Research Topics
Genomes and Genes
| MARY ANNE ENOCHSummaryAffiliation: National Institutes of Health Country: USA Publications
| Collaborators
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Detail Information
Publications
The genetics of alcoholism and alcohol abuseM A Enoch
Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 12420 Parklawn Drive, Park 5 Building, Room 451, MSC 8110, Bethesda, MD 20892 8110, USA
Curr Psychiatry Rep 3:144-51. 2001..All these advances in the understanding of the genetics of alcoholism should facilitate the development of more accurately targeted therapies using molecular diagnostic approaches...
GABRG1 and GABRA2 as independent predictors for alcoholism in two populationsMARY ANNE ENOCH
Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
Neuropsychopharmacology 34:1245-54. 2009..05) extended haplotypes showed an association with AUD that was determined by GABRA2. Our results suggest that there are likely to be independent, complex contributions from both GABRG1 and GABRA2 to alcoholism vulnerability...- Alcohol use disorders and anxiety disorders: relation to the P300 event-related potentialM A Enoch
Laboratory of Neurogenetics, NIAAA, NIH, Bethesda, Maryland 20892 8110, USA
Alcohol Clin Exp Res 25:1293-300. 2001..We were particularly interested in looking at the subgroup of alcohol use disorders accompanied by anxiety disorders. This subgroup has previously been found to have diminished alpha amplitude in the resting EEG... - Does a reduced sensitivity to bitter taste increase the risk of becoming nicotine addicted?M A Enoch
Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892 8110, USA
Addict Behav 26:399-404. 2001..875, 4 df; P=.003), suggesting that nontasters, who are not aversive to the bitter taste of cigarettes, may be more at risk for heavy smoking and therefore more vulnerable to nicotine addiction... - Association between seasonal affective disorder and the 5-HT2A promoter polymorphism, -1438G/AM A Enoch
Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
Mol Psychiatry 4:89-92. 1999..However, these results should be treated with caution until replicated because of the possibility of false-positive findings in case-control association studies... - Association of low-voltage alpha EEG with a subtype of alcohol use disordersM A Enoch
Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892 8110, USA
Alcohol Clin Exp Res 23:1312-9. 1999..e., the low-voltage alpha (LVA) trait, was associated with alcohol use disorders and anxiety disorders... - Genetics of alcoholism and substance abuseM A Enoch
Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, USA
Psychiatr Clin North Am 22:289-99, viii. 1999..These advances in the understanding of the genetics of addictive disorders should facilitate the development of specific pharmacotherapies and the more accurate targeting of therapies using molecular diagnostic approaches... - Haplotype architecture of the norepinephrine transporter gene SLC6A2 in four populationsInna Belfer
Pain and Neurosensory Mechanisms Branch, National Institute of Dental and Craniofacial Research, Bethesda, MD, USA
J Hum Genet 49:232-45. 2004..The SLC6A2 haplotype map and 25-marker panel (excluding the monomorphic one) is a comprehensive tool for genetic linkage studies on phenotypes related to NET function... - Haplotype-based study of the association of alcohol-metabolizing genes with alcohol dependence in four independent populationsJixia Liu
From the Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, Maryland 20892, USA
Alcohol Clin Exp Res 35:304-16. 2011..We investigated whether variation in alcohol metabolism genes might alter the AD risk in four non-East Asian populations by performing systematic haplotype association analyses to maximize the chances of capturing functional variation... - Haplotype-based analysis of alpha 2A, 2B, and 2C adrenergic receptor genes captures information on common functional loci at each geneInna Belfer
Pain and Neurosensory Mechanisms Branch, National Institute of Dental and Craniofacial Research, Bethesda, MD 20892, USA
J Hum Genet 50:12-20. 2005..The alpha2-AR haplotype maps and marker panels are useful tools for genetic linkage studies to detect effects of known and unknown alpha2-AR functional loci... - Thr105Ile, a functional polymorphism of histamine N-methyltransferase, is associated with alcoholism in two independent populationsGabor Oroszi
Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, USA
Alcohol Clin Exp Res 29:303-9. 2005..In two ethnically distinct populations, we tested whether the Thr105Ile polymorphism was associated with alcoholism and with harm avoidance, a dimensional measure of anxious personality... - Genetics of alcoholism using intermediate phenotypesMARY ANNE ENOCH
Laboratory of Neurogenetics, NIAAA, NIH, Bethesda, Maryland 20892 8110, USA
Alcohol Clin Exp Res 27:169-76. 2003..Schuckit; and (4) Pharmacogenomic approaches to alcoholism treatment: toward a hypothesis, by Bankole A. Johnson... - The influence of GABRA2, childhood trauma, and their interaction on alcohol, heroin, and cocaine dependenceMARY ANNE ENOCH
Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, Maryland 20892 9412, USA
