Luigi Ferrucci

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Genome-wide association analysis of total cholesterol and high-density lipoprotein cholesterol levels using the Framingham heart study data
    Li Ma
    Department of Animal Science, University of Minnesota, USA
    BMC Med Genet 11:55. 2010
  2. pmc Effects of the diabetes linked TCF7L2 polymorphism in a representative older population
    David Melzer
    Peninsula Medical School, RD and E Wonford Site, Barrack Road, Exeter, EX2 5DW, UK
    BMC Med 4:34. 2006
  3. ncbi request reprint Neurological examination findings to predict limitations in mobility and falls in older persons without a history of neurological disease
    Luigi Ferrucci
    Longitudinal Studies Section, Clinical Research Branch, National Instituts on Aging, National Institute of Health, Baltimore, Maryland 21225, USA
    Am J Med 116:807-15. 2004
  4. pmc Common variation in the beta-carotene 15,15'-monooxygenase 1 gene affects circulating levels of carotenoids: a genome-wide association study
    Luigi Ferrucci
    Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, United States of America
    Am J Hum Genet 84:123-33. 2009
  5. pmc Association of hormonal dysregulation with metabolic syndrome in older women: data from the InCHIANTI study
    Marcello Maggio
    National Institute on Aging, NIH, NIA ASTRA Unit at Harbor Hospital, 3001 S Hanover St, Baltimore, MD 21225, USA
    Am J Physiol Endocrinol Metab 292:E353-8. 2007
  6. pmc Low testosterone levels and the risk of anemia in older men and women
    Luigi Ferrucci
    Clinical Research Branch, Longitudinal Studies Section, National Institute on Aging, Baltimore, MD 21225, USA
    Arch Intern Med 166:1380-8. 2006
  7. ncbi request reprint A flame burning within
    Luigi Ferrucci
    Intramural Research Program, National Institute on Aging, Baltimore, MD, USA
    Aging Clin Exp Res 16:240-3. 2004
  8. ncbi request reprint The origins of age-related proinflammatory state
    Luigi Ferrucci
    Intramural Research Program, National Institute on Aging, Longitudinal Studies Section, Clinical Research Branch, ASTRA Unit, Harbor Hospital 5th Floor, 3001 S Hanover St, Baltimore, MD, USA
    Blood 105:2294-9. 2005
  9. pmc Proinflammatory state, hepcidin, and anemia in older persons
    Luigi Ferrucci
    Intramural Research Program, National Institute on Aging, Baltimore, MD 21225, USA
    Blood 115:3810-6. 2010
  10. ncbi request reprint Proinflammatory state and circulating erythropoietin in persons with and without anemia
    Luigi Ferrucci
    Clinical Research Branch, National Institute on Aging, Longitudinal Studies Section Clinical Research Branch, ASTRA Unit, Harbor Hospital Baltimore, MD 21225, USA
    Am J Med 118:1288. 2005

Collaborators

Detail Information

Publications159 found, 100 shown here

  1. pmc Genome-wide association analysis of total cholesterol and high-density lipoprotein cholesterol levels using the Framingham heart study data
    Li Ma
    Department of Animal Science, University of Minnesota, USA
    BMC Med Genet 11:55. 2010
    ..Here, we report single-locus and epistasis SNP effects on TC and HDL-C using the Framingham Heart Study (FHS) data...
  2. pmc Effects of the diabetes linked TCF7L2 polymorphism in a representative older population
    David Melzer
    Peninsula Medical School, RD and E Wonford Site, Barrack Road, Exeter, EX2 5DW, UK
    BMC Med 4:34. 2006
    ..We aimed to estimate associations of the marker rs7903146 (C/T) polymorphism with fasting glucose, lipids, diabetes prevalence and complications in an older general population...
  3. ncbi request reprint Neurological examination findings to predict limitations in mobility and falls in older persons without a history of neurological disease
    Luigi Ferrucci
    Longitudinal Studies Section, Clinical Research Branch, National Instituts on Aging, National Institute of Health, Baltimore, Maryland 21225, USA
    Am J Med 116:807-15. 2004
    ..To estimate the prevalence of neurological signs and their association with limitations in mobility and falls in a sample of older persons without known neurological disease...
  4. pmc Common variation in the beta-carotene 15,15'-monooxygenase 1 gene affects circulating levels of carotenoids: a genome-wide association study
    Luigi Ferrucci
    Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, United States of America
    Am J Hum Genet 84:123-33. 2009
    ..002). Our findings might shed light on the controversial relationship between lipid-soluble anti-oxidant nutrients and human health...
  5. pmc Association of hormonal dysregulation with metabolic syndrome in older women: data from the InCHIANTI study
    Marcello Maggio
    National Institute on Aging, NIH, NIA ASTRA Unit at Harbor Hospital, 3001 S Hanover St, Baltimore, MD 21225, USA
    Am J Physiol Endocrinol Metab 292:E353-8. 2007
    ..Further studies are needed to support the notion that raising SHBG is a potential therapeutic target for prevention and treatment of MetS...
