Research Topics
Genomes and Genes
Species | Luigi FerrucciSummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
Genome-wide association analysis of total cholesterol and high-density lipoprotein cholesterol levels using the Framingham heart study dataLi Ma
Department of Animal Science, University of Minnesota, USA
BMC Med Genet 11:55. 2010..Here, we report single-locus and epistasis SNP effects on TC and HDL-C using the Framingham Heart Study (FHS) data...
Effects of the diabetes linked TCF7L2 polymorphism in a representative older populationDavid Melzer
Peninsula Medical School, RD and E Wonford Site, Barrack Road, Exeter, EX2 5DW, UK
BMC Med 4:34. 2006..We aimed to estimate associations of the marker rs7903146 (C/T) polymorphism with fasting glucose, lipids, diabetes prevalence and complications in an older general population...- Common variation in the beta-carotene 15,15'-monooxygenase 1 gene affects circulating levels of carotenoids: a genome-wide association studyLuigi Ferrucci
Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, United States of America
Am J Hum Genet 84:123-33. 2009..002). Our findings might shed light on the controversial relationship between lipid-soluble anti-oxidant nutrients and human health... - Mapping the road to resilience: novel math for the study of frailtyLuigi Ferrucci
Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD 21225, United States
Mech Ageing Dev 129:677-9. 2008.... 
The origins of age-related proinflammatory stateLuigi Ferrucci
Intramural Research Program, National Institute on Aging, Longitudinal Studies Section, Clinical Research Branch, ASTRA Unit, Harbor Hospital 5th Floor, 3001 S Hanover St, Baltimore, MD, USA
Blood 105:2294-9. 2005..Part of the "proinflammatory state" in older persons is related to the high prevalence of cardiovascular risk factor and morbidity...- Epidemiology of agingLuigi Ferrucci
Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, National Institutes of Health, MD, USA
Radiol Clin North Am 46:643-52, v. 2008..We come to this enormous challenge unprepared... - Proinflammatory state and circulating erythropoietin in persons with and without anemiaLuigi Ferrucci
Clinical Research Branch, National Institute on Aging, Longitudinal Studies Section Clinical Research Branch, ASTRA Unit, Harbor Hospital Baltimore, MD 21225, USA
Am J Med 118:1288. 2005..High circulating levels of proinflammatory cytokines cause anemia, perhaps by interacting with erythropoietin production or biological activity. We characterize the relationships of systemic inflammation, erythropoietin, and hemoglobin... - Relationship of plasma polyunsaturated fatty acids to circulating inflammatory markersLuigi Ferrucci
Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, National Institutes of Health, Harbor Hospital, 5th Floor, 3001 Hanover Street, Baltimore, MD 21225, USA
J Clin Endocrinol Metab 91:439-46. 2006..The protective effect of PUFAs is mediated by multiple mechanisms, including their antiinflammatory properties. The association of physiological PUFA levels with pro- and antiinflammatory markers has not been established... - Proinflammatory state, hepcidin, and anemia in older personsLuigi Ferrucci
Intramural Research Program, National Institute on Aging, Baltimore, MD 21225, USA
Blood 115:3810-6. 2010..Future studies should test whether hepcidin production becomes up-regulated only in situations of overt inflammation... - Low testosterone levels and the risk of anemia in older men and womenLuigi Ferrucci
Clinical Research Branch, Longitudinal Studies Section, National Institute on Aging, Baltimore, MD 21225, USA
Arch Intern Med 166:1380-8. 2006..Anemia is a frequent feature of male hypogonadism and anti-androgenic treatment. We hypothesized that the presence of low testosterone levels in older persons is a risk factor for anemia... - Association of hormonal dysregulation with metabolic syndrome in older women: data from the InCHIANTI studyMarcello Maggio
National Institute on Aging, NIH, NIA ASTRA Unit at Harbor Hospital, 3001 S Hanover St, Baltimore, MD 21225, USA
Am J Physiol Endocrinol Metab 292:E353-8. 2007..Further studies are needed to support the notion that raising SHBG is a potential therapeutic target for prevention and treatment of MetS... - Unexplained anaemia in older persons is characterised by low erythropoietin and low levels of pro-inflammatory markersLuigi Ferrucci
Intramural Research Program, National Institute on Aging, Baltimore, MD 21225, USA
Br J Haematol 136:849-55. 2007..Unexplained anaemia was characterised by unexpectedly low EPO and low lymphocyte count. Unexplained anaemia is associated with reduced kidney EPO response, low levels of pro-inflammatory markers and low lymphocyte counts... - A flame burning withinLuigi Ferrucci
Intramural Research Program, National Institute on Aging, Baltimore, MD, USA
