A S Fauci

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Evaluation of lymph node virus burden in human immunodeficiency virus-infected patients receiving efavirenz-based protease inhibitor--sparing highly active antiretroviral therapy
    M Dybul
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institute of Health, Bethesda, MD 20892, USA
    J Infect Dis 181:1273-9. 2000
  2. pmc Short-cycle structured intermittent treatment of chronic HIV infection with highly active antiretroviral therapy: effects on virologic, immunologic, and toxicity parameters
    M Dybul
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 98:15161-6. 2001
  3. pmc Natural killer cells in HIV-1 infection: dichotomous effects of viremia on inhibitory and activating receptors and their functional correlates
    Domenico Mavilio
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 100:15011-6. 2003
  4. ncbi request reprint A proof-of-concept study of short-cycle intermittent antiretroviral therapy with a once-daily regimen of didanosine, lamivudine, and efavirenz for the treatment of chronic HIV infection
    Mark Dybul
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, United States Department of Health and Human Services, Bethesda, Maryland 20892, USA
    J Infect Dis 189:1974-82. 2004
  5. pmc CD25(+)CD4(+) regulatory T cells from the peripheral blood of asymptomatic HIV-infected individuals regulate CD4(+) and CD8(+) HIV-specific T cell immune responses in vitro and are associated with favorable clinical markers of disease status
    Audrey L Kinter
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, 10 Center Dr, Bethesda, MD 20892, USA
    J Exp Med 200:331-43. 2004
  6. ncbi request reprint Seasonal and pandemic influenza preparedness: science and countermeasures
    Anthony S Fauci
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Infect Dis 194:S73-6. 2006
  7. ncbi request reprint Infectious diseases: considerations for the 21st century
    A S Fauci
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Clin Infect Dis 32:675-85. 2001
  8. ncbi request reprint Deleterious effect of HIV-1 plasma viremia on B cell costimulatory function
    Angela Malaspina
    Department of Health and Human Services, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 170:5965-72. 2003
  9. ncbi request reprint Differential effects of CD40 ligand/trimer stimulation on the ability of dendritic cells to replicate and transmit HIV infection: evidence for CC-chemokine-dependent and -independent mechanisms
    J F McDyer
    Clinical Immunology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 162:3711-7. 1999
  10. ncbi request reprint Dendritic cells express multiple chemokine receptors used as coreceptors for HIV entry
    A Rubbert
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1576, USA
    J Immunol 160:3933-41. 1998

Collaborators

Detail Information

Publications125 found, 100 shown here

  1. ncbi request reprint Evaluation of lymph node virus burden in human immunodeficiency virus-infected patients receiving efavirenz-based protease inhibitor--sparing highly active antiretroviral therapy
    M Dybul
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institute of Health, Bethesda, MD 20892, USA
    J Infect Dis 181:1273-9. 2000
    ..There was no evidence of development of resistance to either regimen in virus isolated from LNMC. These data support the use of efavirenz as an alternative to a PI in initial HAART regimens...
  2. pmc Short-cycle structured intermittent treatment of chronic HIV infection with highly active antiretroviral therapy: effects on virologic, immunologic, and toxicity parameters
    M Dybul
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 98:15161-6. 2001
    ..In addition, there was a decrease in serum cholesterol and triglyceride levels. Intermittent therapy may be an important strategy to reduce cost and toxicity for HIV-infected individuals...
  3. pmc Natural killer cells in HIV-1 infection: dichotomous effects of viremia on inhibitory and activating receptors and their functional correlates
    Domenico Mavilio
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 100:15011-6. 2003
    ..This phenomenon is not attributed to a direct HIV-1 infection of NK cells; thus, this study may provide insight into the mechanisms of impaired host defenses in HIV-1 viremic patients...
  4. ncbi request reprint A proof-of-concept study of short-cycle intermittent antiretroviral therapy with a once-daily regimen of didanosine, lamivudine, and efavirenz for the treatment of chronic HIV infection
    Mark Dybul
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, United States Department of Health and Human Services, Bethesda, Maryland 20892, USA
    J Infect Dis 189:1974-82. 2004
    ..Adherence to such a regimen may be problematic for certain patients...
  5. pmc CD25(+)CD4(+) regulatory T cells from the peripheral blood of asymptomatic HIV-infected individuals regulate CD4(+) and CD8(+) HIV-specific T cell immune responses in vitro and are associated with favorable clinical markers of disease status
    Audrey L Kinter
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, 10 Center Dr, Bethesda, MD 20892, USA
    J Exp Med 200:331-43. 2004
    ..These in vitro data suggest that CD25(+)CD4(+) T reg cells may contribute to the diminution of HIV-specific T cell immune responses in vivo in the early stages of HIV disease...
