Research Topics
| D H EpsteinSummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
Abuse liability, behavioral pharmacology, and physical-dependence potential of opioids in humans and laboratory animals: lessons from tramadolDavid H Epstein
NIDA Intramural Research Program, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
Biol Psychol 73:90-9. 2006..Nonetheless, it is suggested that abuse-potential screening of new medications would benefit from an organized, integrated cross-species program...
TGI Monday?: drug-dependent outpatients report lower stress and more happiness at work than elsewhereDavid H Epstein
Treatment Section, Clinical Pharmacology and Therapeutics Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
Am J Addict 21:189-98. 2012....- Does cannabis use predict poor outcome for heroin-dependent patients on maintenance treatment? Past findings and more evidence againstD H Epstein
Clinical Pharmacology and Therapeutics Branch, Treatment Section, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA
Addiction 98:269-79. 2003.... - Toward a model of drug relapse: an assessment of the validity of the reinstatement procedureDavid H Epstein
Clinical Pharmacology and Therapeutics Research Branch, IRP NIDA NIH DHHS, Baltimore, MD 21224, USA
Psychopharmacology (Berl) 189:1-16. 2006..The model's construct validity faces more substantial challenges and is yet to be established, but we argue that some of the criticisms of the model in this regard may have been overstated... - Promoting abstinence from cocaine and heroin with a methadone dose increase and a novel contingencyDavid H Epstein
Treatment Section, Clinical Pharmacology and Therapeutics Branch, Intramural Research Branch of the National Institute on Drug Abuse, 251 Bayview Blvd, Suite 200, Baltimore, MD 21224, USA
Drug Alcohol Depend 101:92-100. 2009..For a split contingency to promote simultaneous abstinence from cocaine and heroin, a relatively high dose of methadone appears necessary but not sufficient; an increase in overall incentive amount may also be required... - The reinstatement model and relapse prevention: a clinical perspectiveDavid H Epstein
NIDA IRP Treatment Section, Intramural Research Program, National Institute on Drug Abuse, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
Psychopharmacology (Berl) 168:31-41. 2003..This commentary assesses the degree to which the reinstatement model is homologous to the human experience of relapse... - Cognitive-behavioral therapy plus contingency management for cocaine use: findings during treatment and across 12-month follow-upDavid H Epstein
Clinical Pharmacology and Therapeutics Branch, National Institute on Drug Abuse, Intramural Research Program Treatment Section, Baltimore, Maryland 21224, USA
Psychol Addict Behav 17:73-82. 2003..Posttreatment, there were signs of additive benefits, significant in 3- versus 12-month contrasts. Former CBT participants were also more likely to acknowledge cocaine use and its effects and to report employment... - Real-time electronic diary reports of cue exposure and mood in the hours before cocaine and heroin craving and useDavid H Epstein
National Institute on Drug Abuse Intramural Research Program, Treatment Section, Clinical Pharmacology and Therapeutics Branch, Baltimore, MD 21224, USA
Arch Gen Psychiatry 66:88-94. 2009..Ecological momentary assessment has greatly enhanced the study of tobacco addiction, but its use has rarely been attempted in individuals with cocaine or heroin addiction... - Tobacco, cocaine, and heroin: Craving and use during daily lifeDavid H Epstein
Clinical Pharmacology and Therapeutics Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
Addict Behav 35:318-24. 2010..Relationships among tobacco smoking, tobacco craving, and other drug use and craving may have treatment implications in polydrug-dependent individuals... - Daily life hour by hour, with and without cocaine: an ecological momentary assessment studyDavid H Epstein
Treatment Section, Clinical Pharmacology and Therapeutics Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Room 01B 606, 251 Bayview Blvd, Suite 200, Baltimore, MD 21224, USA
Psychopharmacology (Berl) 211:223-32. 2010..For misusers of illicit drugs, patterns of daily activities and moods have not been studied in a way that is amenable to statistical aggregation... 