Aging Clin Exp Res 16:240-3. 2004..Given that the inflammatory response is a critical age-related process, understanding its regulatory action is essential in avoiding hazardous consequences in old age... - Neurological examination findings to predict limitations in mobility and falls in older persons without a history of neurological diseaseLuigi Ferrucci
Longitudinal Studies Section, Clinical Research Branch, National Instituts on Aging, National Institute of Health, Baltimore, Maryland 21225, USA
Am J Med 116:807-15. 2004..To estimate the prevalence of neurological signs and their association with limitations in mobility and falls in a sample of older persons without known neurological disease... - Designing randomized, controlled trials aimed at preventing or delaying functional decline and disability in frail, older persons: a consensus reportLuigi Ferrucci
Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA
J Am Geriatr Soc 52:625-34. 2004.... - Oxidative protein damage is associated with poor grip strength among older women living in the communityCaitlin Howard
Johns Hopkins Medical Institutions, Baltimore, MD, USA
J Appl Physiol 103:17-20. 2007..043). These results suggest oxidative protein damage is independently associated with low grip strength among older women living in the community. Increased oxidative stress may be contributing to loss of muscle strength in older adults... - Circulating selenium and carboxymethyl-lysine, an advanced glycation endproduct, are independent predictors of anemia in older community-dwelling adultsCindy N Roy
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Nutrition 28:762-6. 2012..To assess whether selenium and carboxymethyl-lysine (CML), two biomarkers of oxidative stress, are independent predictors of anemia in older community-dwelling adults... - Use of the Frank-Starling mechanism during exercise is linked to exercise-induced changes in arterial loadPaul D Chantler
Intramural Research Program, National Institute on Aging, Baltimore, Maryland 21225, USA
Am J Physiol Heart Circ Physiol 302:H349-58. 2012..These findings provide interesting insights into the dynamic cardiovascular alterations during exercise... - Correlation between testosterone and the inflammatory marker soluble interleukin-6 receptor in older menMarcello Maggio
Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, Intramural Research Program, National Institutes of Health, Baltimore, Maryland 21225, USA
J Clin Endocrinol Metab 91:345-7. 2006..05). T was not correlated with any other inflammatory marker. CONCLUSIONS: These preliminary findings suggest an inverse relationship between T and sIL-6r. Longitudinal studies are needed to establish the causality of this association... - Advanced glycation end products and their circulating receptors and level of kidney function in older community-dwelling womenRichard D Semba
Johns Hopkins Medical Institutions, 550 N Broadway, Baltimore, MD 21205, USA
Am J Kidney Dis 53:51-8. 2009..Advanced glycation end products (AGEs) and the receptor for AGE (RAGE) are implicated in the pathogenesis of kidney disease; however, their relation with level of kidney function has not been well characterized... 
Single nucleotide polymorphisms and the likelihood of prostate cancer at a given prostate specific antigen levelStacy Loeb
James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
J Urol 182:101-4; discussion 105. 2009..Prostate specific antigen is used for prostate cancer screening but its specificity is limited. Specificity might be increased by considering genotype associated prostate specific antigen levels...- Carboxymethyl-lysine, an advanced glycation end product, and decline of renal function in older community-dwelling adultsRichard D Semba
Johns Hopkins University School of Medicine, 550N Broadway, Suite 700, Baltimore, MD 21205, USA
Eur J Nutr 48:38-44. 2009..AGEs have been associated with impaired renal function in diabetes and in uremia. The relationship between AGEs and renal function in community-dwelling adults has not been well characterized... - Relationship of low plasma klotho with poor grip strength in older community-dwelling adults: the InCHIANTI studyRichard D Semba
Department of Ophthalmology, The Johns Hopkins University School of Medicine, Smith Building, M015, 400 N Broadway, Baltimore, MD 21287, USA
Eur J Appl Physiol 112:1215-20. 2012..20, standard error = 0.35, P = 0.0009) in adults with plasma klotho <681 pg/mL. These results suggest that older adults with lower plasma klotho have poor skeletal muscle strength... - Serum carboxymethyl-lysine, a dominant advanced glycation end product, is associated with chronic kidney disease: the Baltimore longitudinal study of agingRichard D Semba
Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
J Ren Nutr 20:74-81. 2010..Our objective was to characterize the relationship between AGEs and renal function in community-dwelling adults... - Serum antioxidants and inflammation predict red cell distribution width in older women: the Women's Health and Aging Study IRichard D Semba
Johns Hopkins University School of Medicine, Baltimore, MD 21287, United States
