Research Topics
Genomes and Genes
| A S FauciSummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
Guidelines for using antiretroviral agents among HIV-infected adults and adolescentsMark Dybul
National Institutes of Health, Bethesda, Maryland, USA
Ann Intern Med 137:381-433. 2002..Because concepts regarding HIV management are evolving rapidly, readers should check regularly for additional information and updates at the HIV/AIDS Treatment Information Service website ( http://www.hivatis.org )...
HIV-infected individuals receiving effective antiviral therapy for extended periods of time continually replenish their viral reservoirTae Wook Chun
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20892, USA
J Clin Invest 115:3250-5. 2005..Such events may allow continual replenishment of the CD4+ T cell reservoir and resetting of the half-life of the latently infected, resting CD4+ T cells despite prolonged periods of aviremia...
The world must build on three decades of scientific advances to enable a new generation to live free of HIV/AIDSAnthony S Fauci
National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA
Health Aff (Millwood) 31:1529-36. 2012..If these challenges can be met, the world will have a clear path toward an "AIDS-free generation" in which new HIV infections, as well as illness and death due to AIDS, are increasingly rare...- Benefits and risks of influenza research: lessons learnedAnthony S Fauci
National Institutes of Health, Bethesda, MD 20892, USA
Science 336:1522-3. 2012..Recent public concern over two H5N1 influenza manuscripts that studied the transmissibility of influenza viruses has triggered intense discussion on dual-use research and the way forward... - Lasker Public Service Award. The expanding global health agenda: a welcome developmentAnthony S Fauci
National Institute of Allergy and Infectious Diseases, 9000 Rockville Pike, Building 31, Room 7A-03, National Institutes of Health, Bethesda, Maryland 20892, USA
Nat Med 13:1169-71. 2007 - 25 years of HIV/AIDS science: reaching the poor with research advancesAnthony S Fauci
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Cell 131:429-32. 2007..Although much has been accomplished in HIV/AIDS research, much remains to be done, especially regarding delivery of HIV/AIDS therapies and care and prevention interventions to the poorest countries that need them most... - The global challenge of infectious diseases: the evolving role of the National Institutes of Health in basic and clinical researchAnthony S Fauci
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892-2520, USA
Nat Immunol 6:743-7. 2005 - Emerging and re-emerging infectious diseases: influenza as a prototype of the host-pathogen balancing actAnthony S Fauci
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Cell 124:665-70. 2006..The importance of understanding host-pathogen interactions is underscored by the emergence of virulent H5N1 avian influenza viruses and their transmission to humans, and the potential pandemic threat they pose... - Pathogenesis of HIV disease: opportunities for new prevention interventionsAnthony S Fauci
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Clin Infect Dis 45:S206-12. 2007.... - Pandemic influenza threat and preparednessAnthony S Fauci
National Institutes of Health, Bethesda, Maryland 20892 2520, USA
Emerg Infect Dis 12:73-7. 2006..We describe recent research progress in preparing for pandemic influenza... - The ASCI, the spring meetings, and growing up in academic medicine: a personal perspectiveAnthony S Fauci
National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA
J Clin Invest 118:1214-7. 2008..The ASCI continues to provide this meeting forum for young investigators who aspire to emulate their idols and mentors just as I did in 1969 when I attended the spring meetings in Atlantic City for the first time... - NK cells in HIV infection: paradigm for protection or targets for ambushAnthony S Fauci
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 31, Room 7A04, 31 Center Drive, MSC 2520, Bethesda, Maryland 20892 2520, USA