  6. ncbi request reprint Seasonal and pandemic influenza preparedness: science and countermeasures
    Anthony S Fauci
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Infect Dis 194:S73-6. 2006
    ..Until these approaches are firmly linked, the community will not have optimized its preparedness for a pandemic...
  7. ncbi request reprint Infectious diseases: considerations for the 21st century
    A S Fauci
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Clin Infect Dis 32:675-85. 2001
    ..Increasingly, infectious disease research will be linked to the development of the medical infrastructure and training needed in developing countries to translate scientific advances into operational reality...
  8. ncbi request reprint Deleterious effect of HIV-1 plasma viremia on B cell costimulatory function
    Angela Malaspina
    Department of Health and Human Services, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 170:5965-72. 2003
    ....
  9. ncbi request reprint Differential effects of CD40 ligand/trimer stimulation on the ability of dendritic cells to replicate and transmit HIV infection: evidence for CC-chemokine-dependent and -independent mechanisms
    J F McDyer
    Clinical Immunology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 162:3711-7. 1999
    ..Together, these results show that CD40LT stimulation of DCs suppresses HIV replication and transmission to CD4+ T cells by two potentially different mechanisms...
  10. ncbi request reprint Dendritic cells express multiple chemokine receptors used as coreceptors for HIV entry
    A Rubbert
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1576, USA
    J Immunol 160:3933-41. 1998
    ..Delineation of the spectrum of coreceptor usage on DC may offer new approaches to interfere with the initiation and propagation of HIV infection...
  11. ncbi request reprint Neonatal natural killer cells produce chemokines and suppress HIV replication in vitro
    Helene B Bernstein
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20814, USA
    AIDS Res Hum Retroviruses 20:1189-95. 2004
    ..Our results show that nNK cells can inhibit HIV replication via a chemokine-mediated mechanism, and support a potential role for the innate immune system in preventing perinatal transmission of HIV in a noncytolytic manner...
  12. pmc Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy
    T W Chun
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 94:13193-7. 1997
    ..In addition, the presence of unintegrated HIV-1 DNA in infected resting CD4+ T cells from patients receiving HAART, even those with undetectable plasma viremia, suggests persistent active virus replication in vivo...
  13. ncbi request reprint Compromised B cell responses to influenza vaccination in HIV-infected individuals
    Angela Malaspina
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA
    J Infect Dis 191:1442-50. 2005
    ..We assessed the impact of HIV disease on B cell responses to influenza vaccination...
  14. ncbi request reprint Defective clonogenic potential of CD8+ T lymphocytes in patients with AIDS. Expansion in vivo of a nonclonogenic CD3+CD8+DR+CD25- T cell population
    G Pantaleo
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892
    J Immunol 144:1696-704. 1990
    ..We have shown that a large proportion of CD3+DR+CD25- cells (50 to 80% in the different patients with AIDS analyzed) expressed VLA-2 Ag.(ABSTRACT TRUNCATED AT 400 WORDS)..
  15. pmc The qualitative nature of the primary immune response to HIV infection is a prognosticator of disease progression independent of the initial level of plasma viremia
    G Pantaleo
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 94:254-8. 1997
    ....
  16. ncbi request reprint The role of CD4+ T cell help and CD40 ligand in the in vitro expansion of HIV-1-specific memory cytotoxic CD8+ T cell responses
    M A Ostrowski
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 165:6133-41. 2000
    ..Finally, it was demonstrated that IL-15 produced by CD40LT-stimulated dendritic cells may be an additional mechanism by which CD40LT induces the expansion of memory CTL in CD4(+) T cell-depleted conditions, where IL-2 is lacking...
  17. ncbi request reprint Induction of HIV-1 replication by allogeneic stimulation
    H Moriuchi
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    J Immunol 162:7543-8. 1999
    ..These observations suggest that allogeneic stimulation may play a role in the transmission, replication, and phenotypic transition of HIV-1...
  18. ncbi request reprint Recombinant gp120 specifically enhances tumor necrosis factor-alpha production and Ig secretion in B lymphocytes from HIV-infected individuals but not from seronegative donors
    P Rieckmann
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892
    J Immunol 147:2922-7. 1991
    ....
  19. pmc Human immunodeficiency virus type 1 bound to B cells: relationship to virus replicating in CD4+ T cells and circulating in plasma
    Angela Malaspina
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Virol 76:8855-63. 2002
    ..These findings also indicate that most of the virus in plasma originates from cells other than CD4(+) T cells in the peripheral blood and lymph nodes...