Biol Psychiatry 67:20-7. 2010..Early life stress has been shown to alter GABRA2 expression in adult rodents. We hypothesized that childhood trauma, GABRA2 variation, and their interaction would influence addiction vulnerability... - Sex differences in the influence of COMT Val158Met on alcoholism and smoking in plains American IndiansMARY ANNE ENOCH
Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, Maryland 20892 9412, USA
Alcohol Clin Exp Res 30:399-406. 2006.... - Increased anxiety and other similarities in temperament of alcoholics with and without antisocial personality disorder across three diverse populationsFrancesca Ducci
Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, NIH, 5625 Fishers Lane, Room 3S32, MSC 9412, Bethesda, MD 20892, USA
Alcohol 41:3-12. 2007..Even in alcoholics with long-term exposure to the anxiogenic effects of repeated cycles of alcohol withdrawal, genetic and other familial influences seem to play a role in moderating anxiety... - Genetic origins of anxiety in women: a role for a functional catechol-O-methyltransferase polymorphismMARY ANNE ENOCH
Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, USA
Psychiatr Genet 13:33-41. 2003.... - Genome-wide association identifies candidate genes that influence the human electroencephalogramColin A Hodgkinson
Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD 20852, USA
Proc Natl Acad Sci U S A 107:8695-700. 2010..We also found association of SGIP1 with alcoholism, an effect that may be mediated via the same brain mechanisms accessed by theta EEG, and which also provides validation of the use of EEG as an endophenotype for alcoholism... - The relationship between two intermediate phenotypes for alcoholism: low voltage alpha EEG and low P300 ERP amplitudeMARY ANNE ENOCH
Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland 20892 8110, USA
J Stud Alcohol 63:509-17. 2002..A few studies have demonstrated a modest correlation between pre-stimulus alpha power and P300 amplitude. We aimed to test this finding in community volunteers, hypothesizing that LVA would be associated with low P300 amplitude... - Neurophysiological and genetic distinctions between pure and comorbid anxiety disordersMARY ANNE ENOCH
Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892, USA
Depress Anxiety 25:383-92. 2008..This refinement of the anxiety phenotype may have implications for therapeutic interventions... - Linkage disequilibrium and association analysis of alpha-synuclein and alcohol and drug dependence in two American Indian populationsJordi Clarimon
Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA
Alcohol Clin Exp Res 31:546-54. 2007..Recent studies, in humans and in rat and monkey models, have suggested that alpha-synuclein may play a role in the development and maintenance of certain addictive disorders... - BDNF variation and mood disorders: a novel functional promoter polymorphism and Val66Met are associated with anxiety but have opposing effectsXueying Jiang
Section on Molecular Genetics, Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
Neuropsychopharmacology 30:1353-61. 2005..01). Our results suggest that in this population, the low activity -281 A allele may be protective against anxiety and psychiatric morbidity, whereas Met 66 may be a risk allele... - Common genetic origins for EEG, alcoholism and anxiety: the role of CRH-BPMARY ANNE ENOCH
Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, USA
PLoS ONE 3:e3620. 2008..Our results suggest a likely role for CRH-BP in stress-related alcoholism and highlight the use of the resting EEG as an intermediate phenotype for arousal-related behaviors such as anxiety and addiction... - Using ancestry-informative markers to define populations and detect population stratificationMARY ANNE ENOCH
Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA
J Psychopharmacol 20:19-26. 2006.... - Dimensional anxiety mediates linkage of GABRA2 haplotypes with alcoholismMARY ANNE ENOCH
Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, Maryland 20892, USA
Am J Med Genet B Neuropsychiatr Genet 141:599-607. 2006..Our results suggest that within the distal GABRA2 region is a functional locus or loci that may differ between populations but that alters risk for alcoholism via the mediating action of anxiety... - Leptin regulates dopamine responses to sustained stress in humansPaul R Burghardt
Molecular and Behavioral Neuroscience Institute, Department of Psychiatry, University of Michigan, Ann Arbor, Michigan 48109, USA
J Neurosci 32:15369-76. 2012..The capacity for leptin to influence stress-induced dopaminergic function is of importance for pathological states where dopamine is thought to play an integral role, such as mood, substance-use disorders, eating disorders, and obesity... - GABAergic gene expression in postmortem hippocampus from alcoholics and cocaine addicts; corresponding findings in alcohol-naïve P and NP ratsMARY ANNE ENOCH
National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, United States of America
PLoS ONE 7:e29369. 2012.... - Association of SOD2, a mitochondrial antioxidant enzyme, with gray matter volume shrinkage in alcoholicsVibhuti Srivastava
Laboratory of Neurogenetics, NIAAA, NIH, Bethesda, MD 20851, USA
Neuropsychopharmacology 35:1120-8. 2010..The risk/protective effect was observed in alcoholics with lower levels of lifetime alcohol consumption. Highest levels of exposure may overwhelm the protective action of the SOD2 enzyme... - Haplotype structure of the beta adrenergic receptor genes in US Caucasians and African AmericansInna Belfer
