Robert A Fenton

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Increased collecting duct urea transporter expression in Dahl salt-sensitive rats
    Robert A Fenton
    Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung, and BIood Institute, National Institutes of Health, Bethesda, MD 20892 1603, USA
    Am J Physiol Renal Physiol 285:F143-51. 2003
  2. pmc Renal phenotype of UT-A urea transporter knockout mice
    Robert A Fenton
    Laboratory of Kidney Electrolyte Metabolism, National Heart, Lung and Blood Institutes, National Institutes of Health, 10 Center Drive, Building 10, Room 6N260, Bethesda, MD 20892 1603, USA
    J Am Soc Nephrol 16:1583-92. 2005
  3. pmc Urinary concentrating defect in mice with selective deletion of phloretin-sensitive urea transporters in the renal collecting duct
    Robert A Fenton
    Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health, 10 Center Drive, Building 10, Room 6N260, Bethesda, MD 20892 1603, USA
    Proc Natl Acad Sci U S A 101:7469-74. 2004
  4. pmc Quantitative analysis of aquaporin-2 phosphorylation
    Luke Xie
    Epithelial Systems Biology Laboratory, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Am J Physiol Renal Physiol 298:F1018-23. 2010
  5. pmc Vasopressin increases phosphorylation of Ser84 and Ser486 in Slc14a2 collecting duct urea transporters
    Shelly Hwang
    Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
    Am J Physiol Renal Physiol 299:F559-67. 2010
  6. ncbi request reprint Gamble's "economy of water" revisited: studies in urea transporter knockout mice
    Robert A Fenton
    Laboratory of Kidney and Electrolyte Metabolism, National Hearth, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA, and Faculty of Life Sciences, University of Manchester, UK
    Am J Physiol Renal Physiol 291:F148-54. 2006
  7. pmc Identification of phosphorylation-dependent binding partners of aquaporin-2 using protein mass spectrometry
    Nicholas A Zwang
    Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Proteome Res 8:1540-54. 2009
  8. pmc Magnetic resonance imaging of urea transporter knockout mice shows renal pelvic abnormalities
    Vinitha A Jacob
    Laboratory of Kidney and Electrolyte Metabolism, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892 1603, USA
    Kidney Int 74:1202-8. 2008
  9. pmc UT-A urea transporter promoter, UT-Aalpha, targets principal cells of the renal inner medullary collecting duct
    Robert A Fenton
    Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
    Am J Physiol Renal Physiol 290:F188-95. 2006
  10. ncbi request reprint Effects of expression of p53 and Gadd45 on osmotic tolerance of renal inner medullary cells
    Qi Cai
    Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892 1603, USA
    Am J Physiol Renal Physiol 291:F341-9. 2006

