Rick D Fannin
Affiliation: National Institutes of Health
- Gene expression profiles from discordant monozygotic twins suggest that molecular pathways are shared among multiple systemic autoimmune diseasesTerrance P O'Hanlon
Environmental Autoimmunity Group, National Institute of Environmental Health Sciences, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
Arthritis Res Ther 13:R69. 2011..The objective of this study is to determine if multiple systemic autoimmune diseases (SAID) share gene expression pathways that could provide insights into pathogenic mechanisms common to these disorders...
- Differential gene expression profiling in whole blood during acute systemic inflammation in lipopolysaccharide-treated ratsRick D Fannin
National Center for Toxicogenomics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
Physiol Genomics 21:92-104. 2005..These studies indicate that, in whole blood, changes in gene expression profiles can be detected that are reflective of inflammation, despite the adaptive shifts in leukocyte populations that accompany such inflammatory processes...
- Acetaminophen dosing of humans results in blood transcriptome and metabolome changes consistent with impaired oxidative phosphorylationRick D Fannin
National Institute of Environmental Health Sciences Microarray Group, National Institutes of Health NIH, Research Triangle Park, NC 27709, USA
Hepatology 51:227-36. 2010..The timing of the changes and the correlation with NAPQI production are consistent with mechanisms known to underlie APAP hepatoxicity. These studies support the further exploration of the blood transcriptome for biomarkers of DILI...
- Altered gene expression and DNA damage in peripheral blood cells from Friedreich's ataxia patients: cellular model of pathologyAstrid C Haugen
Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
PLoS Genet 6:e1000812. 2010..Furthermore, the identification of potential biomarkers, including the DNA damage found in peripheral blood, may have predictive value in future clinical trials...