M Ernst

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Decision-making in a risk-taking task: a PET study
    Monique Ernst
    Intramural Research Program of the National Institute on Drug Abuse, Johns Hopkins School of Medicine, Baltimore, MD 21224, USA
    Neuropsychopharmacology 26:682-91. 2002
  2. ncbi request reprint Decision making in adolescents with behavior disorders and adults with substance abuse
    Monique Ernst
    NIH NIMH MAP, 15K North Dr, Room 118, MSC 2670, Bethesda, MD 20892 2670, USA
    Am J Psychiatry 160:33-40. 2003
  3. ncbi request reprint Reward-related processes in pediatric bipolar disorder: a pilot study
    Monique Ernst
    Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, 15K North Drive, Room 118, Bethesda, MD 20892 2670, USA
    J Affect Disord 82:S89-S101. 2004
  4. ncbi request reprint Choice selection and reward anticipation: an fMRI study
    Monique Ernst
    Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, 15K North Drive, Bethesda, MD 20892 2670, USA
    Neuropsychologia 42:1585-97. 2004
  5. ncbi request reprint Neuroimaging and mechanisms of drug abuse: interface of molecular imaging and molecular genetics
    Monique Ernst
    Mood and Anxiety Disorders Program, Department of Health and Human Services, National Institute of Mental Health, National Institutes of Health, 15K North Drive, Room 118, MSC 2670, Bethesda, MD 20892 2670, USA
    Neuroimaging Clin N Am 13:833-49. 2003
  6. ncbi request reprint Amygdala and nucleus accumbens in responses to receipt and omission of gains in adults and adolescents
    Monique Ernst
    Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, 15K North Drive, Bethesda, MD 20892 2670, USA
    Neuroimage 25:1279-91. 2005
  7. ncbi request reprint Smoking history and nicotine effects on cognitive performance
    M Ernst
    Brain Imaging Center, National Institute on Drug Abuse, Baltimore, MD, USA
    Neuropsychopharmacology 25:313-9. 2001
  8. ncbi request reprint Behavioral and neural consequences of prenatal exposure to nicotine
    M Ernst
    Brain Imaging Center in the Neuroimaging Branch of the Intramural Research Program of the National Institute on Drug Abuse, Bethesda, MD 20892 0135, USA
    J Am Acad Child Adolesc Psychiatry 40:630-41. 2001
  9. ncbi request reprint Neural substrates of decision making in adults with attention deficit hyperactivity disorder
    Monique Ernst
    Intramural Research Program, NIMH, Natioanl Institute on Drug Abuse, Baltimore, MD, USA
    Am J Psychiatry 160:1061-70. 2003
  10. ncbi request reprint Abnormal attention modulation of fear circuit function in pediatric generalized anxiety disorder
    Erin B McClure
    Emotional Development and Affective Neuroscience Branch, Mood and Anxiety Disorders Program, National Institute of Mental Health, NIH DHHS, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 64:97-106. 2007

Detail Information

Publications95

  1. ncbi request reprint Decision-making in a risk-taking task: a PET study
    Monique Ernst
    Intramural Research Program of the National Institute on Drug Abuse, Johns Hopkins School of Medicine, Baltimore, MD 21224, USA
    Neuropsychopharmacology 26:682-91. 2002
    ..The findings provide a framework for future investigations of decision-making in maladaptive behaviors...
  2. ncbi request reprint Decision making in adolescents with behavior disorders and adults with substance abuse
    Monique Ernst
    NIH NIMH MAP, 15K North Dr, Room 118, MSC 2670, Bethesda, MD 20892 2670, USA
    Am J Psychiatry 160:33-40. 2003
    ....
  3. ncbi request reprint Reward-related processes in pediatric bipolar disorder: a pilot study
    Monique Ernst
    Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, 15K North Drive, Room 118, Bethesda, MD 20892 2670, USA
    J Affect Disord 82:S89-S101. 2004
    ..We hypothesized that relative to healthy children, children with BPD would select risky options more frequently, be less confident in a favorable outcome, and report stronger emotional responses to outcomes...
  4. ncbi request reprint Choice selection and reward anticipation: an fMRI study
    Monique Ernst
    Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, 15K North Drive, Bethesda, MD 20892 2670, USA
    Neuropsychologia 42:1585-97. 2004
    ....
  5. ncbi request reprint Neuroimaging and mechanisms of drug abuse: interface of molecular imaging and molecular genetics
    Monique Ernst
    Mood and Anxiety Disorders Program, Department of Health and Human Services, National Institute of Mental Health, National Institutes of Health, 15K North Drive, Room 118, MSC 2670, Bethesda, MD 20892 2670, USA
    Neuroimaging Clin N Am 13:833-49. 2003
    ..We expect PET to play a prominent role in the elucidation of substance abuse mechanisms and contribute significantly to the development of innovative treatment strategies...
  6. ncbi request reprint Amygdala and nucleus accumbens in responses to receipt and omission of gains in adults and adolescents
    Monique Ernst
    Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, 15K North Drive, Bethesda, MD 20892 2670, USA
    Neuroimage 25:1279-91. 2005
    ..These developmental differences, if replicated, may have important implications for the development of early-onset disorders of emotion and motivation...