  6. pmc Low testosterone levels and the risk of anemia in older men and women
    Luigi Ferrucci
    Clinical Research Branch, Longitudinal Studies Section, National Institute on Aging, Baltimore, MD 21225, USA
    Arch Intern Med 166:1380-8. 2006
    ..Anemia is a frequent feature of male hypogonadism and anti-androgenic treatment. We hypothesized that the presence of low testosterone levels in older persons is a risk factor for anemia...
  7. ncbi request reprint A flame burning within
    Luigi Ferrucci
    Intramural Research Program, National Institute on Aging, Baltimore, MD, USA
    Aging Clin Exp Res 16:240-3. 2004
    ..Given that the inflammatory response is a critical age-related process, understanding its regulatory action is essential in avoiding hazardous consequences in old age...
  8. ncbi request reprint The origins of age-related proinflammatory state
    Luigi Ferrucci
    Intramural Research Program, National Institute on Aging, Longitudinal Studies Section, Clinical Research Branch, ASTRA Unit, Harbor Hospital 5th Floor, 3001 S Hanover St, Baltimore, MD, USA
    Blood 105:2294-9. 2005
    ..Part of the "proinflammatory state" in older persons is related to the high prevalence of cardiovascular risk factor and morbidity...
  9. pmc Proinflammatory state, hepcidin, and anemia in older persons
    Luigi Ferrucci
    Intramural Research Program, National Institute on Aging, Baltimore, MD 21225, USA
    Blood 115:3810-6. 2010
    ..Future studies should test whether hepcidin production becomes up-regulated only in situations of overt inflammation...
  10. ncbi request reprint Proinflammatory state and circulating erythropoietin in persons with and without anemia
    Luigi Ferrucci
    Clinical Research Branch, National Institute on Aging, Longitudinal Studies Section Clinical Research Branch, ASTRA Unit, Harbor Hospital Baltimore, MD 21225, USA
    Am J Med 118:1288. 2005
    ..High circulating levels of proinflammatory cytokines cause anemia, perhaps by interacting with erythropoietin production or biological activity. We characterize the relationships of systemic inflammation, erythropoietin, and hemoglobin...
  11. ncbi request reprint Designing randomized, controlled trials aimed at preventing or delaying functional decline and disability in frail, older persons: a consensus report
    Luigi Ferrucci
    Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA
    J Am Geriatr Soc 52:625-34. 2004
    ....
  12. pmc Mapping the road to resilience: novel math for the study of frailty
    Luigi Ferrucci
    Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD 21225, United States
    Mech Ageing Dev 129:677-9. 2008
    ....
  13. ncbi request reprint Relationship of plasma polyunsaturated fatty acids to circulating inflammatory markers
    Luigi Ferrucci
    Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, National Institutes of Health, Harbor Hospital, 5th Floor, 3001 Hanover Street, Baltimore, MD 21225, USA
    J Clin Endocrinol Metab 91:439-46. 2006
    ..The protective effect of PUFAs is mediated by multiple mechanisms, including their antiinflammatory properties. The association of physiological PUFA levels with pro- and antiinflammatory markers has not been established...
  14. pmc Epidemiology of aging
    Luigi Ferrucci
    Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, National Institutes of Health, MD, USA
    Radiol Clin North Am 46:643-52, v. 2008
    ..We come to this enormous challenge unprepared...
  15. pmc Unexplained anaemia in older persons is characterised by low erythropoietin and low levels of pro-inflammatory markers
    Luigi Ferrucci
    Intramural Research Program, National Institute on Aging, Baltimore, MD 21225, USA
    Br J Haematol 136:849-55. 2007
    ..Unexplained anaemia was characterised by unexpectedly low EPO and low lymphocyte count. Unexplained anaemia is associated with reduced kidney EPO response, low levels of pro-inflammatory markers and low lymphocyte counts...
  16. pmc Alzheimer risk variant CLU and brain function during aging
    Madhav Thambisetty
    Laboratory of Behavioral Neuroscience, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
    Biol Psychiatry 73:399-405. 2013
    ....
  17. pmc Oxidative protein damage is associated with poor grip strength among older women living in the community
    Caitlin Howard
    Johns Hopkins Medical Institutions, Baltimore, MD, USA
    J Appl Physiol (1985) 103:17-20. 2007
    ..043). These results suggest oxidative protein damage is independently associated with low grip strength among older women living in the community. Increased oxidative stress may be contributing to loss of muscle strength in older adults...
  18. pmc Higher serum concentrations of dietary antioxidants are associated with lower levels of inflammatory biomarkers during the year after hip fracture
    Christopher R D'Adamo
    Department of Epidemiology and Public Health, University of Maryland School of Medicine, 520 W Lombard Street, East Hall, Baltimore, MD 21201, USA
    Clin Nutr 31:659-65. 2012
    ....
  19. pmc Circulating selenium and carboxymethyl-lysine, an advanced glycation endproduct, are independent predictors of anemia in older community-dwelling adults
    Cindy N Roy
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Nutrition 28:762-6. 2012
    ..To assess whether selenium and carboxymethyl-lysine (CML), two biomarkers of oxidative stress, are independent predictors of anemia in older community-dwelling adults...
  20. pmc Use of the Frank-Starling mechanism during exercise is linked to exercise-induced changes in arterial load
    Paul D Chantler
    Intramural Research Program, National Institute on Aging, Baltimore, Maryland 21225, USA
    Am J Physiol Heart Circ Physiol 302:H349-58. 2012
    ..These findings provide interesting insights into the dynamic cardiovascular alterations during exercise...
