MARY ANNE ENOCH

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint The genetics of alcoholism and alcohol abuse
    M A Enoch
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 12420 Parklawn Drive, Park 5 Building, Room 451, MSC 8110, Bethesda, MD 20892 8110, USA
    Curr Psychiatry Rep 3:144-51. 2001
  2. ncbi request reprint Association between seasonal affective disorder and the 5-HT2A promoter polymorphism, -1438G/A
    M A Enoch
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Psychiatry 4:89-92. 1999
  3. ncbi request reprint Genetics of alcoholism and substance abuse
    M A Enoch
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, USA
    Psychiatr Clin North Am 22:289-99, viii. 1999
  4. ncbi request reprint Association of low-voltage alpha EEG with a subtype of alcohol use disorders
    M A Enoch
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892 8110, USA
    Alcohol Clin Exp Res 23:1312-9. 1999
  5. ncbi request reprint Does a reduced sensitivity to bitter taste increase the risk of becoming nicotine addicted?
    M A Enoch
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892 8110, USA
    Addict Behav 26:399-404. 2001
  6. ncbi request reprint Alcohol use disorders and anxiety disorders: relation to the P300 event-related potential
    M A Enoch
    Laboratory of Neurogenetics, NIAAA, NIH, Bethesda, Maryland 20892 8110, USA
    Alcohol Clin Exp Res 25:1293-300. 2001
  7. pmc GABRG1 and GABRA2 as independent predictors for alcoholism in two populations
    MARY ANNE ENOCH
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Neuropsychopharmacology 34:1245-54. 2009
  8. ncbi request reprint Haplotype-based linkage of tryptophan hydroxylase 2 to suicide attempt, major depression, and cerebrospinal fluid 5-hydroxyindoleacetic acid in 4 populations
    Zhifeng Zhou
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville 20852, USA
    Arch Gen Psychiatry 62:1109-18. 2005
  9. ncbi request reprint Haplotype architecture of the norepinephrine transporter gene SLC6A2 in four populations
    Inna Belfer
    Pain and Neurosensory Mechanisms Branch, National Institute of Dental and Craniofacial Research, Bethesda, MD, USA
    J Hum Genet 49:232-45. 2004
  10. ncbi request reprint Haplotype-based analysis of alpha 2A, 2B, and 2C adrenergic receptor genes captures information on common functional loci at each gene
    Inna Belfer
    Pain and Neurosensory Mechanisms Branch, National Institute of Dental and Craniofacial Research, Bethesda, MD 20892, USA
    J Hum Genet 50:12-20. 2005

Collaborators

Detail Information

Publications47

  1. ncbi request reprint The genetics of alcoholism and alcohol abuse
    M A Enoch
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 12420 Parklawn Drive, Park 5 Building, Room 451, MSC 8110, Bethesda, MD 20892 8110, USA
    Curr Psychiatry Rep 3:144-51. 2001
    ..All these advances in the understanding of the genetics of alcoholism should facilitate the development of more accurately targeted therapies using molecular diagnostic approaches...
  2. ncbi request reprint Association between seasonal affective disorder and the 5-HT2A promoter polymorphism, -1438G/A
    M A Enoch
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Psychiatry 4:89-92. 1999
    ..However, these results should be treated with caution until replicated because of the possibility of false-positive findings in case-control association studies...
  3. ncbi request reprint Genetics of alcoholism and substance abuse
    M A Enoch
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, USA
    Psychiatr Clin North Am 22:289-99, viii. 1999
    ..These advances in the understanding of the genetics of addictive disorders should facilitate the development of specific pharmacotherapies and the more accurate targeting of therapies using molecular diagnostic approaches...
  4. ncbi request reprint Association of low-voltage alpha EEG with a subtype of alcohol use disorders
    M A Enoch
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892 8110, USA
    Alcohol Clin Exp Res 23:1312-9. 1999
    ..e., the low-voltage alpha (LVA) trait, was associated with alcohol use disorders and anxiety disorders...
  5. ncbi request reprint Does a reduced sensitivity to bitter taste increase the risk of becoming nicotine addicted?
    M A Enoch
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892 8110, USA
    Addict Behav 26:399-404. 2001
    ..875, 4 df; P=.003), suggesting that nontasters, who are not aversive to the bitter taste of cigarettes, may be more at risk for heavy smoking and therefore more vulnerable to nicotine addiction...