Nat Rev Immunol 5:835-43. 2005..This Review focuses on the role of natural killer cells in controlling HIV infection and on the impact of HIV and HIV-viraemia-induced immune activation on natural-killer-cell function... - Emerging and reemerging infectious diseases: the perpetual challengeAnthony S Fauci
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bldg 31, Room 7A03, MSC 2520, 9000 Rockville Pike, Bethesda, MD 20892 2520, USA
Acad Med 80:1079-85. 2005..In this regard, partnerships between government, industry, and academia are necessary as we struggle to maintain and update our armamentarium in the struggle to outwit the microbes that pose a never-ending threat to mankind... - HIV vaccine research: the way forwardAnthony S Fauci
National Institute of Allergy and Infectious Diseases, National Institutes of Health, 31 Center Drive, Bethesda, MD 20892, USA
Science 321:530-2. 2008..This article summarizes progress and challenges in HIV vaccine research, the priorities arising from a recent summit at NIAID, and the actions needed, some already under way, to address those priorities... - Host-based antipoxvirus therapeutic strategies: turning the tablesAnthony S Fauci
National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20892 2520, USA
J Clin Invest 115:231-3. 2005..Drugs that target the ErbB-signaling pathways represent a promising new class of antiviral agents... - Suppression of HIV replication in the resting CD4+ T cell reservoir by autologous CD8+ T cells: implications for the development of therapeutic strategiesT W Chun
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 98:253-8. 2001.... - CCR5 signal transduction in macrophages by human immunodeficiency virus and simian immunodeficiency virus envelopesJ Arthos
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
J Virol 74:6418-24. 2000..The data presented here are consistent with this hypothesis and suggest that the differential capacity of viral envelopes to signal through CCR5 may influence their ability to replicate in macrophages... - CD40 ligand trimer and IL-12 enhance peripheral blood mononuclear cells and CD4+ T cell proliferation and production of IFN-gamma in response to p24 antigen in HIV-infected individuals: potential contribution of anergy to HIV-specific unresponsivenessM Dybul
Laboratory of Immunoregulation and Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, and Warren Magneson Clinical Research Center, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 165:1685-91. 2000..They also indicate the potential for CD40LT and IL-12 as immune-based therapies for HIV infection... - Deleterious effect of HIV-1 plasma viremia on B cell costimulatory functionAngela Malaspina
Department of Health and Human Services, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 170:5965-72. 2003.... - Both memory and CD45RA+/CD62L+ naive CD4(+) T cells are infected in human immunodeficiency virus type 1-infected individualsM A Ostrowski
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
J Virol 73:6430-5. 1999..Our findings suggest that naive CD4(+) T cells may be a significant viral reservoir for HIV, particularly in those patients harboring CXCR4-using viruses... - HIV-1 and T cell dynamics after interruption of highly active antiretroviral therapy (HAART) in patients with a history of sustained viral suppressionR T Davey
National Institute of Allergy and Infectious Diseases, NIAID, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 96:15109-14. 1999..Virologic relapse occurs rapidly in patients who discontinue suppressive drug therapy, even in patients with a markedly diminished pool of resting, latently infected CD4(+) T cells... - Evaluation of lymph node virus burden in human immunodeficiency virus-infected patients receiving efavirenz-based protease inhibitor--sparing highly active antiretroviral therapyM Dybul
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institute of Health, Bethesda, MD 20892, USA
J Infect Dis 181:1273-9. 2000..There was no evidence of development of resistance to either regimen in virus isolated from LNMC. These data support the use of efavirenz as an alternative to a PI in initial HAART regimens... 