  21. ncbi request reprint Correlation between testosterone and the inflammatory marker soluble interleukin-6 receptor in older men
    Marcello Maggio
    Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, Intramural Research Program, National Institutes of Health, Baltimore, Maryland 21225, USA
    J Clin Endocrinol Metab 91:345-7. 2006
    ..An age-associated decline in testosterone (T) levels and an increase in proinflammatory cytokines contribute to chronic diseases in older men. Whether and how these changes are related is unclear...
  22. pmc Advanced glycation end products and their circulating receptors and level of kidney function in older community-dwelling women
    Richard D Semba
    Johns Hopkins Medical Institutions, 550 N Broadway, Baltimore, MD 21205, USA
    Am J Kidney Dis 53:51-8. 2009
    ..Advanced glycation end products (AGEs) and the receptor for AGE (RAGE) are implicated in the pathogenesis of kidney disease; however, their relation with level of kidney function has not been well characterized...
  23. doi request reprint Single nucleotide polymorphisms and the likelihood of prostate cancer at a given prostate specific antigen level
    Stacy Loeb
    James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Urol 182:101-4; discussion 105. 2009
    ..Prostate specific antigen is used for prostate cancer screening but its specificity is limited. Specificity might be increased by considering genotype associated prostate specific antigen levels...
  24. pmc Carboxymethyl-lysine, an advanced glycation end product, and decline of renal function in older community-dwelling adults
    Richard D Semba
    Johns Hopkins University School of Medicine, 550N Broadway, Suite 700, Baltimore, MD 21205, USA
    Eur J Nutr 48:38-44. 2009
    ..AGEs have been associated with impaired renal function in diabetes and in uremia. The relationship between AGEs and renal function in community-dwelling adults has not been well characterized...
  25. pmc Effect of complement CR1 on brain amyloid burden during aging and its modification by APOE genotype
    Madhav Thambisetty
    Laboratory of Behavioral Neuroscience, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA
    Biol Psychiatry 73:422-8. 2013
    ..We examined the association between rs3818361 and brain amyloid deposition in nondemented older individuals...
  26. pmc Apolipoprotein E ε4 allele interacts with sex and cognitive status to influence all-cause and cause-specific mortality in U.S. older adults
    May A Beydoun
    National Institute on Aging, National Institutes of Health, Intramural Research Program, Baltimore, MD 21224, USA
    J Am Geriatr Soc 61:525-34. 2013
    ..To confirm associations of apolipoprotein E (ApoE) ε4 carrier status, sex, and time-dependent cognitive status with mortality risk and to investigate these joint effects of these associations in a cohort of community-dwelling U.S. adults...
  27. pmc Relationship of low plasma klotho with poor grip strength in older community-dwelling adults: the InCHIANTI study
    Richard D Semba
    Department of Ophthalmology, The Johns Hopkins University School of Medicine, Smith Building, M015, 400 N Broadway, Baltimore, MD 21287, USA
    Eur J Appl Physiol 112:1215-20. 2012
    ..20, standard error = 0.35, P = 0.0009) in adults with plasma klotho <681 pg/mL. These results suggest that older adults with lower plasma klotho have poor skeletal muscle strength...
  28. pmc Advanced glycation end products and their circulating receptors predict cardiovascular disease mortality in older community-dwelling women
    Richard D Semba
    Johns Hopkins University School of Medicine, 550 N Broadway, Suite 700, Baltimore, MD 21205, USA
    Aging Clin Exp Res 21:182-90. 2009
    ..To characterize the relationship between advanced glycation end products (AGEs) and circulating receptors for AGEs (RAGE) with cardiovascular disease mortality...
  29. pmc Serum antioxidants and inflammation predict red cell distribution width in older women: the Women's Health and Aging Study I
    Richard D Semba
    Johns Hopkins University School of Medicine, Baltimore, MD 21287, United States
    Clin Nutr 29:600-4. 2010
    ..The aims were to determine whether total serum carotenoids, α-tocopherol, selenium, protein carbonyls, and interleukin-6 (IL-6) are associated with RDW and predict RDW over time...
  30. pmc White blood cell count and mortality in the Baltimore Longitudinal Study of Aging
    Carmelinda Ruggiero
    Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21225, USA
    J Am Coll Cardiol 49:1841-50. 2007
    ..We investigated the secular trend in white blood cell (WBC) count and the relationship between WBC count and mortality between 1958 and 2002...
  31. pmc Elevated serum advanced glycation end products and their circulating receptors are associated with anaemia in older community-dwelling women
    Richard D Semba
    Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Age Ageing 38:283-9. 2009
    ..to determine whether serum carboxymethyl-lysine, a dominant advanced glycation end product (AGE), and circulating total receptor for AGEs (sRAGE) and endogenous secretory receptor for AGEs (esRAGE) are associated with anaemia...
  32. pmc Serum carboxymethyl-lysine, a dominant advanced glycation end product, is associated with chronic kidney disease: the Baltimore longitudinal study of aging
    Richard D Semba
    Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Ren Nutr 20:74-81. 2010
    ..Our objective was to characterize the relationship between AGEs and renal function in community-dwelling adults...