  6. ncbi request reprint Alcohol use disorders and anxiety disorders: relation to the P300 event-related potential
    M A Enoch
    Laboratory of Neurogenetics, NIAAA, NIH, Bethesda, Maryland 20892 8110, USA
    Alcohol Clin Exp Res 25:1293-300. 2001
    ..We were particularly interested in looking at the subgroup of alcohol use disorders accompanied by anxiety disorders. This subgroup has previously been found to have diminished alpha amplitude in the resting EEG...
  7. pmc GABRG1 and GABRA2 as independent predictors for alcoholism in two populations
    MARY ANNE ENOCH
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Neuropsychopharmacology 34:1245-54. 2009
    ..05) extended haplotypes showed an association with AUD that was determined by GABRA2. Our results suggest that there are likely to be independent, complex contributions from both GABRG1 and GABRA2 to alcoholism vulnerability...
  8. ncbi request reprint Haplotype-based linkage of tryptophan hydroxylase 2 to suicide attempt, major depression, and cerebrospinal fluid 5-hydroxyindoleacetic acid in 4 populations
    Zhifeng Zhou
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville 20852, USA
    Arch Gen Psychiatry 62:1109-18. 2005
    ..Tryptophan hydroxylase 2 (TPH2) encodes the rate-limiting enzyme for brain serotonin biosynthesis. It was recently reported that the TPH2 haplotype was linked to depression in humans...
  9. ncbi request reprint Haplotype architecture of the norepinephrine transporter gene SLC6A2 in four populations
    Inna Belfer
    Pain and Neurosensory Mechanisms Branch, National Institute of Dental and Craniofacial Research, Bethesda, MD, USA
    J Hum Genet 49:232-45. 2004
    ..The SLC6A2 haplotype map and 25-marker panel (excluding the monomorphic one) is a comprehensive tool for genetic linkage studies on phenotypes related to NET function...
  10. ncbi request reprint Haplotype-based analysis of alpha 2A, 2B, and 2C adrenergic receptor genes captures information on common functional loci at each gene
    Inna Belfer
    Pain and Neurosensory Mechanisms Branch, National Institute of Dental and Craniofacial Research, Bethesda, MD 20892, USA
    J Hum Genet 50:12-20. 2005
    ..The alpha2-AR haplotype maps and marker panels are useful tools for genetic linkage studies to detect effects of known and unknown alpha2-AR functional loci...
  11. pmc Haplotype-based study of the association of alcohol-metabolizing genes with alcohol dependence in four independent populations
    Jixia Liu
    From the Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, Maryland 20892, USA
    Alcohol Clin Exp Res 35:304-16. 2011
    ..We investigated whether variation in alcohol metabolism genes might alter the AD risk in four non-East Asian populations by performing systematic haplotype association analyses to maximize the chances of capturing functional variation...
  12. pmc The influence of GABRA2, childhood trauma, and their interaction on alcohol, heroin, and cocaine dependence
    MARY ANNE ENOCH
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, Maryland 20892 9412, USA
    Biol Psychiatry 67:20-7. 2010
    ..Early life stress has been shown to alter GABRA2 expression in adult rodents. We hypothesized that childhood trauma, GABRA2 variation, and their interaction would influence addiction vulnerability...
  13. ncbi request reprint Genetics of alcoholism using intermediate phenotypes
    MARY ANNE ENOCH
    Laboratory of Neurogenetics, NIAAA, NIH, Bethesda, Maryland 20892 8110, USA
    Alcohol Clin Exp Res 27:169-76. 2003
    ..Schuckit; and (4) Pharmacogenomic approaches to alcoholism treatment: toward a hypothesis, by Bankole A. Johnson...
  14. ncbi request reprint Thr105Ile, a functional polymorphism of histamine N-methyltransferase, is associated with alcoholism in two independent populations
    Gabor Oroszi
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, USA
    Alcohol Clin Exp Res 29:303-9. 2005
    ..In two ethnically distinct populations, we tested whether the Thr105Ile polymorphism was associated with alcoholism and with harm avoidance, a dimensional measure of anxious personality...
  15. ncbi request reprint Sex differences in the influence of COMT Val158Met on alcoholism and smoking in plains American Indians
    MARY ANNE ENOCH
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, Maryland 20892 9412, USA
    Alcohol Clin Exp Res 30:399-406. 2006
    ....