Clin Nutr 29:600-4. 2010..The aims were to determine whether total serum carotenoids, α-tocopherol, selenium, protein carbonyls, and interleukin-6 (IL-6) are associated with RDW and predict RDW over time... - Advanced glycation end products and their circulating receptors predict cardiovascular disease mortality in older community-dwelling womenRichard D Semba
Johns Hopkins University School of Medicine, 550 N Broadway, Suite 700, Baltimore, MD 21205, USA
Aging Clin Exp Res 21:182-90. 2009..To characterize the relationship between advanced glycation end products (AGEs) and circulating receptors for AGEs (RAGE) with cardiovascular disease mortality... - White blood cell count and mortality in the Baltimore Longitudinal Study of AgingCarmelinda Ruggiero
Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21225, USA
J Am Coll Cardiol 49:1841-50. 2007..We investigated the secular trend in white blood cell (WBC) count and the relationship between WBC count and mortality between 1958 and 2002... - Elevated serum advanced glycation end products and their circulating receptors are associated with anaemia in older community-dwelling womenRichard D Semba
Johns Hopkins University School of Medicine, Baltimore, MD, USA
Age Ageing 38:283-9. 2009..to determine whether serum carboxymethyl-lysine, a dominant advanced glycation end product (AGE), and circulating total receptor for AGEs (sRAGE) and endogenous secretory receptor for AGEs (esRAGE) are associated with anaemia... - Haemoglobin concentration and the risk of death in older adults: differences by race/ethnicity in the NHANES III follow-upKushang V Patel
Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, NIH, Bethesda, MD 20892 9205, USA
Br J Haematol 145:514-23. 2009..In conclusion, the haemoglobin threshold below which mortality rises significantly is a full g/dl lower in non-Hispanic blacks than in non-Hispanic whites and Mexican Americans... - Plasma klotho and mortality risk in older community-dwelling adultsRichard D Semba
Baltimore, MD 21287, USA
J Gerontol A Biol Sci Med Sci 66:794-800. 2011..It is not known whether there is a relationship between plasma levels of secreted klotho protein and longevity in humans... - Oxidative stress is associated with greater mortality in older women living in the communityRichard D Semba
Department of Ophthalmology, National Institute on Aging, Baltimore, Maryland, USA
J Am Geriatr Soc 55:1421-5. 2007..To determine whether oxidative stress, as implied by oxidative damage to proteins, is associated with greater mortality in older women living in the community... - Types of anemia and mortality among older disabled women living in the community: the Women's Health and Aging Study IRichard D Semba
The Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
Aging Clin Exp Res 19:259-64. 2007..To classify the different types of anemia among moderately to severely disabled women living in the community and examine the relationship between types of anemia and mortality... - Usefulness of uric acid to predict changes in C-reactive protein and interleukin-6 in 3-year period in Italians aged 21 to 98 yearsCarmelinda Ruggiero
Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA
Am J Cardiol 100:115-21. 2007..In conclusion, our study suggests that in a population-based cohort, baseline UA and changes in circulating UA during 3 years of follow-up predict changes in circulating CRP independent of relevant confounders, including baseline IL-6... - Trait antagonism and the progression of arterial thickening: women with antagonistic traits have similar carotid arterial thickness as menAngelina R Sutin
National Institute on Aging, National Institutes of Health, Department of Health and HumanServices, Baltimore, MD 21224
Hypertension 56:617-22. 2010..Antagonistic individuals, especially those who are manipulative and aggressive, have greater increases in arterial thickening, independent of traditional cardiovascular risk factors... - Low serum carotenoids and development of severe walking disability among older women living in the community: the women's health and aging study IRichard D Semba
The Johns Hopkins Medical Institutions, Baltimore, MD, USA
Age Ageing 36:62-7. 2007..to determine whether low serum carotenoid levels, an indicator of low intake of fruits and vegetables, are associated with the progression of disability in older women... - Is longitudinal pulse pressure a better predictor of 24-hour urinary albumin excretion than other indices of blood pressure?S Morteza Farasat
MedStar Research Institute, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA
Hypertension 55:415-21. 2010..The pulsatile component of BP confers the highest risk for BP-induced renal microvascular injury. Future studies should examine whether PP reduction provides additional renoprotection beyond that attained by conventional BP goals alone... - Midlife obesity and trajectories of brain volume changes in older adultsIra Driscoll
Laboratory of Personality and Cognition, National Institute on Aging, Baltimore, MD 21224, USA
