Heinz Feldmann

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Viral hemorrhagic fevers: advancing the level of treatment
    Giuseppe Ippolito
    National Institute for Infectious Diseases Lazzaro Spallanzani, Rome, Italy
    BMC Med 10:31. 2012
  2. pmc Ebola haemorrhagic fever
    Heinz Feldmann
    Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT, USA
    Lancet 377:849-62. 2011
  3. pmc Vesicular stomatitis virus-based vaccine protects hamsters against lethal challenge with Andes virus
    Kyle S Brown
    Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada
    J Virol 85:12781-91. 2011
  4. pmc In vitro and in vivo activity of ribavirin against Andes virus infection
    David Safronetz
    Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America
    PLoS ONE 6:e23560. 2011
  5. pmc Pathogenesis and host response in Syrian hamsters following intranasal infection with Andes virus
    David Safronetz
    Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, Montana, United States of America
    PLoS Pathog 7:e1002426. 2011
  6. pmc Protective efficacy of a bivalent recombinant vesicular stomatitis virus vaccine in the Syrian hamster model of lethal Ebola virus infection
    Yoshimi Tsuda
    Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA
    J Infect Dis 204:S1090-7. 2011
  7. pmc Host response dynamics following lethal infection of rhesus macaques with Zaire ebolavirus
    Hideki Ebihara
    Laboratory of Virology, Rocky Mountain Veterinary Branch, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, Montana 59840, USA
    J Infect Dis 204:S991-9. 2011
  8. pmc Vesicular stomatitis virus-based Ebola vaccines with improved cross-protective efficacy
    Andrea Marzi
    Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institute of Health, Hamilton, Montana 59840, USA
    J Infect Dis 204:S1066-74. 2011
  9. pmc Clinical outcome of henipavirus infection in hamsters is determined by the route and dose of infection
    Barry Rockx
    Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA
    J Virol 85:7658-71. 2011
  10. pmc Comparative pathogenesis of three human and zoonotic SARS-CoV strains in cynomolgus macaques
    Barry Rockx
    Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America
    PLoS ONE 6:e18558. 2011