  7. ncbi request reprint Smoking history and nicotine effects on cognitive performance
    M Ernst
    Brain Imaging Center, National Institute on Drug Abuse, Baltimore, MD, USA
    Neuropsychopharmacology 25:313-9. 2001
    ....
  8. ncbi request reprint Behavioral and neural consequences of prenatal exposure to nicotine
    M Ernst
    Brain Imaging Center in the Neuroimaging Branch of the Intramural Research Program of the National Institute on Drug Abuse, Bethesda, MD 20892 0135, USA
    J Am Acad Child Adolesc Psychiatry 40:630-41. 2001
    ..The relatively high rate of tobacco smoking among pregnant women (25% of all pregnancies in the U.S.) underlines the seriousness of these concerns...
  9. ncbi request reprint Neural substrates of decision making in adults with attention deficit hyperactivity disorder
    Monique Ernst
    Intramural Research Program, NIMH, Natioanl Institute on Drug Abuse, Baltimore, MD, USA
    Am J Psychiatry 160:1061-70. 2003
    ..The study examined reward responsivity in ADHD by comparing the neural correlates of decision making in adults with childhood-onset ADHD and in healthy adults...
  10. ncbi request reprint Abnormal attention modulation of fear circuit function in pediatric generalized anxiety disorder
    Erin B McClure
    Emotional Development and Affective Neuroscience Branch, Mood and Anxiety Disorders Program, National Institute of Mental Health, NIH DHHS, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 64:97-106. 2007
    ..However, in pediatric anxiety, no research has examined attention modulation of neural response to threat cues...
  11. ncbi request reprint Effects of triazolam on brain activity during episodic memory encoding: a PET study
    M Z Mintzer
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, 5510 Nathan Shock Drive, Baltimore, MD 21224, USA
    Neuropsychopharmacology 25:744-56. 2001
    ..Results are discussed in relation to triazolam's effects on mnemonic versus attentional processes...
  12. pmc Neural substrates of choice selection in adults and adolescents: development of the ventrolateral prefrontal and anterior cingulate cortices
    Neir Eshel
    Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 2670, USA
    Neuropsychologia 45:1270-9. 2007
    ..Consistent with predictions, these results suggest that adolescents engage prefrontal regulatory structures to a lesser extent than adults when making risky economic choices...
  13. pmc Orbitofrontal cortex dysfunction in abstinent cocaine abusers performing a decision-making task
    K I Bolla
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Neuroimage 19:1085-94. 2003
    ..Compromised decision-making could contribute to the development of addiction and undermine attempts at abstinence...
  14. ncbi request reprint Cognitive performance and autonomic reactivity in abstinent drug abusers and nonusers
    Diana Fishbein
    RTI International, Rockville, MD, USA
    Exp Clin Psychopharmacol 13:25-40. 2005
    ..In conclusion, complex tasks involving decision making, sensitivity to consequences, and emotional regulation discriminated between drug abusers and controls...
  15. ncbi request reprint Increased amygdala activity during successful memory encoding in adolescent major depressive disorder: An FMRI study
    Roxann Roberson-Nay
    Section on Development and Affective Neuroscience, National Institute of Mental Health Intramural Research Program, Bethesda, Maryland, USA
    Biol Psychiatry 60:966-73. 2006
    ..This study tests the hypothesis that adolescent MDD is associated with abnormal amygdala activity during evocative-face viewing...
  16. pmc Grey matter volume correlates with virtual water maze task performance in boys with androgen excess
    S C Mueller
    Department of Experimental Clinical and Health Psychology, Ghent University, Belgium
    Neuroscience 197:225-32. 2011
    ..These data provide novel insight into the relation between testosterone and brain development and suggest that morphological differences in a spatial navigation network covary with performance in spatial ability...
  17. pmc Effect of nicotine on brain activation during performance of a working memory task
    M Ernst
    Brain Imaging Center and Clinical Pharmacology and Therapeutics Branch, National Institute on Drug Abuse, Baltimore, MD 21224, USA
    Proc Natl Acad Sci U S A 98:4728-33. 2001
    ..Furthermore, the lack of enhancement of activation after nicotine administration in smokers likely reflects tolerance...
  18. doi request reprint Cerebral maturation in adolescence: behavioral vulnerability
    M Ernst
    Emotional Development and Affective Neuroscience National Institute of Mental Health NIH DHHS, Bethesda, Maryland, USA
    Encephale 35:S182-9. 2009
    ..The role of genetic or environmental factors will not be addressed here, despite their critical roles in determining and modulating the balance among the nodes of the triadic model...
  19. pmc Early hyperandrogenism affects the development of hippocampal function: preliminary evidence from a functional magnetic resonance imaging study of boys with familial male precocious puberty
    Sven C Mueller
    Emotional Development and Affective Neuroscience Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
    J Child Adolesc Psychopharmacol 19:41-50. 2009
    ..In contrast, no significant activation of the amygdala was found. These data are consistent with previous studies of the effects of sex hormones on brain function and support the role of testosterone on emotional development...