Hum Brain Mapp 33:2204-10. 2012..Moreover, the discrepancies in findings between studies may be in part due to participant sampling and methodological differences... - Hearing loss and cognition in the Baltimore Longitudinal Study of AgingFrank R Lin
Department of Otolaryngology Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
Neuropsychology 25:763-70. 2011..We hypothesized a priori that greater hearing loss is associated with lower cognitive test scores on tests of memory and executive function... - Inflammation and race and gender differences in computerized tomography-measured adipose depotsLydia E Beasley
Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, Maryland, USA
Obesity (Silver Spring) 17:1062-9. 2009..Despite the previously established differences in abdominal fat distribution across gender and race, visceral fat remained a significant predictor of inflammatory marker concentration across all four subgroups examined... - Longitudinal patterns of β-amyloid deposition in nondemented older adultsJitka Sojkova
Laboratory of Behavioral Neuroscience, National Institutes of Health Biomedical Research Center, National Institute on Aging, Intramural Research Program, 251 Bayview Blvd, Baltimore, MD 21224, USA
Arch Neurol 68:644-9. 2011..High levels of β-amyloid (Aβ) characterize Alzheimer disease... - Circulating oxidized low-density lipoproteins are associated with overweight, obesity, and low serum carotenoids in older community-dwelling womenJustine Beck
Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
Nutrition 24:964-8. 2008.... - Hearing loss and incident dementiaFrank R Lin
Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins School of Medicine, JHOC 6120, 601 N Caroline St, Baltimore, MD 21287, USA
Arch Neurol 68:214-20. 2011..To determine whether hearing loss is associated with incident all-cause dementia and Alzheimer disease (AD)... - Adipocytokines and the metabolic syndrome among older persons with and without obesity: the InCHIANTI studySari Stenholm
Clinical Research Branch, National Institute on Aging, 3001 S Hanover Street, Baltimore, MD 21225, USA
Clin Endocrinol (Oxf) 73:55-65. 2010..The purpose of this study was to: (1) examine the role of adipocytokines in the association between obesity and the MetS and (2) to determine whether the association is different in obese and non-obese persons... - Carotid atherosclerosis and prospective risk of dementiaCarrington R Wendell
Intramural Research Program, National Institute on Aging, NIH, 251 Bayview Blvd, Baltimore, MD 21224, USA
Stroke 43:3319-24. 2012..Although vascular risk factors have been implicated in the development of all-cause dementia and Alzheimer disease (AD), few studies have examined the association between subclinical atherosclerosis and prospective risk of dementia... - Fear of falling and visual field loss from glaucomaPradeep Y Ramulu
Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland 21287, USA
Ophthalmology 119:1352-8. 2012..To determine if visual field (VF) loss resulting from glaucoma is associated with greater fear of falling... - Selective contribution of regional adiposity, skeletal muscle, and adipokines to glucose disposal in older adultsRamona Ramachandran
Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21225, USA
J Am Geriatr Soc 60:707-12. 2012..To study the relationships between muscle mass, regional adiposity, and adipokines and glucose disposal in an older population... - Serum fibroblast growth factor-23 and risk of incident chronic kidney disease in older community-dwelling womenRichard D Semba
Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
Clin J Am Soc Nephrol 7:85-91. 2012..This study aimed to determine whether circulating FGF23 predicts incident CKD in community-dwelling women... - Relationship of serum fibroblast growth factor 21 with abnormal glucose metabolism and insulin resistance: the Baltimore Longitudinal Study of AgingRichard D Semba
Department of Opthalmology, Johns Hopkins School of Medicine, Smith Building, 400 North Broadway, M015, Baltimore, Maryland 21287, USA
J Clin Endocrinol Metab 97:1375-82. 2012..The relationship of fibroblast growth factor 21 (FGF21) with glucose metabolism and insulin resistance has not been well characterized in community-dwelling adults... - Serum 25-hydroxyvitamin D, transitions between frailty states, and mortality in older adults: the Invecchiare in Chianti StudyMichelle Shardell
Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland, USA
J Am Geriatr Soc 60:256-64. 2012..To assess whether serum 25-hydroxyvitamin D (25(OH)D) concentrations relate to transitions between the states of robustness, prefrailty, and frailty and to mortality in older adults... - Does prostate growth confound prostate specific antigen velocity? Data from the Baltimore longitudinal study of agingStacy Loeb
The James Buchanan Brady Urological Institute, The Johns Hopkins Medical Institutions and National Institute on Aging, National Institutes of Health Clinical Research Branch, Baltimore, Maryland, USA