  20. pmc Early establishment of a pool of latently infected, resting CD4(+) T cells during primary HIV-1 infection
    T W Chun
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 95:8869-73. 1998
    ....
  21. pmc Induction of HIV-1 replication in latently infected CD4+ T cells using a combination of cytokines
    T W Chun
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Exp Med 188:83-91. 1998
    ....
  22. pmc Interleukin 7 reduces the levels of spontaneous apoptosis in CD4+ and CD8+ T cells from HIV-1-infected individuals
    Lia Vassena
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 104:2355-60. 2007
    ..These results provide a further rationale for consideration of IL-7 as an agent of immune reconstitution in HIV-1 infection...
  23. doi request reprint Evaluation of the pathogenesis of decreasing CD4(+) T cell counts in human immunodeficiency virus type 1-infected patients receiving successfully suppressive antiretroviral therapy
    Elizabeth Nies-Kraske
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, MD, USA
    J Infect Dis 199:1648-56. 2009
    ..All 4 patients had significant fibrosis of the T cell zone of lymphoid tissue, which appeared to be an important factor in the failure to reconstitute T cells...
  24. ncbi request reprint HIV envelope induces virus expression from resting CD4+ T cells isolated from HIV-infected individuals in the absence of markers of cellular activation or apoptosis
    Audrey L Kinter
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 170:2449-55. 2003
    ....
  25. ncbi request reprint Fluorodeoxyglucose imaging in healthy subjects with HIV infection: impact of disease stage and therapy on pattern of nodal activation
    Douglas Brust
    National Institute of Allergy and Infectious Disease, and the Nuclear Medicine Department, Warren G Magnuson Clinical Center of the National Institutes of Health, 10 Center Drive, MSC 1180, Bethesda, MD 20892, USA
    AIDS 20:985-93. 2006
    ..We evaluated the utility of fluorodeoxyglucose scanning as a tool to study HIV pathogenesis...
  26. pmc Appearance of immature/transitional B cells in HIV-infected individuals with advanced disease: correlation with increased IL-7
    Angela Malaspina
    Laboratory of Immunoregulation, and Office of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 103:2262-7. 2006
    ..Taken together, these data offer insight into human B cell development as well as B cell dysfunction in advanced HIV disease that may be linked to IL-7-dependent homeostatic events...
  27. pmc Factors secreted by human T lymphotropic virus type I (HTLV-I)-infected cells can enhance or inhibit replication of HIV-1 in HTLV-I-uninfected cells: implications for in vivo coinfection with HTLV-I and HIV-1
    H Moriuchi
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Exp Med 187:1689-97. 1998
    ..Our data suggest that the net effect of HTLV-I coinfection in HIV-infected individuals favors the transition from M- to T-tropic HIV phenotype, which is generally indicative of progressive HIV disease...
  28. ncbi request reprint Expression of chemokine receptors CXCR4 and CCR5 in HIV-1-infected and uninfected individuals
    M A Ostrowski
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892 1576, USA
    J Immunol 161:3195-201. 1998
    ..Patients who harbored syncytium-inducing viruses, however, could not be distinguished from those who harbored nonsyncytium-inducing viruses based on the level of CD4+ T cell activation or chemokine receptor expression...
  29. pmc Evidence for rapid disappearance of initially expanded HIV-specific CD8+ T cell clones during primary HIV infection
    G Pantaleo
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 94:9848-53. 1997
    ..These findings should provide insights into how HIV, and possibly other viruses, elude the host immune response during primary infection...
  30. ncbi request reprint Intercellular adhesion molecules (ICAM)-1 ICAM-2 and ICAM-3 function as counter-receptors for lymphocyte function-associated molecule 1 in human immunodeficiency virus-mediated syncytia formation
    L Butini
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892
    Eur J Immunol 24:2191-5. 1994
    ..These results indicate that the interaction between LFA-1 and ICAM is a critical step in HIV-mediated syncytia formation, and that ICAM-1, ICAM-2 and ICAM-3 are the receptor molecules for the LFA-1-dependent syncytia formation...
  31. ncbi request reprint Guidelines for using antiretroviral agents among HIV-infected adults and adolescents
    Mark Dybul
    National Institutes of Health, Bethesda, Maryland, USA
    Ann Intern Med 137:381-433. 2002
    ..Because concepts regarding HIV management are evolving rapidly, readers should check regularly for additional information and updates at the HIV/AIDS Treatment Information Service website ( http://www.hivatis.org )...