  20. pmc Altered amygdala and hippocampus function in adolescents with hypercortisolemia: a functional magnetic resonance imaging study of Cushing syndrome
    Francoise S Maheu
    National Institute of Mental Health, Bethesda, MD, 20892 2670, USA
    Dev Psychopathol 20:1177-89. 2008
    ....
  21. ncbi request reprint A developmental examination of gender differences in brain engagement during evaluation of threat
    Erin B McClure
    Section on Development and Affective Neuroscience, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    Biol Psychiatry 55:1047-55. 2004
    ..Recent theoretical models suggest that developmental changes in brain functioning play important roles in the emergence of such gender differences...
  22. ncbi request reprint Brain imaging studies of cocaine abuse: implications for medication development
    E D London
    The Brain Imaging Center, National Institute on Drug Abuse, Baltimore, MD 21224, USA
    Crit Rev Neurobiol 13:227-42. 1999
    ..The future directions of in vivo brain imaging to identify functional and structural alterations in the brains of cocaine abusers are discussed in relation to the development of medications to treat cocaine dependence...
  23. ncbi request reprint High midbrain [18F]DOPA accumulation in children with attention deficit hyperactivity disorder
    M Ernst
    Laboratory of Cerebral Metabolism, NIMH, Bethesda, MD, USA
    Am J Psychiatry 156:1209-15. 1999
    ..Converging evidence, however, suggests a primary role of the dopaminergic system...
  24. ncbi request reprint Cognitive control under contingencies in anxious and depressed adolescents: an antisaccade task
    Sandra Jazbec
    Section of Developmental and Affective Neuroscience, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Biol Psychiatry 58:632-9. 2005
    ..Antisaccade paradigms are particularly well suited for this endeavor because they provide exquisite behavioral measures of modulation of response errors...
  25. ncbi request reprint Emotion recognition deficits in pediatric anxiety disorders: implications for amygdala research
    Josh Easter
    Section on Development and Affective Neuroscience, Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, Maryland 20892 2670, USA
    J Child Adolesc Psychopharmacol 15:563-70. 2005
    ..This study examines the relationship between face-emotion recognition and anxiety in a sample of children and adolescents participating in a brain-imaging study of amygdala structure and function...
  26. ncbi request reprint Increased occupancy of dopamine receptors in human striatum during cue-elicited cocaine craving
    Dean F Wong
    The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21287 0807, USA
    Neuropsychopharmacology 31:2716-27. 2006
    ..These results provide direct evidence that occupancy of dopamine receptors in human dorsal striatum increased in proportion to subjective craving, presumably because of increased release of intrasynaptic dopamine...
  27. ncbi request reprint Follow-up of radial arterial catheterization for positron emission tomography studies
    P H Jons
    Laboratory of Cerebral Metabolism, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 1384, USA
    Hum Brain Mapp 5:119-23. 1997
    ..Of these eight cases, three (37.5%) were inpatients diagnosed with anorexia nervosa, a condition that may represent a risk factor. All abnormalities were benign, did not affect motor function, and did not require medical intervention...
  28. pmc The influence of context valence in the neural coding of monetary outcomes
    Michael G Hardin
    Emotional Development and Affective Neuroscience Branch, National Institute of Mental Health, NIH DHHS, Bethesda, MD 20892 2670, USA
    Neuroimage 48:249-57. 2009
    ..The results of this work provide evidence of complex valence-based regional dissociations that are influenced by contextual factors...
  29. pmc The adolescent brain: insights from functional neuroimaging research
    Monique Ernst
    Emotional Development and Affective Neuroscience Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    Dev Neurobiol 68:729-43. 2008
    ..The conclusion places this functional neuroimaging research in relation to clinical and molecular work, and shows how answers will ultimately come from the combined efforts of these disciplines...
  30. pmc A developmental examination of amygdala response to facial expressions
    Amanda E Guyer
    National Institutes of Health NIH, Bethesda, MD 20892 2670, USA
    J Cogn Neurosci 20:1565-82. 2008
    ....
  31. pmc Amygdala function in adolescents with congenital adrenal hyperplasia: a model for the study of early steroid abnormalities
    Monique Ernst
    Emotional Development and Affective Neuroscience Branch, National Institute of Mental Health, National Institutes of Health, MD 20892 2670, USA
    Neuropsychologia 45:2104-13. 2007
    ..This study provides data that can be further tested in a model of the neurobiological mechanisms underlying early androgen organizational effects on amygdala function...
  32. pmc Incentive-related modulation of cognitive control in healthy, anxious, and depressed adolescents: development and psychopathology related differences
    Michael G Hardin
    Emotional Development and Affective Neuroscience Branch, Mood and Anxiety Disorders Program, National Institute of Mental Health, NIH DHHS, Bethesda, MD 20892, USA
    J Child Psychol Psychiatry 48:446-54. 2007
    ....
