Rick M Fairhust

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Hemoglobin C modulates the surface topography of Plasmodium falciparum-infected erythrocytes
    Takayuki Arie
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    J Struct Biol 150:163-9. 2005
  2. pmc Ex-vivo cytoadherence phenotypes of Plasmodium falciparum strains from Malian children with hemoglobins A, S, and C
    Jeanette T Beaudry
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom
    PLoS ONE 9:e92185. 2014
  3. pmc Plasmodium falciparum clearance rates in response to artesunate in Malian children with malaria: effect of acquired immunity
    Tatiana M Lopera-Mesa
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    J Infect Dis 207:1655-63. 2013
  4. pmc A potential role for plasma uric acid in the endothelial pathology of Plasmodium falciparum malaria
    Neida K Mita-Mendoza
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, USA
    PLoS ONE 8:e54481. 2013
  5. pmc A role for fetal hemoglobin and maternal immune IgG in infant resistance to Plasmodium falciparum malaria
    Chanaki Amaratunga
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 6:e14798. 2011
  6. pmc Plasma uric acid levels correlate with inflammation and disease severity in Malian children with Plasmodium falciparum malaria
    Tatiana M Lopera-Mesa
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 7:e46424. 2012
  7. pmc α-Thalassemia impairs the cytoadherence of Plasmodium falciparum-infected erythrocytes
    Michael A Krause
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 7:e37214. 2012
  8. pmc Artemisinin-resistant malaria: research challenges, opportunities, and public health implications
    Rick M Fairhurst
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Am J Trop Med Hyg 87:231-41. 2012
  9. pmc Abnormal PfEMP1/knob display on Plasmodium falciparum-infected erythrocytes containing hemoglobin variants: fresh insights into malaria pathogenesis and protection
    Rick M Fairhurst
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Microbes Infect 14:851-62. 2012
  10. pmc Using CF11 cellulose columns to inexpensively and effectively remove human DNA from Plasmodium falciparum-infected whole blood samples
    Meera Venkatesan
    Howard Hughes Medical Institute, University of Maryland School of Medicine, Baltimore, MD, USA
    Malar J 11:41. 2012