J Urol 180:1314-7; discussion 1317. 2008..Thus, we investigated the relationship between changes in prostate size and prostate specific antigen changes in a large cohort of men without prostate cancer... - Oxidative protein damage is associated with elevated serum interleukin-6 levels among older moderately to severely disabled women living in the communityMargaret Dayhoff-Brannigan
John Hopkins Medical Institutes, Baltimore, MD, USA
J Gerontol A Biol Sci Med Sci 63:179-83. 2008..Elevated interleukin (IL)-6 is associated with adverse outcomes. Our objective was to determine whether serum protein carbonyls, an indicator of oxidative protein damage and oxidative stress, were associated with IL-6... - The central arterial burden of the metabolic syndrome is similar in men and women: the SardiNIA StudyAngelo Scuteri
Laboratory of Cardiovascular Sciences, National Institute on Aging, NIH, Baltimore, USA
Eur Heart J 31:602-13. 2010..We evaluated whether specific clusters of metabolic syndrome (MetS) components differentially impact on arterial structure and function, and whether the impact is similar in men and in women... - Low serum selenium concentrations are associated with poor grip strength among older women living in the communityJustine Beck
Johns Hopkins Medical Institutions, Baltimore, MD, USA
Biofactors 29:37-44. 2007..04). This study supports the idea that selenium is important to muscle strength in older women... - Association between hormones and metabolic syndrome in older Italian menMarcello Maggio
Clinical Research Branch, National Institute on Aging, Baltimore, Maryland 21225, USA
J Am Geriatr Soc 54:1832-8. 2006.... - Uric acid and inflammatory markersCarmelinda Ruggiero
Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, NIH, Baltimore, MD, USA
Eur Heart J 27:1174-81. 2006..Epidemiological studies have recently shown that UA may be a risk factor for cardiovascular diseases and a negative prognostic marker for mortality in subjects with pre-existing heart failure... - Relationship between low levels of anabolic hormones and 6-year mortality in older men: the aging in the Chianti Area (InCHIANTI) studyMarcello Maggio
National Institute on Aging, National Institutes of Health, NIA Clinical Research Branch at Harbor Hospital, 3001 S Hanover Street, Baltimore, MD 21225, USA
Arch Intern Med 167:2249-54. 2007..We hypothesized that in older men a parallel age-associated decline in bioavailable testosterone, IGF-1, and DHEA-S secretion is associated with higher mortality independent of potential confounders... - What constitutes normal hemoglobin concentration in community-dwelling disabled older women?Paulo H M Chaves
Johns Hopkins Center on Aging and Health, 2024 E Monument Street, Baltimore, MD 21205, USA
J Am Geriatr Soc 52:1811-6. 2004.... - Personality and metabolic syndromeAngelina R Sutin
Laboratory of Personality and Cognition, National Institute on Aging, NIH, DHHS, 251 Bayview Blvd, Baltimore, MD 21224, USA
Age (Dordr) 32:513-9. 2010..The present research indicates that those with fewer psychological resources are more vulnerable to metabolic syndrome and suggests a psychological component to other established risk factors... - Arterial stiffness and bone demineralization: the Baltimore longitudinal study of agingFrancesco Giallauria
Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, Baltimore, Maryland, USA
Am J Hypertens 24:970-5. 2011..The aims of this study were to evaluate whether the association between arterial stiffness and bone demineralization is independent of age, and to explore putative mechanisms that may mediate their relationship... - Lower plasma vitamin E levels are associated with the frailty syndrome: the InCHIANTI studyAlessandro Ble
Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD 21225, USA
J Gerontol A Biol Sci Med Sci 61:278-83. 2006..30; 95% confidence interval, 0.10-0.91). CONCLUSIONS: Our findings show an association between low circulating levels of one of the most important components of the human antioxidant system and the presence of frailty... - Relation of angiotensin-converting enzyme inhibitor treatment to insulin-like growth factor-1 serum levels in subjects >65 years of age (the InCHIANTI study)Marcello Maggio
Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, Intramural Research Program, National Institutes of Health, Bethesda, Maryland, USA
Am J Cardiol 97:1525-9. 2006..This may be 1 of the mechanisms by which ACE inhibitors might slow the decreases in muscle strength and physical function that are often observed in older subjects... - Low-serum carotenoid concentrations and carotenoid interactions predict mortality in US adults: the Third National Health and Nutrition Examination SurveyMichelle D Shardell
Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Nutr Res 31:178-89. 2011..Interventions of balanced carotenoid combinations are needed for confirmation... - Serum vitamin E concentrations and recovery of physical function during the year after hip fractureChristopher R D'Adamo