  33. pmc Fear conditioning in adolescents with anxiety disorders: results from a novel experimental paradigm
    Jennifer Y F Lau
    Mood and Anxiety Disorders Program, National Institute of Mental Health National Institutes of Health, 15K North Drive, MSC 2670, Bethesda, MD 20892 2670, USA
    J Am Acad Child Adolesc Psychiatry 47:94-102. 2008
    ..Adult data suggest that anxiety disorders involve elevated fear but intact differential conditioning. We used a novel paradigm to assess fear conditioning in pediatric anxiety patients...
  34. ncbi request reprint Specificity of facial expression labeling deficits in childhood psychopathology
    Amanda E Guyer
    Mood and Anxiety Program MAP, National Institute of Mental Health NIMH, National Institutes of Health NIH, Department of Health and Human Services DHHS, Bethesda, MD, USA
    J Child Psychol Psychiatry 48:863-71. 2007
    ..We examined whether face-emotion labeling deficits are illness-specific or an epiphenomenon of generalized impairment in pediatric psychiatric disorders involving mood and behavioral dysregulation...
  35. pmc Steroid abnormalities and the developing brain: declarative memory for emotionally arousing and neutral material in children with congenital adrenal hyperplasia
    Francoise S Maheu
    Mood and Anxiety Disorders Program, Emotional Development and Affective Neuroscience Section, National Institute of Mental Health, 15K North Drive, Room 300 C, Bethesda, MD 20892 2670, USA
    Psychoneuroendocrinology 33:238-45. 2008
    ..Such memory impairments may result from abnormal brain organization and function following hormonal dysfunction during critical periods of development...
  36. ncbi request reprint Adolescents in smoking cessation treatment: relationship between externalizing symptoms, smoking history and outcome
    Eric T Moolchan
    TTATRC, NIDA IRP, NIH, DHHS, Baltimore, MD 21224, USA
    Psychiatry Res 152:281-5. 2007
    ..Our findings highlight the importance of addressing externalizing behaviors in adolescent smoking cessation programs...
  37. pmc Body image in adolescents with disorders of steroidogenesis
    Cong Ning
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA
    J Pediatr Endocrinol Metab 21:771-80. 2008
    ..Little is known about body image in children with endocrine conditions. We evaluated body image in children with congenital adrenal hyperplasia (CAH), familial male precocious puberty (FMPP), and Cushing's syndrome (CS)...
  38. pmc Amygdala and ventrolateral prefrontal cortex function during anticipated peer evaluation in pediatric social anxiety
    Amanda E Guyer
    Mood and Anxiety Program, National Institute of Mental Health, National Institutes of Health, 15K North Dr, Room 208, Bethesda, MD 20892 2670, USA
    Arch Gen Psychiatry 65:1303-12. 2008
    ..Such fear-circuitry dysfunction may also manifest when anticipated social evaluation leads socially anxious adolescents to misperceive peers as threatening...
  39. pmc Imaging-genetics applications in child psychiatry
    Daniel S Pine
    National Institute of Mental Health Intramural Research Program, Mood and Anxiety Disorders Program, Bethesda, MD 20892 2670, USA
    J Am Acad Child Adolesc Psychiatry 49:772-82. 2010
    ..To place imaging-genetics research in the context of child psychiatry...
  40. pmc Early-life stress is associated with impairment in cognitive control in adolescence: an fMRI study
    Sven C Mueller
    Section of Developmental and Affective Neuroscience, Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, 15K North Drive, Bethesda, MD 20892, USA
    Neuropsychologia 48:3037-44. 2010
    ..incorrect "change" responses recruited the inferior prefrontal cortex (BA 44/46) more strongly in ES subjects than controls. These data suggest impaired cognitive control in youth who experienced ES...
  41. pmc Perturbed reward processing in pediatric bipolar disorder: an antisaccade study
    Sven C Mueller
    Section of Developmental and Affective Neuroscience National Institute of Mental Health, National Institute of Health, 15K North Drive, Bethesda, MD 20814, USA
    J Psychopharmacol 24:1779-84. 2010
    ..By comparison, no group differences were found on prosaccade trials. The results provide further evidence for deficits in cognitive and reward processing in bipolar disorder...
  42. doi request reprint Decision-making and facial emotion recognition as predictors of substance-use initiation among adolescents
    Monique Ernst
    Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Addict Behav 35:286-9. 2010
    ..In conclusion, adolescents who initiate drug use present vulnerability in the form of bias towards negative emotion but not toward decisions that involve risk...
  43. pmc Normative data on development of neural and behavioral mechanisms underlying attention orienting toward social-emotional stimuli: an exploratory study
    Kara M Lindstrom
    Mood and Anxiety Program, National Institutes of Mental Health, National Institute of Health, Bethesda, MD 20892 2670, USA
    Brain Res 1292:61-70. 2009
    ..Implications for future work on developmental changes in attention-emotion processing are discussed...