Collaborators

Detail Information

Publications24

  1. ncbi request reprint Increased collecting duct urea transporter expression in Dahl salt-sensitive rats
    Robert A Fenton
    Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung, and BIood Institute, National Institutes of Health, Bethesda, MD 20892 1603, USA
    Am J Physiol Renal Physiol 285:F143-51. 2003
    ....
  2. pmc Renal phenotype of UT-A urea transporter knockout mice
    Robert A Fenton
    Laboratory of Kidney Electrolyte Metabolism, National Heart, Lung and Blood Institutes, National Institutes of Health, 10 Center Drive, Building 10, Room 6N260, Bethesda, MD 20892 1603, USA
    J Am Soc Nephrol 16:1583-92. 2005
    ..These results support our conclusion that the urinary concentrating defect in UT-A1/3(-/-) mice is caused by a failure of urea transport from the IMCD lumen to the inner medullary interstitium, resulting in osmotic diuresis...
  3. pmc Urinary concentrating defect in mice with selective deletion of phloretin-sensitive urea transporters in the renal collecting duct
    Robert A Fenton
    Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health, 10 Center Drive, Building 10, Room 6N260, Bethesda, MD 20892 1603, USA
    Proc Natl Acad Sci U S A 101:7469-74. 2004
    ..Thus, these results do not corroborate the predictions of passive medullary concentrating models stating that NaCl accumulation in the inner medulla depends on rapid vasopressin-regulated urea transport across the IMCD epithelium...
  4. pmc Quantitative analysis of aquaporin-2 phosphorylation
    Luke Xie
    Epithelial Systems Biology Laboratory, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Am J Physiol Renal Physiol 298:F1018-23. 2010
    ..We suggest from these studies that Ser269 phosphorylation may be a more consistent indicator of vasopressin action and AQP2 membrane abundance than is Ser256 phosphorylation...
  5. pmc Vasopressin increases phosphorylation of Ser84 and Ser486 in Slc14a2 collecting duct urea transporters
    Shelly Hwang
    Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
    Am J Physiol Renal Physiol 299:F559-67. 2010
    ..The findings add to prior evidence for vasopressin-induced phosphorylation of UT-A1, providing evidence that UT-A3 may be regulated by phosphorylation as well...
  6. ncbi request reprint Gamble's "economy of water" revisited: studies in urea transporter knockout mice
    Robert A Fenton
    Laboratory of Kidney and Electrolyte Metabolism, National Hearth, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA, and Faculty of Life Sciences, University of Manchester, UK
    Am J Physiol Renal Physiol 291:F148-54. 2006
    ....
  7. pmc Identification of phosphorylation-dependent binding partners of aquaporin-2 using protein mass spectrometry
    Nicholas A Zwang
    Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Proteome Res 8:1540-54. 2009
    ..These results suggest that phosphorylation of AQP2 at Ser-256 may regulate AQP2 trafficking in part by mediating differential binding of hsp70 family proteins to the COOH-terminal tail...
  8. pmc Magnetic resonance imaging of urea transporter knockout mice shows renal pelvic abnormalities
    Vinitha A Jacob
    Laboratory of Kidney and Electrolyte Metabolism, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892 1603, USA
    Kidney Int 74:1202-8. 2008
    ..Our studies show that real time imaging of renal pelvic structure in genetically manipulated mice provides a tool for the non-destructive, temporal evaluation of kidney structure...
  9. pmc UT-A urea transporter promoter, UT-Aalpha, targets principal cells of the renal inner medullary collecting duct
    Robert A Fenton
    Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
    Am J Physiol Renal Physiol 290:F188-95. 2006
    ..These results demonstrate that 4.2 kb of the UT-Aalpha promoter is sufficient to drive expression of a heterologous reporter gene in a tissue-specific and cell-specific fashion in transgenic mice...
  10. ncbi request reprint Effects of expression of p53 and Gadd45 on osmotic tolerance of renal inner medullary cells
    Qi Cai
    Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892 1603, USA
    Am J Physiol Renal Physiol 291:F341-9. 2006
    ....
  11. pmc Calmodulin is required for vasopressin-stimulated increase in cyclic AMP production in inner medullary collecting duct
    Jason D Hoffert
    Laboratory of Kidney and Electrolyte Metabolism, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 280:13624-30. 2005
    ..These studies demonstrate the importance of calmodulin in the regulation of collecting duct adenylyl cyclase activity and transport function...
  12. pmc Vasopressin-stimulated increase in phosphorylation at Ser269 potentiates plasma membrane retention of aquaporin-2
    Jason D Hoffert
    NHLBI, National Institutes of Health, Bethesda, Maryland 20892 1603, USA
