S Ferre

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Coaggregation, cointernalization, and codesensitization of adenosine A2A receptors and dopamine D2 receptors
    Joelle Hillion
    Department of Neuroscience, Karolinska Institute, 17177 Stockholm, Sweden
    J Biol Chem 277:18091-7. 2002
  2. ncbi request reprint Existence and theoretical aspects of homomeric and heteromeric dopamine receptor complexes and their relevance for neurological diseases
    Luigi Francesco Agnati
    Department of Biomedical Sciences, University of Modena and Reggio Emilia, Via Campi 287, 41100 Modena, Italy
    Neuromolecular Med 7:61-78. 2005
  3. pmc Dopamine D4 receptor, but not the ADHD-associated D4.7 variant, forms functional heteromers with the dopamine D2S receptor in the brain
    S Gonzalez
    Department of Biochemistry and Molecular Biology, Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas, University of Barcelona, Barcelona, Spain
    Mol Psychiatry 17:650-62. 2012
  4. pmc Striatal pre- and postsynaptic profile of adenosine A(2A) receptor antagonists
    Marco Orru
    National Institute on Drug Abuse, IRP, NIH, DHHS, Baltimore, Maryland, United States of America
    PLoS ONE 6:e16088. 2011
  5. pmc Adenosine A(2A) Receptors and A(2A) Receptor Heteromers as Key Players in Striatal Function
    Sergi Ferre
    National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, U S Department of Health and Human Services Baltimore, MD, USA
    Front Neuroanat 5:36. 2011
  6. ncbi request reprint G protein-coupled receptor oligomerization revisited: functional and pharmacological perspectives
    Sergi Ferre
    Integrative Neurobiology Section, National Institute on Drug Abuse, Intramural Research Program, National Institutes on Drug Abuse, Department of Health and Human Services, 333 Cassell Drive, Baltimore, Maryland 21224
    Pharmacol Rev 66:413-34. 2014
  7. pmc Neurotransmitter receptor heteromers and their integrative role in 'local modules': the striatal spine module
    Sergi Ferre
    Behavioral Neuroscience Branch, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Nathan Shock Drive, Baltimore, MD 21224, USA
    Brain Res Rev 55:55-67. 2007
  8. pmc Looking for the role of cannabinoid receptor heteromers in striatal function
    Sergi Ferre
    National Institute on Drug Abuse, Intramural Research Program, Biomedical Research Center, National Institutes of Health, Department of Health and Human Services, 251 Bayview Boulevard, Baltimore, MD 21224, USA
    Neuropharmacology 56:226-34. 2009
  9. pmc Adenosine A2A receptors in ventral striatum, hypothalamus and nociceptive circuitry implications for drug addiction, sleep and pain
    S Ferre
    Preclinical Pharmacology Section, National Institute on Drug Abuse, Intramural Research Program, Department of Health and Human Services, Baltimore, MD 21224, USA
    Prog Neurobiol 83:332-47. 2007
  10. ncbi request reprint Functional relevance of neurotransmitter receptor heteromers in the central nervous system
    Sergi Ferre
    Behavioral Neuroscience Branch, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, MD 21224, USA
    Trends Neurosci 30:440-6. 2007

Detail Information

Publications41

  1. ncbi request reprint Coaggregation, cointernalization, and codesensitization of adenosine A2A receptors and dopamine D2 receptors
    Joelle Hillion
    Department of Neuroscience, Karolinska Institute, 17177 Stockholm, Sweden
    J Biol Chem 277:18091-7. 2002
    ..These results give a molecular basis for adenosine-dopamine antagonism at the membrane level and have implications for treatment of Parkinson's disease and schizophrenia, in which D(2)R are involved...
  2. ncbi request reprint Existence and theoretical aspects of homomeric and heteromeric dopamine receptor complexes and their relevance for neurological diseases
    Luigi Francesco Agnati
    Department of Biomedical Sciences, University of Modena and Reggio Emilia, Via Campi 287, 41100 Modena, Italy
    Neuromolecular Med 7:61-78. 2005
    ....