  33. pmc Haemoglobin concentration and the risk of death in older adults: differences by race/ethnicity in the NHANES III follow-up
    Kushang V Patel
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, NIH, Bethesda, MD 20892 9205, USA
    Br J Haematol 145:514-23. 2009
    ..In conclusion, the haemoglobin threshold below which mortality rises significantly is a full g/dl lower in non-Hispanic blacks than in non-Hispanic whites and Mexican Americans...
  34. pmc Plasma klotho and mortality risk in older community-dwelling adults
    Richard D Semba
    Baltimore, MD 21287, USA
    J Gerontol A Biol Sci Med Sci 66:794-800. 2011
    ..It is not known whether there is a relationship between plasma levels of secreted klotho protein and longevity in humans...
  35. pmc Trait antagonism and the progression of arterial thickening: women with antagonistic traits have similar carotid arterial thickness as men
    Angelina R Sutin
    National Institute on Aging, National Institutes of Health, Department of Health and HumanServices, Baltimore, MD 21224
    Hypertension 56:617-22. 2010
    ..Antagonistic individuals, especially those who are manipulative and aggressive, have greater increases in arterial thickening, independent of traditional cardiovascular risk factors...
  36. pmc Usefulness of uric acid to predict changes in C-reactive protein and interleukin-6 in 3-year period in Italians aged 21 to 98 years
    Carmelinda Ruggiero
    Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA
    Am J Cardiol 100:115-21. 2007
    ..In conclusion, our study suggests that in a population-based cohort, baseline UA and changes in circulating UA during 3 years of follow-up predict changes in circulating CRP independent of relevant confounders, including baseline IL-6...
  37. pmc Oxidative stress is associated with greater mortality in older women living in the community
    Richard D Semba
    Department of Ophthalmology, National Institute on Aging, Baltimore, Maryland, USA
    J Am Geriatr Soc 55:1421-5. 2007
    ..To determine whether oxidative stress, as implied by oxidative damage to proteins, is associated with greater mortality in older women living in the community...
  38. pmc Is longitudinal pulse pressure a better predictor of 24-hour urinary albumin excretion than other indices of blood pressure?
    S Morteza Farasat
    MedStar Research Institute, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA
    Hypertension 55:415-21. 2010
    ..The pulsatile component of BP confers the highest risk for BP-induced renal microvascular injury. Future studies should examine whether PP reduction provides additional renoprotection beyond that attained by conventional BP goals alone...
  39. pmc Low serum carotenoids and development of severe walking disability among older women living in the community: the women's health and aging study I
    Richard D Semba
    The Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Age Ageing 36:62-7. 2007
    ..to determine whether low serum carotenoid levels, an indicator of low intake of fruits and vegetables, are associated with the progression of disability in older women...
  40. pmc Types of anemia and mortality among older disabled women living in the community: the Women's Health and Aging Study I
    Richard D Semba
    The Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    Aging Clin Exp Res 19:259-64. 2007
    ..To classify the different types of anemia among moderately to severely disabled women living in the community and examine the relationship between types of anemia and mortality...
  41. pmc Personality and resilience to Alzheimer's disease neuropathology: a prospective autopsy study
    Antonio Terracciano
    National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Neurobiol Aging 34:1045-50. 2013
    ..In sum, a resilient personality profile is associated with lower risk or delay of clinical dementia even in persons with AD neuropathology...
  42. pmc The relationship between plasma carotenoids and depressive symptoms in older persons
    Yuri Milaneschi
    Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, Baltimore, MD 21225, USA
    World J Biol Psychiatry 13:588-98. 2012
    ..We examined the cross-sectional and longitudinal relationship between plasma carotenoids and depressive symptoms over a 6-year follow-up in older persons...
  43. pmc Midlife obesity and trajectories of brain volume changes in older adults
    Ira Driscoll
    Laboratory of Personality and Cognition, National Institute on Aging, Baltimore, MD 21224, USA
    Hum Brain Mapp 33:2204-10. 2012
    ..Moreover, the discrepancies in findings between studies may be in part due to participant sampling and methodological differences...
  44. pmc Hearing loss and cognition in the Baltimore Longitudinal Study of Aging
    Frank R Lin
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
    Neuropsychology 25:763-70. 2011
    ..We hypothesized a priori that greater hearing loss is associated with lower cognitive test scores on tests of memory and executive function...
  45. pmc Circulating oxidized low-density lipoproteins are associated with overweight, obesity, and low serum carotenoids in older community-dwelling women
    Justine Beck
    Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Nutrition 24:964-8. 2008
    ....
  46. pmc Inflammation and race and gender differences in computerized tomography-measured adipose depots
    Lydia E Beasley
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, Maryland, USA
    Obesity (Silver Spring) 17:1062-9. 2009
    ..Despite the previously established differences in abdominal fat distribution across gender and race, visceral fat remained a significant predictor of inflammatory marker concentration across all four subgroups examined...
  47. pmc Longitudinal patterns of β-amyloid deposition in nondemented older adults
    Jitka Sojkova
    Laboratory of Behavioral Neuroscience, National Institutes of Health Biomedical Research Center, National Institute on Aging, Intramural Research Program, 251 Bayview Blvd, Baltimore, MD 21224, USA
    Arch Neurol 68:644-9. 2011
    ..High levels of β-amyloid (Aβ) characterize Alzheimer disease...