Baltimore, MD 21201, USA
J Gerontol A Biol Sci Med Sci 66:784-93. 2011..Low serum concentrations of vitamin E have been associated with decline in physical function among older adults, but the role of vitamin E in physical recovery from hip fracture has never been explored... - Real-world assessment of physical activity in glaucoma using an accelerometerPradeep Y Ramulu
Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland 21287, USA
Ophthalmology 119:1159-66. 2012..To determine the association between glaucomatous visual field (VF) loss and the amount of physical activity and walking in normal life... - Baseline total and specific differential white blood cell counts and 5-year all-cause mortality in community-dwelling older womenSean X Leng
Division of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Exp Gerontol 40:982-7. 2005..They provide a basis for further investigation into the role of leukocytes in age-related inflammation and its associated adverse outcomes in older adults... - Endogenous secretory receptor for advanced glycation end products and chronic kidney disease in the elderly populationMansi Dalal
Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Am J Nephrol 33:313-8. 2011..The aim of the study was to determine whether plasma esRAGE is associated with CKD and is predictive of developing CKD in older adults... - Abnormalities in arterial-ventricular coupling in older healthy persons are attenuated by sodium nitroprussidePaul D Chantler
Laboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA
Am J Physiol Heart Circ Physiol 300:H1914-22. 2011..This is relevant to common conditions in older subjects associated with a significant impairment of exercise performance such as frailty or heart failure with preserved ejection fraction... - PSA doubling time versus PSA velocity to predict high-risk prostate cancer: data from the Baltimore Longitudinal Study of AgingStacy Loeb
Department of Urology, The Johns Hopkins University School of Medicine, The James Buchanan Brady Urological Institute, The Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
Eur Urol 54:1073-80. 2008..Less is known about the relative utility of pretreatment PSA doubling time (PSA DT) to predict tumor aggressiveness... - Gender differences in the accuracy of time-dependent blood pressure indices for predicting coronary heart disease: A random-effects modeling approachLarry J Brant
Research Resources Branch, National Institute on Aging, Baltimore, Maryland, USA
Gend Med 7:616-27. 2010.... - High basal metabolic rate is a risk factor for mortality: the Baltimore Longitudinal Study of AgingCarmelinda Ruggiero
National Institute on Aging, NIH, Harbor Hospital, Baltimore, MD 21225, USA
J Gerontol A Biol Sci Med Sci 63:698-706. 2008..We evaluate the longitudinal changes in BMR and the relationship between BMR and mortality in the Baltimore Longitudinal Study of Aging (BLSA) participants... - Relation of plasma leptin to C-reactive protein in older adults (from the Invecchiare nel Chianti study)Alessandro Ble
Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA
Am J Cardiol 96:991-5. 2005..In conclusion, these findings suggest that leptin may directly stimulate the production of CRP independent of fat-cell produced cytokines in older adults... - Joint association of obesity and metabolic syndrome with incident mobility limitation in older men and women--results from the Health, Aging, and Body Composition StudySari Stenholm
Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, Harbor Hospital, 3001 South Hanover Street, Baltimore, MD 21225, USA
J Gerontol A Biol Sci Med Sci 65:84-92. 2010..Although both obesity and the metabolic syndrome (MetS) are known risk factors for decline in physical function, the joint association of obesity and metabolic alterations with risk of incident mobility limitation is unknown... - Relationship between plasma ghrelin, insulin, leptin, interleukin 6, adiponectin, testosterone and longevity in the Baltimore Longitudinal Study of AgingSari Stenholm
National Institute on Aging, Clinical Research Branch, Longitudinal Studies Section, Baltimore, MD 21225, USA
Aging Clin Exp Res 23:153-8. 2011..In this study we examine the association between other potential biomarkers related to CR and extended lifespan in healthy humans... - Body fat distribution and inflammation among obese older adults with and without metabolic syndromeAnnemarie Koster
Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, Maryland, USA
Obesity (Silver Spring) 18:2354-61. 2010.... - Characteristics of 400-meter walk test performance and subsequent mortality in older adultsSonja Vestergaard
Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892 9205, USA
Rejuvenation Res 12:177-84. 2009..We conclude that multiple aspects of performance in the 400-meter walk test provide complementary information on mortality prognosis in older persons... - Glucose and insulin measurements from the oral glucose tolerance test and mortality predictionE Jeffrey Metter
Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, Intramural Research Program, National Institutes of Health, Baltimore, Maryland 21225, USA
Diabetes Care 31:1026-30. 2008..To verify what information from oral glucose tolerance tests (OGTTs) independently predicts mortality... - The interplay between uric acid and antioxidants in relation to physical function in older personsCarmelinda Ruggiero
Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21225, USA
J Am Geriatr Soc 55:1206-15. 2007..To investigate the relationship between circulating uric acid (UA) levels and plasma antioxidants and whether antioxidant levels modulate the association between UA and physical function... - Renal function, erythropoietin, and anemia of older persons: the InCHIANTI studyAlessandro Ble
Longitudinal Studies Section, National Institute on Aging, National Institutes of Health, Baltimore, MD 21225, USA
Arch Intern Med 165:2222-7. 2005..Whether moderate kidney impairment in older persons is associated with a progressively increasing risk of anemia remains to be determined... - Low serum 25-hydroxyvitamin D concentrations are associated with greater all-cause mortality in older community-dwelling womenRichard D Semba
Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, MD 21287, USA
Nutr Res 29:525-30. 2009..4 nmol/L) of 25(OH)D in a multivariate Cox proportional hazards model adjusting for demographics, season, and conventional risk factors. Older community-dwelling women with low 25(OH)D levels are at an increased risk of death... - Relationship of an advanced glycation end product, plasma carboxymethyl-lysine, with slow walking speed in older adults: the InCHIANTI studyRichard D Semba
Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Eur J Appl Physiol 108:191-5. 2010..R. 1.87, 95% C.I. 1.15-3.04, P = 0.01) adjusting for the same covariates. In older community-dwelling adults, elevated plasma CML is independently associated with slow walking speed... - Sarcopenic obesity: definition, cause and consequencesSari Stenholm
Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, Baltimore, Maryland 21225 1233, USA
Curr Opin Clin Nutr Metab Care 11:693-700. 2008..Tantamount to this discussion is whether low muscle mass or, rather, muscle weakness should be used for the definition... - The frailty syndrome: a critical issue in geriatric oncologyLuigi Ferrucci
Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA
Crit Rev Oncol Hematol 46:127-37. 2003..Improvements in the definition of the frailty syndrome may profit from the clinical experience of oncologists... - Upregulated ex vivo expression of stress-responsive inflammatory pathway genes by LPS-challenged CD14(+) monocytes in frail older adultsTao Qu
Johns Hopkins University School of Medicine, Biology of Frailty Program, Division of Geriatric Medicine and Gerontology, Department of Medicine, Baltimore, MD, USA
Mech Ageing Dev 130:161-6. 2009..These findings suggest upregulated expression of specific stress-responsive genes in monocyte-mediated inflammatory pathway in the syndrome of frailty with potential mechanistic and interventional implications... - Insulin-like growth factor I and interleukin-6 contribute synergistically to disability and mortality in older womenAnne R Cappola
Department of Medicine, University of Maryland, Baltimore, Maryland 21201, USA
J Clin Endocrinol Metab 88:2019-25. 2003..The joint effects of IGF-I and IL-6 may be important targets for treatments to prevent or minimize disability associated with aging... - Red cell distribution width and mortality in older adults: a meta-analysisKushang V Patel
Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, Maryland 20892 9205, USA
J Gerontol A Biol Sci Med Sci 65:258-65. 2010..Whether RDW is prognostic in more representative community-based populations is unclear... - Handgrip strength and cause-specific and total mortality in older disabled women: exploring the mechanismTaina Rantanen
Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA
J Am Geriatr Soc 51:636-41. 2003.... - Variants of the serotonin transporter gene and NEO-PI-R Neuroticism: No association in the BLSA and SardiNIA samplesAntonio Terracciano
National Institute on Aging, NIH, DHHS, Baltimore, Maryland 21224, USA
Am J Med Genet B Neuropsychiatr Genet 150:1070-7. 2009..Along with other large studies that used different phenotypic measures and found no association, this study substantially increases the evidence against a link between 5-HTT variants and Neuroticism-related traits... - Sex-specific correlates of walking speed in a wide age-ranged populationMagdalena I Tolea
Clinical Research Branch, National Institute on Aging, Harbor Hospital, 3001 South Hanover Street, Baltimore, MD 21225, USA
J Gerontol B Psychol Sci Soc Sci 65:174-84. 2010..If these patterns are confirmed in longitudinal studies, personality may be an important target for prevention... - Anabolic and catabolic biomarkers as predictors of muscle strength decline: the InCHIANTI studySari Stenholm
