Patricia A Fair

Summary

Affiliation: National Oceanic and Atmospheric Administration
Country: USA

Publications

  1. doi request reprint Associations between perfluoroalkyl compounds and immune and clinical chemistry parameters in highly exposed bottlenose dolphins (Tursiops truncatus)
    Patricia A Fair
    National Oceanic and Atmospheric Administration, National Ocean Service, Center for Coastal Environmental Health and Biomolecular Research, Charleston, South Carolina, USA
    Environ Toxicol Chem 32:736-46. 2013
  2. doi request reprint Immune function in female B(6)C(3)F(1) mice is modulated by DE-71, a commercial polybrominated diphenyl ether mixture
    Patricia A Fair
    National Oceanic and Atmospheric Administration, National Ocean Services, Center for Coastal Environmental Health and Biomolecular Research, Charleston, SC 29412, USA
    J Immunotoxicol 9:96-107. 2012
  3. doi request reprint Assessment of perfluorinated compounds (PFCs) in plasma of bottlenose dolphins from two southeast US estuarine areas: relationship with age, sex and geographic locations
    Patricia A Fair
    National Oceanic and Atmospheric Administration, National Ocean Service, Center for Coastal Environmental Health and Biomolecular Research, 219 Fort Johnson Road, Charleston, SC 29412 9110, USA
    Mar Pollut Bull 64:66-74. 2012
  4. doi request reprint Influences of biological variables and geographic location on circulating concentrations of thyroid hormones in wild bottlenose dolphins (Tursiops truncatus)
    Patricia A Fair
    NOAA s Ocean Service, Center for Coastal Environmental Health and Biomolecular Research, 219 Fort Johnson Road, Charleston, SC 29412 9110, USA
    Gen Comp Endocrinol 174:184-94. 2011
  5. doi request reprint Contaminant blubber burdens in Atlantic bottlenose dolphins (Tursiops truncatus) from two southeastern US estuarine areas: concentrations and patterns of PCBs, pesticides, PBDEs, PFCs, and PAHs
    Patricia A Fair
    National Oceanic and Atmospheric Administration, National Ocean Service, Center for Coastal Environmental Health and Biomolecular Research, Charleston, SC 29412, USA
    Sci Total Environ 408:1577-97. 2010
  6. doi request reprint Occurrence of triclosan in plasma of wild Atlantic bottlenose dolphins (Tursiops truncatus) and in their environment
    Patricia A Fair
    National Oceanic and Atmospheric Administration, National Ocean Services, Center for Coastal Environmental Health and Biomolecular Research, 219 Fort Johnson Road, Charleston, SC 29412 9110, USA
    Environ Pollut 157:2248-54. 2009
  7. ncbi request reprint Polybrominated diphenyl ethers (PBDEs) in blubber of free-ranging bottlenose dolphins (Tursiops truncatus) from two southeast Atlantic estuarine areas
    Patricia A Fair
    National Oceanic and Atmospheric Administration, National Ocean Service, Center for Coastal Environmental Health and Biomolecular Research, 219 Fort Johnson Road, Charleston, SC 29412, USA
    Arch Environ Contam Toxicol 53:483-94. 2007
  8. pmc Effects of environmentally-relevant levels of perfluorooctane sulfonate on clinical parameters and immunological functions in B6C3F1 mice
    Patricia A Fair
    National Oceanic and Atmospheric Administration, National Ocean Service, Center for Coastal Environmental Health and Biomolecular Research, Charleston, SC, USA
    J Immunotoxicol 8:17-29. 2011
  9. ncbi request reprint Trace element concentrations in blood of free-ranging bottlenose dolphins (Tursiops truncatus): influence of age, sex and location
    Hui Chen W Stavros
    National Oceanic and Atmospheric Administration, National Ocean Service, Center for Coastal Environmental Health and Biomolecular Research, Charleston, SC 29412 9110, USA
    Mar Pollut Bull 56:371-9. 2008
  10. doi request reprint Correlation and toxicological inference of trace elements in tissues from stranded and free-ranging bottlenose dolphins (Tursiops truncatus)
    Hui Chen W Stavros
    National Oceanic and Atmospheric Administration, National Ocean Service, Center for Coastal Environmental Health and Biomolecular Research, Charleston, SC 29412, USA
    Chemosphere 82:1649-61. 2011

Collaborators

Detail Information

Publications31

  1. doi request reprint Associations between perfluoroalkyl compounds and immune and clinical chemistry parameters in highly exposed bottlenose dolphins (Tursiops truncatus)
    Patricia A Fair
    National Oceanic and Atmospheric Administration, National Ocean Service, Center for Coastal Environmental Health and Biomolecular Research, Charleston, South Carolina, USA
    Environ Toxicol Chem 32:736-46. 2013
    ..The results contribute to the emerging data on PFC health effects in this first study to describe associations between PFCs and health parameters in dolphins...