Pain and Neurosensory Mechanisms Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
Eur J Hum Genet 13:341-51. 2005..This study demonstrates the utility of using beta-AR gene haplotype maps and marker panels as tools for linkage studies on beta-AR function... - Zhou et al. replyZhifeng Zhou
Laboratory of Neurogenetics, NIAAA, NIH, Bethesda, Maryland 20892, USA
Nature 458:E7. 2009..Association of NPY with the complex trait of anxiety, especially when measured differently, is not the first place we would look to validate our results... - Genetic variation in human NPY expression affects stress response and emotionZhifeng Zhou
Laboratory of Neurogenetics, NIAAA, NIH, Bethesda, Maryland 20892, USA
Nature 452:997-1001. 2008..These convergent findings are consistent with the function of NPY as an anxiolytic peptide and help to explain inter-individual variation in resiliency to stress, a risk factor for many diseases... - Pharmacogenomics of alcohol response and addictionMARY ANNE ENOCH
Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institute of Health, Bethesda, Maryland 20892 8110, USA
Am J Pharmacogenomics 3:217-32. 2003..Some progress has been made in elucidating the pharmacogenomic responses to these drugs, particularly in the context of the type 1/type 2 classification system for alcoholics... - The role of GABA(A) receptors in the development of alcoholismMARY ANNE ENOCH
Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD, USA
Pharmacol Biochem Behav 90:95-104. 2008..The influence of the interaction between ethanol and GABA(A) receptors in the reward pathway on the development of alcoholism together with genetic and epigenetic vulnerabilities will be explored in this review... - Problem drinking and alcoholism: diagnosis and treatmentMARY ANNE ENOCH
Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland 20892 8110, USA
Am Fam Physician 65:441-8. 2002.... - Genetic and environmental influences on the development of alcoholism: resilience vs. riskMARY ANNE ENOCH
Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, Maryland, USA
Ann N Y Acad Sci 1094:193-201. 2006..Risk-resilience factors can best be determined in longitudinal studies, preferably starting during pregnancy. This kind of research is important for planning future measures to prevent harmful drinking in adolescence... - How can I help my patient stop drinking?MARY ANNE ENOCH
National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland, USA
Am Fam Physician 65:1475-6. 2002 - Interaction between FKBP5 and childhood trauma and risk of aggressive behaviorLaura Bevilacqua
LNG NIAAA, NIH, Rockville, MD 20852, USA
Arch Gen Psychiatry 69:62-70. 2012..Childhood trauma may predispose individuals to aggressive behavior, and both childhood trauma and aggressive behavior are associated with hypothalamic-pituitary-adrenal axis dysregulation... - The role of early life stress as a predictor for alcohol and drug dependenceMARY ANNE ENOCH
NIH NIAAA DICBR LNG, 5625 Fishers Lane, Room 3S32, MSC 9412, Bethesda, MD 20892 9412, USA
Psychopharmacology (Berl) 214:17-31. 2011..Exposure to early life stress, that is unfortunately common in the general population, has been shown to predict a wide range of psychopathology, including addiction... - The influence of gene-environment interactions on the development of alcoholism and drug dependenceMARY ANNE ENOCH
NIH NIAAA DICBR LNG, 5625 Fishers Lane, Room 3S32, MSC 9412, Bethesda, MD 20892 9412, USA
Curr Psychiatry Rep 14:150-8. 2012..In this article, the current state of the field is critically reviewed and suggestions are put forth for future research... - Association of galanin haplotypes with alcoholism and anxiety in two ethnically distinct populationsI Belfer
Pain and Neurosensory Mechanisms Branch, National Institute of Dental and Craniofacial Research, Bethesda, MD 20892, USA
Mol Psychiatry 11:301-11. 2006..Our results from two independent populations suggest that GAL may contribute to vulnerability to alcoholism, perhaps mediated by dimensional anxiety... - Neurocognitive impairment due to chronic alcohol consumption in an American Indian communityC R Harris
Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892 8110, USA
J Stud Alcohol 64:458-66. 2003.... - Alcoholism is associated with GALR3 but not two other galanin receptor genesI Belfer
Pain and Neurosensory Mechanisms Branch, National Institute of Dental and Craniofacial Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, DHHS, Bethesda, MD 20892, USA
Genes Brain Behav 6:473-81. 2007..6) as compared with the effect of either GAL (2.0) or GALR3 alone (1.6). There was no effect of GALR1 or GALR2 on alcoholism risk. This evidence suggests that GALR3 mediates the alcoholism-related actions of galanin... - Sexually dimorphic relationship of a 5-HT2A promoter polymorphism with obsessive-compulsive disorderM A Enoch
Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland 20892 8110, USA
Biol Psychiatry 49:385-8. 2001..We hypothesized that the 5-HT2A promoter polymorphism, -1438G>A, previously associated with anorexia nervosa, would be more abundant in women with obsessive-compulsive disorder... - 5-HT2A promoter polymorphism -1438G/A, anorexia nervosa, and obsessive-compulsive disorderM A Enoch
Lancet 351:1785-6. 1998