  44. pmc Inhibitory control in anxious and healthy adolescents is modulated by incentive and incidental affective stimuli
    Michael G Hardin
    Emotional Development and Affective Neuroscience Branch, Mood and Anxiety Disorders Program, National Institute of Mental Health, NIH DHHS, Bethesda, MD 20892, USA
    J Child Psychol Psychiatry 50:1550-8. 2009
    ..Recent evidence also suggests exaggerated responses to incentives. How these characteristics influence cognitive control is under debate and is the focus of the present study...
  45. pmc Early tobacco smoking in adolescents with externalizing disorders: inferences for reward function
    Will M Aklin
    Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Nicotine Tob Res 11:750-5. 2009
    ..The present study examined the relationship between the externalizing disorders and the temporal progression of smoking among adolescent smokers...
  46. pmc Adverse rearing experiences enhance responding to both aversive and rewarding stimuli in juvenile rhesus monkeys
    Eric E Nelson
    Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda 20892, USA
    Biol Psychiatry 66:702-4. 2009
    ..This study examines the effects that early life emotional adversity has on response to both threatening and appetitive stimuli in juvenile rhesus monkeys...
  47. pmc Reward circuitry in resilience to severe trauma: an fMRI investigation of resilient special forces soldiers
    Meena Vythilingam
    Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, MD, 20892, USA
    Psychiatry Res 172:75-7. 2009
    ..Findings in this group of resilient individuals revealed unique patterns of activation during expectation of reward in the subgenual prefrontal cortex and nucleus accumbens area, regions pivotal to reward processes...
  48. doi request reprint Neurobiology of the development of motivated behaviors in adolescence: a window into a neural systems model
    Monique Ernst
    Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, 15K North Drive, Bethesda MD 10892, United States
    Pharmacol Biochem Behav 93:199-211. 2009
    ..However, it provides clear directions for future research...
  49. pmc Impaired spatial navigation in pediatric anxiety
    Sven C Mueller
    MAP, NIMH, NIH, Bethesda, MD 20892, USA
    J Child Psychol Psychiatry 50:1227-34. 2009
    ..Deficits in spatial navigation in anxious children suggest that the hippocampal network involved in spatial orientation is also implicated in anxiety disorders...
  50. pmc A developmental neurobiological model of motivated behavior: anatomy, connectivity and ontogeny of the triadic nodes
    Monique Ernst
    Mood and Anxiety Disorders, Program National Institute of Mental Health, National Institutes of Health, 15K North Drive, Bethesda, MD 20892, United States
    Neurosci Biobehav Rev 33:367-82. 2009
    ..Each of these system-representatives will be described from a functional anatomy perspective that includes a review of their connectivity and what is known of their ontogenic changes...
  51. doi request reprint Psychiatric characterization of children with genetic causes of hyperandrogenism
    Sven C Mueller
    Section of Developmental and Affective Neuroscience, National Institute of Mental Health, NIH, 15K North Drive, Bethesda, Maryland 20892 1932, USA
    Eur J Endocrinol 163:801-10. 2010
    ..Very little is known about the mental health status in children with genetic causes of hyperandrogenism. This study sought to characterize psychiatric morbidity in this group...
  52. ncbi request reprint A neuroimaging method for the study of threat in adolescents
    Christopher S Monk
    Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Dev Psychobiol 43:359-66. 2003
    ..Those who reported increased fear showed right amygdala activation during the threat condition and left amygdala activation in the safe condition. These procedures offer a promising tool for studying youth with anxiety disorders...
  53. pmc Age-related influence of contingencies on a saccade task
    Sandra Jazbec
    Emotional Development and Affective Neuroscience Branch, Mood and Anxiety Disorders Program, NIMH NIH HHS, Bethesda, MD 20892, USA
    Exp Brain Res 174:754-62. 2006
    ..These findings suggest that this task can be used in neuroimaging studies as a probe of the influence of incentives on cognitive control from a developmental perspective as well as in health and disease...
  54. ncbi request reprint Imaging genomics applied to anxiety, stress response, and resiliency
    Ke Xu
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcohollism, National Institute of Health, Rockville, MD 20852, USA
    Neuroinformatics 4:51-64. 2006
    ..These results suggest that functional variants of 5-HTT and COMT impact brain functions involved in stress and anxiety...
  55. pmc Triadic model of the neurobiology of motivated behavior in adolescence
    Monique Ernst
    Section of Developmental and Affective Neuroscience, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Psychol Med 36:299-312. 2006
    ..We present a triadic, neuroscience systems-based model of adolescent decision-making...
  56. ncbi request reprint Safety and efficacy of the nicotine patch and gum for the treatment of adolescent tobacco addiction
    Eric T Moolchan
    Teen Tobacco Addiction Research Clinic, Clinical Pharmacology and Therapeutics Research Branch, National Institute on Drug Abuse, Intramural Research Program, 5500 Nathan Shock Dr, Baltimore, Maryland 21224, USA
    Pediatrics 115:e407-14. 2005
    ..To determine the safety and efficacy of the nicotine patch and gum for adolescents who want to quit smoking...
