15. 2009
  4. pmc Dual role for RhoA in suppression and induction of cytokines in the human neutrophil
    Michael B Fessler
    Department of Medicine, National Jewish Medical and Research Center, Denver, CO, USA
    Blood 109:1248-56. 2007
  5. pmc Myeloid differentiation primary response protein 88 couples reverse cholesterol transport to inflammation
    Kathleen A Smoak
    Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Cell Metab 11:493-502. 2010
  6. pmc ATP-binding cassette transporter G1 deficiency dysregulates host defense in the lung
    David W Draper
    National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Am J Respir Crit Care Med 182:404-12. 2010
  7. pmc Myeloid deletion of SIRT1 induces inflammatory signaling in response to environmental stress
    Thaddeus T Schug
    Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Mol Cell Biol 30:4712-21. 2010
  8. pmc The structure of the dust mite allergen Der p 7 reveals similarities to innate immune proteins
    Geoffrey A Mueller
    Laboratory of Structural Biology, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA
    J Allergy Clin Immunol 125:909-917.e4. 2010
  9. ncbi request reprint The IL-1 type 1 receptor is required for the development of LPS-induced airways disease
    David M Brass
    National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    J Allergy Clin Immunol 120:121-7. 2007
  10. ncbi request reprint A role for hydroxy-methylglutaryl coenzyme a reductase in pulmonary inflammation and host defense
    Michael B Fessler
    Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson Street, D403 Neustadt, Denver, CO 80206, USA
    Am J Respir Crit Care Med 171:606-15. 2005