  2. doi request reprint Immune function in female B(6)C(3)F(1) mice is modulated by DE-71, a commercial polybrominated diphenyl ether mixture
    Patricia A Fair
    National Oceanic and Atmospheric Administration, National Ocean Services, Center for Coastal Environmental Health and Biomolecular Research, Charleston, SC 29412, USA
    J Immunotoxicol 9:96-107. 2012
    ..5, 5, and 100 mg/kg TAD. This study provides an assessment of the systemic toxicity and immunotoxicity of DE-71, and indicates that immune parameters are modulated at exposure concentrations lower than previously reported...
  3. doi request reprint Assessment of perfluorinated compounds (PFCs) in plasma of bottlenose dolphins from two southeast US estuarine areas: relationship with age, sex and geographic locations
    Patricia A Fair
    National Oceanic and Atmospheric Administration, National Ocean Service, Center for Coastal Environmental Health and Biomolecular Research, 219 Fort Johnson Road, Charleston, SC 29412 9110, USA
    Mar Pollut Bull 64:66-74. 2012
    ..These observations suggest PFC accumulation in these two dolphin populations are influenced by site-specific exposures with significantly higher levels in CHS dolphins...
  4. doi request reprint Influences of biological variables and geographic location on circulating concentrations of thyroid hormones in wild bottlenose dolphins (Tursiops truncatus)
    Patricia A Fair
    NOAA s Ocean Service, Center for Coastal Environmental Health and Biomolecular Research, 219 Fort Johnson Road, Charleston, SC 29412 9110, USA
    Gen Comp Endocrinol 174:184-94. 2011
    ....
  5. doi request reprint Contaminant blubber burdens in Atlantic bottlenose dolphins (Tursiops truncatus) from two southeastern US estuarine areas: concentrations and patterns of PCBs, pesticides, PBDEs, PFCs, and PAHs
    Patricia A Fair
    National Oceanic and Atmospheric Administration, National Ocean Service, Center for Coastal Environmental Health and Biomolecular Research, Charleston, SC 29412, USA
    Sci Total Environ 408:1577-97. 2010
    ....
  6. doi request reprint Occurrence of triclosan in plasma of wild Atlantic bottlenose dolphins (Tursiops truncatus) and in their environment
    Patricia A Fair
    National Oceanic and Atmospheric Administration, National Ocean Services, Center for Coastal Environmental Health and Biomolecular Research, 219 Fort Johnson Road, Charleston, SC 29412 9110, USA
    Environ Pollut 157:2248-54. 2009
    ..5 ng/L (n = 18) ranging from 4.9 to 14 ng/L. This is the first study to report bioaccumulation of anthropogenic triclosan in a marine mammal highlighting the need for further monitoring and assessment...
  7. ncbi request reprint Polybrominated diphenyl ethers (PBDEs) in blubber of free-ranging bottlenose dolphins (Tursiops truncatus) from two southeast Atlantic estuarine areas
    Patricia A Fair
    National Oceanic and Atmospheric Administration, National Ocean Service, Center for Coastal Environmental Health and Biomolecular Research, 219 Fort Johnson Road, Charleston, SC 29412, USA
    Arch Environ Contam Toxicol 53:483-94. 2007
    ..The levels of PBDEs in Charleston dolphins represent some of the highest measured in marine mammals and warrants further investigation of these emerging, bioaccumulative chemicals and their potential deleterious effects...