National Institute on Aging, Clinical Research Branch, Longitudinal Studies Section, Baltimore, Maryland 21225, USA
Rejuvenation Res 13:3-11. 2010..This study aims to examine whether high levels of multiple catabolic and low levels of multiple anabolic biomarkers predict accelerated decline of muscle strength... - Characteristic gait patterns in older adults with obesity--results from the Baltimore Longitudinal Study of AgingSeung uk Ko
Clinical Research Branch, NIA, Harbor Hospital, 3001 S Hanover Street, Baltimore, MD 21225, USA
J Biomech 43:1104-10. 2010..Since forward progression forces are mainly implicated in normal walking, this pattern found in obese participants is suggestive of lower energetic efficiency... - The energetic pathway to mobility loss: an emerging new framework for longitudinal studies on agingJennifer A Schrack
Center on Aging and Health, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, Maryland 21205, USA
J Am Geriatr Soc 58:S329-36. 2010..The main premise is simple: the biochemical processes that maintain life, secure homeostatic equilibrium, and prevent the collapse of health require energy. If energy becomes deficient, adaptive behaviors develop to conserve energy... - Impact of reduced meal frequency without caloric restriction on glucose regulation in healthy, normal-weight middle-aged men and womenOlga Carlson
Diabetes Section, Laboratory of Clinical Investigation, National Institute on Aging Intramural Research Program, Baltimore, MD, USA
Metabolism 56:1729-34. 2007..The impaired glucose tolerance was reversible and was not associated with alterations in the levels of adipokines or BDNF... - Association between mild anemia and executive function impairment in community-dwelling older women: The Women's Health and Aging Study IIPaulo H M Chaves
Center on Aging and Health and Department of Medicine, Johns Hopkins University, Baltimore, Maryland 21205, USA
J Am Geriatr Soc 54:1429-35. 2006..To evaluate the relationship between mild anemia and executive function in community-dwelling older women... - Age-related mechanical work expenditure during normal walking: the Baltimore Longitudinal Study of AgingSeung uk Ko
National Institute on Aging NIA, Clinical Research Branch, Harbor Hospital, 3001 S Hanover Street, Baltimore MD 21225 United States
J Biomech 42:1834-9. 2009..003). These age-related gait patterns may represent a compensatory effort to maintain balance and may also reflect mobility limitations... - Associations between lower extremity ischemia, upper and lower extremity strength, and functional impairment with peripheral arterial diseaseMary M McDermott
Department of Medicine, National Institute on Aging, Bethesda, Maryland, USA
J Am Geriatr Soc 56:724-9. 2008..To determine whether poorer strength may mediate poorer lower extremity performance in persons with lower arterial brachial index (ABI) levels... - Sarcopenic obesity and inflammation in the InCHIANTI studyMatthew A Schrager
Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD 21225, USA
J Appl Physiol 102:919-25. 2007..These results suggest that proinflammatory cytokines may be critical in both the development and progression of sarcopenic obesity... - Detection of life-threatening prostate cancer with prostate-specific antigen velocity during a window of curabilityH Ballentine Carter
Department of Urology, Marburg 403, Johns Hopkins School of Medicine, 600 N Wolfe St, Baltimore, MD 21287, USA
J Natl Cancer Inst 98:1521-7. 2006..The rate at which serum PSA levels change (PSA velocity) may be an important indicator of the presence of life-threatening disease... - Does accumulation of advanced glycation end products contribute to the aging phenotype?Richard D Semba
Department of Ophthalmology, Johns Hopkins University School of Medicine, Smith Building, M015, 400 North Broadway, Baltimore, MD 21287, USA
J Gerontol A Biol Sci Med Sci 65:963-75. 2010.... - Progression of lower-extremity disability in older women with diabetes: the Women's Health and Aging StudyStefano Volpato
Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, Bethesda, Maryland, USA
Diabetes Care 26:70-5. 2003..We evaluated the pace of decline in lower-extremity function and the risk for progression of disability in older women with diabetes... - Model choice can obscure results in longitudinal studiesChristopher H Morrell
Gerontology Research Center, National Institute on Aging, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
J Gerontol A Biol Sci Med Sci 64:215-22. 2009..This article examines how different parameterizations of age and time in modeling observational longitudinal data can affect results... - Executive function correlates with walking speed in older persons: the InCHIANTI studyAlesandro Ble
Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland
J Am Geriatr Soc 53:410-5. 2005..CONCLUSION: In nondemented older persons, executive function is independently associated with tasks of lower extremity function that require high attentional demand...