Research Topics
| Patricia A FairSummaryAffiliation: National Oceanic and Atmospheric Administration Country: USA Publications
| Collaborators
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Detail Information
Publications
Associations between perfluoroalkyl compounds and immune and clinical chemistry parameters in highly exposed bottlenose dolphins (Tursiops truncatus)Patricia A Fair
National Oceanic and Atmospheric Administration, National Ocean Service, Center for Coastal Environmental Health and Biomolecular Research, Charleston, South Carolina, USA
Environ Toxicol Chem 32:736-46. 2013..The results contribute to the emerging data on PFC health effects in this first study to describe associations between PFCs and health parameters in dolphins...- Immune function in female B(6)C(3)F(1) mice is modulated by DE-71, a commercial polybrominated diphenyl ether mixturePatricia A Fair
National Oceanic and Atmospheric Administration, National Ocean Services, Center for Coastal Environmental Health and Biomolecular Research, Charleston, SC 29412, USA
J Immunotoxicol 9:96-107. 2012..5, 5, and 100 mg/kg TAD. This study provides an assessment of the systemic toxicity and immunotoxicity of DE-71, and indicates that immune parameters are modulated at exposure concentrations lower than previously reported... - Assessment of perfluorinated compounds (PFCs) in plasma of bottlenose dolphins from two southeast US estuarine areas: relationship with age, sex and geographic locationsPatricia A Fair
National Oceanic and Atmospheric Administration, National Ocean Service, Center for Coastal Environmental Health and Biomolecular Research, 219 Fort Johnson Road, Charleston, SC 29412 9110, USA
Mar Pollut Bull 64:66-74. 2012..These observations suggest PFC accumulation in these two dolphin populations are influenced by site-specific exposures with significantly higher levels in CHS dolphins... - Occurrence of triclosan in plasma of wild Atlantic bottlenose dolphins (Tursiops truncatus) and in their environmentPatricia A Fair
National Oceanic and Atmospheric Administration, National Ocean Services, Center for Coastal Environmental Health and Biomolecular Research, 219 Fort Johnson Road, Charleston, SC 29412 9110, USA
Environ Pollut 157:2248-54. 2009..5 ng/L (n = 18) ranging from 4.9 to 14 ng/L. This is the first study to report bioaccumulation of anthropogenic triclosan in a marine mammal highlighting the need for further monitoring and assessment... 
Polybrominated diphenyl ethers (PBDEs) in blubber of free-ranging bottlenose dolphins (Tursiops truncatus) from two southeast Atlantic estuarine areasPatricia A Fair
National Oceanic and Atmospheric Administration, National Ocean Service, Center for Coastal Environmental Health and Biomolecular Research, 219 Fort Johnson Road, Charleston, SC 29412, USA
Arch Environ Contam Toxicol 53:483-94. 2007..The levels of PBDEs in Charleston dolphins represent some of the highest measured in marine mammals and warrants further investigation of these emerging, bioaccumulative chemicals and their potential deleterious effects...- Contaminant blubber burdens in Atlantic bottlenose dolphins (Tursiops truncatus) from two southeastern US estuarine areas: concentrations and patterns of PCBs, pesticides, PBDEs, PFCs, and PAHsPatricia A Fair
National Oceanic and Atmospheric Administration, National Ocean Service, Center for Coastal Environmental Health and Biomolecular Research, Charleston, SC 29412, USA
Sci Total Environ 408:1577-97. 2010.... - Influences of biological variables and geographic location on circulating concentrations of thyroid hormones in wild bottlenose dolphins (Tursiops truncatus)Patricia A Fair
NOAA s Ocean Service, Center for Coastal Environmental Health and Biomolecular Research, 219 Fort Johnson Road, Charleston, SC 29412 9110, USA
Gen Comp Endocrinol 174:184-94. 2011.... 