  57. ncbi request reprint Neurobiology of decision making: a selective review from a neurocognitive and clinical perspective
    Monique Ernst
    Section of Developmental and Affective Neuroscience, National Institute of Mental Health, National Institutes of Health, 15K North Drive, Bethesda, MD 20892, USA
    Biol Psychiatry 58:597-604. 2005
    ..This approach can be used to follow developmental trajectories of the different stages of decision making and to identify unique deficits associated with distinct psychiatric disorders...
  58. ncbi request reprint Attention bias to threat in maltreated children: implications for vulnerability to stress-related psychopathology
    Daniel S Pine
    Section on Development and Affective Neuroscience, National Institute of Mental Health Intramurral Research Program, Bethesda, MD 20817 2670, USA
    Am J Psychiatry 162:291-6. 2005
    ..They tested the hypothesis that attention bias to threatening facial photographs is associated with maltreatment and PTSD...
  59. pmc Prefrontal cortical dysfunction in abstinent cocaine abusers
    Karen Bolla
    Department of Neurology, Johns Hopkins University School of Medicine, 4940 Eastern Avenue, Baltimore, Maryland 21224, USA
    J Neuropsychiatry Clin Neurosci 16:456-64. 2004
    ..Since impairment in ECF may be a common feature of various neuropsychiatric disorders, these findings have applicability beyond the neurobiology of addiction...
  60. ncbi request reprint Experience-dependent plasticity for attention to threat: Behavioral and neurophysiological evidence in humans
    Christopher S Monk
    National Institute of Mental Health, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland 20892, USA
    Biol Psychiatry 56:607-10. 2004
    ..Examination of plasticity of attention bias with individuals at risk for anxiety disorders may reveal how threatening stimuli come to be categorized differently in this population over time...
  61. ncbi request reprint Developmental differences in neuronal engagement during implicit encoding of emotional faces: an event-related fMRI study
    Eric E Nelson
    Section on Development and Affective Neuroscience, Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, MD 20892 1381, USA
    J Child Psychol Psychiatry 44:1015-24. 2003
    ..Prior studies document strong interactions between emotional and mnemonic processes. These interactions have been shown to vary across development and psychopathology, particularly mood and anxiety disorders...
  62. ncbi request reprint Adolescent immaturity in attention-related brain engagement to emotional facial expressions
    Christopher S Monk
    Section on Development and Affective Neuroscience and Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Neuroimage 20:420-8. 2003
    ..These findings suggest that adults show greater modulation of activity in relevant brain structures based on attentional demands, whereas adolescents exhibit greater modulation based on emotional content...
  63. ncbi request reprint 2-[18F]F-A-85380: PET imaging of brain nicotinic acetylcholine receptors and whole body distribution in humans
    Alane S Kimes
    NIDA Intramural Research Program Baltimore, Maryland 21224, USA
    FASEB J 17:1331-3. 2003
    ..180 +/- 30 mSv/MBq or 0.7 rem/mCi with a 2.4 h void interval) suggests that multiple studies could be performed in a single subject. The results predict that quantitative PET imaging of nAChRs in human brain with 2-[18F]FA is feasible...
  64. ncbi request reprint Behavioral predictors of substance-use initiation in adolescents with and without attention-deficit/hyperactivity disorder
    Monique Ernst
    Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, MD 20892 2670, USA
    Pediatrics 117:2030-9. 2006
    ..Our goal was to examine substance-use initiation in healthy adolescents and in adolescents who have been diagnosed with attention-deficit/hyperactivity disorder...
  65. ncbi request reprint Striatal functional alteration in adolescents characterized by early childhood behavioral inhibition
    Amanda E Guyer
    Emotional Development and Affective Neuroscience Branch, National Institute of Mental Health, National Institutes of Health NIH, Bethesda, Maryland 20892, USA
    J Neurosci 26:6399-405. 2006
    ....
  66. ncbi request reprint Behavioral alterations in reward system function: the role of childhood maltreatment and psychopathology
    Amanda E Guyer
    Mood and Anxiety Program, National Institute of Mental Health, Bethesda, MD 20892 2670, USA
    J Am Acad Child Adolesc Psychiatry 45:1059-67. 2006
    ..To examine in children the influence of maltreatment and associated psychiatric sequelae on behavioral responses to reward stimuli...
  67. ncbi request reprint Orbitofrontal cortex and human drug abuse: functional imaging
    E D London
    Brain Imaging Center, National Institute on Drug Abuse, Baltimore, MD 21224, USA
    Cereb Cortex 10:334-42. 2000
    ....
  68. ncbi request reprint Functional neuroimaging in child psychiatry
    M Ernst
    Brain Imaging Center, National Institute on Drug Abuse, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Curr Psychiatry Rep 2:124-30. 2000
    ..Finally, it is the integration of scientific knowledge across the various fields of neuroscience and clinical research that will push the limits of our understanding of health and disease...
  69. ncbi request reprint Laboratory and diagnostic testing in child and adolescent psychiatry: a review of the past 10 years
    A J Zametkin
    National Institute of Mental Health, NIH, Bethesda, MD 20892, USA
    J Am Acad Child Adolesc Psychiatry 37:464-72. 1998
    ..To review in a critical fashion the literature of the past decade covering diagnostic and laboratory testing in the field of child and adolescent psychiatry...
