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Genomes and Genes | Robert A FentonSummaryAffiliation: National Institutes of Health Country: USA Publications
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Publications
Increased collecting duct urea transporter expression in Dahl salt-sensitive ratsRobert A Fenton
Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung, and BIood Institute, National Institutes of Health, Bethesda, MD 20892 1603, USA
Am J Physiol Renal Physiol 285:F143-51. 2003....
Renal phenotype of UT-A urea transporter knockout miceRobert A Fenton
Laboratory of Kidney Electrolyte Metabolism, National Heart, Lung and Blood Institutes, National Institutes of Health, 10 Center Drive, Building 10, Room 6N260, Bethesda, MD 20892 1603, USA
J Am Soc Nephrol 16:1583-92. 2005..These results support our conclusion that the urinary concentrating defect in UT-A1/3(-/-) mice is caused by a failure of urea transport from the IMCD lumen to the inner medullary interstitium, resulting in osmotic diuresis...- Urinary concentrating defect in mice with selective deletion of phloretin-sensitive urea transporters in the renal collecting ductRobert A Fenton
Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health, 10 Center Drive, Building 10, Room 6N260, Bethesda, MD 20892 1603, USA
Proc Natl Acad Sci U S A 101:7469-74. 2004..Thus, these results do not corroborate the predictions of passive medullary concentrating models stating that NaCl accumulation in the inner medulla depends on rapid vasopressin-regulated urea transport across the IMCD epithelium... - Quantitative analysis of aquaporin-2 phosphorylationLuke Xie
Epithelial Systems Biology Laboratory, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
Am J Physiol Renal Physiol 298:F1018-23. 2010..We suggest from these studies that Ser269 phosphorylation may be a more consistent indicator of vasopressin action and AQP2 membrane abundance than is Ser256 phosphorylation... - Vasopressin increases phosphorylation of Ser84 and Ser486 in Slc14a2 collecting duct urea transportersShelly Hwang
Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
Am J Physiol Renal Physiol 299:F559-67. 2010..The findings add to prior evidence for vasopressin-induced phosphorylation of UT-A1, providing evidence that UT-A3 may be regulated by phosphorylation as well... - Gamble's "economy of water" revisited: studies in urea transporter knockout miceRobert A Fenton
Laboratory of Kidney and Electrolyte Metabolism, National Hearth, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA, and Faculty of Life Sciences, University of Manchester, UK
Am J Physiol Renal Physiol 291:F148-54. 2006.... - Identification of phosphorylation-dependent binding partners of aquaporin-2 using protein mass spectrometryNicholas A Zwang
Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
J Proteome Res 8:1540-54. 2009..These results suggest that phosphorylation of AQP2 at Ser-256 may regulate AQP2 trafficking in part by mediating differential binding of hsp70 family proteins to the COOH-terminal tail... - Magnetic resonance imaging of urea transporter knockout mice shows renal pelvic abnormalitiesVinitha A Jacob
Laboratory of Kidney and Electrolyte Metabolism, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892 1603, USA
Kidney Int 74:1202-8. 2008..Our studies show that real time imaging of renal pelvic structure in genetically manipulated mice provides a tool for the non-destructive, temporal evaluation of kidney structure... - UT-A urea transporter promoter, UT-Aalpha, targets principal cells of the renal inner medullary collecting ductRobert A Fenton
Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
Am J Physiol Renal Physiol 290:F188-95. 2006..These results demonstrate that 4.2 kb of the UT-Aalpha promoter is sufficient to drive expression of a heterologous reporter gene in a tissue-specific and cell-specific fashion in transgenic mice... - Effects of expression of p53 and Gadd45 on osmotic tolerance of renal inner medullary cellsQi Cai
Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892 1603, USA
Am J Physiol Renal Physiol 291:F341-9. 2006.... - Calmodulin is required for vasopressin-stimulated increase in cyclic AMP production in inner medullary collecting ductJason D Hoffert
Laboratory of Kidney and Electrolyte Metabolism, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 280:13624-30. 2005..These studies demonstrate the importance of calmodulin in the regulation of collecting duct adenylyl cyclase activity and transport function... - Vasopressin-stimulated increase in phosphorylation at Ser269 potentiates plasma membrane retention of aquaporin-2Jason D Hoffert