Collaborators

Detail Information

Publications24

  1. pmc Intracellular lipid flux and membrane microdomains as organizing principles in inflammatory cell signaling
    Michael B Fessler
    Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    J Immunol 187:1529-35. 2011
    ....
  2. doi request reprint Relationship of serum cholesterol levels to atopy in the US population
    M B Fessler
    Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
    Allergy 65:859-64. 2010
    ....
  3. doi request reprint Novel relationship of serum cholesterol with asthma and wheeze in the United States
    Michael B Fessler
    Department of Health and Human Services, Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    J Allergy Clin Immunol 124:967-74.e1-15. 2009
    ..Cholesterol exerts complex effects on inflammation. There has been little investigation of whether serum cholesterol is associated with asthma, an inflammatory airways disease with great public health impact...
  4. pmc Dual role for RhoA in suppression and induction of cytokines in the human neutrophil
    Michael B Fessler
    Department of Medicine, National Jewish Medical and Research Center, Denver, CO, USA
    Blood 109:1248-56. 2007
    ..The p65 subunit of NF-kappaB coprecipitates with RhoA in a manner sensitive to the RhoA activation state. Our findings suggest a new, 2-faced role for RhoA as a checkpoint in innate immunity...
  5. pmc Myeloid differentiation primary response protein 88 couples reverse cholesterol transport to inflammation
    Kathleen A Smoak
    Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Cell Metab 11:493-502. 2010
    ....
  6. pmc ATP-binding cassette transporter G1 deficiency dysregulates host defense in the lung
    David W Draper
    National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Am J Respir Crit Care Med 182:404-12. 2010
    ..Mice with genetic deletion of the cholesterol efflux transporter, ATP-binding cassette (ABC) G1, have pulmonary lipidosis and chronic pulmonary inflammation. Whether ABCG1 regulates host defense is unknown...
  7. pmc Myeloid deletion of SIRT1 induces inflammatory signaling in response to environmental stress
    Thaddeus T Schug
    Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Mol Cell Biol 30:4712-21. 2010
    ....
  8. pmc The structure of the dust mite allergen Der p 7 reveals similarities to innate immune proteins
    Geoffrey A Mueller
    Laboratory of Structural Biology, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA
    J Allergy Clin Immunol 125:909-917.e4. 2010
    ..Allergen function might contribute to allergenicity, as shown for the protease activity of group 1 mite allergens and the interaction with the innate immune system by group 2 mite allergens...
  9. ncbi request reprint The IL-1 type 1 receptor is required for the development of LPS-induced airways disease
    David M Brass
    National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    J Allergy Clin Immunol 120:121-7. 2007
    ..The contribution of IL-1beta signaling through the IL-1 type 1 receptor (IL-1R1) to the development of persistent LPS-induced airway disease has not been investigated...
  10. ncbi request reprint A role for hydroxy-methylglutaryl coenzyme a reductase in pulmonary inflammation and host defense
    Michael B Fessler
    Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson Street, D403 Neustadt, Denver, CO 80206, USA
    Am J Respir Crit Care Med 171:606-15. 2005
    ..No studies to date, however, have addressed whether statins modulate pulmonary inflammation triggered by aerogenic stimuli or whether they affect host defense...
  11. ncbi request reprint Lipopolysaccharide stimulation of the human neutrophil: an analysis of changes in gene transcription and protein expression by oligonucleotide microarrays and proteomics
    Michael B Fessler
    Department of Medicine, National Jewish Medical and Research Center and University of Colorado Health Sciences Center, Denver, 80262, USA
    Chest 121:75S-76S. 2002
  12. ncbi request reprint Lipid rafts regulate lipopolysaccharide-induced activation of Cdc42 and inflammatory functions of the human neutrophil
    Michael B Fessler
    Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    J Biol Chem 279:39989-98. 2004
    ..In sum, these findings provide evidence for an important regulatory role of cholesterol in both transmission of the lipopolysaccharide signal and the inflammatory phenotype of the human neutrophil...
  13. ncbi request reprint Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF)-mediated signaling contributes to innate immune responses in the lung during Escherichia coli pneumonia
    Samithamby Jeyaseelan
    Division of Respiratory Infections, Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson Street Neustadt D 403, Denver, CO 80206, USA
    J Immunol 178:3153-60. 2007
    ..coli burden in the lungs and E. coli dissemination. Thus, rapid activation of TRIF-dependent TLR4-mediated signaling cascade serves to augment pulmonary host defense against a Gram-negative pathogen...
  14. ncbi request reprint Inhibition of c-Jun N-terminal kinase limits lipopolysaccharide-induced pulmonary neutrophil influx
    Patrick G Arndt
    Division of Pulmonary and Critical Care Medicine, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Denver, CO 80206, USA
    Am J Respir Crit Care Med 171:978-86. 2005
    ....
  15. doi request reprint Dyslipidemia induces opposing effects on intrapulmonary and extrapulmonary host defense through divergent TLR response phenotypes
    Jennifer H Madenspacher
    Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    J Immunol 185:1660-9. 2010
    ..We propose that the airspace is a "privileged" site, thereby uniquely sensitive to dyslipidemia...
  16. ncbi request reprint Phospholipid flip-flop and phospholipid scramblase 1 (PLSCR1) co-localize to uropod rafts in formylated Met-Leu-Phe-stimulated neutrophils
    S Courtney Frasch
    Department of Pediatrics, Division of Cell Biology, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    J Biol Chem 279:17625-33. 2004
    ..Of note, PS exposure, phospholipid uptake, and FM 1-43 staining also localized to the uropod following stimulation demonstrating that both PLSCR1 and phospholipid flip-flop characterize this specialized domain of polarized neutrophils...
  17. pmc Quantitative proteomics analysis of macrophage rafts reveals compartmentalized activation of the proteasome and of proteasome-mediated ERK activation in response to lipopolysaccharide
    Suraj Dhungana
    Laboratories of Respiratory Biology, NIEHS, National Institutes of Health, United States Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
    Mol Cell Proteomics 8:201-13. 2009
    ..Taken together, our findings indicate a critical, selective role for raft compartmentalization and regulation of proteasome activity in activation of the MEK-ERK pathway...
  18. pmc Effects of liver X receptor agonist treatment on pulmonary inflammation and host defense
    Kathleen Smoak
    Laboratory of Respiratory Biology, Department of Health and Human Services, Cellular and Molecular Pathology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    J Immunol 180:3305-12. 2008
    ..Taken together, these data define a novel role for LXR in lung pathophysiology and neutrophil biology and identify pharmacologic activation of LXR as a potential tool for modulation of innate immunity in the lung...
  19. ncbi request reprint Genetic polymorphisms and sepsis
    John Arcaroli
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Shock 24:300-12. 2005
    ..Future therapeutic trials as well as actual treatment regimens for patients with sepsis are likely to be designed to target specific genotypes and associated cellular responses, maximizing clinical response and patient safety...
  20. ncbi request reprint Lovastatin enhances clearance of apoptotic cells (efferocytosis) with implications for chronic obstructive pulmonary disease
    Konosuke Morimoto
    COPD Center, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, 80262, USA
    J Immunol 176:7657-65. 2006
    ..These findings indicate that statins enhance efferocytosis in vitro and in vivo, and suggest that they may play an important therapeutic role in diseases where efferocytosis is impaired and inflammation is dysregulated...
  21. ncbi request reprint A genomic and proteomic analysis of activation of the human neutrophil by lipopolysaccharide and its mediation by p38 mitogen-activated protein kinase
    Michael B Fessler
    Department of Medicine, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center and National Jewish Medical and Research Center, Denver, Colorado 80262, USA
    J Biol Chem 277:31291-302. 2002
    ....
  22. pmc Enhanced Pseudomonas aeruginosa biofilm development mediated by human neutrophils
    Travis S Walker
    National Jewish Medical and Research Center, D202, 1400 Jackson Street, Denver, CO 80206, USA
    Infect Immun 73:3693-701. 2005
    ..When the host fails to eradicate the infection, cellular components from necrotic neutrophils can serve as a biological matrix to facilitate P. aeruginosa biofilm formation...
  23. doi request reprint Epitope mapping by differential chemical modification of antigens
    Suraj Dhungana
    Laboratory of Structural Biology, National Institute of Environmental Health Sciences, NIH, DHHS, 111 T W Alexander Drive, PO Box 12233, Research Triangle Park, NC 27709, USA
    Methods Mol Biol 524:119-34. 2009
    ..The steps involved in epitope mapping approaches using differential chemical modification and H/D exchange on the antigen are discussed in detail, with particular emphasis on the experimental protocols...
  24. ncbi request reprint Statins enhance clearance of apoptotic cells through modulation of Rho-GTPases
    Konosuke Morimoto
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, 4200 East Ninth Ave, C272, Denver, 80220, USA
    Proc Am Thorac Soc 3:516-7. 2006