  70. ncbi request reprint Pictorial Instrument for Children and Adolescents (PICA-III-R)
    M Ernst
    Brain Imaging Center, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
    J Am Acad Child Adolesc Psychiatry 39:94-9. 2000
    ..The Pictorial Instrument for Children and Adolescents (PICA-III-R) is presented as part of a comprehensive review of the tools used to diagnose psychiatric disorders in children and adolescents...
  71. ncbi request reprint Functional neuroimaging of autistic disorders
    J M Rumsey
    Clinical Neuroscience Branch, National Institute of Mental Health, Bethesda, Maryland 20892, USA
    Ment Retard Dev Disabil Res Rev 6:171-9. 2000
    ..Investigations of the serotonergic and dopaminergic systems, limbic-based memory and emotional systems, and the role of epileptiform activity in autism represent priorities for future research...
  72. pmc Early androgen exposure modulates spatial cognition in congenital adrenal hyperplasia (CAH)
    S C Mueller
    MAP, NIMH, NIH, 15K North Drive, Bethesda, MD 20892, United States
    Psychoneuroendocrinology 33:973-80. 2008
    ..Such finding suggests a pivotal role of hormonal function on brain development in humans, mirroring results from the animal literature...
  73. ncbi request reprint Adolescents with conduct disorder: early smoking and treatment requests
    Kara S Bagot
    The National Institute on Drug Abuse, Intramural Research Program, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Am J Addict 16:62-6. 2007
    ..These findings suggest that in addition to addressing disruptive behaviors, early prevention and access to interventions for tobacco use are needed for youths with CD...
  74. ncbi request reprint Neural systems and cue-induced cocaine craving
    Katherine R Bonson
    Brain Imaging Center, National Institute on Drug Abuse, Baltimore, MD 21224, USA
    Neuropsychopharmacology 26:376-86. 2002
    ....
  75. ncbi request reprint Dose effects of triazolam on brain activity during episodic memory encoding: a PET study
    Miriam Z Mintzer
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 188:445-61. 2006
    ..Although it is well established that acute benzodiazepine administration impairs episodic memory encoding, little is known about the neuroanatomical substrates of this effect...
  76. pmc Early childhood temperament predicts substance use in young adults
    A Lahat
    Department of Human Development, University of Maryland, College Park, MD 20742, USA
    Transl Psychiatry 2:e157. 2012
    ..These longitudinal data delineate one developmental pathway involving early biology and brain mechanisms for substance use in young adulthood...
  77. pmc Appetitive conditioning: neural bases and implications for psychopathology
    C Martin-Soelch
    Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
    Neurosci Biobehav Rev 31:426-40. 2007
    ..The ultimate goal of this review is to stimulate new avenues of research that have direct links to molecular biology, and thus could prove to be invaluable to progress in the understanding and treatment of psychiatric disabilities...
  78. ncbi request reprint The role of functional neuroimaging in pediatric brain injury
    Suzanne Munson
    Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 2670, USA
    Pediatrics 117:1372-81. 2006
    ..Limitations and advantages associated with the use of functional neuroimaging in pediatric populations are discussed...
  79. ncbi request reprint Clinical predictors of posttraumatic stress disorder after closed head injury in children
    Joan P Gerring
    Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Am Acad Child Adolesc Psychiatry 41:157-65. 2002
    ..To describe injury, demographic, and neuropsychiatric characteristics of children who develop posttraumatic stress disorder (PTSD) and posttraumatic stress symptoms (PTSS) after closed head injury (CHI)...
  80. ncbi request reprint An fMRI examination of developmental differences in the neural correlates of uncertainty and decision-making
    Amy L Krain
    NYU Child Study Center, NYU School of Medicine, New York, NY 10016, USA
    J Child Psychol Psychiatry 47:1023-30. 2006
    ..The present study examines potential developmental differences in frontal regions associated with uncertain decision-making, and tests the impact of IU on these circuits...
  81. pmc Effect of cigarette smoking on prefrontal cortical function in nondeprived smokers performing the Stroop Task
    Jiansong Xu
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA
    Neuropsychopharmacology 32:1421-8. 2007
    ..Even after brief abstinence from smoking, therefore, smokers exhibit compromised functional efficiency in the right FEF and adjacent precentral sulcus in a test of selective attention; and smoking ameliorates this condition...
  82. ncbi request reprint fMRI predictors of treatment outcome in pediatric anxiety disorders
    Erin B McClure
    Department of Psychology, Georgia State University, P O Box 5010, Atlanta, GA 30302 5010, USA
    Psychopharmacology (Berl) 191:97-105. 2007
    ..Interest has emerged in this phenomenon as a possible biological marker for individuals who are likely to benefit from tailored treatment approaches...
  83. ncbi request reprint A functional magnetic resonance imaging investigation of uncertainty in adolescents with anxiety disorders
    Amy L Krain
    New York University Child Study Center, New York University School of Medicine, New York, NY 10016, USA
    Biol Psychiatry 63:563-8. 2008
    ..As such, the present study examines the relationship between IU and neural responses to uncertainty in anxious adolescents...