  32. pmc Lysis of endogenously infected CD4+ T cell blasts by rIL-2 activated autologous natural killer cells from HIV-infected viremic individuals
    Manuela Fogli
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Pathog 4:e1000101. 2008
    ....
  33. ncbi request reprint Guidelines for using antiretroviral agents among HIV-infected adults and adolescents. Recommendations of the Panel on Clinical Practices for Treatment of HIV
    Mark Dybul
    National Institutes of Health, Bethesda, Maryland, USA
    MMWR Recomm Rep 51:1-55. 2002
    ..Because concepts regarding HIV management are evolving rapidly, readers should check regularly for additional information and updates at the HIV/AIDS Treatment Information Service website (http://www.hivatis.org)...
  34. ncbi request reprint An HIV vaccine--evolving concepts
    Margaret I Johnston
    Division of AIDS, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    N Engl J Med 356:2073-81. 2007
  35. pmc Defective plasmacytoid dendritic cell-NK cell cross-talk in HIV infection
    K N Reitano
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health DHHS, SAIC Frederick, NCI, Frederick, MD 21702, USA
    AIDS Res Hum Retroviruses 25:1029-37. 2009
    ..These findings suggest a novel mechanism by which HIV is capable of suppressing an innate immune function in infected individuals...
  36. pmc Differentiation of promonocytic U937 subclones into macrophagelike phenotypes regulates a cellular factor(s) which modulates fusion/entry of macrophagetropic human immunodeficiency virus type 1
    H Moriuchi
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Virol 72:3394-400. 1998
    ....
  37. ncbi request reprint Host factors in the pathogenesis of HIV disease
    O J Cohen
    National Institute of Allergy and Infectious Diseases, Laboratory of Immunoregulation, Bethesda, Maryland, USA
    Immunol Rev 159:31-48. 1997
    ..HIV-specific immune responses, including cytotoxic T-lymphocyte (CTL) responses and neutralizing antibody responses, also appear to play salutary roles in protecting against disease progression...
  38. ncbi request reprint Active Wegener's granulomatosis is associated with HLA-DR+ CD4+ T cells exhibiting an unbalanced Th1-type T cell cytokine pattern: reversal with IL-10
    B R Ludviksson
    Mucosal Immunity Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA
    J Immunol 160:3602-9. 1998
    ..These data suggest that T cells from WG patients overproduce IFN-gamma and TNF-alpha, probably due to dysregulated IL-12 secretion, and that IL-10 may therefore have therapeutic implications for this disease...
  39. ncbi request reprint HIV and AIDS: 20 years of science
    Anthony S Fauci
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 2520, USA
    Nat Med 9:839-43. 2003
  40. ncbi request reprint Race against time
    Anthony S Fauci
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 2520, USA
    Nature 435:423-4. 2005
  41. pmc Natural killer cells from human immunodeficiency virus (HIV)-infected individuals are an important source of CC-chemokines and suppress HIV-1 entry and replication in vitro
    A Oliva
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Invest 102:223-31. 1998
    ..These data suggest that activated NK cells may be an important source of CC-chemokines in vivo and may suppress HIV replication by CC-chemokine-mediated mechanisms in addition to classic NK-mediated lytic mechanisms...
  42. pmc CXCR4 and CCR5 genetic polymorphisms in long-term nonprogressive human immunodeficiency virus infection: lack of association with mutations other than CCR5-Delta32
    O J Cohen
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892 1876, USA
    J Virol 72:6215-7. 1998
    ..Polymorphisms in the CXCR4 and CCR5 coding sequences other than CCR5-Delta32 do not appear to play a dominant mechanistic role in nonprogression among HIV-infected individuals...
  43. pmc HIV-1 induces phenotypic and functional perturbations of B cells in chronically infected individuals
    S Moir
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, and Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 98:10362-7. 2001
    ..These results indicate that HIV viremia induces the appearance of a subset of B cells whose function is impaired and which may be responsible for the hypergammaglobulinemia associated with HIV disease...
  44. pmc Human immunodeficiency virus type 1 (HIV-1) non-B subtypes are similar to HIV-1 subtype B in that coreceptor specificity is a determinant of cytopathicity in human lymphoid tissue infected ex vivo
    N Malkevich
    Laboratory of Cellular and Molecular Biophysics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Virol 75:10520-2. 2001
    ..Thus, at least for the viruses within subtypes A, B, C, and E that were tested, coreceptor specificity is a critical factor that determines the ability of HIV-1 to deplete CD4(+) T cells in human lymphoid tissue infected ex vivo...
  45. ncbi request reprint Expression of chemokine and inhibitory receptors on natural killer cells: effect of immune activation and HIV viremia
    S Kottilil
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Infect Dis 189:1193-8. 2004
    ....