Nonreporting of cannabis use: Predictors and relationship to treatment outcome in methadone maintained patientsUdi E Ghitza
Clinical Pharmacology and Therapeutics Branch, Treatment Section Intramural Research Program IRP, National Institute on Drug Abuse NIDA, National Institutes of Health NIH, 5500 Nathan Shock Drive Baltimore, MD 21224, USA
Addict Behav 32:938-49. 2007..Nonreporting of THC use is a significant predictor of greater cocaine and heroin use. This association can be eliminated with contingency management therapy...- Shaping cocaine abstinence by successive approximationK L Preston
Intramural Research Program, National Institute on Drug Abuse, Baltimore, Maryland 21224, USA
J Consult Clin Psychol 69:643-54. 2001..A 2nd phase of the study showed that abstinence induced by escalating-value vouchers can be maintained by a nonescalating schedule, suggesting that contingency management can be practical as a maintenance treatment... - Randomized trial comparing two treatment strategies using prize-based reinforcement of abstinence in cocaine and opiate usersKenzie L Preston
National Institute on Drug Abuse, USA
J Appl Behav Anal 41:551-63. 2008..Opiate abstinence was greater in the opiate-cocaine group post-CM, and heroin craving was reduced in this group during and post-CM. Draws earned per cocaine-negative urine (four vs. one) did not affect cocaine use... - Low-dose oral cocaine in humans: acquisition of discrimination and time-course of effectsD H Epstein
NIH, NIDA Intramural Research Program, Baltimore, Maryland, USA
Behav Pharmacol 10:531-42. 1999..Overall, the results support the sensitivity of the behavioral-testing procedure used, and show that 50 mg oral cocaine can serve as a discriminative stimulus in adult humans... - Smoking rates and topography predict adolescent smoking cessation following treatment with nicotine replacement therapyFrederick H Franken
Department of Health and Human Services, National Institute on Drug Abuse, Intramural Research Program, Baltimore, MD 21224, USA
Cancer Epidemiol Biomarkers Prev 15:154-7. 2006..If confirmed in a larger sample, our findings suggest that puff topography, and possibly CPD, might predict cessation outcome better than Fagerström scores in adolescent smokers... - Neurobiology of relapse to heroin and cocaine seeking: an update and clinical implicationsJennifer M Bossert
Behavioral Neuroscience Branch, IRP/NIDA/NIH/DHHS, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
Eur J Pharmacol 526:36-50. 2005.... - Hemodynamic and cognitive effects of lofexidine and methadone coadministration: a pilot studyJennifer R Schroeder
Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA
Pharmacotherapy 27:1111-9. 2007..To determine the hemodynamic and cognitive effects of lofexidine and methadone coadministration... - The Fagerstrom Test for Nicotine Dependence and the Diagnostic Interview Schedule: do they diagnose the same smokers?Eric T Moolchan
Clinical Pharmacology and Therapeutics Research Branch, National Institutes of Health, National Institute on Drug Abuse Intramural Research Program, Baltimore MD, 21224, USA
Addict Behav 27:101-13. 2002..Disagreements between the FTND and the DSM are likely to become greater with the changes in the DSM-IV... - Abstinence reinforcement maintenance contingency and one-year follow-upKenzie L Preston
National Institute on Drug Abuse NIDA Intramural Research Program, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
Drug Alcohol Depend 67:125-37. 2002..In the prior study (induction phase, 8 weeks) participants received vouchers for each opiate-negative urine screen or noncontingently... - Randomized trial of prize-based reinforcement density for simultaneous abstinence from cocaine and heroinUdi E Ghitza
Treatment Section, Clinical Pharmacology and Therapeutics Branch, Intramural Research Program IRP, National Institute on Drug Abuse NIDA, National Institute of Health NIH, MD, USA
J Consult Clin Psychol 75:765-74. 2007..Computerized drawing with higher-density prizes enhanced reduction of cocaine use; abstinence reinforcement had long-term therapeutic benefits... - Hepatitis C and human immunodeficiency virus risk behaviors in polydrug users on methadone maintenanceJessica Willner-Reid
National Institute on Drug Abuse, Baltimore, MD 21224, USA
J Subst Abuse Treat 35:78-86. 2008..These findings demonstrate that both drug- and sex-related risk behaviors decrease during MMT and emphasize the benefits of methadone programs for public health and HIV/HCV prevention... - Contingency management reduces injection-related HIV risk behaviors in heroin and cocaine using outpatientsUdi E Ghitza