  84. ncbi request reprint Responses to conflict and cooperation in adolescents with anxiety and mood disorders
    Erin B McClure
    Department of Psychology, Georgia State University, P O Box 5010, Atlanta, GA 30302 5010, USA
    J Abnorm Child Psychol 35:567-77. 2007
    ..These findings offer a first step toward elucidating the mechanisms underlying social impairment in youth with internalizing disorders...
  85. ncbi request reprint Intramuscular testosterone treatment in elderly men: evidence of memory decline and altered brain function
    Pauline M Maki
    Center for Cognitive Medicine, Neuropsychiatric Institute MC 913, University of Illinois at Chicago, 912 South Wood Street, Chicago, Illinois 60612, USA
    J Clin Endocrinol Metab 92:4107-14. 2007
    ..Recent clinical trials of im testosterone in eugonadal men suggest positive effects on verbal memory, but other studies find no effect...
  86. ncbi request reprint Amygdala and nucleus accumbens activation to emotional facial expressions in children and adolescents at risk for major depression
    Christopher S Monk
    Department of Psychology, University of Michigan, Ann Arbor, MI 48109, USA
    Am J Psychiatry 165:90-8. 2008
    ..This study compares amygdala and nucleus accumbens activation in children and adolescents at high and low risk for major depression under varying attentional and emotional conditions...
  87. pmc Recognition of facial emotions among maltreated children with high rates of post-traumatic stress disorder
    Carrie L Masten
    Department of Psychology, University of California, 1285 Franz Hall, Box 951563, Los Angeles, CA 90095, USA
    Child Abuse Negl 32:139-53. 2008
    ..However, research has provided little evidence indicating how high rates of PTSD might relate to maltreated children's processing of emotions...
  88. ncbi request reprint Ventrolateral prefrontal cortex activation and attentional bias in response to angry faces in adolescents with generalized anxiety disorder
    Christopher S Monk
    Department of Psychology, University of Michigan, 2000 East Hall, 530 Church St, Ann Arbor, MI 48109, USA
    Am J Psychiatry 163:1091-7. 2006
    ....
  89. pmc Amygdala and ventrolateral prefrontal cortex activation to masked angry faces in children and adolescents with generalized anxiety disorder
    Christopher S Monk
    Department of Psychology, University of Michigan, 530 Church St, Ann Arbor, MI 48109 1043, USA
    Arch Gen Psychiatry 65:568-76. 2008
    ..Disturbed interactions between these structures may underlie pediatric anxiety. To date, no study has selectively examined responses to briefly presented threats in GAD or in pediatric anxiety...
  90. pmc Effects of acute smoking on brain activity vary with abstinence in smokers performing the N-Back task: a preliminary study
    Jiansong Xu
    Department of Psychiatry, University of California Los Angeles, Los Angeles, CA 90024, USA
    Psychiatry Res 148:103-9. 2006
    ..This interaction merits further examination in larger studies specifically designed to consider this issue...
  91. pmc Attention alters neural responses to evocative faces in behaviorally inhibited adolescents
    Koraly Perez-Edgar
    Department of Psychology, George Mason University, USA
    Neuroimage 35:1538-46. 2007
    ..These patterns of reactivity may help sustain early temperamental biases over time and contribute to the observed relation between BI and anxiety...
  92. pmc Brain activity in cigarette smokers performing a working memory task: effect of smoking abstinence
    Jiansong Xu
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA
    Biol Psychiatry 58:143-50. 2005
    ..Our aim, therefore, was to identify abnormalities in the circuitry that mediates working memory in nicotine-dependent subjects after they initiate abstinence from smoking...
  93. pmc Working memory in cigarette smokers: comparison to non-smokers and effects of abstinence
    Adrianna Mendrek
    Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, Los Angeles, CA, USA
    Addict Behav 31:833-44. 2006
    ..These findings provide further evidence for a deficit in working memory associated with acute abstinence from smoking, which may contribute to the difficulty of smoking cessation...
  94. ncbi request reprint Selective reduction in amygdala volume in pediatric anxiety disorders: a voxel-based morphometry investigation
    Michael P Milham
    Beckman Institute, University of Illinois, Urbana, Illinois, USA
    Biol Psychiatry 57:961-6. 2005
    ..We examine the neural correlates of pediatric anxiety disorders, to consider the validity of the categorization scheme used in recent treatment studies...
  95. pmc Cerebral metabolism and mood in remitted opiate dependence
    Igor I Galynker
    Department of Psychiatry and Behavioral Sciences, Beth Israel Medical Center, Albert Einstein College of Medicine, First Avenue at 16th Street, New York, NY 10003, USA
    Drug Alcohol Depend 90:166-74. 2007
    ..Methadone-maintenance therapy (MMT) may mitigate this vulnerability, but controversy surrounds its long-term use. Little is known about the neurobiology of mood dysregulation in individuals receiving or removed from MMT...