Valerie Fadok

Summary

Affiliation: National Jewish Medical and Research Center
Country: USA

Publications

  1. ncbi CD36 is required for phagocytosis of apoptotic cells by human macrophages that use either a phosphatidylserine receptor or the vitronectin receptor (alpha v beta 3)
    V A Fadok
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 161:6250-7. 1998
  2. ncbi Defective apoptotic cell phagocytosis attenuates prostaglandin E2 and 15-hydroxyeicosatetraenoic acid in severe asthma alveolar macrophages
    Mai Lan N Huynh
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Am J Respir Crit Care Med 172:972-9. 2005
  3. ncbi The role of phosphatidylserine in recognition of apoptotic cells by phagocytes
    V A Fadok
    Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, Colorado 80206 USA
    Cell Death Differ 5:551-62. 1998
  4. ncbi Clearance: the last and often forgotten stage of apoptosis
    V A Fadok
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    J Mammary Gland Biol Neoplasia 4:203-11. 1999
  5. ncbi A receptor for phosphatidylserine-specific clearance of apoptotic cells
    V A Fadok
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Nature 405:85-90. 2000
  6. ncbi Loss of phospholipid asymmetry and surface exposure of phosphatidylserine is required for phagocytosis of apoptotic cells by macrophages and fibroblasts
    V A Fadok
    Program in Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    J Biol Chem 276:1071-7. 2001
  7. ncbi Differential effects of apoptotic versus lysed cells on macrophage production of cytokines: role of proteases
    V A Fadok
    Program in Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    J Immunol 166:6847-54. 2001
  8. ncbi If phosphatidylserine is the death knell, a new phosphatidylserine-specific receptor is the bellringer
    V A Fadok
    Program in Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado, CO 80206, USA
    Cell Death Differ 8:582-7. 2001
  9. ncbi Apoptosis: giving phosphatidylserine recognition an assist--with a twist
    Valerie A Fadok
    Program in Cell Biology, Dept. Pediatrics, National Jewish Medical and Research Center, D509, 1400 Jackson Street, Denver, CO 80206, USA
    Curr Biol 13:R655-7. 2003
  10. ncbi Activation of SHIP by NADPH oxidase-stimulated Lyn leads to enhanced apoptosis in neutrophils
    Shyra Gardai
    Department of Pathology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Biol Chem 277:5236-46. 2002