B cells of HIV-1-infected patients bind virions through CD21-complement interactions and transmit infectious virus to activated T cellsS Moir
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
J Exp Med 192:637-46. 2000..Furthermore, B cells possess the added capability of circulating in peripheral blood and migrating through tissues where they can potentially interact with and pass virus to T cells...- Natural killer cells from human immunodeficiency virus (HIV)-infected individuals are an important source of CC-chemokines and suppress HIV-1 entry and replication in vitroA Oliva
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
J Clin Invest 102:223-31. 1998..These data suggest that activated NK cells may be an important source of CC-chemokines in vivo and may suppress HIV replication by CC-chemokine-mediated mechanisms in addition to classic NK-mediated lytic mechanisms... - Effect of interleukin-2 on the pool of latently infected, resting CD4+ T cells in HIV-1-infected patients receiving highly active anti-retroviral therapyT W Chun
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Nat Med 5:651-5. 1999..These results indicate that the intermittent administration of IL-2 with continuous HAART may lead to a substantial reduction in the pool of resting CD4+ T cells that contain replication-competent HIV... - Defective clonogenic potential of CD8+ T lymphocytes in patients with AIDS. Expansion in vivo of a nonclonogenic CD3+CD8+DR+CD25- T cell populationG Pantaleo
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892
J Immunol 144:1696-704. 1990..We have shown that a large proportion of CD3+DR+CD25- cells (50 to 80% in the different patients with AIDS analyzed) expressed VLA-2 Ag.(ABSTRACT TRUNCATED AT 400 WORDS).. - The qualitative nature of the primary immune response to HIV infection is a prognosticator of disease progression independent of the initial level of plasma viremiaG Pantaleo
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 94:254-8. 1997.... - Induction of phosphorylation and intracellular association of CC chemokine receptor 5 and focal adhesion kinase in primary human CD4+ T cells by macrophage-tropic HIV envelopeC Cicala
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
J Immunol 163:420-6. 1999..Activation of this signaling pathway by HIV-1 envelope may be an important pathogenic mechanism of dysregulated cellular activation and trafficking during HIV infection... - Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapyT W Chun
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 94:13193-7. 1997..In addition, the presence of unintegrated HIV-1 DNA in infected resting CD4+ T cells from patients receiving HAART, even those with undetectable plasma viremia, suggests persistent active virus replication in vivo... - Expression of chemokine receptors CXCR4 and CCR5 in HIV-1-infected and uninfected individualsM A Ostrowski
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892 1576, USA
J Immunol 161:3195-201. 1998..Patients who harbored syncytium-inducing viruses, however, could not be distinguished from those who harbored nonsyncytium-inducing viruses based on the level of CD4+ T cell activation or chemokine receptor expression... - Induction of HIV-1 replication by allogeneic stimulationH Moriuchi
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
J Immunol 162:7543-8. 1999..These observations suggest that allogeneic stimulation may play a role in the transmission, replication, and phenotypic transition of HIV-1... - Early establishment of a pool of latently infected, resting CD4(+) T cells during primary HIV-1 infectionT W Chun
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 95:8869-73. 1998.... - Exposure to bacterial products renders macrophages highly susceptible to T-tropic HIV-1M Moriuchi
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
J Clin Invest 102:1540-50. 1998.... - Neonatal natural killer cells produce chemokines and suppress HIV replication in vitroHelene B Bernstein
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20814, USA
AIDS Res Hum Retroviruses 20:1189-95. 2004..Our results show that nNK cells can inhibit HIV replication via a chemokine-mediated mechanism, and support a potential role for the innate immune system in preventing perinatal transmission of HIV in a noncytolytic manner... - Induction of HIV-1 replication in latently infected CD4+ T cells using a combination of cytokinesT W Chun
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
J Exp Med 188:83-91. 1998.... - Compromised B cell responses to influenza vaccination in HIV-infected individualsAngela Malaspina
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA
J Infect Dis 191:1442-50. 2005..CD4+ T cell count is a critical determinant of responsiveness to influenza vaccination, and the contribution of plasma HIV RNA level is suggestive and warrants further investigation... - Defective plasmacytoid dendritic cell-NK cell cross-talk in HIV infectionK N Reitano
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health DHHS, SAIC Frederick, NCI, Frederick, MD 21702, USA
AIDS Res Hum Retroviruses 25:1029-37. 2009..These findings suggest a novel mechanism by which HIV is capable of suppressing an innate immune function in infected individuals... - Relationship between pre-existing viral reservoirs and the re-emergence of plasma viremia after discontinuation of highly active anti-retroviral therapyT W Chun
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Nat Med 6:757-61. 2000.... - Differentiation of promonocytic U937 subclones into macrophagelike phenotypes regulates a cellular factor(s) which modulates fusion/entry of macrophagetropic human immunodeficiency virus type 1H Moriuchi
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
J Virol 72:3394-400. 1998.... - Effect of immune activation on the dynamics of human immunodeficiency virus replication and on the distribution of viral quasispeciesM A Ostrowski
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
J Virol 72:7772-84. 1998..These findings illustrate certain mechanisms whereby antigenic stimulation may influence the dynamics of HIV replication, including the relative expression of different viral variants... - HIV-1 envelope induces activation of caspase-3 and cleavage of focal adhesion kinase in primary human CD4(+) T cellsC Cicala
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 97:1178-83. 2000..En-velope treatment of lymphocytes led to the cleavage of FAK in a manner consistent with caspase-mediated cleavage... - Selection of HIV-specific immunogenic epitopes by screening random peptide libraries with HIV-1-positive seraG Scala
Laboratory of Immunoregulation, and Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
J Immunol 162:6155-61. 1999..These results demonstrate that pools of HIV-1 mimotopes can be selected from combinatorial peptide libraries by taking advantage of the HIV-specific Ab repertoire induced by the natural infection... - Evidence for rapid disappearance of initially expanded HIV-specific CD8+ T cell clones during primary HIV infectionG Pantaleo
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 94:9848-53. 1997..These findings should provide insights into how HIV, and possibly other viruses, elude the host immune response during primary infection... - HIV-1 induces phenotypic and functional perturbations of B cells in chronically infected individualsS Moir
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, and Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 98:10362-7. 2001..These results indicate that HIV viremia induces the appearance of a subset of B cells whose function is impaired and which may be responsible for the hypergammaglobulinemia associated with HIV disease... - Expression of chemokine and inhibitory receptors on natural killer cells: effect of immune activation and HIV viremiaS Kottilil
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
J Infect Dis 189:1193-8. 2004.... - The role of CD4+ T cell help and CD40 ligand in the in vitro expansion of HIV-1-specific memory cytotoxic CD8+ T cell responsesM A Ostrowski
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 165:6133-41. 2000..Finally, it was demonstrated that IL-15 produced by CD40LT-stimulated dendritic cells may be an additional mechanism by which CD40LT induces the expansion of memory CTL in CD4(+) T cell-depleted conditions, where IL-2 is lacking... - Short-cycle structured intermittent treatment of chronic HIV infection with highly active antiretroviral therapy: effects on virologic, immunologic, and toxicity parametersM Dybul
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 98:15161-6. 2001..In addition, there was a decrease in serum cholesterol and triglyceride levels. Intermittent therapy may be an important strategy to reduce cost and toxicity for HIV-infected individuals... - Differential effects of CD40 ligand/trimer stimulation on the ability of dendritic cells to replicate and transmit HIV infection: evidence for CC-chemokine-dependent and -independent mechanismsJ F McDyer
Clinical Immunology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 162:3711-7. 1999..Together, these results show that CD40LT stimulation of DCs suppresses HIV replication and transmission to CD4+ T cells by two potentially different mechanisms... - Recombinant gp120 specifically enhances tumor necrosis factor-alpha production and Ig secretion in B lymphocytes from HIV-infected individuals but not from seronegative donorsP Rieckmann
