D H Epstein

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Abuse liability, behavioral pharmacology, and physical-dependence potential of opioids in humans and laboratory animals: lessons from tramadol
    David H Epstein
    NIDA Intramural Research Program, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Biol Psychol 73:90-9. 2006
  2. ncbi request reprint Progression to daily smoking: is there a gender difference among cessation treatment seekers?
    Elissa D Thorner
    Department of Health and Human Services, National Institutes of Health, National Institute on Drug Abuse Intramural Research Program, Baltimore, MD 21224, USA
    Subst Use Misuse 42:829-35. 2007
  3. pmc TGI Monday?: drug-dependent outpatients report lower stress and more happiness at work than elsewhere
    David H Epstein
    Treatment Section, Clinical Pharmacology and Therapeutics Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
    Am J Addict 21:189-98. 2012
  4. pmc Does cannabis use predict poor outcome for heroin-dependent patients on maintenance treatment? Past findings and more evidence against
    D H Epstein
    Clinical Pharmacology and Therapeutics Branch, Treatment Section, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA
    Addiction 98:269-79. 2003
  5. pmc Toward a model of drug relapse: an assessment of the validity of the reinstatement procedure
    David H Epstein
    Clinical Pharmacology and Therapeutics Research Branch, IRP NIDA NIH DHHS, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 189:1-16. 2006
  6. pmc Promoting abstinence from cocaine and heroin with a methadone dose increase and a novel contingency
    David H Epstein
    Treatment Section, Clinical Pharmacology and Therapeutics Branch, Intramural Research Branch of the National Institute on Drug Abuse, 251 Bayview Blvd, Suite 200, Baltimore, MD 21224, USA
    Drug Alcohol Depend 101:92-100. 2009
  7. pmc The reinstatement model and relapse prevention: a clinical perspective
    David H Epstein
    NIDA IRP Treatment Section, Intramural Research Program, National Institute on Drug Abuse, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 168:31-41. 2003
  8. pmc Cognitive-behavioral therapy plus contingency management for cocaine use: findings during treatment and across 12-month follow-up
    David H Epstein
    Clinical Pharmacology and Therapeutics Branch, National Institute on Drug Abuse, Intramural Research Program Treatment Section, Baltimore, Maryland 21224, USA
    Psychol Addict Behav 17:73-82. 2003
  9. pmc Real-time electronic diary reports of cue exposure and mood in the hours before cocaine and heroin craving and use
    David H Epstein
    National Institute on Drug Abuse Intramural Research Program, Treatment Section, Clinical Pharmacology and Therapeutics Branch, Baltimore, MD 21224, USA
    Arch Gen Psychiatry 66:88-94. 2009
  10. pmc Tobacco, cocaine, and heroin: Craving and use during daily life
    David H Epstein
    Clinical Pharmacology and Therapeutics Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
    Addict Behav 35:318-24. 2010

Collaborators

Detail Information

Publications54

  1. pmc Abuse liability, behavioral pharmacology, and physical-dependence potential of opioids in humans and laboratory animals: lessons from tramadol
    David H Epstein
    NIDA Intramural Research Program, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Biol Psychol 73:90-9. 2006
    ..Nonetheless, it is suggested that abuse-potential screening of new medications would benefit from an organized, integrated cross-species program...
  2. ncbi request reprint Progression to daily smoking: is there a gender difference among cessation treatment seekers?
    Elissa D Thorner
    Department of Health and Human Services, National Institutes of Health, National Institute on Drug Abuse Intramural Research Program, Baltimore, MD 21224, USA
    Subst Use Misuse 42:829-35. 2007
    ..Additional research is needed to explore the specific factors that differentially affect smoking trajectory in girls compared to boys...
  3. pmc TGI Monday?: drug-dependent outpatients report lower stress and more happiness at work than elsewhere
    David H Epstein
    Treatment Section, Clinical Pharmacology and Therapeutics Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
    Am J Addict 21:189-98. 2012
    ....
  4. pmc Does cannabis use predict poor outcome for heroin-dependent patients on maintenance treatment? Past findings and more evidence against
    D H Epstein
    Clinical Pharmacology and Therapeutics Branch, Treatment Section, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA
    Addiction 98:269-79. 2003
    ....