  46. ncbi request reprint Protection of rhesus macaques against disease progression from pathogenic SHIV-89.6PD by vaccination with phage-displayed HIV-1 epitopes
    X Chen
    Laboratory of Immunoregulation, NIAID, NIH, Bethesda, Maryland, USA
    Nat Med 7:1225-31. 2001
    ..These results provide a new approach to the design of broadly protective HIV-1 vaccines...
  47. ncbi request reprint Chemokines, cytokines and HIV: a complex network of interactions that influence HIV pathogenesis
    A Kinter
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Immunol Rev 177:88-98. 2000
    ..Finally, the interaction between chemokine receptors and chemokines or HIV envelope has significant effects on cellular functions which likely play a role in HIV pathogenesis...
  48. pmc Suppression of HIV replication in the resting CD4+ T cell reservoir by autologous CD8+ T cells: implications for the development of therapeutic strategies
    T W Chun
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 98:253-8. 2001
    ....
  49. ncbi request reprint Selection of HIV-specific immunogenic epitopes by screening random peptide libraries with HIV-1-positive sera
    G Scala
    Laboratory of Immunoregulation, and Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Immunol 162:6155-61. 1999
    ..These results demonstrate that pools of HIV-1 mimotopes can be selected from combinatorial peptide libraries by taking advantage of the HIV-specific Ab repertoire induced by the natural infection...
  50. ncbi request reprint Peripheral blood-derived CD34+ progenitor cells: CXC chemokine receptor 4 and CC chemokine receptor 5 expression and infection by HIV
    M E Ruiz
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1576, USA
    J Immunol 161:4169-76. 1998
    ....
  51. ncbi request reprint Effect of interleukin-2 on the pool of latently infected, resting CD4+ T cells in HIV-1-infected patients receiving highly active anti-retroviral therapy
    T W Chun
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Med 5:651-5. 1999
    ..These results indicate that the intermittent administration of IL-2 with continuous HAART may lead to a substantial reduction in the pool of resting CD4+ T cells that contain replication-competent HIV...
  52. ncbi request reprint Induction of phosphorylation and intracellular association of CC chemokine receptor 5 and focal adhesion kinase in primary human CD4+ T cells by macrophage-tropic HIV envelope
    C Cicala
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    J Immunol 163:420-6. 1999
    ..Activation of this signaling pathway by HIV-1 envelope may be an important pathogenic mechanism of dysregulated cellular activation and trafficking during HIV infection...
  53. pmc Both memory and CD45RA+/CD62L+ naive CD4(+) T cells are infected in human immunodeficiency virus type 1-infected individuals
    M A Ostrowski
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Virol 73:6430-5. 1999
    ..Our findings suggest that naive CD4(+) T cells may be a significant viral reservoir for HIV, particularly in those patients harboring CXCR4-using viruses...
  54. pmc Latent reservoirs of HIV: obstacles to the eradication of virus
    T W Chun
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 96:10958-61. 1999
    ..Here we discuss recent developments in studies of the latent reservoir of HIV in patients receiving HAART and implications for the long-term treatment of infected individuals and eradication of the infection...
  55. pmc Exposure to bacterial products renders macrophages highly susceptible to T-tropic HIV-1
    M Moriuchi
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Invest 102:1540-50. 1998
    ....
  56. pmc HIV-1 envelope induces activation of caspase-3 and cleavage of focal adhesion kinase in primary human CD4(+) T cells
    C Cicala
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 97:1178-83. 2000
    ..En-velope treatment of lymphocytes led to the cleavage of FAK in a manner consistent with caspase-mediated cleavage...
  57. ncbi request reprint Macrophage-tropic HIV and SIV envelope proteins induce a signal through the CCR5 chemokine receptor
    D Weissman
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 389:981-5. 1997
    ..Alternatively, envelope-mediated CCR5 signal transduction may influence viral-associated cytopathicity or apoptosis...
  58. ncbi request reprint CD40 ligand trimer and IL-12 enhance peripheral blood mononuclear cells and CD4+ T cell proliferation and production of IFN-gamma in response to p24 antigen in HIV-infected individuals: potential contribution of anergy to HIV-specific unresponsiveness
    M Dybul
    Laboratory of Immunoregulation and Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, and Warren Magneson Clinical Research Center, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 165:1685-91. 2000
    ..They also indicate the potential for CD40LT and IL-12 as immune-based therapies for HIV infection...
  59. ncbi request reprint Relationship between pre-existing viral reservoirs and the re-emergence of plasma viremia after discontinuation of highly active anti-retroviral therapy
    T W Chun
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Med 6:757-61. 2000
    ....