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892
J Immunol 147:2922-7. 1991.... - Human immunodeficiency virus type 1 bound to B cells: relationship to virus replicating in CD4+ T cells and circulating in plasmaAngela Malaspina
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
J Virol 76:8855-63. 2002..These findings also indicate that most of the virus in plasma originates from cells other than CD4(+) T cells in the peripheral blood and lymph nodes... - Dendritic cells express multiple chemokine receptors used as coreceptors for HIV entryA Rubbert
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1576, USA
J Immunol 160:3933-41. 1998..Delineation of the spectrum of coreceptor usage on DC may offer new approaches to interfere with the initiation and propagation of HIV infection... - Factors secreted by human T lymphotropic virus type I (HTLV-I)-infected cells can enhance or inhibit replication of HIV-1 in HTLV-I-uninfected cells: implications for in vivo coinfection with HTLV-I and HIV-1H Moriuchi
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
J Exp Med 187:1689-97. 1998..Our data suggest that the net effect of HTLV-I coinfection in HIV-infected individuals favors the transition from M- to T-tropic HIV phenotype, which is generally indicative of progressive HIV disease... - CXCR4 and CCR5 genetic polymorphisms in long-term nonprogressive human immunodeficiency virus infection: lack of association with mutations other than CCR5-Delta32O J Cohen
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892 1876, USA
J Virol 72:6215-7. 1998..Polymorphisms in the CXCR4 and CCR5 coding sequences other than CCR5-Delta32 do not appear to play a dominant mechanistic role in nonprogression among HIV-infected individuals... - Cathepsin G, a neutrophil-derived serine protease, increases susceptibility of macrophages to acute human immunodeficiency virus type 1 infectionH Moriuchi
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
J Virol 74:6849-55. 2000.... - Interleukin 7 reduces the levels of spontaneous apoptosis in CD4+ and CD8+ T cells from HIV-1-infected individualsLia Vassena
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 104:2355-60. 2007..These results provide a further rationale for consideration of IL-7 as an agent of immune reconstitution in HIV-1 infection... - Evaluation of the pathogenesis of decreasing CD4(+) T cell counts in human immunodeficiency virus type 1-infected patients receiving successfully suppressive antiretroviral therapyElizabeth Nies-Kraske
National Institute of Allergy and Infectious Diseases, National Institutes of Health, MD, USA
J Infect Dis 199:1648-56. 2009..All 4 patients had significant fibrosis of the T cell zone of lymphoid tissue, which appeared to be an important factor in the failure to reconstitute T cells... - Active Wegener's granulomatosis is associated with HLA-DR+ CD4+ T cells exhibiting an unbalanced Th1-type T cell cytokine pattern: reversal with IL-10B R Ludviksson
Mucosal Immunity Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA
J Immunol 160:3602-9. 1998..These data suggest that T cells from WG patients overproduce IFN-gamma and TNF-alpha, probably due to dysregulated IL-12 secretion, and that IL-10 may therefore have therapeutic implications for this disease... - Host factors in the pathogenesis of HIV diseaseO J Cohen
National Institute of Allergy and Infectious Diseases, Laboratory of Immunoregulation, Bethesda, Maryland, USA
Immunol Rev 159:31-48. 1997..HIV-specific immune responses, including cytotoxic T-lymphocyte (CTL) responses and neutralizing antibody responses, also appear to play salutary roles in protecting against disease progression... - Fluorodeoxyglucose imaging in healthy subjects with HIV infection: impact of disease stage and therapy on pattern of nodal activationDouglas Brust
National Institute of Allergy and Infectious Disease, and the Nuclear Medicine Department, Warren G. Magnuson Clinical Center of the National Institutes of Health, 10 Center Drive, MSC 1180, Bethesda, MD 20892, USA
AIDS 20:985-93. 2006..CONCLUSION: Abnormal fluorodeoxyglucose accumulation occurs in the nodes of individuals with detectable viral loads. Interruption of effective HAART results in the activation of previously quiescent nodal areas... - HIV envelope induces virus expression from resting CD4+ T cells isolated from HIV-infected individuals in the absence of markers of cellular activation or apoptosisAudrey L Kinter