  5. pmc Toward a model of drug relapse: an assessment of the validity of the reinstatement procedure
    David H Epstein
    Clinical Pharmacology and Therapeutics Research Branch, IRP NIDA NIH DHHS, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 189:1-16. 2006
    ..The reinstatement model is widely used to study relapse to drug addiction. However, the model's validity is open to question...
  6. pmc Promoting abstinence from cocaine and heroin with a methadone dose increase and a novel contingency
    David H Epstein
    Treatment Section, Clinical Pharmacology and Therapeutics Branch, Intramural Research Branch of the National Institute on Drug Abuse, 251 Bayview Blvd, Suite 200, Baltimore, MD 21224, USA
    Drug Alcohol Depend 101:92-100. 2009
    ..For a split contingency to promote simultaneous abstinence from cocaine and heroin, a relatively high dose of methadone appears necessary but not sufficient; an increase in overall incentive amount may also be required...
  7. pmc The reinstatement model and relapse prevention: a clinical perspective
    David H Epstein
    NIDA IRP Treatment Section, Intramural Research Program, National Institute on Drug Abuse, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 168:31-41. 2003
    ..This commentary assesses the degree to which the reinstatement model is homologous to the human experience of relapse...
  8. pmc Cognitive-behavioral therapy plus contingency management for cocaine use: findings during treatment and across 12-month follow-up
    David H Epstein
    Clinical Pharmacology and Therapeutics Branch, National Institute on Drug Abuse, Intramural Research Program Treatment Section, Baltimore, Maryland 21224, USA
    Psychol Addict Behav 17:73-82. 2003
    ..Posttreatment, there were signs of additive benefits, significant in 3- versus 12-month contrasts. Former CBT participants were also more likely to acknowledge cocaine use and its effects and to report employment...
  9. pmc Real-time electronic diary reports of cue exposure and mood in the hours before cocaine and heroin craving and use
    David H Epstein
    National Institute on Drug Abuse Intramural Research Program, Treatment Section, Clinical Pharmacology and Therapeutics Branch, Baltimore, MD 21224, USA
    Arch Gen Psychiatry 66:88-94. 2009
    ..Ecological momentary assessment has greatly enhanced the study of tobacco addiction, but its use has rarely been attempted in individuals with cocaine or heroin addiction...
  10. pmc Tobacco, cocaine, and heroin: Craving and use during daily life
    David H Epstein
    Clinical Pharmacology and Therapeutics Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
    Addict Behav 35:318-24. 2010
    ..Relationships among tobacco smoking, tobacco craving, and other drug use and craving may have treatment implications in polydrug-dependent individuals...
  11. pmc Daily life hour by hour, with and without cocaine: an ecological momentary assessment study
    David H Epstein
    Treatment Section, Clinical Pharmacology and Therapeutics Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Room 01B 606, 251 Bayview Blvd, Suite 200, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 211:223-32. 2010
    ..For misusers of illicit drugs, patterns of daily activities and moods have not been studied in a way that is amenable to statistical aggregation...
  12. ncbi request reprint Nonreporting of cannabis use: Predictors and relationship to treatment outcome in methadone maintained patients
    Udi E Ghitza
    Clinical Pharmacology and Therapeutics Branch, Treatment Section Intramural Research Program IRP, National Institute on Drug Abuse NIDA, National Institutes of Health NIH, 5500 Nathan Shock Drive Baltimore, MD 21224, USA
    Addict Behav 32:938-49. 2007
    ..Nonreporting of THC use is a significant predictor of greater cocaine and heroin use. This association can be eliminated with contingency management therapy...
  13. ncbi request reprint Shaping cocaine abstinence by successive approximation
    K L Preston
    Intramural Research Program, National Institute on Drug Abuse, Baltimore, Maryland 21224, USA
    J Consult Clin Psychol 69:643-54. 2001
    ..A 2nd phase of the study showed that abstinence induced by escalating-value vouchers can be maintained by a nonescalating schedule, suggesting that contingency management can be practical as a maintenance treatment...
  14. pmc Randomized trial comparing two treatment strategies using prize-based reinforcement of abstinence in cocaine and opiate users
    Kenzie L Preston
    National Institute on Drug Abuse, USA
    J Appl Behav Anal 41:551-63. 2008
    ..Opiate abstinence was greater in the opiate-cocaine group post-CM, and heroin craving was reduced in this group during and post-CM. Draws earned per cocaine-negative urine (four vs. one) did not affect cocaine use...