  8. pmc Effects of environmentally-relevant levels of perfluorooctane sulfonate on clinical parameters and immunological functions in B6C3F1 mice
    Patricia A Fair
    National Oceanic and Atmospheric Administration, National Ocean Service, Center for Coastal Environmental Health and Biomolecular Research, Charleston, SC, USA
    J Immunotoxicol 8:17-29. 2011
    ....
  9. ncbi request reprint Trace element concentrations in blood of free-ranging bottlenose dolphins (Tursiops truncatus): influence of age, sex and location
    Hui Chen W Stavros
    National Oceanic and Atmospheric Administration, National Ocean Service, Center for Coastal Environmental Health and Biomolecular Research, Charleston, SC 29412 9110, USA
    Mar Pollut Bull 56:371-9. 2008
  10. doi request reprint Correlation and toxicological inference of trace elements in tissues from stranded and free-ranging bottlenose dolphins (Tursiops truncatus)
    Hui Chen W Stavros
    National Oceanic and Atmospheric Administration, National Ocean Service, Center for Coastal Environmental Health and Biomolecular Research, Charleston, SC 29412, USA
    Chemosphere 82:1649-61. 2011
    ..The present study provides the first application of trace element concentrations derived from stranded bottlenose dolphins to predict liver concentrations in free-ranging populations...
  11. doi request reprint Gene expression changes in bottlenose dolphin, Tursiops truncatus, skin cells following exposure to methylmercury (MeHg) or perfluorooctane sulfonate (PFOS)
    Meagan A M Mollenhauer
    Department of Pediatrics, Medical University of South Carolina, Charleston, SC, USA
    Aquat Toxicol 91:10-8. 2009
    ..Alterations in normal cellular biology, like those observed, may lead to changes in health in marine mammals exposed to contaminants; however, this warrants further investigation...
  12. doi request reprint Comparison of in vitro cytotoxicity, estrogenicity and anti-estrogenicity of triclosan, perfluorooctane sulfonate and perfluorooctanoic acid
    Natasha D Henry
    National Oceanic and Atmospheric Administration National Ocean Service Center for Coastal Environmental Health and Biomolecular Research, 219 Fort Johnson Road, Charleston, SC 29412 9110, USA
    J Appl Toxicol 33:265-72. 2013
    ..Each of these compounds could provide a source of xenoestrogens to humans and wildlife in the environment. Published 2011. This article is a US Government work and is in the public domain in the USA...
  13. doi request reprint Effects of perfluorooctane sulfonate (PFOS) exposure on markers of inflammation in female B6C3F1 mice
    Meagan A M Mollenhauer
    Molecular and Cellular Biology and Pathobiology, Medical University of South Carolina, Charleston, South Carolina, USA
    J Environ Sci Health A Tox Hazard Subst Environ Eng 46:97-108. 2011
    ..Overall, these data suggest that PFOS exposure can alter some inflammatory processes, which could potentially lead to misdirected inflammatory responses...
  14. ncbi request reprint Trace element concentrations in skin of free-ranging bottlenose dolphins (Tursiops truncatus) from the southeast Atlantic coast
    Hui Chen W Stavros
    National Oceanic and Atmospheric Administration, National Ocean Service, Center for Coastal Environmental Health and Biomolecular Research, 219 Fort Johnson Road, Charleston, South Carolina 29412, USA
    Sci Total Environ 388:300-15. 2007
    ....