  3. pmc Dopamine D4 receptor, but not the ADHD-associated D4.7 variant, forms functional heteromers with the dopamine D2S receptor in the brain
    S Gonzalez
    Department of Biochemistry and Molecular Biology, Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas, University of Barcelona, Barcelona, Spain
    Mol Psychiatry 17:650-62. 2012
    ..It is therefore postulated that dysfunctional D(2S)-D(4.7) heteromers may impair presynaptic dopaminergic control of corticostriatal glutamatergic neurotransmission and explain functional deficits associated with ADHD...
  4. pmc Striatal pre- and postsynaptic profile of adenosine A(2A) receptor antagonists
    Marco Orru
    National Institute on Drug Abuse, IRP, NIH, DHHS, Baltimore, Maryland, United States of America
    PLoS ONE 6:e16088. 2011
    ..On the basis of their preferential pre- versus postsynaptic actions, SCH-442416 and KW-6002 may be used as lead compounds to obtain more effective antidyskinetic and antiparkinsonian compounds, respectively...
  5. pmc Adenosine A(2A) Receptors and A(2A) Receptor Heteromers as Key Players in Striatal Function
    Sergi Ferre
    National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, U S Department of Health and Human Services Baltimore, MD, USA
    Front Neuroanat 5:36. 2011
    ..These three different types of A(2A)Rs can be pharmacologically dissected by their ability to bind ligands with different affinity and can therefore provide selective targets for drug development in different basal ganglia disorders...
  6. ncbi request reprint G protein-coupled receptor oligomerization revisited: functional and pharmacological perspectives
    Sergi Ferre
    Integrative Neurobiology Section, National Institute on Drug Abuse, Intramural Research Program, National Institutes on Drug Abuse, Department of Health and Human Services, 333 Cassell Drive, Baltimore, Maryland 21224
    Pharmacol Rev 66:413-34. 2014
    ....
  7. pmc Neurotransmitter receptor heteromers and their integrative role in 'local modules': the striatal spine module
    Sergi Ferre
    Behavioral Neuroscience Branch, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Nathan Shock Drive, Baltimore, MD 21224, USA
    Brain Res Rev 55:55-67. 2007
    ..Finally, dopamine D(2) receptor-non-alpha(7) nicotinic acetylcholine receptor heteromers, which are located in dopaminergic terminals, introduce the new concept of autoreceptor heteromer...
  8. pmc Looking for the role of cannabinoid receptor heteromers in striatal function
    Sergi Ferre
    National Institute on Drug Abuse, Intramural Research Program, Biomedical Research Center, National Institutes of Health, Department of Health and Human Services, 251 Bayview Boulevard, Baltimore, MD 21224, USA
    Neuropharmacology 56:226-34. 2009
    ..The functional properties of these multiple receptor heteromers and their role in striatal function need to be determined...
  9. pmc Adenosine A2A receptors in ventral striatum, hypothalamus and nociceptive circuitry implications for drug addiction, sleep and pain
    S Ferre
    Preclinical Pharmacology Section, National Institute on Drug Abuse, Intramural Research Program, Department of Health and Human Services, Baltimore, MD 21224, USA
    Prog Neurobiol 83:332-47. 2007
    ....
  10. ncbi request reprint Functional relevance of neurotransmitter receptor heteromers in the central nervous system
    Sergi Ferre
    Behavioral Neuroscience Branch, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, MD 21224, USA
    Trends Neurosci 30:440-6. 2007
    ..This is illustrated by the analysis of striatal receptor heteromers that control striatal glutamatergic neurotransmission...
  11. ncbi request reprint Adenosine A1-A2A receptor heteromers: new targets for caffeine in the brain
    Sergi Ferre
    National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, MD 21224, USA
    Front Biosci 13:2391-9. 2008
    ..The analysis of the function of A1-A2A receptor heteromers during chronic treatment with caffeine gives new clues about the well-known phenomenon of tolerance to the psychostimulant effects of caffeine...