  15. ncbi request reprint Low-dose oral cocaine in humans: acquisition of discrimination and time-course of effects
    D H Epstein
    NIH, NIDA Intramural Research Program, Baltimore, Maryland, USA
    Behav Pharmacol 10:531-42. 1999
    ..Overall, the results support the sensitivity of the behavioral-testing procedure used, and show that 50 mg oral cocaine can serve as a discriminative stimulus in adult humans...
  16. ncbi request reprint Smoking rates and topography predict adolescent smoking cessation following treatment with nicotine replacement therapy
    Frederick H Franken
    Department of Health and Human Services, National Institute on Drug Abuse, Intramural Research Program, Baltimore, MD 21224, USA
    Cancer Epidemiol Biomarkers Prev 15:154-7. 2006
    ..If confirmed in a larger sample, our findings suggest that puff topography, and possibly CPD, might predict cessation outcome better than Fagerström scores in adolescent smokers...
  17. ncbi request reprint Neurobiology of relapse to heroin and cocaine seeking: an update and clinical implications
    Jennifer M Bossert
    Behavioral Neuroscience Branch, IRP NIDA NIH DHHS, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Eur J Pharmacol 526:36-50. 2005
    ....
  18. ncbi request reprint Hemodynamic and cognitive effects of lofexidine and methadone coadministration: a pilot study
    Jennifer R Schroeder
    Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA
    Pharmacotherapy 27:1111-9. 2007
    ..To determine the hemodynamic and cognitive effects of lofexidine and methadone coadministration...
  19. ncbi request reprint The Fagerstrom Test for Nicotine Dependence and the Diagnostic Interview Schedule: do they diagnose the same smokers?
    Eric T Moolchan
    Clinical Pharmacology and Therapeutics Research Branch, National Institutes of Health, National Institute on Drug Abuse Intramural Research Program, Baltimore MD, 21224, USA
    Addict Behav 27:101-13. 2002
    ..Disagreements between the FTND and the DSM are likely to become greater with the changes in the DSM-IV...
  20. ncbi request reprint Abstinence reinforcement maintenance contingency and one-year follow-up
    Kenzie L Preston
    National Institute on Drug Abuse NIDA Intramural Research Program, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Drug Alcohol Depend 67:125-37. 2002
    ..In the prior study (induction phase, 8 weeks) participants received vouchers for each opiate-negative urine screen or noncontingently...
  21. pmc Randomized trial of prize-based reinforcement density for simultaneous abstinence from cocaine and heroin
    Udi E Ghitza
    Treatment Section, Clinical Pharmacology and Therapeutics Branch, Intramural Research Program IRP, National Institute on Drug Abuse NIDA, National Institute of Health NIH, MD, USA
    J Consult Clin Psychol 75:765-74. 2007
    ..Computerized drawing with higher-density prizes enhanced reduction of cocaine use; abstinence reinforcement had long-term therapeutic benefits...
  22. pmc Hepatitis C and human immunodeficiency virus risk behaviors in polydrug users on methadone maintenance
    Jessica Willner-Reid
    National Institute on Drug Abuse, Baltimore, MD 21224, USA
    J Subst Abuse Treat 35:78-86. 2008
    ..These findings demonstrate that both drug- and sex-related risk behaviors decrease during MMT and emphasize the benefits of methadone programs for public health and HIV/HCV prevention...
  23. pmc Contingency management reduces injection-related HIV risk behaviors in heroin and cocaine using outpatients
    Udi E Ghitza
    Clinical Pharmacology and Therapeutics Branch, Treatment Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA
    Addict Behav 33:593-604. 2008
    ..CM targeted toward cocaine and heroin use produces significant reductions in injection-related drug-taking behaviors associated with heightened risk for getting or transmitting HIV...
  24. pmc Self-report of illicit benzodiazepine use on the Addiction Severity Index predicts treatment outcome
    Udi E Ghitza
    Clinical Pharmacology and Therapeutics Research Branch, Treatment Section, Intramural Research Program IRP, National Institute on Drug Abuse NIDA, NIH, Baltimore, MD 21224, USA
    Drug Alcohol Depend 97:150-7. 2008
    ..Thus, in a sample of non-dependent BZD users, self-reported illicit BZD use on the ASI, even at low levels, predicted worse outcome on cocaine use and blunted response to CM...