  15. ncbi request reprint Probabilistic risk assessment of reproductive effects of polychlorinated biphenyls on bottlenose dolphins (Tursiops truncatus) from the Southeast United States Coast
    Lori H Schwacke
    National Ocean Service, Center for Coastal Environmental Health and Biomolecular Research, 219 Fort Johnson Road, Charleston, South Carolina 29412 9110, USA
    Environ Toxicol Chem 21:2752-64. 2002
    ..Females of higher parity, which have previously off-loaded a majority of their PCB burden, exhibit a much lower risk...
  16. doi request reprint Novel diversity of bacterial communities associated with bottlenose dolphin upper respiratory tracts
    Wesley R Johnson
    Department of Biology, College of Charleston, Charleston, SC 29401, USA Hollings Marine Laboratory, 331 Ft Johnson Rd, Charleston, SC 29412, USA J Craig Venter Institute, 9704 Medical Center Dr, Rockville, MD 20850, USA Center for Coastal Environmental Health and Biomolecular Research, NOAA National Ocean Service, 219 Fort Johnson Rd Charleston, SC 29412, USA Georgia Aquarium, 225 Baker St, NW, Atlanta, GA 30313, USA
    Environ Microbiol Rep 1:555-62. 2009
    ....
  17. doi request reprint Isolation of culturable microorganisms from free-ranging bottlenose dolphins (Tursiops truncatus) from the southeastern United States
    Pamela J Morris
    Belle W Baruch Institute for Marine and Coastal Sciences, University of South Carolina, Charleston, SC 29412, USA
    Vet Microbiol 148:440-7. 2011
    ....
  18. doi request reprint Hematologic and serum biochemical reference intervals for free-ranging common bottlenose dolphins (Tursiops truncatus) and variation in the distributions of clinicopathologic values related to geographic sampling site
    Lori H Schwacke
    NOAA Ocean Service, Hollings Marine Laboratory, 331 Ft Johnson Rd, Charleston, SC 29412, USA
    Am J Vet Res 70:973-85. 2009
    ....
  19. doi request reprint In vitro PFOS exposure on immune endpoints in bottlenose dolphins (Tursiops truncatus) and mice
    Jena R Wirth
    Graduate Program in Marine Biology, College of Charleston, 205 Fort Johnson Road, Charleston, SC, 29412, USA
    J Appl Toxicol 34:658-66. 2014
    ..Copyright © 2013 John Wiley & Sons, Ltd. ..
  20. doi request reprint Concentrations of trace elements in blood and skin of Florida manatees (Trichechus manatus latirostris)
    Hui Chen W Stavros
    National Oceanic and Atmospheric Administration, National Ocean Service, Center for Coastal Environmental Health and Biomolecular Research, 219 Fort Johnson Road, Charleston, SC 29412 9110, USA
    Mar Pollut Bull 56:1221-5. 2008
  21. ncbi request reprint A dolphin peripheral blood leukocyte cDNA microarray for studies of immune function and stress reactions
    Annalaura Mancia
    Marine Biomedicine and Environmental Science Center, Medical University of South Carolina, Hollings Marine Laboratory, 331 Ft Johnson Road, Charleston, SC 29412, USA
    Dev Comp Immunol 31:520-9. 2007
    ..The results demonstrate that the array is a reproducible and informative tool for assessing differential gene expression in dolphin PBL and in other tissues...
  22. doi request reprint Organohalogen contaminants in blood of Kemp's ridley (Lepidochelys kempii) and green sea turtles (Chelonia mydas) from the Gulf of Mexico
    Robert F Swarthout
    National Institute of Standards and Technology, Analytical Chemistry Division, Hollings Marine Laboratory, Charleston, SC 29412, USA
    Chemosphere 78:731-41. 2010
    ..kempii. These data help establish baseline contaminant concentrations in live L. kempii and C. mydas...
  23. ncbi request reprint Establishment of epidermal cell lines derived from the skin of the Atlantic bottlenose dolphin (Tursiops truncatus)
    Jin Yu
    Department of Neurosciences and Neuroscience Institute, Medical University of South Carolina, Charleston, South Carolina 29403, USA
    Anat Rec A Discov Mol Cell Evol Biol 287:1246-55. 2005
    ..Epidermal cell lines derived from Tursiops truncatus will provide a unique tool for studying key features of the interaction occurring between dolphins and the environment in which they live at their most crucial interface: the skin...