Clinical Pharmacology and Therapeutics Branch, Treatment Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA
Addict Behav 33:593-604. 2008..CM targeted toward cocaine and heroin use produces significant reductions in injection-related drug-taking behaviors associated with heightened risk for getting or transmitting HIV... - Self-report of illicit benzodiazepine use on the Addiction Severity Index predicts treatment outcomeUdi E Ghitza
Clinical Pharmacology and Therapeutics Research Branch, Treatment Section, Intramural Research Program IRP, National Institute on Drug Abuse NIDA, NIH, Baltimore, MD 21224, USA
Drug Alcohol Depend 97:150-7. 2008..Thus, in a sample of non-dependent BZD users, self-reported illicit BZD use on the ASI, even at low levels, predicted worse outcome on cocaine use and blunted response to CM... - A factor analysis of the Fagerström Test for Nicotine Dependence (FTND)Aleksandras Radzius
Intramural Research Program, National Institute on Drug Abuse National Institutes of Health Baltimore MD 21224, USA
Nicotine Tob Res 5:255-40. 2003..These two dimensions may provide indirect assessment of a smoker's daily nicotine intake. Testing this hypothesis requires correlation of biomarkers and responses to specific items of the FTND... - Cocaine craving and use during daily lifeKenzie L Preston
Treatment Section, Clinical Pharmacology and Therapeutics Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
Psychopharmacology (Berl) 207:291-301. 2009..Craving is often assumed to cause ongoing drug use and relapse and is a major focus of addiction research. However, its relationship to drug use has not been adequately documented... - Effect of reinforcement probability and prize size on cocaine and heroin abstinence in prize-based contingency managementUdi E Ghitza
National Institute on Drug Abuse, Clinical Pharmacology and Therapeutics Research Branch Treatment Section, 251 Bayview Boulevard, Suite 200, Baltimore, Maryland 21224, USA
J Appl Behav Anal 41:539-49. 2008..Higher probability of winning, but not the size of individual prizes, was associated with a greater percentage of cocaine-negative, but not opiate-negative, urines... - Urinary elimination of cocaine metabolites in chronic cocaine users during cessationKenzie L Preston
Clinical Pharmacology and Therapeutics Research Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, Maryland 21224, USA
J Anal Toxicol 26:393-400. 2002.... - Automation in an addiction treatment research clinic: computerised contingency management, ecological momentary assessment and a protocol workflow systemMassoud Vahabzadeh
Biomedical Informatics Section, Administrative Management Branch, Intramural Research Program, National Institute on Drug Abuse, NIH DHHS, Baltimore, Maryland 21224, USA
Drug Alcohol Rev 28:3-11. 2009..Another challenge is the acquisition of large amounts of data in an occasionally hectic environment, along with the provision of seamless methods for exporting, mining and querying the data... - Brain mu-opioid receptor binding predicts treatment outcome in cocaine-abusing outpatientsUdi E Ghitza
Intramural Research Program, Clinical Pharmacology and Therapeutics Research Branch, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland, USA
Biol Psychiatry 68:697-703. 2010..In cocaine-abusing outpatients in treatment, the relationship of mOR binding and treatment outcome is unknown... - Psychosocial functioning and cocaine use during treatment: strength of relationship depends on type of urine-testing methodUdi E Ghitza
Clinical Pharmacology and Therapeutics Branch, Treatment Section, Intramural Research Program IRP, National Institute on Drug Abuse NIDA, NIH DHHS, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
Drug Alcohol Depend 91:169-77. 2007..Cocaine use during treatment, especially when measured with New Uses criteria, can predict psychosocial functioning, but cannot substitute for direct measures of psychosocial functioning... - Adverse events among patients in a behavioral treatment trial for heroin and cocaine dependence: effects of age, race, and genderJennifer R Schroeder
Intramural Research Program, National Institute on Drug Abuse, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
Drug Alcohol Depend 80:45-51. 2005..Nonetheless, the data reported here should help provide a context in which investigators and IRBs can interpret the patterns of AEs they encounter... - QT interval increased after single dose of lofexidineJohn Schmittner
National Institutes of Health, National Institute on Drug Abuse, Intramural Research Program, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