Research Grants

  1. PHOSPHATIDYLSERINE-SPECIFIC RECEPTOR FOR APOPTOTIC CELLS
    Valerie Fadok; Fiscal Year: 2004

Collaborators

Detail Information

Publications27

  1. ncbi CD36 is required for phagocytosis of apoptotic cells by human macrophages that use either a phosphatidylserine receptor or the vitronectin receptor (alpha v beta 3)
    V A Fadok
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 161:6250-7. 1998
    ..A maximum of 70% inhibition was achieved by combining anti-CD36 with either anti-a(v) or PS liposomes...
  2. ncbi Defective apoptotic cell phagocytosis attenuates prostaglandin E2 and 15-hydroxyeicosatetraenoic acid in severe asthma alveolar macrophages
    Mai Lan N Huynh
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Am J Respir Crit Care Med 172:972-9. 2005
    ..Clearance of apoptotic cells is crucial to the resolution of inflammation and development of fibrosis, but the process is not well understood in normal or diseased human lungs...
  3. ncbi The role of phosphatidylserine in recognition of apoptotic cells by phagocytes
    V A Fadok
    Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, Colorado 80206 USA
    Cell Death Differ 5:551-62. 1998
    ..Whether PS is the sole ligand recognized by phagocytes or whether it associated with other molecules to form a complex ligand remains to be determined...
  4. ncbi Clearance: the last and often forgotten stage of apoptosis
    V A Fadok
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    J Mammary Gland Biol Neoplasia 4:203-11. 1999
    ..The mammary gland, therefore, provides an ideal organ in which to study the mechanisms and consequences of apoptotic cell clearance in vivo...
  5. ncbi A receptor for phosphatidylserine-specific clearance of apoptotic cells
    V A Fadok
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Nature 405:85-90. 2000
    ....
  6. ncbi Loss of phospholipid asymmetry and surface exposure of phosphatidylserine is required for phagocytosis of apoptotic cells by macrophages and fibroblasts
    V A Fadok
    Program in Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    J Biol Chem 276:1071-7. 2001
    ..These observations directly demonstrate that loss of phospholipid asymmetry and PS expression is required for phagocyte engulfment of apoptotic cells and imply a critical, if not obligatory, role for PS recognition in the uptake process...
  7. ncbi Differential effects of apoptotic versus lysed cells on macrophage production of cytokines: role of proteases
    V A Fadok
    Program in Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    J Immunol 166:6847-54. 2001
    ..Therefore, the outcome of an inflammatory reaction and the potential immunogenicity of Ags within the damaged cell will be determined by which signals predominate...
  8. ncbi If phosphatidylserine is the death knell, a new phosphatidylserine-specific receptor is the bellringer
    V A Fadok
    Program in Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado, CO 80206, USA
    Cell Death Differ 8:582-7. 2001
    ..Although highly homologous genes exist in C. elegans and Drosophila melanogaster, their role in engulfment of apoptotic cells remains to be determined...
  9. ncbi Apoptosis: giving phosphatidylserine recognition an assist--with a twist
    Valerie A Fadok
    Program in Cell Biology, Dept. Pediatrics, National Jewish Medical and Research Center, D509, 1400 Jackson Street, Denver, CO 80206, USA
    Curr Biol 13:R655-7. 2003
  10. ncbi Activation of SHIP by NADPH oxidase-stimulated Lyn leads to enhanced apoptosis in neutrophils
    Shyra Gardai
    Department of Pathology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Biol Chem 277:5236-46. 2002
    ..Thus, we propose a role for oxidants and Lyn in SHIP regulation and suggest a novel mechanism for regulating neutrophil apoptosis...
  11. ncbi SiMCAL 1 algorithm for analysis of gene expression data related to the phosphatidylserine receptor
    Daniel Dvorkin
    University of Colorado at Denver and Health Sciences Center, Denver, CO 80217, USA
    Artif Intell Med 35:49-60. 2005
    ..By analyzing the behavior of PSR-related genes in mouse macrophages, we hope to elucidate the mechanisms involved in this important biological process...
  12. ncbi Interaction between phosphatidylserine and the phosphatidylserine receptor inhibits immune responses in vivo
    Peter R Hoffmann
    Department of Pediatrics, Program in Cell Biology, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 174:1393-404. 2005
    ....
  13. ncbi Life after corpse engulfment: phagocytosis of apoptotic cells leads to VEGF secretion and cell growth
    Heiko A Golpon
    Pulmonary Hypertension Center, University of Colorado, Health Sciences Center, Denver, Colorado, USA
    FASEB J 18:1716-8. 2004
    ..We conclude that phagocytosis of apoptotic cells leads to secretion of growth and survival factors by phagocytes that represents a new form of life-promoting cell-cell interaction...
  14. ncbi Beryllium-ferritin: lymphocyte proliferation and macrophage apoptosis in chronic beryllium disease
    Richard T Sawyer
    Department of Medicine, Robert H Hollis Laboratory of Environmental and Occupational Health Sciences, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    Am J Respir Cell Mol Biol 31:470-7. 2004
    ....