  25. ncbi request reprint A factor analysis of the Fagerström Test for Nicotine Dependence (FTND)
    Aleksandras Radzius
    Intramural Research Program, National Institute on Drug Abuse National Institutes of Health Baltimore MD 21224, USA
    Nicotine Tob Res 5:255-40. 2003
    ..These two dimensions may provide indirect assessment of a smoker's daily nicotine intake. Testing this hypothesis requires correlation of biomarkers and responses to specific items of the FTND...
  26. pmc Cocaine craving and use during daily life
    Kenzie L Preston
    Treatment Section, Clinical Pharmacology and Therapeutics Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 207:291-301. 2009
    ..Craving is often assumed to cause ongoing drug use and relapse and is a major focus of addiction research. However, its relationship to drug use has not been adequately documented...
  27. pmc Effect of reinforcement probability and prize size on cocaine and heroin abstinence in prize-based contingency management
    Udi E Ghitza
    National Institute on Drug Abuse, Clinical Pharmacology and Therapeutics Research Branch Treatment Section, 251 Bayview Boulevard, Suite 200, Baltimore, Maryland 21224, USA
    J Appl Behav Anal 41:539-49. 2008
    ..Higher probability of winning, but not the size of individual prizes, was associated with a greater percentage of cocaine-negative, but not opiate-negative, urines...
  28. ncbi request reprint Urinary elimination of cocaine metabolites in chronic cocaine users during cessation
    Kenzie L Preston
    Clinical Pharmacology and Therapeutics Research Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, Maryland 21224, USA
    J Anal Toxicol 26:393-400. 2002
    ....
  29. pmc Automation in an addiction treatment research clinic: computerised contingency management, ecological momentary assessment and a protocol workflow system
    Massoud Vahabzadeh
    Biomedical Informatics Section, Administrative Management Branch, Intramural Research Program, National Institute on Drug Abuse, NIH DHHS, Baltimore, Maryland 21224, USA
    Drug Alcohol Rev 28:3-11. 2009
    ..Another challenge is the acquisition of large amounts of data in an occasionally hectic environment, along with the provision of seamless methods for exporting, mining and querying the data...
  30. pmc Brain mu-opioid receptor binding predicts treatment outcome in cocaine-abusing outpatients
    Udi E Ghitza
    Intramural Research Program, Clinical Pharmacology and Therapeutics Research Branch, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland, USA
    Biol Psychiatry 68:697-703. 2010
    ..In cocaine-abusing outpatients in treatment, the relationship of mOR binding and treatment outcome is unknown...
  31. pmc Psychosocial functioning and cocaine use during treatment: strength of relationship depends on type of urine-testing method
    Udi E Ghitza
    Clinical Pharmacology and Therapeutics Branch, Treatment Section, Intramural Research Program IRP, National Institute on Drug Abuse NIDA, NIH DHHS, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Drug Alcohol Depend 91:169-77. 2007
    ..Cocaine use during treatment, especially when measured with New Uses criteria, can predict psychosocial functioning, but cannot substitute for direct measures of psychosocial functioning...
  32. ncbi request reprint Adverse events among patients in a behavioral treatment trial for heroin and cocaine dependence: effects of age, race, and gender
    Jennifer R Schroeder
    Intramural Research Program, National Institute on Drug Abuse, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Drug Alcohol Depend 80:45-51. 2005
    ..Nonetheless, the data reported here should help provide a context in which investigators and IRBs can interpret the patterns of AEs they encounter...
  33. pmc QT interval increased after single dose of lofexidine
    John Schmittner
    National Institutes of Health, National Institute on Drug Abuse, Intramural Research Program, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    BMJ 329:1075. 2004
  34. ncbi request reprint Recent marijuana blunt smoking impacts carbon monoxide as a measure of adolescent tobacco abstinence
    Eric T Moolchan
    Department of Health and Human Services, National Institutes of Health, National Institute on Drug Abuse, Intramural Research Program, Baltimore, Maryland 21224, USA
    Subst Use Misuse 40:231-40. 2005
    ..013). Blunt occasions also tended to be associated with the more youth-appropriate cutoff CO > or = 6 ppm, compared to non-MJ occasions (p =0.054). Blunt smoking impacted the interpretation of measures of exhaled CO for tobacco cessation...