BMJ 329:1075. 2004 - Recent marijuana blunt smoking impacts carbon monoxide as a measure of adolescent tobacco abstinenceEric T Moolchan
Department of Health and Human Services, National Institutes of Health, National Institute on Drug Abuse, Intramural Research Program, Baltimore, Maryland 21224, USA
Subst Use Misuse 40:231-40. 2005..013). Blunt occasions also tended to be associated with the more youth-appropriate cutoff CO > or = 6 ppm, compared to non-MJ occasions (p =0.054). Blunt smoking impacted the interpretation of measures of exhaled CO for tobacco cessation... - Heroin and cocaine craving and use during treatment: measurement validation and potential relationshipsAdrienne J Heinz
Clinical Pharmacology and Therapeutics Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD 21224, USA
J Subst Abuse Treat 31:355-64. 2006..Treatment dropout and in-treatment drug use were more frequently predicted by scores on the 14- or 45-item CCQ than by VAS ratings. Results suggest that the CCQ/HCQ and the 14-item CCQ provide information that unidimensional VASs do not... - Do noncontingent vouchers increase drug use?Jennifer R Schroeder
Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA
Exp Clin Psychopharmacol 11:195-201. 2003..05, 95% confidence interval: 1.01-1.09). Overall, results do not indicate a causal relationship between noncontingent voucher receipt and increased drug use... - Methadone and metabolite urine concentrations in patients maintained on methadoneKenzie L Preston
Clinical Pharmacology and Therapeutics Research Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, Maryland 21224, USA
J Anal Toxicol 27:332-41. 2003..Nevertheless, variability was too great to permit estimation of methadone dose (or detect a single missed administration) from any single specimen... - Changes in HIV risk behaviors among patients receiving combined pharmacological and behavioral interventions for heroin and cocaine dependenceJennifer R Schroeder
Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD 21224, USA
Addict Behav 31:868-79. 2006..034) but this effect was no longer significant after adjusting for drug-negative urines. These results suggest broad beneficial effects of methadone maintenance augmented with behavioral interventions for reducing HIV risk behaviors... - Menstrual cycle length during methadone maintenanceJohn Schmittner
Intramural Research Program, National Institute on Drug Abuse, National Institute of Health, Baltimore, MD 21224, USA
Addiction 100:829-36. 2005..This study was conducted to evaluate whether cycle length was more regular during methadone maintenance... - Electrocardiographic effects of lofexidine and methadone coadministration: secondary findings from a safety studyJohn Schmittner
Clinical Pharmacology and Therapeutics Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 251 Bayview Boulevard, Baltimore, MD 21224, USA
Pharmacotherapy 29:495-502. 2009..To determine the electrocardiographic effects of coadministration of lofexidine and methadone... - Spiritual/Religious experiences and in-treatment outcome in an inner-city program for heroin and cocaine dependenceAdrienne Heinz
Clinical Pharmacology and Treatment Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD, USA
J Psychoactive Drugs 39:41-9. 2007..The results suggest that spiritual and religious experience plays a role in substance abuse recovery and that demographic characteristics should be considered in the design of spiritually oriented behavioral interventions for addiction... - Cyclazocine: comparison to hydromorphone and interaction with cocaineK L Preston
National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA
Behav Pharmacol 15:91-102. 2004..This study is suggestive but not strongly supportive for the use of kappa-opiate drugs to diminish acute effects of cocaine administration or for the use of these kappa agonists in drug abuse treatment applications... - Puffing behavior during the smoking of a single cigarette in tobacco-dependent adolescentsCharles C Collins
Nicotine Psychopharmacology Section, Intramural Research Program, National Institute on Drug Abuse, 251 Bayview Boulevard, Baltimore, MD 21224, USA
Nicotine Tob Res 12:164-7. 2010..The purpose of this study was to examine the pattern of puffing behavior during the smoking of a single cigarette in adolescents... - Smoking topography and trajectory of asthmatic adolescents requesting cessation treatmentDarin M Zimmerman
Teen Tobacco Addiction Treatment Research Clinic, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, U.S. Department of Health and Human Services, Baltimore, MD 21224, USA