  15. ncbi Cell corpse engulfment mediated by C. elegans phosphatidylserine receptor through CED-5 and CED-12
    Xiaochen Wang
    Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80309, USA
    Science 302:1563-6. 2003
    ..Our findings suggest that PSR-1 is likely an upstream receptor for the signaling pathway containing CED-2, CED-5, CED-10, and CED-12 proteins and plays an important role in recognizing phosphatidylserine during phagocytosis...
  16. ncbi Role of surfactant proteins A, D, and C1q in the clearance of apoptotic cells in vivo and in vitro: calreticulin and CD91 as a common collectin receptor complex
    R William Vandivier
    Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine and Pathology, University of Colorado Health Sciences Center, nd Denver, CO, USA
    J Immunol 169:3978-86. 2002
    ....
  17. ncbi The role of the macrophage in apoptosis: hunter, gatherer, and regulator
    F Jon Geske
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Int J Hematol 76:16-26. 2002
    ..It is also possible that certain malignant tumor cells co-opt the mechanisms for apoptotic cell clearance to avoid immune surveillance by subverting macrophage and dendritic cell responses...
  18. ncbi Phosphatidylserine-dependent ingestion of apoptotic cells promotes TGF-beta1 secretion and the resolution of inflammation
    Mai Lan N Huynh
    Department of Pulmonary and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, Colorado, USA
    J Clin Invest 109:41-50. 2002
    ..In conclusion, apoptotic cell recognition and clearance, via exposure of PS and ligation of its receptor, induce TGF-beta1 secretion, resulting in accelerated resolution of inflammation...
  19. ncbi Elastase-mediated phosphatidylserine receptor cleavage impairs apoptotic cell clearance in cystic fibrosis and bronchiectasis
    R William Vandivier
    Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado, USA
    J Clin Invest 109:661-70. 2002
    ..Therefore, defective airway clearance of apoptotic cells in cystic fibrosis and bronchiectasis may be due to elastase-mediated cleavage of phosphatidylserine receptor on phagocytes and may contribute to ongoing airway inflammation...
  20. ncbi Impaired clearance of apoptotic cells from cystic fibrosis airways
    R William Vandivier
    University of Colorado Health Sciences Center, Denver, CO, USA
    Chest 121:89S. 2002
  21. ncbi Interleukin-15 inhibits spontaneous apoptosis in human eosinophils via autocrine production of granulocyte macrophage-colony stimulating factor and nuclear factor-kappaB activation
    Raweewan Hoontrakoon
    Department of Pediatrics, Division of Allergy and Immunology, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Am J Respir Cell Mol Biol 26:404-12. 2002
    ..Thus, our results suggest that IL-15, either alone or in combination with TNF-alpha, may perpetuate allergic inflammation by reduction of spontaneous eosinophil apoptosis through autocrine production of GM-CSF and NF-kappaB activation...
  22. ncbi Impairment of macrophage survival by NaCl: implications for early pulmonary inflammation in cystic fibrosis
    Gwendolyn S Kerby
    Program in Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Am J Physiol Lung Cell Mol Physiol 283:L188-97. 2002
    ..We speculate that augmentation of macrophage apoptosis in CF airways may result in decreased clearance of neutrophils and in deficiencies in the elimination of common CF pathogens...
  23. ncbi Beryllium induces apoptosis in human lung macrophages
    Lori A Kittle
    Department of Medicine, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Sarcoidosis Vasc Diffuse Lung Dis 19:101-13. 2002
    ..We conclude that Be-induced human lung adherent macrophage apoptosis could contribute to the host's continued re-exposure to Be resulting in chronic granulomatous inflammation...
  24. ncbi The sirens' call
    Valerie A Fadok
    Nat Cell Biol 5:697-9. 2003
  25. ncbi Cross-talk between ERK and p38 MAPK mediates selective suppression of pro-inflammatory cytokines by transforming growth factor-beta
    Yi Qun Xiao
    Program in Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    J Biol Chem 277:14884-93. 2002
    ..Our data provide evidence that TGF-beta selectively inhibits inflammatory cytokine production through cross-talk between MAPKs...
  26. ncbi Do inflammatory cells participate in mammary gland involution?
    Jenifer Monks
    Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, Colorado 80206, USA
    J Mammary Gland Biol Neoplasia 7:163-76. 2002
    ..The ensuing model describes a process of involution that actively suppresses an inflammatory response in the gland, allowing for effective tissue remodeling and damage prevention...
  27. ncbi Epithelial cells remove apoptotic epithelial cells during post-lactation involution of the mouse mammary gland
    Jenifer Monks
    Program in Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Biol Reprod 78:586-94. 2008
    ..Macrophages and other inflammatory cells did not contribute to the clearance of either residual milk or apoptotic cells, which appeared to be due entirely to the epithelium itself...

Research Grants5

  1. PHOSPHATIDYLSERINE-SPECIFIC RECEPTOR FOR APOPTOTIC CELLS
    Valerie Fadok; Fiscal Year: 2004
    ..The investigators hypothesize that PS recognition has been preserved throughout phylogeny as an effective mechanism mediating the removal of apoantibodies. ..