  35. ncbi request reprint Heroin and cocaine craving and use during treatment: measurement validation and potential relationships
    Adrienne J Heinz
    Clinical Pharmacology and Therapeutics Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD 21224, USA
    J Subst Abuse Treat 31:355-64. 2006
    ..Treatment dropout and in-treatment drug use were more frequently predicted by scores on the 14- or 45-item CCQ than by VAS ratings. Results suggest that the CCQ/HCQ and the 14-item CCQ provide information that unidimensional VASs do not...
  36. ncbi request reprint Do noncontingent vouchers increase drug use?
    Jennifer R Schroeder
    Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA
    Exp Clin Psychopharmacol 11:195-201. 2003
    ..05, 95% confidence interval: 1.01-1.09). Overall, results do not indicate a causal relationship between noncontingent voucher receipt and increased drug use...
  37. ncbi request reprint Methadone and metabolite urine concentrations in patients maintained on methadone
    Kenzie L Preston
    Clinical Pharmacology and Therapeutics Research Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, Maryland 21224, USA
    J Anal Toxicol 27:332-41. 2003
    ..Nevertheless, variability was too great to permit estimation of methadone dose (or detect a single missed administration) from any single specimen...
  38. ncbi request reprint Changes in HIV risk behaviors among patients receiving combined pharmacological and behavioral interventions for heroin and cocaine dependence
    Jennifer R Schroeder
    Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD 21224, USA
    Addict Behav 31:868-79. 2006
    ..034) but this effect was no longer significant after adjusting for drug-negative urines. These results suggest broad beneficial effects of methadone maintenance augmented with behavioral interventions for reducing HIV risk behaviors...
  39. ncbi request reprint Menstrual cycle length during methadone maintenance
    John Schmittner
    Intramural Research Program, National Institute on Drug Abuse, National Institute of Health, Baltimore, MD 21224, USA
    Addiction 100:829-36. 2005
    ..This study was conducted to evaluate whether cycle length was more regular during methadone maintenance...
  40. pmc Electrocardiographic effects of lofexidine and methadone coadministration: secondary findings from a safety study
    John Schmittner
    Clinical Pharmacology and Therapeutics Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 251 Bayview Boulevard, Baltimore, MD 21224, USA
    Pharmacotherapy 29:495-502. 2009
    ..To determine the electrocardiographic effects of coadministration of lofexidine and methadone...
  41. ncbi request reprint Spiritual/Religious experiences and in-treatment outcome in an inner-city program for heroin and cocaine dependence
    Adrienne Heinz
    Clinical Pharmacology and Treatment Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD, USA
    J Psychoactive Drugs 39:41-9. 2007
    ..The results suggest that spiritual and religious experience plays a role in substance abuse recovery and that demographic characteristics should be considered in the design of spiritually oriented behavioral interventions for addiction...
  42. ncbi request reprint Cyclazocine: comparison to hydromorphone and interaction with cocaine
    K L Preston
    National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA
    Behav Pharmacol 15:91-102. 2004
    ..This study is suggestive but not strongly supportive for the use of kappa-opiate drugs to diminish acute effects of cocaine administration or for the use of these kappa agonists in drug abuse treatment applications...
  43. pmc Puffing behavior during the smoking of a single cigarette in tobacco-dependent adolescents
    Charles C Collins
    Nicotine Psychopharmacology Section, Intramural Research Program, National Institute on Drug Abuse, 251 Bayview Boulevard, Baltimore, MD 21224, USA
    Nicotine Tob Res 12:164-7. 2010
    ..The purpose of this study was to examine the pattern of puffing behavior during the smoking of a single cigarette in adolescents...
  44. ncbi request reprint Smoking topography and trajectory of asthmatic adolescents requesting cessation treatment
    Darin M Zimmerman
    Teen Tobacco Addiction Treatment Research Clinic, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, U S Department of Health and Human Services, Baltimore, MD 21224, USA
    Prev Med 39:940-2. 2004
    ..Smoke exposure aggravates the clinical course of asthma, yet few reports have examined the association between asthma and smoking topography and trajectory...