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 170:2449-55. 2003.... - Appearance of immature/transitional B cells in HIV-infected individuals with advanced disease: correlation with increased IL-7Angela Malaspina
Laboratory of Immunoregulation, and Office of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 103:2262-7. 2006..Taken together, these data offer insight into human B cell development as well as B cell dysfunction in advanced HIV disease that may be linked to IL-7-dependent homeostatic events... - Macrophage-tropic HIV and SIV envelope proteins induce a signal through the CCR5 chemokine receptorD Weissman
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Nature 389:981-5. 1997..Alternatively, envelope-mediated CCR5 signal transduction may influence viral-associated cytopathicity or apoptosis... - Peripheral blood-derived CD34+ progenitor cells: CXC chemokine receptor 4 and CC chemokine receptor 5 expression and infection by HIVM E Ruiz
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1576, USA
J Immunol 161:4169-76. 1998.... - Chemokines, cytokines and HIV: a complex network of interactions that influence HIV pathogenesisA Kinter
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
Immunol Rev 177:88-98. 2000..Finally, the interaction between chemokine receptors and chemokines or HIV envelope has significant effects on cellular functions which likely play a role in HIV pathogenesis... - Latent reservoirs of HIV: obstacles to the eradication of virusT W Chun
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 96:10958-61. 1999..Here we discuss recent developments in studies of the latent reservoir of HIV in patients receiving HAART and implications for the long-term treatment of infected individuals and eradication of the infection... - Lysis of endogenously infected CD4+ T cell blasts by rIL-2 activated autologous natural killer cells from HIV-infected viremic individualsManuela Fogli
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
PLoS Pathog 4:e1000101. 2008.... - An HIV vaccine--evolving conceptsMargaret I Johnston
Division of AIDS, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
N Engl J Med 356:2073-81. 2007 - 25 years of HIVAnthony S Fauci
National Institute of Allergy and Infectious Diseases (NIAID) at the US National Institutes of Health in Bethesda, Maryland, USA
Nature 453:289-90. 2008 - Guidelines for using antiretroviral agents among HIV-infected adults and adolescents. Recommendations of the Panel on Clinical Practices for Treatment of HIVMark Dybul
National Institutes of Health, Bethesda, Maryland, USA
MMWR Recomm Rep 51:1-55. 2002..Because concepts regarding HIV management are evolving rapidly, readers should check regularly for additional information and updates at the HIV/AIDS Treatment Information Service website (http://www.hivatis.org)... - Infectious diseases: considerations for the 21st centuryA S Fauci
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Clin Infect Dis 32:675-85. 2001..Increasingly, infectious disease research will be linked to the development of the medical infrastructure and training needed in developing countries to translate scientific advances into operational reality... - Protection of rhesus macaques against disease progression from pathogenic SHIV-89.6PD by vaccination with phage-displayed HIV-1 epitopesX Chen
Laboratory of Immunoregulation, NIAID, NIH, Bethesda, Maryland, USA
Nat Med 7:1225-31. 2001..These results provide a new approach to the design of broadly protective HIV-1 vaccines... - Role of dendritic cells in immunopathogenesis of human immunodeficiency virus infectionD Weissman
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 1576, USA
Clin Microbiol Rev 10:358-67. 1997..This review discusses recent data regarding the role of DC in HIV disease with the aim of delineating basic immunopathogenic principles of infection and the development of therapeutic strategies... - Targeted lysis of HIV-infected cells by natural killer cells armed and triggered by a recombinant immunoglobulin fusion protein: implications for immunotherapyNeil Gupta
Laboratory of Immunoregulation, NIAID, NIH Bldg. #10 6A08, 9000 Rockville Pike, Bethesda MD 20892, USA
Virology 332:491-7. 2005..NK cells pre-armed in this manner retain the capacity to kill targets over an extended period of time. This strategy may have application to other disease states including various viral infections and cancers... - HIV and AIDS: 20 years of scienceAnthony S Fauci
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892-2520, USA
Nat Med 9:839-43. 2003 - Race against timeAnthony S Fauci
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892-2520, USA