NHLBI, National Institutes of Health, Bethesda, Maryland 20892 1603, USA
J Biol Chem 283:24617-27. 2008..The data support a model in which vasopressin-mediated phosphorylation of AQP2 at Ser269:(a) depends on prior PKA-mediated phosphorylation of Ser256 and (b) enhances apical plasma membrane retention of AQP2... - Long-term regulation of ENaC expression in kidney by angiotensin IIKathleen T Beutler
Laboratory of Kidney and Electrolyte Metabolism, NHLBI, National Institutes of Health, Bethesda, MD 20892-1603, USA
Hypertension 41:1143-50. 2003..The results support the view that the angiotensin II receptor regulates ENaC abundance, consistent with a role for angiotensin II in regulation of collecting duct function... - Defective glycerol metabolism in aquaporin 9 (AQP9) knockout miceAleksandra M Rojek
The Water and Salt Research Center, University of Aarhus, DK 8000 Aarhus C, Denmark
Proc Natl Acad Sci U S A 104:3609-14. 2007..Thus, AQP9 is important for hepatic glycerol metabolism and may play a role in glycerol and glucose metabolism in diabetes mellitus... - Mouse models and the urinary concentrating mechanism in the new millenniumRobert A Fenton
Water and Salt Research Center, Institute of Anatomy, University of Aarhus, Aarhus, Denmark
Physiol Rev 87:1083-112. 2007.... - Aquaporin-1 is not expressed in descending thin limbs of short-loop nephronsXiao Yue Zhai
Department of Cell Biology, Institute of Anatomy, University of Aarhus, Arhus C, Denmark
J Am Soc Nephrol 18:2937-44. 2007..Likewise, the roles of aquaporin-1 and UT-A2 in the countercurrent multiplier and water conversation may need to be readdressed... - Urea movement across mouse colonic plasma membranes is mediated by UT-A urea transportersGavin S Stewart
School of Biological Sciences, University of Manchester, England
Gastroenterology 126:765-73. 2004..CONCLUSIONS: Functional UT-A transporters are expressed in the plasma membranes of mouse colon, indicating that these proteins may play a key role in host/bacterial interaction... - The basolateral expression of mUT-A3 in the mouse kidneyGavin S Stewart
School of Biological Sciences, University of Manchester, M13 9PT, UK
Am J Physiol Renal Physiol 286:F979-87. 2004..In conclusion, our study indicates that mUT-A3 is a basolateral membrane transporter expressed in IMCD cells... - Characterization of a human colonic cDNA encoding a structurally novel urea transporter, hUT-A6Craig P Smith
School of Biological Sciences, University of Manchester, G 38, Stopford Bldg, Oxford Road, Manchester M13 9PT, United Kingdom
Am J Physiol Cell Physiol 287:C1087-93. 2004.... - Urea and renal function in the 21st century: insights from knockout miceRobert A Fenton
Water and Salt Research Center, Institute of Anatomy, Building 233 234, University of Aarhus, DK 8000 Aarhus, Denmark
J Am Soc Nephrol 18:679-88. 2007.... - Proteomic analysis of lithium-induced nephrogenic diabetes insipidus: mechanisms for aquaporin 2 down-regulation and cellular proliferationJakob Nielsen
Water and Salt Research Center, University of Aarhus, DK 8000 Aarhus C, Denmark
Proc Natl Acad Sci U S A 105:3634-9. 2008..This study provides a comprehensive analysis of the proteins affected by lithium treatment in the IMCD and, as such, provides clues to potential lithium targets in the brain... - Acute regulation of aquaporin-2 phosphorylation at Ser-264 by vasopressinRobert A Fenton
The Water and Salt Research Center, Institute of Anatomy, University of Aarhus, DK 8000 Aarhus C, Denmark
Proc Natl Acad Sci U S A 105:3134-9. 2008..Overall, our results are consistent with a dynamic effect of AVP on the phosphorylation and subcellular distribution of AQP2... - A current view of the mammalian aquaglyceroporinsAleksandra Rojek
Water and Salt Research Center, Institute of Anatomy, University of Aarhus, Aarhus C, Denmark
Annu Rev Physiol 70:301-27. 2008..This review comprehensively discusses the recent discoveries in the field of aquaglyceroporins, alongside a brief overview of the so-called unorthodox aquaporins... - Cellular and subcellular distribution of the type-2 vasopressin receptor in the kidneyRobert A Fenton
The Water and Salt Research Center, Institute of Anatomy, University of Aarhus, Aarhus, Denmark
Am J Physiol Renal Physiol 293:F748-60. 2007..Confocal microscopy of isolated inner medullary collecting duct tubules showed that the V2R is expressed both intracellularly and in basolateral membrane domains...