  60. pmc Cathepsin G, a neutrophil-derived serine protease, increases susceptibility of macrophages to acute human immunodeficiency virus type 1 infection
    H Moriuchi
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Virol 74:6849-55. 2000
    ....
  61. pmc B cells of HIV-1-infected patients bind virions through CD21-complement interactions and transmit infectious virus to activated T cells
    S Moir
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Exp Med 192:637-46. 2000
    ..Furthermore, B cells possess the added capability of circulating in peripheral blood and migrating through tissues where they can potentially interact with and pass virus to T cells...
  62. pmc CCR5 signal transduction in macrophages by human immunodeficiency virus and simian immunodeficiency virus envelopes
    J Arthos
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Virol 74:6418-24. 2000
    ..The data presented here are consistent with this hypothesis and suggest that the differential capacity of viral envelopes to signal through CCR5 may influence their ability to replicate in macrophages...
  63. doi request reprint Dengue and hemorrhagic fever: a potential threat to public health in the United States
    David M Morens
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    JAMA 299:214-6. 2008
  64. doi request reprint Pathogenesis of HIV disease: opportunities for new prevention interventions
    Anthony S Fauci
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Clin Infect Dis 45:S206-12. 2007
    ....
  65. doi request reprint HIV-1 envelope protein binds to and signals through integrin alpha4beta7, the gut mucosal homing receptor for peripheral T cells
    James Arthos
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Immunol 9:301-9. 2008
    ..On CD4+ T cells, engagement of alpha4beta7 by gp120 resulted in rapid activation of LFA-1, the central integrin involved in the establishment of virological synapses, which facilitate efficient cell-to-cell spreading of HIV-1...
  66. ncbi request reprint 25 years of HIV/AIDS science: reaching the poor with research advances
    Anthony S Fauci
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Cell 131:429-32. 2007
    ..Although much has been accomplished in HIV/AIDS research, much remains to be done, especially regarding delivery of HIV/AIDS therapies and care and prevention interventions to the poorest countries that need them most...
  67. pmc Suppression of HIV-specific T cell activity by lymph node CD25+ regulatory T cells from HIV-infected individuals
    Audrey Kinter
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 104:3390-5. 2007
    ....
  68. ncbi request reprint Lasker Public Service Award. The expanding global health agenda: a welcome development
    Anthony S Fauci
    National Institute of Allergy and Infectious Diseases, 9000 Rockville Pike, Building 31, Room 7A 03, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Med 13:1169-71. 2007
  69. ncbi request reprint Innate immunity in HIV infection: enhanced susceptibility to CD95-mediated natural killer cell death and turnover induced by HIV viremia
    Shyam Kottilil
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health NIH, Bethesda, MD 20892, USA
    J Acquir Immune Defic Syndr 46:151-9. 2007
    ..In addition, these NK cells, particularly the CD56(dim) CD16(bright) subset, undergo enhanced cell turnover in vivo, as demonstrated by intracellular Ki67 expression...
  70. ncbi request reprint Emerging and re-emerging infectious diseases: influenza as a prototype of the host-pathogen balancing act
    Anthony S Fauci
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Cell 124:665-70. 2006
    ..The importance of understanding host-pathogen interactions is underscored by the emergence of virulent H5N1 avian influenza viruses and their transmission to humans, and the potential pandemic threat they pose...
  71. pmc R5 and X4 HIV envelopes induce distinct gene expression profiles in primary peripheral blood mononuclear cells
    Claudia Cicala
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 103:3746-51. 2006
    ..Additionally, signaling by R5 gp120 may facilitate the transmission of R5 viruses by inducing a permissive environment for HIV replication...
  72. pmc HIV-1 gp120 inhibits TLR9-mediated activation and IFN-{alpha} secretion in plasmacytoid dendritic cells
    Elena Martinelli
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Disease, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 104:3396-401. 2007
    ....
  73. ncbi request reprint Decay of the HIV reservoir in patients receiving antiretroviral therapy for extended periods: implications for eradication of virus
    Tae Wook Chun
    Laboratory of Immunoregulation, Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Infect Dis 195:1762-4. 2007
    ..6 months. It is projected that it will take up to 7.7 years of continuous therapy to completely eliminate latently infected resting CD4+ T cells in infected individuals who initiate antiviral therapy early in HIV infection...
  74. pmc Pathogenic mechanisms of B-lymphocyte dysfunction in HIV disease
    Susan Moir
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Allergy Clin Immunol 122:12-9; quiz 20-1. 2008
    ....