Effects of environmentally-relevant levels of perfluorooctane sulfonate on clinical parameters and immunological functions in B6C3F1 micePatricia A Fair
National Oceanic and Atmospheric Administration, National Ocean Service, Center for Coastal Environmental Health and Biomolecular Research, Charleston, SC, USA
J Immunotoxicol 8:17-29. 2011....- Trace element concentrations in blood of free-ranging bottlenose dolphins (Tursiops truncatus): influence of age, sex and locationHui-Chen W Stavros
National Oceanic and Atmospheric Administration, National Ocean Service, Center for Coastal Environmental Health and Biomolecular Research, Charleston, SC 29412-9110, USA
Mar Pollut Bull 56:371-9. 2008 - Correlation and toxicological inference of trace elements in tissues from stranded and free-ranging bottlenose dolphins (Tursiops truncatus)Hui Chen W Stavros
National Oceanic and Atmospheric Administration, National Ocean Service, Center for Coastal Environmental Health and Biomolecular Research, Charleston, SC 29412, USA
Chemosphere 82:1649-61. 2011..The present study provides the first application of trace element concentrations derived from stranded bottlenose dolphins to predict liver concentrations in free-ranging populations... - Gene expression changes in bottlenose dolphin, Tursiops truncatus, skin cells following exposure to methylmercury (MeHg) or perfluorooctane sulfonate (PFOS)Meagan A M Mollenhauer
Department of Pediatrics, Medical University of South Carolina, Charleston, SC, USA
Aquat Toxicol 91:10-8. 2009..Alterations in normal cellular biology, like those observed, may lead to changes in health in marine mammals exposed to contaminants; however, this warrants further investigation... - Effects of perfluorooctane sulfonate (PFOS) exposure on markers of inflammation in female B6C3F1 miceMeagan A M Mollenhauer
Molecular and Cellular Biology and Pathobiology, Medical University of South Carolina, Charleston, South Carolina, USA
J Environ Sci Health A Tox Hazard Subst Environ Eng 46:97-108. 2011..Overall, these data suggest that PFOS exposure can alter some inflammatory processes, which could potentially lead to misdirected inflammatory responses... - Trace element concentrations in skin of free-ranging bottlenose dolphins (Tursiops truncatus) from the southeast Atlantic coastHui Chen W Stavros
National Oceanic and Atmospheric Administration, National Ocean Service, Center for Coastal Environmental Health and Biomolecular Research, 219 Fort Johnson Road, Charleston, South Carolina 29412, USA
Sci Total Environ 388:300-15. 2007.... - Probabilistic risk assessment of reproductive effects of polychlorinated biphenyls on bottlenose dolphins (Tursiops truncatus) from the Southeast United States CoastLori H Schwacke
National Ocean Service, Center for Coastal Environmental Health and Biomolecular Research, 219 Fort Johnson Road, Charleston, South Carolina 29412 9110, USA
Environ Toxicol Chem 21:2752-64. 2002..Females of higher parity, which have previously off-loaded a majority of their PCB burden, exhibit a much lower risk... - Hematologic and serum biochemical reference intervals for free-ranging common bottlenose dolphins (Tursiops truncatus) and variation in the distributions of clinicopathologic values related to geographic sampling siteLori H Schwacke
NOAA Ocean Service, Hollings Marine Laboratory, 331 Ft Johnson Rd, Charleston, SC 29412, USA
Am J Vet Res 70:973-85. 2009.... - Isolation of culturable microorganisms from free-ranging bottlenose dolphins (Tursiops truncatus) from the southeastern United StatesPamela J Morris
Belle W Baruch Institute for Marine and Coastal Sciences, University of South Carolina, Charleston, SC 29412, USA
Vet Microbiol 148:440-7. 2011.... - Concentrations of trace elements in blood and skin of Florida manatees (Trichechus manatus latirostris)Hui-Chen W Stavros
National Oceanic and Atmospheric Administration, National Ocean Service, Center for Coastal Environmental Health and Biomolecular Research, 219 Fort Johnson Road, Charleston, SC 29412-9110, USA
Mar Pollut Bull 56:1221-5. 2008 - A dolphin peripheral blood leukocyte cDNA microarray for studies of immune function and stress reactionsAnnalaura Mancia
Marine Biomedicine and Environmental Science Center, Medical University of South Carolina, Hollings Marine Laboratory, 331 Ft Johnson Road, Charleston, SC 29412, USA