  12. pmc An update on adenosine A2A-dopamine D2 receptor interactions: implications for the function of G protein-coupled receptors
    S Ferre
    National Institute on Drug Abuse, IRP, NIH, DHHS, 5500 Nathan Shock Dr, Baltimore, MD 21224, USA
    Curr Pharm Des 14:1468-74. 2008
    ..The analysis of A(2)-D(2) receptor interactions will have implications for the pathophysiology and treatment of basal ganglia disorders and drug addiction...
  13. pmc Building a new conceptual framework for receptor heteromers
    Sergi Ferre
    National Institute on Drug Abuse, IRP, NIH, DHHS, 251 Bayview Boulevard, Baltimore, Maryland 21224, USA
    Nat Chem Biol 5:131-4. 2009
    ..We also consider research questions underlying the proposed nomenclature, with recommendations for receptor heteromer identification in native tissues and their use as targets for drug development...
  14. ncbi request reprint Role of adenosine in the control of homosynaptic plasticity in striatal excitatory synapses
    Sergi Ferre
    National Institute on Drug Abuse, IRP, NIH, DHHS, Baltimore, MD 21224, USA
    J Integr Neurosci 4:445-64. 2005
    ....
  15. ncbi request reprint An update on the mechanisms of the psychostimulant effects of caffeine
    Sergi Ferre
    National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA
    J Neurochem 105:1067-79. 2008
    ....
  16. pmc Calcium-mediated modulation of the quaternary structure and function of adenosine A2A-dopamine D2 receptor heteromers
    Sergi Ferre
    National Institute on Drug Abuse, IRP, NIH, DHHS, Baltimore, MD 21224, USA
    Curr Opin Pharmacol 10:67-72. 2010
    ..These studies provide a first example of a Ca(2+)-mediated modulation of the quaternary structure and function of a receptor heteromer...
  17. pmc Synergistic interaction between adenosine A2A and glutamate mGlu5 receptors: implications for striatal neuronal function
    Sergi Ferre
    Behavioral Neuroscience Branch, National Institute on Drug Abuse, National Institutes of Health, Intramural Research Program, Baltimore, MD 21224, U SA
    Proc Natl Acad Sci U S A 99:11940-5. 2002
    ..The results suggest that a functional mGluR5/A2AR interaction is required to overcome the well-known strong tonic inhibitory effect of dopamine on striatal adenosine A2AR function...
  18. ncbi request reprint Prime time for G-protein-coupled receptor heteromers as therapeutic targets for CNS disorders: the dopamine D₁-D₃ receptor heteromer
    Sergi Ferre
    National Institute on Drug Abuse, IRP, NIH, DHHS, Baltimore, MD 21224, USA
    CNS Neurol Disord Drug Targets 9:596-600. 2010
    ....
  19. pmc Adenosine-cannabinoid receptor interactions. Implications for striatal function
    Sergi Ferre
    National Institute on Drug Abuse, IRP, NIH, DHHS, Baltimore, MD 21224, USA
    Br J Pharmacol 160:443-53. 2010
    ....
  20. doi request reprint Role of the central ascending neurotransmitter systems in the psychostimulant effects of caffeine
    Sergi Ferre
    National Institute on Drug Abuse, IRP, NIH, DHHS, Baltimore, MD 21224, USA
    J Alzheimers Dis 20:S35-49. 2010
    ..Those mechanisms include a direct A1-receptor mediated modulation of the corticopetal basal forebrain system and an indirect A2A-receptor mediated modulation of the hypothalamic histaminergic and orexinergic systems...
  21. ncbi request reprint Comparison between apomorphine and amphetamine-induced rotational behaviour in rats with a unilateral nigrostriatal pathway lesion
    M Casas
    Laboratori de Neuropsicofarmacologia, Hospital de Sant Pau, Barcelona, Spain
    Neuropharmacology 27:657-9. 1988
    ..In addition, we have not found any correlation between apomorphine and amphetamine-induced turning behaviour...