  48. pmc Adipocytokines and the metabolic syndrome among older persons with and without obesity: the InCHIANTI study
    Sari Stenholm
    Clinical Research Branch, National Institute on Aging, 3001 S Hanover Street, Baltimore, MD 21225, USA
    Clin Endocrinol (Oxf) 73:55-65. 2010
    ..The purpose of this study was to: (1) examine the role of adipocytokines in the association between obesity and the MetS and (2) to determine whether the association is different in obese and non-obese persons...
  49. pmc Hearing loss and incident dementia
    Frank R Lin
    Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins School of Medicine, JHOC 6120, 601 N Caroline St, Baltimore, MD 21287, USA
    Arch Neurol 68:214-20. 2011
    ..To determine whether hearing loss is associated with incident all-cause dementia and Alzheimer disease (AD)...
  50. pmc Relationship of low-circulating "anti-aging" klotho hormone with disability in activities of daily living among older community-dwelling adults
    Candace L Crasto
    Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Rejuvenation Res 15:295-301. 2012
    ..Low plasma klotho concentrations were independently associated with ADL disability among older community-dwelling men and women...
  51. pmc Genome-wide meta-analysis of observational studies shows common genetic variants associated with macronutrient intake
    Toshiko Tanaka
    Translational Gerontology Branch, National Institute on Aging, Baltimore, MD 21225, USA
    Am J Clin Nutr 97:1395-402. 2013
    ..Macronutrient intake varies substantially between individuals, and there is evidence that this variation is partly accounted for by genetic variants...
  52. pmc Hearing loss and cognitive decline in older adults
    Frank R Lin
    Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins School of Medicine, and Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    JAMA Intern Med 173:293-9. 2013
    ..Further studies are needed to investigate what the mechanistic basis of this association is and whether hearing rehabilitative interventions could affect cognitive decline...
  53. pmc Carotid atherosclerosis and prospective risk of dementia
    Carrington R Wendell
    Intramural Research Program, National Institute on Aging, NIH, 251 Bayview Blvd, Baltimore, MD 21224, USA
    Stroke 43:3319-24. 2012
    ..Although vascular risk factors have been implicated in the development of all-cause dementia and Alzheimer disease (AD), few studies have examined the association between subclinical atherosclerosis and prospective risk of dementia...
  54. pmc Fear of falling and visual field loss from glaucoma
    Pradeep Y Ramulu
    Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland 21287, USA
    Ophthalmology 119:1352-8. 2012
    ..To determine if visual field (VF) loss resulting from glaucoma is associated with greater fear of falling...
  55. pmc Selective contribution of regional adiposity, skeletal muscle, and adipokines to glucose disposal in older adults
    Ramona Ramachandran
    Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21225, USA
    J Am Geriatr Soc 60:707-12. 2012
    ..To study the relationships between muscle mass, regional adiposity, and adipokines and glucose disposal in an older population...
  56. pmc Serum fibroblast growth factor-23 and risk of incident chronic kidney disease in older community-dwelling women
    Richard D Semba
    Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Clin J Am Soc Nephrol 7:85-91. 2012
    ..This study aimed to determine whether circulating FGF23 predicts incident CKD in community-dwelling women...
  57. pmc Relationship of serum fibroblast growth factor 21 with abnormal glucose metabolism and insulin resistance: the Baltimore Longitudinal Study of Aging
    Richard D Semba
    Department of Opthalmology, Johns Hopkins School of Medicine, Smith Building, 400 North Broadway, M015, Baltimore, Maryland 21287, USA
    J Clin Endocrinol Metab 97:1375-82. 2012
    ..The relationship of fibroblast growth factor 21 (FGF21) with glucose metabolism and insulin resistance has not been well characterized in community-dwelling adults...
  58. pmc Serum 25-hydroxyvitamin D, transitions between frailty states, and mortality in older adults: the Invecchiare in Chianti Study
    Michelle Shardell
    Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland, USA
    J Am Geriatr Soc 60:256-64. 2012
    ..To assess whether serum 25-hydroxyvitamin D (25(OH)D) concentrations relate to transitions between the states of robustness, prefrailty, and frailty and to mortality in older adults...
  59. pmc Low-serum carotenoid concentrations and carotenoid interactions predict mortality in US adults: the Third National Health and Nutrition Examination Survey
    Michelle D Shardell
    Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Nutr Res 31:178-89. 2011
    ..Interventions of balanced carotenoid combinations are needed for confirmation...
  60. pmc The central arterial burden of the metabolic syndrome is similar in men and women: the SardiNIA Study
    Angelo Scuteri
    Laboratory of Cardiovascular Sciences, National Institute on Aging, NIH, Baltimore, USA
    Eur Heart J 31:602-13. 2010
    ..We evaluated whether specific clusters of metabolic syndrome (MetS) components differentially impact on arterial structure and function, and whether the impact is similar in men and in women...