Dev Comp Immunol 31:520-9. 2007..The results demonstrate that the array is a reproducible and informative tool for assessing differential gene expression in dolphin PBL and in other tissues... - Organohalogen contaminants in blood of Kemp's ridley (Lepidochelys kempii) and green sea turtles (Chelonia mydas) from the Gulf of MexicoRobert F Swarthout
National Institute of Standards and Technology, Analytical Chemistry Division, Hollings Marine Laboratory, Charleston, SC 29412, USA
Chemosphere 78:731-41. 2010..kempii. These data help establish baseline contaminant concentrations in live L. kempii and C. mydas... - Establishment of epidermal cell lines derived from the skin of the Atlantic bottlenose dolphin (Tursiops truncatus)Jin Yu
Department of Neurosciences and Neuroscience Institute, Medical University of South Carolina, Charleston, South Carolina 29403, USA
Anat Rec A Discov Mol Cell Evol Biol 287:1246-55. 2005..Epidermal cell lines derived from Tursiops truncatus will provide a unique tool for studying key features of the interaction occurring between dolphins and the environment in which they live at their most crucial interface: the skin... - Geographic variation in polychorinated biphenyl and organochlorine pesticide concentrations in the blubber of bottlenose dolphins from the US Atlantic coastLarry J Hansen
United States Fish and Wildlife Service, Stockton, CA 95205, USA
Sci Total Environ 319:147-72. 2004.... - Polyfluoroalkyl compounds in free-ranging bottlenose dolphins (Tursiops truncatus) from the Gulf of Mexico and the Atlantic OceanMagali Houde
Department of Environmental Biology, University of Guelph, Guelph, Ontario NIG 2W1, Canada
Environ Sci Technol 39:6591-8. 2005..Fluorotelomer 8:2 and 10:2 unsaturated carboxylic acids (FTUCAs), known degradation products of fluorotelomer alcohols and suspected precursors to PFCAs, were detected for the first time at low concentrations in plasma of dolphins... - Polychlorinated biphenyls and hydroxylated polychlorinated biphenyls in plasma of bottlenose dolphins (Tursiops truncatus) from the Western Atlantic and the Gulf of MexicoMagali Houde
Department of Environmental Biology, University of Guelph, Ontario, Canada
Environ Sci Technol 40:5860-6. 2006..Results from this study show that OH-PCB are important environmental contaminants in dolphins and suggest that PCBs, decades after their ban, may still constitute a threat to wildlife... - Blubber morphology in wild bottlenose dolphins (Tursiops truncatus) from the Southeastern United States: influence of geographic location, age class, and reproductive stateEric W Montie
Woods Hole Oceanographic Institution, Woods Hole, Massachusetts 02543, USA
J Morphol 269:496-511. 2008..This study demonstrates that ontogeny, geography, and reproductive state may influence morphological parameters such as structural fiber densities and adipocyte numbers and sizes, measured in bottlenose dolphin blubber... - Cytochrome P4501A1 expression, polychlorinated biphenyls and hydroxylated metabolites, and adipocyte size of bottlenose dolphins from the Southeast United StatesEric W Montie
Woods Hole Oceanographic Institution WHOI, Woods Hole, MA, United States
Aquat Toxicol 86:397-412. 2008..The OH-PCBs thus formed have the potential to interfere with thyroid hormone homeostasis... - Evaluation and comparison of the health status of Atlantic bottlenose dolphins from the Indian River Lagoon, Florida, and Charleston, South CarolinaJohn S Reif
Department of Environmental and Radiological Health Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA
J Am Vet Med Assoc 233:299-307. 2008..To conduct health assessments and compare outcomes in 2 populations of Atlantic bottlenose dolphins. Design-Repeated cross-sectional study... - Hematologic, biochemical, and cytologic findings from apparently healthy atlantic bottlenose dolphins (Tursiops truncatus) inhabiting the Indian River Lagoon, Florida, USAJuli D Goldstein
Division of Marine Mammal Research and Conservation, Harbor Branch Oceanographic Institution, Fort Pierce, Florida 34946, USA
J Wildl Dis 42:447-54. 2006..However, the values remained within the established ranges for this species, and the differences were not likely to be of clinical significance... - Biomagnification of perfluoroalkyl compounds in the bottlenose dolphin (Tursiops truncatus) food webMagali Houde
Department of Environmental Biology, University of Guelph, Guelph, Ontario, N1G 2W1, Canada
Environ Sci Technol 40:4138-44. 2006..The results indicate that using plasma and liver PFC concentrations as surrogate to whole body burden in a top marine predator overestimates the BMFs and TMFs...