Collaborators

Detail Information

Publications32

  1. ncbi request reprint Hemoglobin C modulates the surface topography of Plasmodium falciparum-infected erythrocytes
    Takayuki Arie
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    J Struct Biol 150:163-9. 2005
    ..These data support a model in which large knobs and their aggregates are promoted by hemoglobin C, reducing the adherence of parasitized erythrocytes in the microvasculature and ameliorating the severity of a malaria infection...
  2. pmc Ex-vivo cytoadherence phenotypes of Plasmodium falciparum strains from Malian children with hemoglobins A, S, and C
    Jeanette T Beaudry
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom
    PLoS ONE 9:e92185. 2014
    ..Future studies that identify PfEMP1 domains or amino-acid motifs which are selectively expressed in parasites from HbAS children may provide further insights into the mechanism of malaria protection by the sickle-cell trait. ..
  3. pmc Plasmodium falciparum clearance rates in response to artesunate in Malian children with malaria: effect of acquired immunity
    Tatiana M Lopera-Mesa
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    J Infect Dis 207:1655-63. 2013
    ..Few baseline half-lives have been reported from Africa, where artemisinins were recently introduced...
  4. pmc A potential role for plasma uric acid in the endothelial pathology of Plasmodium falciparum malaria
    Neida K Mita-Mendoza
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, USA
    PLoS ONE 8:e54481. 2013
    ..Since UA is associated with endothelial inflammation in non-malaria diseases, we hypothesized that elevated UA levels contribute to the endothelial pathology of P. falciparum malaria...
  5. pmc A role for fetal hemoglobin and maternal immune IgG in infant resistance to Plasmodium falciparum malaria
    Chanaki Amaratunga
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 6:e14798. 2011
    ..A specific role for maternal immune IgG in infant resistance to malaria has been hypothesized but not yet identified...
  6. pmc Plasma uric acid levels correlate with inflammation and disease severity in Malian children with Plasmodium falciparum malaria
    Tatiana M Lopera-Mesa
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 7:e46424. 2012
    ..These two forms of 'parasite-derived' UA stimulate immune cells to produce inflammatory cytokines in vitro...
  7. pmc α-Thalassemia impairs the cytoadherence of Plasmodium falciparum-infected erythrocytes
    Michael A Krause
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 7:e37214. 2012
    ..We hypothesized that α-thalassemia impairs the adherence of parasitized red blood cells (RBCs) to microvascular endothelial cells (MVECs) and monocytes--two interactions that are centrally involved in the pathogenesis of severe disease...
  8. pmc Artemisinin-resistant malaria: research challenges, opportunities, and public health implications
    Rick M Fairhurst
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Am J Trop Med Hyg 87:231-41. 2012
    ....
  9. pmc Abnormal PfEMP1/knob display on Plasmodium falciparum-infected erythrocytes containing hemoglobin variants: fresh insights into malaria pathogenesis and protection
    Rick M Fairhurst
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Microbes Infect 14:851-62. 2012
    ....
  10. pmc Using CF11 cellulose columns to inexpensively and effectively remove human DNA from Plasmodium falciparum-infected whole blood samples
    Meera Venkatesan
    Howard Hughes Medical Institute, University of Maryland School of Medicine, Baltimore, MD, USA
    Malar J 11:41. 2012
    ..This study was undertaken to determine whether CF11 columns could be adapted to isolate Plasmodium falciparum DNA from parasitized whole blood and achieve current quantity and purity requirements for Illumina sequencing...
  11. pmc Single-nucleotide polymorphism, linkage disequilibrium and geographic structure in the malaria parasite Plasmodium vivax: prospects for genome-wide association studies
    Pamela Orjuela-Sánchez
    Department of Parasitology, Institute of Biomedical Sciences, University of Sao Paulo, Brazil
    BMC Genet 11:65. 2010
    ..However, levels of genetic diversity and LD in field populations of the major human malaria parasite P. vivax remain little characterized...
  12. ncbi request reprint Transgenic parasites: improving our understanding of innate immunity to malaria
    Rick M Fairhurst
    Laboratory of Malaria and Vector Research, NIAID NIH, Bethesda, MD 20892, USA
    Cell Host Microbe 2:75-6. 2007
    ..Research described by D'Ombrain et al. in this Cell Host & Microbe issue probes how the parasite's main virulence factor PfEMP-1 might significantly alter human innate immune responses...
  13. ncbi request reprint Case report: life-threatening hypoglycaemia associated with sulfadoxine-pyrimethamine, a commonly used antimalarial drug
    R M Fairhurst
    Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Trans R Soc Trop Med Hyg 97:595-6. 2003
    ..In this report, we present a case of hypoglycaemic coma associated with SP, an adverse reaction that is likely to be underreported and expected to occur with greater frequency as the use of SP increases...
  14. ncbi request reprint Abnormal display of PfEMP-1 on erythrocytes carrying haemoglobin C may protect against malaria
    Rick M Fairhurst
    Laboratory of Malaria and Vector Research, Research Technologies Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 435:1117-21. 2005
    ..Haemoglobin C might protect against malaria by reducing PfEMP-1-mediated adherence of parasitized erythrocytes, thereby mitigating the effects of their sequestration in the microvasculature...
  15. ncbi request reprint Aberrant development of Plasmodium falciparum in hemoglobin CC red cells: implications for the malaria protective effect of the homozygous state
    Rick M Fairhurst
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 101:3309-15. 2003
    ....
  16. ncbi request reprint Band 3 modifications in Plasmodium falciparum-infected AA and CC erythrocytes assayed by autocorrelation analysis using quantum dots