  22. ncbi request reprint Receptor-receptor interactions involving adenosine A1 or dopamine D1 receptors and accessory proteins
    R Franco
    Molecular Neurobiology Unit, Department of Biochemistry and Molecular Biology, IDIBAPS Institut d Investigacions Biomèdiques August Pi i Sunyer, Universitat de Barcelona, Barcelona, Spain
    J Neural Transm 114:93-104. 2007
    ..Overall, the knowledge of the reason why such complex networks of receptor-receptor and receptor-protein interactions occur in striatal cells is crucial to develop new strategies to combat neurological and neuropsychiatric diseases...
  23. ncbi request reprint Heterodimeric adenosine receptors: a device to regulate neurotransmitter release
    F Ciruela
    Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, Avda Diagonal, 645, 08028, Barcelona, Spain
    Cell Mol Life Sci 63:2427-31. 2006
    ....
  24. pmc G-protein-coupled receptor heteromers: function and ligand pharmacology
    R Franco
    Departament de Bioquimica i Biologia Molecular, Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas, Institut d Investigacio Biomedica August Pi i Sunyer IDIBAPS, Universitat de Barcelona, Barcelona, Spain
    Br J Pharmacol 153:S90-8. 2008
    ..This fact should be taken into account in the development of new drugs...
  25. pmc Key modulatory role of presynaptic adenosine A2A receptors in cortical neurotransmission to the striatal direct pathway
    Cesar Quiroz
    National Institute on Drug Abuse, IRP, NIH, DHHS, Baltimore, MD, USA
    ScientificWorldJournal 9:1321-44. 2009
    ..Presynaptic striatal A2A receptors could provide a new target for the treatment of neuropsychiatric disorders...
  26. ncbi request reprint Involvement of adenosine A1 and A2A receptors in the adenosinergic modulation of the discriminative-stimulus effects of cocaine and methamphetamine in rats
    Zuzana Justinova
    Preclinical Pharmacology Section, NIDA, NIH, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    J Pharmacol Exp Ther 307:977-86. 2003
    ..Therefore, adenosine A1 and A2A receptors appear to play important but differential roles in the modulation of the discriminative-stimulus effects of methamphetamine and cocaine...
  27. ncbi request reprint Heteromeric nicotinic acetylcholine-dopamine autoreceptor complexes modulate striatal dopamine release
    Davide Quarta
    Behavioral Neuroscience Branch, National Institute on Drug Abuse, IRP, NIH, DHHS, Baltimore, MD 21224, USA
    Neuropsychopharmacology 32:35-42. 2007
    ..These results reveal that striatal non-alpha(7) nicotinic acetylcholine receptors form part of heteromeric dopamine autoreceptor complexes that modulate dopamine release...
  28. ncbi request reprint Differential glutamate-dependent and glutamate-independent adenosine A1 receptor-mediated modulation of dopamine release in different striatal compartments
    Janusz Borycz
    Department of Health and Human Services, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, Maryland 21224, USA
    J Neurochem 101:355-63. 2007
    ....
  29. pmc Diminished iron concentrations increase adenosine A(2A) receptor levels in mouse striatum and cultured human neuroblastoma cells
    Seema Gulyani
    Neurology Department, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Exp Neurol 215:236-42. 2009
    ..In conclusion, the A(2A)R is increased across different iron-insufficient conditions. The relation between A(2A)R and cellular iron status may be an important pathway by which adenosine may alter the function of the dopaminergic system...
  30. pmc Dopamine D1 and adenosine A1 receptors form functionally interacting heteromeric complexes
    S Gines
    Department of Biochemistry and Molecular Biology, University of Barcelona, 08028 Barcelona, Spain
    Proc Natl Acad Sci U S A 97:8606-11. 2000
    ....
  31. pmc Sleep deprivation decreases binding of [11C]raclopride to dopamine D2/D3 receptors in the human brain
    Nora D Volkow
    National Institute on Drug Abuse, Bethesda, Maryland 20892, USA
    J Neurosci 28:8454-61. 2008
    ....