  16. pmc Genome-wide association identifies candidate genes that influence the human electroencephalogram
    Colin A Hodgkinson
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD 20852, USA
    Proc Natl Acad Sci U S A 107:8695-700. 2010
    ..We also found association of SGIP1 with alcoholism, an effect that may be mediated via the same brain mechanisms accessed by theta EEG, and which also provides validation of the use of EEG as an endophenotype for alcoholism...
  17. pmc Increased anxiety and other similarities in temperament of alcoholics with and without antisocial personality disorder across three diverse populations
    Francesca Ducci
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, NIH, 5625 Fishers Lane, Room 3S32, MSC 9412, Bethesda, MD 20892, USA
    Alcohol 41:3-12. 2007
    ..Even in alcoholics with long-term exposure to the anxiogenic effects of repeated cycles of alcohol withdrawal, genetic and other familial influences seem to play a role in moderating anxiety...
  18. ncbi request reprint Genetic origins of anxiety in women: a role for a functional catechol-O-methyltransferase polymorphism
    MARY ANNE ENOCH
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, USA
    Psychiatr Genet 13:33-41. 2003
    ....
  19. ncbi request reprint The relationship between two intermediate phenotypes for alcoholism: low voltage alpha EEG and low P300 ERP amplitude
    MARY ANNE ENOCH
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland 20892 8110, USA
    J Stud Alcohol 63:509-17. 2002
    ..A few studies have demonstrated a modest correlation between pre-stimulus alpha power and P300 amplitude. We aimed to test this finding in community volunteers, hypothesizing that LVA would be associated with low P300 amplitude...
  20. ncbi request reprint Neurophysiological and genetic distinctions between pure and comorbid anxiety disorders
    MARY ANNE ENOCH
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892, USA
    Depress Anxiety 25:383-92. 2008
    ..This refinement of the anxiety phenotype may have implications for therapeutic interventions...
  21. ncbi request reprint Linkage disequilibrium and association analysis of alpha-synuclein and alcohol and drug dependence in two American Indian populations
    Jordi Clarimon
    Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA
    Alcohol Clin Exp Res 31:546-54. 2007
    ..Recent studies, in humans and in rat and monkey models, have suggested that alpha-synuclein may play a role in the development and maintenance of certain addictive disorders...
  22. pmc Common genetic origins for EEG, alcoholism and anxiety: the role of CRH-BP
    MARY ANNE ENOCH
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, USA
    PLoS ONE 3:e3620. 2008
    ..Our results suggest a likely role for CRH-BP in stress-related alcoholism and highlight the use of the resting EEG as an intermediate phenotype for arousal-related behaviors such as anxiety and addiction...
  23. ncbi request reprint BDNF variation and mood disorders: a novel functional promoter polymorphism and Val66Met are associated with anxiety but have opposing effects
    Xueying Jiang
    Section on Molecular Genetics, Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Neuropsychopharmacology 30:1353-61. 2005
    ..01). Our results suggest that in this population, the low activity -281 A allele may be protective against anxiety and psychiatric morbidity, whereas Met 66 may be a risk allele...
  24. ncbi request reprint Zhou et al. reply
    Zhifeng Zhou
    Laboratory of Neurogenetics, NIAAA, NIH, Bethesda, Maryland 20892, USA
    Nature 458:E7. 2009
    ..Association of NPY with the complex trait of anxiety, especially when measured differently, is not the first place we would look to validate our results...
  25. ncbi request reprint Dimensional anxiety mediates linkage of GABRA2 haplotypes with alcoholism
    MARY ANNE ENOCH
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, Maryland 20892, USA
    Am J Med Genet B Neuropsychiatr Genet 141:599-607. 2006
    ..Our results suggest that within the distal GABRA2 region is a functional locus or loci that may differ between populations but that alters risk for alcoholism via the mediating action of anxiety...
  26. pmc Leptin regulates dopamine responses to sustained stress in humans
    Paul R Burghardt
    Molecular and Behavioral Neuroscience Institute, Department of Psychiatry, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Neurosci 32:15369-76. 2012
    ..The capacity for leptin to influence stress-induced dopaminergic function is of importance for pathological states where dopamine is thought to play an integral role, such as mood, substance-use disorders, eating disorders, and obesity...
  27. pmc GABAergic gene expression in postmortem hippocampus from alcoholics and cocaine addicts; corresponding findings in alcohol-naïve P and NP rats
    MARY ANNE ENOCH
    National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 7:e29369. 2012
    ....