    Fuyuki Tokumasu
    Biochemical and Biophysical Parasitology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 8132, USA
    J Cell Sci 118:1091-8. 2005
    ..Increased band 3 clustering may enhance recognition sites for autoantibodies, which could contribute to the protective effect of hemoglobin C against malaria...
  17. pmc Altered membrane structure and surface potential in homozygous hemoglobin C erythrocytes
    Fuyuki Tokumasu
    Biophysical and Biochemical Parasitology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 4:e5828. 2009
    ..These findings suggest that CC erythrocytes have a different membrane matrix than AA erythrocytes...
  18. ncbi request reprint Modulation of malaria virulence by determinants of Plasmodium falciparum erythrocyte membrane protein-1 display
    Rick M Fairhurst
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20852 8132, USA
    Curr Opin Hematol 13:124-30. 2006
    ..These binding events enable parasitized erythrocytes to sequester and avoid clearance by the spleen, and they also contribute to disease by causing microvascular inflammation and obstruction...
  19. pmc The impact of malaria parasitism: from corpuscles to communities
    Thomas E Wellems
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20892 8132, USA
    J Clin Invest 119:2496-505. 2009
    ..Advances in genetics and genomics are providing fresh insights into the nature of these evolutionary adaptations, processes of parasite transmission and infection, and the difficult challenges of malaria control...
  20. pmc Subdomain 3 of Plasmodium falciparum VAR2CSA DBL3x is identified as a minimal chondroitin sulfate A-binding region
    Kavita Singh
    Structural Biology Section, Research Technologies Branch, NIAID, National Institutes of Health, Rockville, Maryland 20852, USA
    J Biol Chem 285:24855-62. 2010
    ....
  21. pmc Use of magnetically purified Plasmodium falciparum parasites improves the accuracy of erythrocyte invasion assays
    Adam H Bates
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Exp Parasitol 126:278-80. 2010
    ..The magnetic purification method is an excellent alternative for parasite isolates that do not tolerate or with unknown sensitivity to Percoll-sorbitol exposure...
  22. pmc Sickle cell trait is associated with a delayed onset of malaria: implications for time-to-event analysis in clinical studies of malaria
    Peter D Crompton
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20852, USA
    J Infect Dis 198:1265-75. 2008
    ..Although common red blood cell (RBC) polymorphisms such as sickle hemoglobin (HbS) are known to protect against malaria in Africa, their impact on this end point has not been investigated...
  23. pmc Plasmodium falciparum genome-wide scans for positive selection, recombination hot spots and resistance to antimalarial drugs
    Jianbing Mu
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, Bethesda, Maryland, USA
    Nat Genet 42:268-71. 2010
    ..Parasite half-maximum inhibitory concentrations for seven antimalarial drugs were obtained and used in GWAS to identify genes associated with drug responses. This study provides valuable tools and insight into the P. falciparum genome...
  24. pmc Impaired cytoadherence of Plasmodium falciparum-infected erythrocytes containing sickle hemoglobin
    Rushina Cholera
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 105:991-6. 2008
    ..Coinherited hemoglobin polymorphisms and naturally acquired antibodies to PfEMP-1 may influence the degree of malaria protection in AS children by further weakening cytoadherence interactions...
  25. ncbi request reprint Images in clinical medicine. Homozygous hemoglobin C disease
    Rick M Fairhurst
    National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    N Engl J Med 350:e24. 2004
  26. ncbi request reprint Non-opsonising aggregates of IgG and complement in haemoglobin C erythrocytes
    Nathaniel J Brittain
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Br J Haematol 136:491-500. 2007
    ....
  27. pmc The avian malaria parasite Plasmodium gallinaceum causes marked structural changes on the surface of its host erythrocyte
    Eriko Nagao
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Struct Biol 162:460-7. 2008
    ..gallinaceum-infected erythrocytes do not seem to adhere to microvessels in the host chicken, the furrows might be involved in the pathogenesis of P. gallinaceum infections by some other mechanism involving host-pathogen interactions...
  28. pmc Discrepant prevalence and incidence of Leishmania infection between two neighboring villages in Central Mali based on Leishmanin skin test surveys
    Fabiano Oliveira
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, USA
    PLoS Negl Trop Dis 3:e565. 2009
    ..Here we establish ongoing transmission of Leishmania in Kemena and Sougoula, Central Mali, and are currently investigating the underlying factors that may be responsible for the discrepant infection rates we observed between them...
  29. ncbi request reprint A comparison of anemia in hemoglobin C and normal hemoglobin A children with Plasmodium falciparum malaria
    Dapa A Diallo
    faculté de médecine de pharmacie et d odontostomatologie, University of Bamako, Bamako, Mali
    Acta Trop 90:295-9. 2004
    ..By this measure, HbC, a malaria-protective polymorphism with few deleterious consequences, does not appear to be associated with more frequent anemia than normal HbA in episodes of uncomplicated P. falciparum malaria...
  30. ncbi request reprint Malaria-protective traits at odds in Africa?
    Thomas E Wellems
    Nat Genet 37:1160-2. 2005
  31. pmc X-linked G6PD deficiency protects hemizygous males but not heterozygous females against severe malaria
    Aldiouma Guindo
    Malaria Research and Training Center, Faculty of Medicine, Pharmacy, and Odontostomatology, University of Bamako, Mali
    PLoS Med 4:e66. 2007
    ..These proposals are paradoxical, and they are not consistent with currently hypothesized mechanisms of protection...