  24. ncbi request reprint Geographic variation in polychorinated biphenyl and organochlorine pesticide concentrations in the blubber of bottlenose dolphins from the US Atlantic coast
    Larry J Hansen
    United States Fish and Wildlife Service, Stockton, CA 95205, USA
    Sci Total Environ 319:147-72. 2004
    ....
  25. ncbi request reprint Polyfluoroalkyl compounds in free-ranging bottlenose dolphins (Tursiops truncatus) from the Gulf of Mexico and the Atlantic Ocean
    Magali Houde
    Department of Environmental Biology, University of Guelph, Guelph, Ontario NIG 2W1, Canada
    Environ Sci Technol 39:6591-8. 2005
    ..Fluorotelomer 8:2 and 10:2 unsaturated carboxylic acids (FTUCAs), known degradation products of fluorotelomer alcohols and suspected precursors to PFCAs, were detected for the first time at low concentrations in plasma of dolphins...
  26. ncbi request reprint Polychlorinated biphenyls and hydroxylated polychlorinated biphenyls in plasma of bottlenose dolphins (Tursiops truncatus) from the Western Atlantic and the Gulf of Mexico
    Magali Houde
    Department of Environmental Biology, University of Guelph, Ontario, Canada
    Environ Sci Technol 40:5860-6. 2006
    ..Results from this study show that OH-PCB are important environmental contaminants in dolphins and suggest that PCBs, decades after their ban, may still constitute a threat to wildlife...
  27. ncbi request reprint Blubber morphology in wild bottlenose dolphins (Tursiops truncatus) from the Southeastern United States: influence of geographic location, age class, and reproductive state
    Eric W Montie
    Woods Hole Oceanographic Institution, Woods Hole, Massachusetts 02543, USA
    J Morphol 269:496-511. 2008
    ..This study demonstrates that ontogeny, geography, and reproductive state may influence morphological parameters such as structural fiber densities and adipocyte numbers and sizes, measured in bottlenose dolphin blubber...
  28. doi request reprint Cytochrome P4501A1 expression, polychlorinated biphenyls and hydroxylated metabolites, and adipocyte size of bottlenose dolphins from the Southeast United States
    Eric W Montie
    Woods Hole Oceanographic Institution WHOI, Woods Hole, MA, United States
    Aquat Toxicol 86:397-412. 2008
    ..The OH-PCBs thus formed have the potential to interfere with thyroid hormone homeostasis...
  29. doi request reprint Evaluation and comparison of the health status of Atlantic bottlenose dolphins from the Indian River Lagoon, Florida, and Charleston, South Carolina
    John S Reif
    Department of Environmental and Radiological Health Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA
    J Am Vet Med Assoc 233:299-307. 2008
    ..To conduct health assessments and compare outcomes in 2 populations of Atlantic bottlenose dolphins. Design-Repeated cross-sectional study...
  30. ncbi request reprint Biomagnification of perfluoroalkyl compounds in the bottlenose dolphin (Tursiops truncatus) food web
    Magali Houde
    Department of Environmental Biology, University of Guelph, Guelph, Ontario, N1G 2W1, Canada
    Environ Sci Technol 40:4138-44. 2006
    ..The results indicate that using plasma and liver PFC concentrations as surrogate to whole body burden in a top marine predator overestimates the BMFs and TMFs...
  31. ncbi request reprint Hematologic, biochemical, and cytologic findings from apparently healthy atlantic bottlenose dolphins (Tursiops truncatus) inhabiting the Indian River Lagoon, Florida, USA
    Juli D Goldstein
    Division of Marine Mammal Research and Conservation, Harbor Branch Oceanographic Institution, Fort Pierce, Florida 34946, USA
    J Wildl Dis 42:447-54. 2006
    ..However, the values remained within the established ranges for this species, and the differences were not likely to be of clinical significance...