  45. pmc The anxiogenic drug yohimbine reinstates palatable food seeking in a rat relapse model: a role of CRF1 receptors
    Udi E Ghitza
    Behavioral Neuroscience Branch, NIDA IRP NIH DHHS, Baltimore, MD 21224, USA
    Neuropsychopharmacology 31:2188-96. 2006
    ..These data suggest that CRF is involved in stress-induced relapse to palatable food seeking, and that CRF1 antagonists should be considered for the treatment of maladaptive eating habits...
  46. pmc The neuropharmacology of relapse to food seeking: methodology, main findings, and comparison with relapse to drug seeking
    Sunila G Nair
    Behavioral Neuroscience Branch, NIDA IRP, 251 Bayview Boulevard, Baltimore, MD 21224, USA
    Prog Neurobiol 89:18-45. 2009
    ..3)The neuronal mechanisms underlying reinstatement of food seeking overlap to some degree with those of reinstatement of drug seeking...
  47. ncbi request reprint Determination of total and free concentrations of the enantiomers of methadone and its metabolite (2-ethylidene-1,5-dimethyl-3,3-diphenyl-pyrrolidine) in human plasma by enantioselective liquid chromatography with mass spectrometric detection
    Maria Esther Rodriguez-Rosas
    Bioanalytical and Drug Discovery Unit, Gerontology Research Center, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224 6825, USA
    J Chromatogr A 1073:237-48. 2005
    ..S.D. for the intra- and inter-day precision of the method were < 5.3% and the R.S.D. for accuracy was < 5.0%. The method was used to analyze plasma samples obtained from patients enrolled in a Met-maintenance program...
  48. pmc A focus-group study on spirituality and substance-user treatment
    Adrienne J Heinz
    Clinical Pharmacology and Therapeutics Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, Maryland 21224, USA
    Subst Use Misuse 45:134-53. 2010
    ..One limitation was that all participants identified as strongly spiritual. Studies of more diverse samples will help guide the development and evaluation of spiritually based interventions in formal treatment...
  49. ncbi request reprint Quantitative determination of the enantiomers of methadone and its metabolite (EDDP) in human saliva by enantioselective liquid chromatography with mass spectrometric detection
    Maria Esther Rodriguez Rosas
    Bioanalytical and Drug Discovery Unit, Gerontology Research Center, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224 6825, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 796:355-70. 2003
    ..0%) and accuracy (CVs<4.0%) were obtained. These findings demonstrate the accuracy and precision of the method used to successfully analyze saliva obtained from patients enrolled in a methadone-maintenance program...
  50. ncbi request reprint Long-term methadone maintenance reduces protracted symptoms of heroin abstinence and cue-induced craving in Chinese heroin abusers
    Jie Shi
    Department of Clinical Pharmacology, National Institute on Drug Dependence, Peking University, Beijing 100083, China
    Pharmacol Biochem Behav 87:141-5. 2007
    ..PA symptoms have rarely been compared between drug-free and methadone-maintained former heroin users after similar lengths of heroin abstinence...
  51. ncbi request reprint Gender and stimulus difference in cue-induced responses in abstinent heroin users
    Jiang Yu
    Tangshan Mental Health Hospital, Tangshan, China
    Pharmacol Biochem Behav 86:485-92. 2007
    ..This study examined whether two different stimuli, drug-related imagery scripts and drug-related paraphernalia, produce similar or different patterns of cue reactivity in heroin-dependent men and women...
  52. ncbi request reprint Problems with odds ratios
    David H Epstein
    Am J Psychiatry 160:190-1; author reply 191. 2003
  53. doi request reprint Treatment of methamphetamine dependence
    John Mendelson
    Mayo Clin Proc 83:369-70; author reply 370-1. 2008
  54. pmc Serum cortisol secretion during heroin abstinence is elevated only nocturnally
    Su Xia Li
    National Institute on Drug Dependence, Peking University, Beijing, China
    Am J Drug Alcohol Abuse 34:321-8. 2008
    ..The abstinent heroin-dependent participants had significantly higher plasma cortisol levels nocturnally suggesting a loss of diurnal variation in these heroin subjects...