  75. doi request reprint Induction of unnatural immunity: prospects for a broadly protective universal influenza vaccine
    Gary J Nabel
    National Institute of Allergy and Infectious Diseases, US National Institutes of Health, Bethesda, Maryland, USA
    Nat Med 16:1389-91. 2010
    ..Newer vaccine approaches have succeeded in eliciting broadly neutralizing antibodies to highly conserved yet vulnerable regions of the hemagglutinin and suggest potential pathways for the development of universal influenza vaccines...
  76. pmc Pandemic influenza's 500th anniversary
    David M Morens
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Clin Infect Dis 51:1442-4. 2010
    ..It seems likely that, in the foreseeable future, we may be able to greatly reduce the burden of influenza pandemics with improved vaccines and other scientific and public health approaches...
  77. doi request reprint Pathogenic mechanisms of HIV disease
    Susan Moir
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Annu Rev Pathol 6:223-48. 2011
    ..Further advances in therapeutics and informative technologies, combined with a better understanding of the immunologic and virologic components of HIV disease, hold promise for new preventative and even curative strategies...
  78. pmc Rebound of plasma viremia following cessation of antiretroviral therapy despite profoundly low levels of HIV reservoir: implications for eradication
    Tae Wook Chun
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    AIDS 24:2803-8. 2010
    ..It is of great interest to identify individuals who had received ART for prolonged periods of time with extremely low or undetectable HIV reservoirs and monitor plasma viremia following discontinuation of therapy...
  79. pmc B cells in early and chronic HIV infection: evidence for preservation of immune function associated with early initiation of antiretroviral therapy
    Susan Moir
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Blood 116:5571-9. 2010
    ..These findings provide new insights on B cells in HIV infection and how early initiation of ART may prevent irreversible immune system damage...
  80. pmc The integrin alpha4beta7 forms a complex with cell-surface CD4 and defines a T-cell subset that is highly susceptible to infection by HIV-1
    Claudia Cicala
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 106:20877-82. 2009
    ..The specific affinity of gp120 for alpha(4)beta(7) provides a mechanism for HIV-1 to target activated cells that are critical for efficient virus propagation and dissemination following sexual transmission...
  81. pmc Human immunodeficiency virus and hepatitis C infections induce distinct immunologic imprints in peripheral mononuclear cells
    Shyam Kottilil
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Hepatology 50:34-45. 2009
    ....
  82. pmc Emerging infections: a perpetual challenge
    David M Morens
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Lancet Infect Dis 8:710-9. 2008
    ..Fundamental determinants, typically acting in concert, seem to underlie their emergence, and infections such as these are likely to continue to remain challenges to human survival...
  83. pmc Predominant role of bacterial pneumonia as a cause of death in pandemic influenza: implications for pandemic influenza preparedness
    David M Morens
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    J Infect Dis 198:962-70. 2008
    ..Despite the availability of published data on 4 pandemics that have occurred over the past 120 years, there is little modern information on the causes of death associated with influenza pandemics...
  84. doi request reprint HIV vaccine research: the way forward
    Anthony S Fauci
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, 31 Center Drive, Bethesda, MD 20892, USA
    Science 321:530-2. 2008
    ..This article summarizes progress and challenges in HIV vaccine research, the priorities arising from a recent summit at NIAID, and the actions needed, some already under way, to address those priorities...
  85. pmc Evidence for HIV-associated B cell exhaustion in a dysfunctional memory B cell compartment in HIV-infected viremic individuals
    Susan Moir
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 205:1797-805. 2008
    ..These data suggest that HIV-associated premature exhaustion of B cells may contribute to poor antibody responses against HIV in infected individuals...
  86. ncbi request reprint The National Institute of Allergy and Infectious Diseases' asthma research programs: a retrospective
    Daniel Rotrosen
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda MD, USA
    J Allergy Clin Immunol 119:258-62. 2007
  87. pmc HIV-1 envelope, integrins and co-receptor use in mucosal transmission of HIV
    Claudia Cicala
    Laboratory of Immunoregulation National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Transl Med 9:S2. 2011
    ....
  88. pmc B cells in HIV infection and disease
    Susan Moir
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland 20892, USA
    Nat Rev Immunol 9:235-45. 2009
    ..This Review focuses on advances in our understanding of the mechanisms of B-cell dysfunction in HIV-associated disease and discusses similarities with other diseases that are associated with B-cell dysfunction...