Collaborators

Detail Information

Publications31

  1. pmc Viral hemorrhagic fevers: advancing the level of treatment
    Giuseppe Ippolito
    National Institute for Infectious Diseases Lazzaro Spallanzani, Rome, Italy
    BMC Med 10:31. 2012
    ..Here we discuss the current knowledge about VHF clinical management to propose a way to step up the approach to VHFs beyond the mere application of infection control measures...
  2. pmc Ebola haemorrhagic fever
    Heinz Feldmann
    Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT, USA
    Lancet 377:849-62. 2011
    ....
  3. pmc Vesicular stomatitis virus-based vaccine protects hamsters against lethal challenge with Andes virus
    Kyle S Brown
    Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada
    J Virol 85:12781-91. 2011
    ..Overall, our data suggest the potential for the use of the VSV platform as a fast-acting and effective prophylaxis/postexposure treatment against lethal hantavirus infections...
  4. pmc In vitro and in vivo activity of ribavirin against Andes virus infection
    David Safronetz
    Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America
    PLoS ONE 6:e23560. 2011
    ....
  5. pmc Pathogenesis and host response in Syrian hamsters following intranasal infection with Andes virus
    David Safronetz
    Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, Montana, United States of America
    PLoS Pathog 7:e1002426. 2011
    ....
  6. pmc Protective efficacy of a bivalent recombinant vesicular stomatitis virus vaccine in the Syrian hamster model of lethal Ebola virus infection
    Yoshimi Tsuda
    Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA
    J Infect Dis 204:S1090-7. 2011
    ..Outbreaks of filoviral hemorrhagic fever occur sporadically and unpredictably across wide regions in central Africa and overlap with the occurrence of other infectious diseases of public health importance...
  7. pmc Host response dynamics following lethal infection of rhesus macaques with Zaire ebolavirus
    Hideki Ebihara
    Laboratory of Virology, Rocky Mountain Veterinary Branch, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, Montana 59840, USA
    J Infect Dis 204:S991-9. 2011
    ..These results highlight the pathological analogies between EHF and severe sepsis and not only contribute to our understanding of the pathogenic process, but will also help to establish novel postexposure treatment modalities...
  8. pmc Vesicular stomatitis virus-based Ebola vaccines with improved cross-protective efficacy
    Andrea Marzi
    Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institute of Health, Hamilton, Montana 59840, USA
    J Infect Dis 204:S1066-74. 2011
    ..Our data demonstrate that cross-protection between the EBOV species can be achieved, although EBOV-GP alone cannot induce the required immune response...
  9. pmc Clinical outcome of henipavirus infection in hamsters is determined by the route and dose of infection
    Barry Rockx
    Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA
    J Virol 85:7658-71. 2011
    ....
  10. pmc Comparative pathogenesis of three human and zoonotic SARS-CoV strains in cynomolgus macaques
    Barry Rockx
    Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America
    PLoS ONE 6:e18558. 2011
    ..This study characterizes critical disease models in the evaluation and licensure of therapeutic strategies against SARS-CoV for human use...
  11. pmc Antagonism of type I interferon responses by new world hantaviruses
    Jessica R Levine
    Rocky Mountain Laboratories, Hamilton, MT 59840, USA
    J Virol 84:11790-801. 2010
    ..These data suggest that IFN antagonism strategies by hantaviruses are quite variable, even between species with similar disease phenotypes, and may help to better elucidate species-specific pathogenesis...
  12. pmc New World hantaviruses activate IFNlambda production in type I IFN-deficient vero E6 cells
    Joseph Prescott
    Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Disease, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, Montana, USA
    PLoS ONE 5:e11159. 2010
    ..Interferon lambda, a more recently characterized type III IFN, is transcriptionally controlled much like the type I IFNs, and activates the innate immune system in a similar manner...
  13. pmc The Ebola virus glycoprotein contributes to but is not sufficient for virulence in vivo
    Allison Groseth
    Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA
    PLoS Pathog 8:e1002847. 2012
    ..Thus, while these findings provide direct evidence that GP contributes to filovirus virulence in vivo, they also clearly indicate that other factors are needed for the acquisition of full virulence...
  14. pmc Nipah virus transmission in a hamster model
    Emmie de Wit
    Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA
    PLoS Negl Trop Dis 5:e1432. 2011
    ..The data provide new and much-needed insights into the modes and efficiency of Nipah virus transmission and have important public health implications with regards to the risk assessment and management of future Nipah virus outbreaks...
  15. pmc Thoracic radiography as a refinement methodology for the study of H1N1 influenza in cynomologus macaques (Macaca fascicularis)
    Douglas L Brining
    Rocky Mountain Veterinary Branch, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA
    Comp Med 60:389-95. 2010
    ..The radiographic evaluation allowed for noninvasive assessment of lung involvement, disease onset, progression, and resolution of radiographic changes associated with H1N1 influenza infection...
  16. pmc A new Ebola virus nonstructural glycoprotein expressed through RNA editing
    Masfique Mehedi
    Department of Medical Microbiology, University of Manitoba, Public Health Agency of Canada, Winnipeg, Manitoba, Canada
    J Virol 85:5406-14. 2011
    ..While ssGP appears to share similar structural properties with sGP, it does not appear to have the same anti-inflammatory function on endothelial cells as sGP...
  17. pmc Assessment of rodents as animal models for Reston ebolavirus
    Emmie de Wit
    Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA
    J Infect Dis 204:S968-72. 2011
    ..Moreover, REBOV Pennsylvania was more pathogenic than REBOV Reston08-A in this model. Thus, STAT1(-)(/-) mice may be used for research of REBOV pathogenicity and intervention strategies...
  18. pmc A novel model of lethal Hendra virus infection in African green monkeys and the effectiveness of ribavirin treatment
    Barry Rockx
    Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 S 4th Street, Hamilton, Montana, USA
    J Virol 84:9831-9. 2010
    ....
  19. pmc A replicating cytomegalovirus-based vaccine encoding a single Ebola virus nucleoprotein CTL epitope confers protection against Ebola virus
    Yoshimi Tsuda
    Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America
    PLoS Negl Trop Dis 5:e1275. 2011
    ....
  20. pmc Validation of assays to monitor immune responses in the Syrian golden hamster (Mesocricetus auratus)
    Marko Zivcec
    Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA
    J Immunol Methods 368:24-35. 2011
    ..Ribosomal protein L18 was identified as the most stable internal reference gene. In conclusion, these new assays will greatly improve the use of the hamster as an important small animal model in infectious disease research...
  21. pmc Pandemic swine-origin H1N1 influenza A virus isolates show heterogeneous virulence in macaques
    David Safronetz
    Laboratory of Virology, Hamilton, Montana, USA
    J Virol 85:1214-23. 2011
    ..Differences in virulence may explain more severe disease, as was seen with certain individuals infected with the emerged pandemic influenza virus. Thus, the nonhuman primate model closely mimics influenza in humans...
  22. pmc Modern dosimetric tools for (60)Co irradiation at high containment laboratories
    Barri Twardoski
    Radiation Safety Department, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, NIH, Rocky Mountain Laboratories, Hamilton, MT 59840, USA
    Int J Radiat Biol 87:1039-44. 2011
    ....
  23. pmc Protective efficacy of neutralizing monoclonal antibodies in a nonhuman primate model of Ebola hemorrhagic fever
    Andrea Marzi
    Laboratory of Virology, Rocky Mountain Laboratories, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA
    PLoS ONE 7:e36192. 2012
    ..Our results indicate that EBOV neutralizing antibodies, particularly in combination with other therapeutic strategies, might be beneficial in reducing viral loads and prolonging disease progression during EHF...
  24. pmc The immune response to Nipah virus infection
    Joseph Prescott
    Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA
    Arch Virol 157:1635-41. 2012
    ..This review summarizes our current understanding of the immune response to Nipah virus infection and emphasizes the need for further research...
  25. pmc Progress in filovirus vaccine development: evaluating the potential for clinical use
    Darryl Falzarano
    Laboratory of Virology, Rocky Mountain Laboratories, Division of Intramural Research, National Institute of Allergy and Infectious Disease, National Institutes of Health, 903 South 4th Street, Hamilton, MT 59840, USA
    Expert Rev Vaccines 10:63-77. 2011
    ..These results demonstrate that achieving a vaccine that is protective against filoviruses is possible; the challenge now is to prove its safety and efficacy in order to obtain a vaccine that is ready for human use...
  26. pmc The Syrian hamster model of hantavirus pulmonary syndrome
    David Safronetz
    Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 South 4th Street, Hamilton, MT 59840, USA
    Antiviral Res 95:282-92. 2012
    ..The purpose of this article is to review the current understanding of HPS disease progression in Syrian hamsters and discuss the suitability of utilizing this model to evaluate potential medical countermeasures against HPS...
  27. pmc Tackling Ebola: new insights into prophylactic and therapeutic intervention strategies
    Emmie de Wit
    Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, 903 South 4th Street, MT 59840, USA
    Genome Med 3:5. 2011
    ..Here, we review the current state of Ebolavirus research, with emphasis on prophylactic and therapeutic intervention strategies...
  28. pmc Current ebola vaccines
    Thomas Hoenen
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Division of Intramural Research, Rocky Mountain Laboratories, Disease Modelling and Transmission Unit Laboratory of Virology, 2A120A, 903 S 4th St, Hamilton, MT, USA
    Expert Opin Biol Ther 12:859-72. 2012
    ..However, a number of vaccine candidates have been developed in the last decade that are highly protective in NHPs, the gold standard animal model for ebola hemorrhagic fever...
  29. pmc Ebola virion attachment and entry into human macrophages profoundly effects early cellular gene expression
    Victoria Wahl-Jensen
    Integrated Research Facility at Fort Detrick, Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Fort Detrick, Maryland, United States of America
    PLoS Negl Trop Dis 5:e1359. 2011
    ..In contrast, VLP(VP40) (particles lacking GP(1,2)) caused an aberrant response. This suggests that GP(1,2) binding to macrophages plays an important role in the immediate cellular response...
  30. pmc Detection of Lassa virus, Mali
    David Safronetz
    National Institutes of Health, Hamilton, Montana 59840, USA
    Emerg Infect Dis 16:1123-6. 2010
    ..We report the isolation and genetic characterization of Lassa virus from an area previously unknown for Lassa fever...
  31. pmc Chimeric human parainfluenza virus bearing the Ebola virus glycoprotein as the sole surface protein is immunogenic and highly protective against Ebola virus challenge
    Alexander Bukreyev
    National Institute of Allergy and Infectious Diseases, Building 50, Room 6505, NIAID, National Institutes of Health, 50 South Dr MSC 8007, Bethesda, MD 20892 8007, USA
    Virology 383:348-61. 2009
    ..Despite the attenuation, the virus was highly immunogenic, and a single IN dose completely protected the animals against a highly lethal intraperitoneal challenge of guinea pig-adapted EBOV...