Benjamin Feldman

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Pre-gastrula expression of zebrafish extraembryonic genes
    Sung Kook Hong
    Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    BMC Dev Biol 10:42. 2010
  2. pmc Embryonic mesoderm and endoderm induction requires the actions of non-embryonic Nodal-related ligands and Mxtx2
    Sung Kook Hong
    Medical Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA
    Development 138:787-95. 2011
  3. pmc Transcriptional profiling of endogenous germ layer precursor cells identifies dusp4 as an essential gene in zebrafish endoderm specification
    Jamie L Brown
    Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 105:12337-42. 2008
  4. pmc Cumulative ligand activity of NODAL mutations and modifiers are linked to human heart defects and holoprosencephaly
    Erich Roessler
    Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892 3717, USA
    Mol Genet Metab 98:225-34. 2009
  5. pmc A model of Costeff Syndrome reveals metabolic and protective functions of mitochondrial OPA3
    Wuhong Pei
    Medical Genetics Branch, National Human Genome Research Institute, Bethesda, MD 20892, USA
    Development 137:2587-96. 2010
  6. pmc Mutations in the human SIX3 gene in holoprosencephaly are loss of function
    Sabina Domené
    1Medical Genetics Branch, National Human Genome Research Institute, Bethesda, MD 20892, USA
    Hum Mol Genet 17:3919-28. 2008
  7. pmc Identification of common and unique modifiers of zebrafish midline bifurcation and cyclopia
    Wuhong Pei
    Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, 9000 Rockville Pike, Building 35, Room 1B 205, Bethesda, MD 20892, USA
    Dev Biol 326:201-11. 2009
  8. pmc Reduced NODAL signaling strength via mutation of several pathway members including FOXH1 is linked to human heart defects and holoprosencephaly
    Erich Roessler
    Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Am J Hum Genet 83:18-29. 2008
  9. pmc OPA3, mutated in 3-methylglutaconic aciduria type III, encodes two transcripts targeted primarily to mitochondria
    Marjan Huizing
    Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Genet Metab 100:149-54. 2010
  10. pmc An early requirement for maternal FoxH1 during zebrafish gastrulation
    Wuhong Pei
    Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, 9000 Rockville Pike, Building 35, Room 1B 205, Bethesda, MD 20892, USA
    Dev Biol 310:10-22. 2007

Collaborators

Detail Information

Publications10

  1. pmc Pre-gastrula expression of zebrafish extraembryonic genes
    Sung Kook Hong
    Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    BMC Dev Biol 10:42. 2010
    ..The yolk syncytial layer initially forms below the margin, in a domain called the external yolk syncytial layer (E-YSL)...
  2. pmc Embryonic mesoderm and endoderm induction requires the actions of non-embryonic Nodal-related ligands and Mxtx2
    Sung Kook Hong
    Medical Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA
    Development 138:787-95. 2011
    ..In summary, the induction of mesoderm and endoderm depends upon the combined actions of Mxtx2 and Nodal-related ligands from non-embryonic sources...
  3. pmc Transcriptional profiling of endogenous germ layer precursor cells identifies dusp4 as an essential gene in zebrafish endoderm specification
    Jamie L Brown
    Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 105:12337-42. 2008
    ..This specific loss of sox17 establishes a new class of endoderm specification defect...
  4. pmc Cumulative ligand activity of NODAL mutations and modifiers are linked to human heart defects and holoprosencephaly
    Erich Roessler
    Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892 3717, USA
    Mol Genet Metab 98:225-34. 2009
    ....
  5. pmc A model of Costeff Syndrome reveals metabolic and protective functions of mitochondrial OPA3
    Wuhong Pei
    Medical Genetics Branch, National Human Genome Research Institute, Bethesda, MD 20892, USA
    Development 137:2587-96. 2010
    ..In summary, this paper introduces a faithful Costeff Syndrome model and demonstrates a requirement for mitochondrial OPA3 to limit HMG-CoA-derived MGC and protect the electron transport chain against inhibitory compounds...
  6. pmc Mutations in the human SIX3 gene in holoprosencephaly are loss of function
    Sabina Domené
    1Medical Genetics Branch, National Human Genome Research Institute, Bethesda, MD 20892, USA
    Hum Mol Genet 17:3919-28. 2008
    ..Our data indicate that SIX3 is a frequent target in the pathogenesis of HPE and demonstrate how this can inform the genetic counseling of families...
  7. pmc Identification of common and unique modifiers of zebrafish midline bifurcation and cyclopia
    Wuhong Pei
    Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, 9000 Rockville Pike, Building 35, Room 1B 205, Bethesda, MD 20892, USA
    Dev Biol 326:201-11. 2009
    ..In summary, we find that MB arises after gastrulation in regions that fail to express wnt5b, and we show that two complex dysmorphologies - MB and cyclopia - can be promoted by either common or unique risk factors...
  8. pmc Reduced NODAL signaling strength via mutation of several pathway members including FOXH1 is linked to human heart defects and holoprosencephaly
    Erich Roessler
    Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Am J Hum Genet 83:18-29. 2008
    ....
  9. pmc OPA3, mutated in 3-methylglutaconic aciduria type III, encodes two transcripts targeted primarily to mitochondria
    Marjan Huizing
    Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Genet Metab 100:149-54. 2010
    ..These findings thus place the cellular metabolic defect of 3-MGCA type III in the mitochondrion rather than the peroxisome and implicate loss of OPA3A rather than gain of OPA3B in disease etiology...
  10. pmc An early requirement for maternal FoxH1 during zebrafish gastrulation
    Wuhong Pei
    Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, 9000 Rockville Pike, Building 35, Room 1B 205, Bethesda, MD 20892, USA
    Dev Biol 310:10-22. 2007
    ..Our studies thus point to an essential role for maternal FoxH1 and downstream keratins during gastrulation that is epistatic to Nodal signaling...