  89. ncbi request reprint Biochemical and biological characterization of a dodecameric CD4-Ig fusion protein: implications for therapeutic and vaccine strategies
    James Arthos
    Laboratory of Immunoregulation, NIAID, and the Molecular Interactions Resource Division of Bioengineering and Physical Science, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 277:11456-64. 2002
    ..This protein does not enhance viral replication at suboptimal concentrations. These observations may aid in the design of new therapeutics and vaccines...
  90. ncbi request reprint Productive HIV infection of resting CD4+ T cells: role of lymphoid tissue microenvironment and effect of immunomodulating agents
    Audrey Kinter
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases NIH, MSC 1576, Building 10, Room 6A33, 10 Center Drive, Bethesda, MD 20892 1576, USA
    AIDS Res Hum Retroviruses 19:847-56. 2003
    ..The ability of resting CD4+ T cells to support HIV replication in the microenvironment of the lymphoid tissue has implications in the pathogenesis of HIV disease and may provide an additional avenue for therapeutic intervention...
  91. pmc Genetic characterization of rebounding human immunodeficiency virus type 1 in plasma during multiple interruptions of highly active antiretroviral therapy
    Mark Dybul
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Virol 77:3229-37. 2003
    ..In addition, the data suggest that there may be multiple compartments contributing to the rebound of plasma viremia and to viral diversity from cycle to cycle of intermittent therapy...
  92. pmc Identification of NKG2A and NKp80 as specific natural killer cell markers in rhesus and pigtailed monkeys
    Domenico Mavilio
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 10 Center Dr, Bldg 10, Rm 6A08A, MSC 1576, Bethesda, MD 20814, USA
    Blood 106:1718-25. 2005
    ..This new phenotypic and functional characterization of NKG2A and NKp80 in rhesus and pigtailed macaque NK cells provides a new approach in the analysis of their innate immune system...
  93. pmc Pandemic influenza threat and preparedness
    Anthony S Fauci
    National Institutes of Health, Bethesda, Maryland 20892 2520, USA
    Emerg Infect Dis 12:73-7. 2006
    ..We describe recent research progress in preparing for pandemic influenza...
  94. pmc Characterization of CD56-/CD16+ natural killer (NK) cells: a highly dysfunctional NK subset expanded in HIV-infected viremic individuals
    Domenico Mavilio
    Laboratory of Immunoregulation and Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 102:2886-91. 2005
    ..These data suggest that the expansion of this highly dysfunctional CD56(-) NK cell subset in HIV-viremic individuals largely accounts for the impaired function of the total NK cell population...
  95. pmc Host-based antipoxvirus therapeutic strategies: turning the tables
    Anthony S Fauci
    National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20892 2520, USA
    J Clin Invest 115:231-3. 2005
    ..Drugs that target the ErbB-signaling pathways represent a promising new class of antiviral agents...
  96. pmc Decreased survival of B cells of HIV-viremic patients mediated by altered expression of receptors of the TNF superfamily
    Susan Moir
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bldg 10, Rm 6A02, 10 Center Dr, Bethesda, MD 20892, USA
    J Exp Med 200:587-99. 2004
    ....
  97. ncbi request reprint Decreased survival of B cells of HIV-viremic patients mediated by altered expression of receptors of the TNF superfamily
    Susan Moir
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 200:587-99. 2004
    ....
  98. ncbi request reprint HIV-1 gp120 induces NFAT nuclear translocation in resting CD4+ T-cells
    Claudia Cicala
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1876, USA
    Virology 345:105-14. 2006
    ..These observations provide insight into a potential mechanism by which HIV is able to establish infection in resting cells, which may have implications for both transmission of HIV and the persistence of viral reservoirs...
  99. pmc HIV envelope induces a cascade of cell signals in non-proliferating target cells that favor virus replication
    Claudia Cicala
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 99:9380-5. 2002
    ..These observations provide evidence that envelope-mediated signaling contributes to the productive infection of HIV in suboptimally activated T cells...
  100. ncbi request reprint Ethics of clinical research in the developing world
    Jack Killen
    National Institutes of Health, 9000 Rockville Pike, Bethesda, 20892 Maryland, USA
    Nat Rev Immunol 2:210-5. 2002
    ..Using HIV/AIDS research as an example, we show how this 'Uniform Care Requirement' can undermine biomedical research aimed at improving global health, and then we point towards a more rational and balanced approach to ethical assessment...
  101. ncbi request reprint Innate immune dysfunction in HIV infection: effect of HIV envelope-NK cell interactions
    Shyam Kottilil
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 176:1107-14. 2006
    ..Identification of specific surface receptors on NK cells that interact with HIV envelope proteins might explain how HIV is capable of circumventing innate immune defense mechanisms and establishing infection in susceptible individuals...