    J Biol Chem 283:24617-27. 2008
    ..The data support a model in which vasopressin-mediated phosphorylation of AQP2 at Ser269:(a) depends on prior PKA-mediated phosphorylation of Ser256 and (b) enhances apical plasma membrane retention of AQP2...
  13. ncbi request reprint Long-term regulation of ENaC expression in kidney by angiotensin II
    Kathleen T Beutler
    Laboratory of Kidney and Electrolyte Metabolism, NHLBI, National Institutes of Health, Bethesda, MD 20892 1603, USA
    Hypertension 41:1143-50. 2003
    ..The results support the view that the angiotensin II receptor regulates ENaC abundance, consistent with a role for angiotensin II in regulation of collecting duct function...
  14. pmc Defective glycerol metabolism in aquaporin 9 (AQP9) knockout mice
    Aleksandra M Rojek
    The Water and Salt Research Center, University of Aarhus, DK 8000 Aarhus C, Denmark
    Proc Natl Acad Sci U S A 104:3609-14. 2007
    ..Thus, AQP9 is important for hepatic glycerol metabolism and may play a role in glycerol and glucose metabolism in diabetes mellitus...
  15. ncbi request reprint Mouse models and the urinary concentrating mechanism in the new millennium
    Robert A Fenton
    Water and Salt Research Center, Institute of Anatomy, University of Aarhus, Aarhus, Denmark
    Physiol Rev 87:1083-112. 2007
    ....
  16. ncbi request reprint Aquaporin-1 is not expressed in descending thin limbs of short-loop nephrons
    Xiao Yue Zhai
    Department of Cell Biology, Institute of Anatomy, University of Aarhus, Arhus C, Denmark
    J Am Soc Nephrol 18:2937-44. 2007
    ..Likewise, the roles of aquaporin-1 and UT-A2 in the countercurrent multiplier and water conversation may need to be readdressed...
  17. ncbi request reprint Urea movement across mouse colonic plasma membranes is mediated by UT-A urea transporters
    Gavin S Stewart
    School of Biological Sciences, University of Manchester, England
    Gastroenterology 126:765-73. 2004
    ..The aim of this study was to determine whether UT-A proteins are expressed in the mouse colon and, if so, whether they have a functional role in transcellular urea transport...
  18. ncbi request reprint The basolateral expression of mUT-A3 in the mouse kidney
    Gavin S Stewart
    School of Biological Sciences, University of Manchester, M13 9PT, UK
    Am J Physiol Renal Physiol 286:F979-87. 2004
    ..In conclusion, our study indicates that mUT-A3 is a basolateral membrane transporter expressed in IMCD cells...
  19. ncbi request reprint Characterization of a human colonic cDNA encoding a structurally novel urea transporter, hUT-A6
    Craig P Smith
    School of Biological Sciences, University of Manchester, G 38, Stopford Bldg, Oxford Road, Manchester M13 9PT, United Kingdom
    Am J Physiol Cell Physiol 287:C1087-93. 2004
    ....
  20. ncbi request reprint Urea and renal function in the 21st century: insights from knockout mice
    Robert A Fenton
    Water and Salt Research Center, Institute of Anatomy, Building 233 234, University of Aarhus, DK 8000 Aarhus, Denmark
    J Am Soc Nephrol 18:679-88. 2007
    ....
  21. pmc Proteomic analysis of lithium-induced nephrogenic diabetes insipidus: mechanisms for aquaporin 2 down-regulation and cellular proliferation
    Jakob Nielsen
    Water and Salt Research Center, University of Aarhus, DK 8000 Aarhus C, Denmark
    Proc Natl Acad Sci U S A 105:3634-9. 2008
    ..This study provides a comprehensive analysis of the proteins affected by lithium treatment in the IMCD and, as such, provides clues to potential lithium targets in the brain...
  22. pmc Acute regulation of aquaporin-2 phosphorylation at Ser-264 by vasopressin
    Robert A Fenton
    The Water and Salt Research Center, Institute of Anatomy, University of Aarhus, DK 8000 Aarhus C, Denmark
    Proc Natl Acad Sci U S A 105:3134-9. 2008
    ..Overall, our results are consistent with a dynamic effect of AVP on the phosphorylation and subcellular distribution of AQP2...
  23. ncbi request reprint A current view of the mammalian aquaglyceroporins
    Aleksandra Rojek
    Water and Salt Research Center, Institute of Anatomy, University of Aarhus, Aarhus C, Denmark
    Annu Rev Physiol 70:301-27. 2008
    ..This review comprehensively discusses the recent discoveries in the field of aquaglyceroporins, alongside a brief overview of the so-called unorthodox aquaporins...
  24. ncbi request reprint Cellular and subcellular distribution of the type-2 vasopressin receptor in the kidney
    Robert A Fenton
    The Water and Salt Research Center, Institute of Anatomy, University of Aarhus, Aarhus, Denmark
    Am J Physiol Renal Physiol 293:F748-60. 2007
    ..Confocal microscopy of isolated inner medullary collecting duct tubules showed that the V2R is expressed both intracellularly and in basolateral membrane domains...