Prev Med 39:940-2. 2004..These findings highlight the need for more effective health counseling of asthmatic youth regarding the physical and behavioral effects of smoking... - The anxiogenic drug yohimbine reinstates palatable food seeking in a rat relapse model: a role of CRF1 receptorsUdi E Ghitza
Behavioral Neuroscience Branch, NIDA/IRP/NIH/DHHS, Baltimore, MD 21224, USA
Neuropsychopharmacology 31:2188-96. 2006..These data suggest that CRF is involved in stress-induced relapse to palatable food seeking, and that CRF1 antagonists should be considered for the treatment of maladaptive eating habits... - Progression to daily smoking: is there a gender difference among cessation treatment seekers?Elissa D Thorner
Department of Health and Human Services, National Institutes of Health, National Institute on Drug Abuse Intramural Research Program, Baltimore, MD 21224, USA
Subst Use Misuse 42:829-35. 2007..Additional research is needed to explore the specific factors that differentially affect smoking trajectory in girls compared to boys... - The neuropharmacology of relapse to food seeking: methodology, main findings, and comparison with relapse to drug seekingSunila G Nair
Behavioral Neuroscience Branch, NIDA IRP, 251 Bayview Boulevard, Baltimore, MD 21224, USA
Prog Neurobiol 89:18-45. 2009..3)The neuronal mechanisms underlying reinstatement of food seeking overlap to some degree with those of reinstatement of drug seeking... - Determination of total and free concentrations of the enantiomers of methadone and its metabolite (2-ethylidene-1,5-dimethyl-3,3-diphenyl-pyrrolidine) in human plasma by enantioselective liquid chromatography with mass spectrometric detectionMaria Esther Rodriguez-Rosas
Bioanalytical and Drug Discovery Unit, Gerontology Research Center, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224-6825, USA
J Chromatogr A 1073:237-48. 2005..S.D. for the intra- and inter-day precision of the method were < 5.3% and the R.S.D. for accuracy was < 5.0%. The method was used to analyze plasma samples obtained from patients enrolled in a Met-maintenance program... - A focus-group study on spirituality and substance-user treatmentAdrienne J Heinz
Clinical Pharmacology and Therapeutics Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, Maryland 21224, USA
Subst Use Misuse 45:134-53. 2010..One limitation was that all participants identified as strongly spiritual. Studies of more diverse samples will help guide the development and evaluation of spiritually based interventions in formal treatment... - Quantitative determination of the enantiomers of methadone and its metabolite (EDDP) in human saliva by enantioselective liquid chromatography with mass spectrometric detectionMaria Esther Rodriguez Rosas
Bioanalytical and Drug Discovery Unit, Gerontology Research Center, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224-6825, USA
J Chromatogr B Analyt Technol Biomed Life Sci 796:355-70. 2003..0%) and accuracy (CVs<4.0%) were obtained. These findings demonstrate the accuracy and precision of the method used to successfully analyze saliva obtained from patients enrolled in a methadone-maintenance program... - Long-term methadone maintenance reduces protracted symptoms of heroin abstinence and cue-induced craving in Chinese heroin abusersJie Shi
Department of Clinical Pharmacology, National Institute on Drug Dependence, Peking University, Beijing 100083, China
Pharmacol Biochem Behav 87:141-5. 2007..PA symptoms have rarely been compared between drug-free and methadone-maintained former heroin users after similar lengths of heroin abstinence... - Gender and stimulus difference in cue-induced responses in abstinent heroin usersJiang Yu
Tangshan Mental Health Hospital, Tangshan, China
Pharmacol Biochem Behav 86:485-92. 2007..This study examined whether two different stimuli, drug-related imagery scripts and drug-related paraphernalia, produce similar or different patterns of cue reactivity in heroin-dependent men and women... - Problems with odds ratiosDavid H Epstein
Am J Psychiatry 160:190-1; author reply 191. 2003 - Treatment of methamphetamine dependenceJohn Mendelson
Mayo Clin Proc 83:369-70; author reply 370-1. 2008 - Serum cortisol secretion during heroin abstinence is elevated only nocturnallySu Xia Li
National Institute on Drug Dependence, Peking University, Beijing, China
Am J Drug Alcohol Abuse 34:321-8. 2008..The abstinent heroin-dependent participants had significantly higher plasma cortisol levels nocturnally suggesting a loss of diurnal variation in these heroin subjects...