  61. pmc Relationship between low levels of anabolic hormones and 6-year mortality in older men: the aging in the Chianti Area (InCHIANTI) study
    Marcello Maggio
    National Institute on Aging, National Institutes of Health, NIA Clinical Research Branch at Harbor Hospital, 3001 S Hanover Street, Baltimore, MD 21225, USA
    Arch Intern Med 167:2249-54. 2007
    ..We hypothesized that in older men a parallel age-associated decline in bioavailable testosterone, IGF-1, and DHEA-S secretion is associated with higher mortality independent of potential confounders...
  62. pmc Oxidative protein damage is associated with elevated serum interleukin-6 levels among older moderately to severely disabled women living in the community
    Margaret Dayhoff-Brannigan
    John Hopkins Medical Institutes, Baltimore, MD, USA
    J Gerontol A Biol Sci Med Sci 63:179-83. 2008
    ..Elevated interleukin (IL)-6 is associated with adverse outcomes. Our objective was to determine whether serum protein carbonyls, an indicator of oxidative protein damage and oxidative stress, were associated with IL-6...
  63. pmc Serum vitamin E concentrations and recovery of physical function during the year after hip fracture
    Christopher R D'Adamo
    Baltimore, MD 21201, USA
    J Gerontol A Biol Sci Med Sci 66:784-93. 2011
    ..Low serum concentrations of vitamin E have been associated with decline in physical function among older adults, but the role of vitamin E in physical recovery from hip fracture has never been explored...
  64. pmc Does prostate growth confound prostate specific antigen velocity? Data from the Baltimore longitudinal study of aging
    Stacy Loeb
    The James Buchanan Brady Urological Institute, The Johns Hopkins Medical Institutions and National Institute on Aging, National Institutes of Health Clinical Research Branch, Baltimore, Maryland, USA
    J Urol 180:1314-7; discussion 1317. 2008
    ..Thus, we investigated the relationship between changes in prostate size and prostate specific antigen changes in a large cohort of men without prostate cancer...
  65. pmc Arterial stiffness and bone demineralization: the Baltimore longitudinal study of aging
    Francesco Giallauria
    Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, Baltimore, Maryland, USA
    Am J Hypertens 24:970-5. 2011
    ..The aims of this study were to evaluate whether the association between arterial stiffness and bone demineralization is independent of age, and to explore putative mechanisms that may mediate their relationship...
  66. pmc Personality and metabolic syndrome
    Angelina R Sutin
    Laboratory of Personality and Cognition, National Institute on Aging, NIH, DHHS, 251 Bayview Blvd, Baltimore, MD 21224, USA
    Age (Dordr) 32:513-9. 2010
    ..The present research indicates that those with fewer psychological resources are more vulnerable to metabolic syndrome and suggests a psychological component to other established risk factors...
  67. pmc Association between hormones and metabolic syndrome in older Italian men
    Marcello Maggio
    Clinical Research Branch, National Institute on Aging, Baltimore, Maryland 21225, USA
    J Am Geriatr Soc 54:1832-8. 2006
    ....
  68. ncbi request reprint What constitutes normal hemoglobin concentration in community-dwelling disabled older women?
    Paulo H M Chaves
    Johns Hopkins Center on Aging and Health, 2024 E Monument Street, Baltimore, MD 21205, USA
    J Am Geriatr Soc 52:1811-6. 2004
    ....
  69. pmc Uric acid and inflammatory markers
    Carmelinda Ruggiero
    Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, NIH, Baltimore, MD, USA
    Eur Heart J 27:1174-81. 2006
    ..Epidemiological studies have recently shown that UA may be a risk factor for cardiovascular diseases and a negative prognostic marker for mortality in subjects with pre-existing heart failure...
  70. ncbi request reprint Lower plasma vitamin E levels are associated with the frailty syndrome: the InCHIANTI study
    Alessandro Ble
    Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD 21225, USA
    J Gerontol A Biol Sci Med Sci 61:278-83. 2006
    ....
  71. pmc Relation of angiotensin-converting enzyme inhibitor treatment to insulin-like growth factor-1 serum levels in subjects >65 years of age (the InCHIANTI study)
    Marcello Maggio
    Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, Intramural Research Program, National Institutes of Health, Bethesda, Maryland, USA
    Am J Cardiol 97:1525-9. 2006
    ..This may be 1 of the mechanisms by which ACE inhibitors might slow the decreases in muscle strength and physical function that are often observed in older subjects...
  72. pmc Low serum selenium concentrations are associated with poor grip strength among older women living in the community
    Justine Beck
    Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Biofactors 29:37-44. 2007
    ..04). This study supports the idea that selenium is important to muscle strength in older women...
  73. pmc Real-world assessment of physical activity in glaucoma using an accelerometer
    Pradeep Y Ramulu
    Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland 21287, USA
    Ophthalmology 119:1159-66. 2012
    ..To determine the association between glaucomatous visual field (VF) loss and the amount of physical activity and walking in normal life...
  74. pmc PSA doubling time versus PSA velocity to predict high-risk prostate cancer: data from the Baltimore Longitudinal Study of Aging
    Stacy Loeb
    Department of Urology, The Johns Hopkins University School of Medicine, The James Buchanan Brady Urological Institute, The Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
    Eur Urol 54:1073-80. 2008
    ..Less is known about the relative utility of pretreatment PSA doubling time (PSA DT) to predict tumor aggressiveness...