Nature 435:423-4. 2005 - Cloning and analysis of the promoter region of CXCR4, a coreceptor for HIV-1 entryM Moriuchi
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1576, USA
J Immunol 159:4322-9. 1997.... - Human immunodeficiency virus type 1 (HIV-1) non-B subtypes are similar to HIV-1 subtype B in that coreceptor specificity is a determinant of cytopathicity in human lymphoid tissue infected ex vivoN Malkevich
Laboratory of Cellular and Molecular Biophysics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
J Virol 75:10520-2. 2001..Thus, at least for the viruses within subtypes A, B, C, and E that were tested, coreceptor specificity is a critical factor that determines the ability of HIV-1 to deplete CD4(+) T cells in human lymphoid tissue infected ex vivo... - Intercellular adhesion molecules (ICAM)-1 ICAM-2 and ICAM-3 function as counter-receptors for lymphocyte function-associated molecule 1 in human immunodeficiency virus-mediated syncytia formationL Butini
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892
Eur J Immunol 24:2191-5. 1994..These results indicate that the interaction between LFA-1 and ICAM is a critical step in HIV-mediated syncytia formation, and that ICAM-1, ICAM-2 and ICAM-3 are the receptor molecules for the LFA-1-dependent syncytia formation... - cDNA cloning of the B cell membrane protein CD22: a mediator of B-B cell interactionsG L Wilson
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892
J Exp Med 173:137-46. 1991..Additionally, both normal tonsil B cells and a B cell line were found to adhere to COS transfected with BL-CAM in the sense but not the antisense direction.(ABSTRACT TRUNCATED AT 400 WORDS).. - Emerging infections: a perpetual challengeDavid M Morens
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Lancet Infect Dis 8:710-9. 2008..Fundamental determinants, typically acting in concert, seem to underlie their emergence, and infections such as these are likely to continue to remain challenges to human survival... - Decay of the HIV reservoir in patients receiving antiretroviral therapy for extended periods: implications for eradication of virusTae Wook Chun
Laboratory of Immunoregulation, Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Infect Dis 195:1762-4. 2007..6 months. It is projected that it will take up to 7.7 years of continuous therapy to completely eliminate latently infected resting CD4+ T cells in infected individuals who initiate antiviral therapy early in HIV infection... - Ethics of clinical research in the developing worldJack Killen
National Institutes of Health, 9000 Rockville Pike, Bethesda, 20892 Maryland, USA
Nat Rev Immunol 2:210-5. 2002..Using HIV/AIDS research as an example, we show how this 'Uniform Care Requirement' can undermine biomedical research aimed at improving global health, and then we point towards a more rational and balanced approach to ethical assessment... - Innate immunity in HIV infection: enhanced susceptibility to CD95-mediated natural killer cell death and turnover induced by HIV viremiaShyam Kottilil
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health NIH, Bethesda, MD 20892, USA
J Acquir Immune Defic Syndr 46:151-9. 2007..In addition, these NK cells, particularly the CD56(dim) CD16(bright) subset, undergo enhanced cell turnover in vivo, as demonstrated by intracellular Ki67 expression... - HIV-1 envelope, integrins and co-receptor use in mucosal transmission of HIVClaudia Cicala
Laboratory of Immunoregulation National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Transl Med 9:S2. 2011.... - Biochemical and biological characterization of a dodecameric CD4-Ig fusion protein: implications for therapeutic and vaccine strategiesJames Arthos
Laboratory of Immunoregulation, NIAID, and the Molecular Interactions Resource Division of Bioengineering and Physical Science, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 277:11456-64. 2002..This protein does not enhance viral replication at suboptimal concentrations. These observations may aid in the design of new therapeutics and vaccines... - Pandemic influenza's 500th anniversaryDavid M Morens
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Clin Infect Dis 51:1442-4. 2010..It seems likely that, in the foreseeable future, we may be able to greatly reduce the burden of influenza pandemics with improved vaccines and other scientific and public health approaches... - Dengue and hemorrhagic fever: a potential threat to public health in the United StatesDavid M Morens
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
JAMA 299:214-6. 2008 - Rebound of plasma viremia following cessation of antiretroviral therapy despite profoundly low levels of HIV reservoir: implications for eradicationTae Wook Chun