  32. ncbi request reprint Role of electrostatic interaction in receptor-receptor heteromerization
    Amina S Woods
    National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, MD 21224, USA
    J Mol Neurosci 26:125-32. 2005
    ....
  33. pmc Effects of chronic caffeine exposure on adenosinergic modulation of the discriminative-stimulus effects of nicotine, methamphetamine, and cocaine in rats
    Zuzana Justinova
    Preclinical Pharmacology Section, Behavioral Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, NIH, DHHS, Biomedical Research Center, 251 Bayview Blvd, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 203:355-67. 2009
    ..Adenosine receptors are involved in cocaine and methamphetamine discrimination and exposure to caffeine can affect behavioral effects of nicotine in rats...
  34. pmc Amazing stability of the arginine-phosphate electrostatic interaction
    Amina S Woods
    National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health DHHS, 5000 Nathan Shock Drive, Baltimore, MD 21224, USA
    J Proteome Res 4:1397-402. 2005
    ..Although analyzed here in the frame of receptor heteromerization, the arginine-phosphate electrostatic interaction most likely represents a general mechanism in protein-protein interactions...
  35. pmc Up-regulation of striatal adenosine A(2A) receptors with iron deficiency in rats: effects on locomotion and cortico-striatal neurotransmission
    Cesar Quiroz
    National Institute on Drug Abuse, IRP, NIH, DHHS, Baltimore, MD 21224, USA
    Exp Neurol 224:292-8. 2010
    ..These results indicate that brain iron deficiency induces a functional up-regulation of both striatal pre- and postsynaptic A(2A) receptor, which could be involved in sensory-motor disorders associated with iron deficiency such as RLS...
  36. pmc How calmodulin interacts with the adenosine A(2A) and the dopamine D(2) receptors
    Amina S Woods
    National Institute on Drug Abuse, IRP, NIH, DHHS, Baltimore, MD 21224, USA
    J Proteome Res 7:3428-34. 2008
    ..A model is introduced with the possible functional implications of A(2A)-D(2)-CaM interactions. These in vitro findings imply a possible regulatory role for CaM in receptor heteromers formation...
  37. ncbi request reprint Adenosine receptor heteromers and their integrative role in striatal function
    Sergi Ferre
    National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, MD 21224, USA
    ScientificWorldJournal 7:74-85. 2007
    ..For instance, the adenosine A2A-dopamine D2 receptor heteromers work as integrators of two different neurotransmitters in the striatal spine module...
  38. ncbi request reprint 5-HT 1B receptor-mediated serotoninergic modulation of methylphenidate-induced locomotor activation in rats
    Janusz Borycz
    Department of Health and Human Services, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA
    Neuropsychopharmacology 33:619-26. 2008
    ..p.) strongly and dose-dependently potentiated methylphenidate-induced locomotor activation. The 5-HT 1B receptor-mediated modulation of methylphenidate-induced locomotor activation in rat could have implications for the treatment of ADHD...
  39. ncbi request reprint Rotational behaviour induced by theophylline in 6-OHDA nigrostriatal denervated rats is dependent on the supersensitivity of striatal dopaminergic receptors
    M Casas
    Laboratori de Neuropsicofarmacología i Programa Sant Pau CITRAN Hospital de Sant Pau, Barcelona, Spain
    Pharmacol Biochem Behav 33:609-13. 1989
    ....
  40. doi request reprint G protein-coupled receptor heteromers as new targets for drug development
    Sergi Ferre
    National Institute on Drug Abuse, IRP, NIH, DHHS, Baltimore, Maryland, USA
    Prog Mol Biol Transl Sci 91:41-52. 2010
    ....
  41. ncbi request reprint Nanomolar concentrations of kynurenic acid reduce extracellular dopamine levels in the striatum
    Arash Rassoulpour
    Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, Maryland 21218, USA
    J Neurochem 93:762-5. 2005
    ....