  75. ncbi request reprint High basal metabolic rate is a risk factor for mortality: the Baltimore Longitudinal Study of Aging
    Carmelinda Ruggiero
    National Institute on Aging, NIH, Harbor Hospital, Baltimore, MD 21225, USA
    J Gerontol A Biol Sci Med Sci 63:698-706. 2008
    ..We evaluate the longitudinal changes in BMR and the relationship between BMR and mortality in the Baltimore Longitudinal Study of Aging (BLSA) participants...
  76. pmc Endogenous secretory receptor for advanced glycation end products and chronic kidney disease in the elderly population
    Mansi Dalal
    Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Am J Nephrol 33:313-8. 2011
    ..The aim of the study was to determine whether plasma esRAGE is associated with CKD and is predictive of developing CKD in older adults...
  77. pmc Gender differences in the accuracy of time-dependent blood pressure indices for predicting coronary heart disease: A random-effects modeling approach
    Larry J Brant
    Research Resources Branch, National Institute on Aging, Baltimore, Maryland, USA
    Gend Med 7:616-27. 2010
    ....
  78. pmc Glucose and insulin measurements from the oral glucose tolerance test and mortality prediction
    E Jeffrey Metter
    Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, Intramural Research Program, National Institutes of Health, Baltimore, Maryland 21225, USA
    Diabetes Care 31:1026-30. 2008
    ..To verify what information from oral glucose tolerance tests (OGTTs) independently predicts mortality...
  79. pmc Relationship between plasma ghrelin, insulin, leptin, interleukin 6, adiponectin, testosterone and longevity in the Baltimore Longitudinal Study of Aging
    Sari Stenholm
    National Institute on Aging, Clinical Research Branch, Longitudinal Studies Section, Baltimore, MD 21225, USA
    Aging Clin Exp Res 23:153-8. 2011
    ..In this study we examine the association between other potential biomarkers related to CR and extended lifespan in healthy humans...
  80. ncbi request reprint Baseline total and specific differential white blood cell counts and 5-year all-cause mortality in community-dwelling older women
    Sean X Leng
    Division of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Exp Gerontol 40:982-7. 2005
    ..They provide a basis for further investigation into the role of leukocytes in age-related inflammation and its associated adverse outcomes in older adults...
  81. pmc Abnormalities in arterial-ventricular coupling in older healthy persons are attenuated by sodium nitroprusside
    Paul D Chantler
    Laboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA
    Am J Physiol Heart Circ Physiol 300:H1914-22. 2011
    ..This is relevant to common conditions in older subjects associated with a significant impairment of exercise performance such as frailty or heart failure with preserved ejection fraction...
  82. ncbi request reprint Relation of plasma leptin to C-reactive protein in older adults (from the Invecchiare nel Chianti study)
    Alessandro Ble
    Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA
    Am J Cardiol 96:991-5. 2005
    ..In conclusion, these findings suggest that leptin may directly stimulate the production of CRP independent of fat-cell produced cytokines in older adults...
  83. pmc Body fat distribution and inflammation among obese older adults with and without metabolic syndrome
    Annemarie Koster
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, Maryland, USA
    Obesity (Silver Spring) 18:2354-61. 2010
    ....
  84. pmc Characteristics of 400-meter walk test performance and subsequent mortality in older adults
    Sonja Vestergaard
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892 9205, USA
    Rejuvenation Res 12:177-84. 2009
    ..We conclude that multiple aspects of performance in the 400-meter walk test provide complementary information on mortality prognosis in older persons...
  85. pmc Joint association of obesity and metabolic syndrome with incident mobility limitation in older men and women--results from the Health, Aging, and Body Composition Study
    Sari Stenholm
    Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, Harbor Hospital, 3001 South Hanover Street, Baltimore, MD 21225, USA
    J Gerontol A Biol Sci Med Sci 65:84-92. 2010
    ..Although both obesity and the metabolic syndrome (MetS) are known risk factors for decline in physical function, the joint association of obesity and metabolic alterations with risk of incident mobility limitation is unknown...
  86. pmc The interplay between uric acid and antioxidants in relation to physical function in older persons
    Carmelinda Ruggiero
    Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21225, USA
    J Am Geriatr Soc 55:1206-15. 2007
    ..To investigate the relationship between circulating uric acid (UA) levels and plasma antioxidants and whether antioxidant levels modulate the association between UA and physical function...
  87. ncbi request reprint Renal function, erythropoietin, and anemia of older persons: the InCHIANTI study
    Alessandro Ble
    Longitudinal Studies Section, National Institute on Aging, National Institutes of Health, Baltimore, MD 21225, USA
    Arch Intern Med 165:2222-7. 2005
    ..We tested the hypothesis that the age-related decline in kidney function is associated with an increased prevalence of anemia and that such an increase is accompanied by a concomitant decrement in erythropoietin levels...
  88. pmc Sex-specific correlates of walking speed in a wide age-ranged population
    Magdalena I Tolea
    Clinical Research Branch, National Institute on Aging, Harbor Hospital, 3001 South Hanover Street, Baltimore, MD 21225, USA
    J Gerontol B Psychol Sci Soc Sci 65:174-84. 2010
    ..If these patterns are confirmed in longitudinal studies, personality may be an important target for prevention...