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
AIDS 24:2803-8. 2010..It is of great interest to identify individuals who had received ART for prolonged periods of time with extremely low or undetectable HIV reservoirs and monitor plasma viremia following discontinuation of therapy... - HIV-1 envelope protein binds to and signals through integrin alpha4beta7, the gut mucosal homing receptor for peripheral T cellsJames Arthos
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Nat Immunol 9:301-9. 2008..On CD4+ T cells, engagement of alpha4beta7 by gp120 resulted in rapid activation of LFA-1, the central integrin involved in the establishment of virological synapses, which facilitate efficient cell-to-cell spreading of HIV-1... - The integrin alpha4beta7 forms a complex with cell-surface CD4 and defines a T-cell subset that is highly susceptible to infection by HIV-1Claudia Cicala
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 106:20877-82. 2009..The specific affinity of gp120 for alpha(4)beta(7) provides a mechanism for HIV-1 to target activated cells that are critical for efficient virus propagation and dissemination following sexual transmission... - Pathogenic mechanisms of B-lymphocyte dysfunction in HIV diseaseSusan Moir
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Allergy Clin Immunol 122:12-9; quiz 20-1. 2008.... - Human immunodeficiency virus and hepatitis C infections induce distinct immunologic imprints in peripheral mononuclear cellsShyam Kottilil
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
Hepatology 50:34-45. 2009.... - B cells in HIV infection and diseaseSusan Moir
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland 20892, USA
Nat Rev Immunol 9:235-45. 2009..This Review focuses on advances in our understanding of the mechanisms of B-cell dysfunction in HIV-associated disease and discusses similarities with other diseases that are associated with B-cell dysfunction... - Evidence for HIV-associated B cell exhaustion in a dysfunctional memory B cell compartment in HIV-infected viremic individualsSusan Moir
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Exp Med 205:1797-805. 2008..These data suggest that HIV-associated premature exhaustion of B cells may contribute to poor antibody responses against HIV in infected individuals... - The National Institute of Allergy and Infectious Diseases' asthma research programs: a retrospectiveDaniel Rotrosen
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda MD, USA
J Allergy Clin Immunol 119:258-62. 2007 - Predominant role of bacterial pneumonia as a cause of death in pandemic influenza: implications for pandemic influenza preparednessDavid M Morens
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
J Infect Dis 198:962-70. 2008..Despite the availability of published data on 4 pandemics that have occurred over the past 120 years, there is little modern information on the causes of death associated with influenza pandemics... - HIV envelope induces a cascade of cell signals in non-proliferating target cells that favor virus replicationClaudia Cicala
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 99:9380-5. 2002..These observations provide evidence that envelope-mediated signaling contributes to the productive infection of HIV in suboptimally activated T cells... - HIV-1 gp120 inhibits TLR9-mediated activation and IFN-{alpha} secretion in plasmacytoid dendritic cellsElena Martinelli
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Disease, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 104:3396-401. 2007.... - Innate immune dysfunction in HIV infection: effect of HIV envelope-NK cell interactionsShyam Kottilil
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 176:1107-14. 2006..Identification of specific surface receptors on NK cells that interact with HIV envelope proteins might explain how HIV is capable of circumventing innate immune defense mechanisms and establishing infection in susceptible individuals... - HIV-1 gp120 induces NFAT nuclear translocation in resting CD4+ T-cellsClaudia Cicala
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1876, USA
Virology 345:105-14. 2006..These observations provide insight into a potential mechanism by which HIV is able to establish infection in resting cells, which may have implications for both transmission of HIV and the persistence of viral reservoirs... - Relationship between the frequency of HIV-specific CD8+ T cells and the level of CD38+CD8+ T cells in untreated HIV-infected individualsTae Wook Chun
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 101:2464-9. 2004....