  89. ncbi request reprint Insulin-like growth factor I and interleukin-6 contribute synergistically to disability and mortality in older women
    Anne R Cappola
    Department of Medicine, University of Maryland, Baltimore, Maryland 21201, USA
    J Clin Endocrinol Metab 88:2019-25. 2003
    ..The joint effects of IGF-I and IL-6 may be important targets for treatments to prevent or minimize disability associated with aging...
  90. ncbi request reprint The frailty syndrome: a critical issue in geriatric oncology
    Luigi Ferrucci
    Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA
    Crit Rev Oncol Hematol 46:127-37. 2003
    ..Improvements in the definition of the frailty syndrome may profit from the clinical experience of oncologists...
  91. pmc Characteristic gait patterns in older adults with obesity--results from the Baltimore Longitudinal Study of Aging
    Seung uk Ko
    Clinical Research Branch, NIA, Harbor Hospital, 3001 S Hanover Street, Baltimore, MD 21225, USA
    J Biomech 43:1104-10. 2010
    ..Since forward progression forces are mainly implicated in normal walking, this pattern found in obese participants is suggestive of lower energetic efficiency...
  92. pmc Variants of the serotonin transporter gene and NEO-PI-R Neuroticism: No association in the BLSA and SardiNIA samples
    Antonio Terracciano
    National Institute on Aging, NIH, DHHS, Baltimore, Maryland 21224, USA
    Am J Med Genet B Neuropsychiatr Genet 150:1070-7. 2009
    ..Along with other large studies that used different phenotypic measures and found no association, this study substantially increases the evidence against a link between 5-HTT variants and Neuroticism-related traits...
  93. pmc Anabolic and catabolic biomarkers as predictors of muscle strength decline: the InCHIANTI study
    Sari Stenholm
    National Institute on Aging, Clinical Research Branch, Longitudinal Studies Section, Baltimore, Maryland 21225, USA
    Rejuvenation Res 13:3-11. 2010
    ..This study aims to examine whether high levels of multiple catabolic and low levels of multiple anabolic biomarkers predict accelerated decline of muscle strength...
  94. pmc Red cell distribution width and mortality in older adults: a meta-analysis
    Kushang V Patel
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, Maryland 20892 9205, USA
    J Gerontol A Biol Sci Med Sci 65:258-65. 2010
    ..Whether RDW is prognostic in more representative community-based populations is unclear...
  95. pmc Sarcopenic obesity: definition, cause and consequences
    Sari Stenholm
    Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, Baltimore, Maryland 21225 1233, USA
    Curr Opin Clin Nutr Metab Care 11:693-700. 2008
    ..Tantamount to this discussion is whether low muscle mass or, rather, muscle weakness should be used for the definition...
  96. pmc Relationship of an advanced glycation end product, plasma carboxymethyl-lysine, with slow walking speed in older adults: the InCHIANTI study
    Richard D Semba
    Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Eur J Appl Physiol 108:191-5. 2010
    ..R. 1.87, 95% C.I. 1.15-3.04, P = 0.01) adjusting for the same covariates. In older community-dwelling adults, elevated plasma CML is independently associated with slow walking speed...
  97. pmc Upregulated ex vivo expression of stress-responsive inflammatory pathway genes by LPS-challenged CD14(+) monocytes in frail older adults
    Tao Qu
    Johns Hopkins University School of Medicine, Biology of Frailty Program, Division of Geriatric Medicine and Gerontology, Department of Medicine, Baltimore, MD, USA
    Mech Ageing Dev 130:161-6. 2009
    ..These findings suggest upregulated expression of specific stress-responsive genes in monocyte-mediated inflammatory pathway in the syndrome of frailty with potential mechanistic and interventional implications...
  98. pmc Low serum 25-hydroxyvitamin D concentrations are associated with greater all-cause mortality in older community-dwelling women
    Richard D Semba
    Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, MD 21287, USA
    Nutr Res 29:525-30. 2009
    ..4 nmol/L) of 25(OH)D in a multivariate Cox proportional hazards model adjusting for demographics, season, and conventional risk factors. Older community-dwelling women with low 25(OH)D levels are at an increased risk of death...
  99. ncbi request reprint Handgrip strength and cause-specific and total mortality in older disabled women: exploring the mechanism
    Taina Rantanen
    Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA
    J Am Geriatr Soc 51:636-41. 2003
    ....
  100. pmc The energetic pathway to mobility loss: an emerging new framework for longitudinal studies on aging
    Jennifer A Schrack
    Center on Aging and Health, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Am Geriatr Soc 58:S329-36. 2010
    ..The main premise is simple: the biochemical processes that maintain life, secure homeostatic equilibrium, and prevent the collapse of health require energy. If energy becomes deficient, adaptive behaviors develop to conserve energy...
  101. pmc Age-related mechanical work expenditure during normal walking: the Baltimore Longitudinal Study of Aging
    Seung uk Ko
    National Institute on Aging NIA, Clinical Research Branch, Harbor Hospital, 3001 S Hanover Street, Baltimore MD 21225 United States
    J Biomech 42:1834-9. 2009
    ..003). These age-related gait patterns may represent a compensatory effort to maintain balance and may also reflect mobility limitations...