  28. ncbi request reprint Using ancestry-informative markers to define populations and detect population stratification
    MARY ANNE ENOCH
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA
    J Psychopharmacol 20:19-26. 2006
    ....
  29. pmc Genetic variation in human NPY expression affects stress response and emotion
    Zhifeng Zhou
    Laboratory of Neurogenetics, NIAAA, NIH, Bethesda, Maryland 20892, USA
    Nature 452:997-1001. 2008
    ..These convergent findings are consistent with the function of NPY as an anxiolytic peptide and help to explain inter-individual variation in resiliency to stress, a risk factor for many diseases...
  30. pmc Association of SOD2, a mitochondrial antioxidant enzyme, with gray matter volume shrinkage in alcoholics
    Vibhuti Srivastava
    Laboratory of Neurogenetics, NIAAA, NIH, Bethesda, MD 20851, USA
    Neuropsychopharmacology 35:1120-8. 2010
    ..The risk/protective effect was observed in alcoholics with lower levels of lifetime alcohol consumption. Highest levels of exposure may overwhelm the protective action of the SOD2 enzyme...
  31. pmc Independent effects of 5' and 3' functional variants in the serotonin transporter gene on suicidal behavior in the context of childhood trauma
    MARY ANNE ENOCH
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD, USA
    J Psychiatr Res 47:900-7. 2013
    ..25 in individuals without either risk variant. Our findings suggest that the 5' and 3'SLC6A4 functional variants have independent effects on the risk for suicidal behavior in CT exposed individuals...
  32. ncbi request reprint Haplotype structure of the beta adrenergic receptor genes in US Caucasians and African Americans
    Inna Belfer
    Pain and Neurosensory Mechanisms Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Eur J Hum Genet 13:341-51. 2005
    ..This study demonstrates the utility of using beta-AR gene haplotype maps and marker panels as tools for linkage studies on beta-AR function...
  33. pmc Loss of metabotropic glutamate receptor 2 escalates alcohol consumption
    Zhifeng Zhou
    Laboratories of Neurogenetics and Clinical and Translational Studies and Section on Synaptic Pharmacology, Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892
    Proc Natl Acad Sci U S A 110:16963-8. 2013
    ..Together, these data point to mGluR2 as an origin of alcohol preference and a potential therapeutic target. ..
  34. ncbi request reprint Pharmacogenomics of alcohol response and addiction
    MARY ANNE ENOCH
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institute of Health, Bethesda, Maryland 20892 8110, USA
    Am J Pharmacogenomics 3:217-32. 2003
    ..Some progress has been made in elucidating the pharmacogenomic responses to these drugs, particularly in the context of the type 1/type 2 classification system for alcoholics...
  35. pmc The role of GABA(A) receptors in the development of alcoholism
    MARY ANNE ENOCH
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD, USA
    Pharmacol Biochem Behav 90:95-104. 2008
    ..The influence of the interaction between ethanol and GABA(A) receptors in the reward pathway on the development of alcoholism together with genetic and epigenetic vulnerabilities will be explored in this review...
  36. ncbi request reprint Problem drinking and alcoholism: diagnosis and treatment
    MARY ANNE ENOCH
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland 20892 8110, USA
    Am Fam Physician 65:441-8. 2002
    ....
  37. ncbi request reprint Genetic and environmental influences on the development of alcoholism: resilience vs. risk
    MARY ANNE ENOCH
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, Maryland, USA
    Ann N Y Acad Sci 1094:193-201. 2006
    ..Risk-resilience factors can best be determined in longitudinal studies, preferably starting during pregnancy. This kind of research is important for planning future measures to prevent harmful drinking in adolescence...
  38. pmc A factor analysis of global GABAergic gene expression in human brain identifies specificity in response to chronic alcohol and cocaine exposure
    MARY ANNE ENOCH
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, USA
    PLoS ONE 8:e64014. 2013
    ..These findings might have implications for combating stress-related craving and relapse...
  39. pmc Interaction between FKBP5 and childhood trauma and risk of aggressive behavior
    Laura Bevilacqua
    LNG NIAAA, NIH, Rockville, MD 20852, USA
    Arch Gen Psychiatry 69:62-70. 2012
    ..Childhood trauma may predispose individuals to aggressive behavior, and both childhood trauma and aggressive behavior are associated with hypothalamic-pituitary-adrenal axis dysregulation...
  40. pmc The role of early life stress as a predictor for alcohol and drug dependence
    MARY ANNE ENOCH
    NIH NIAAA DICBR LNG, 5625 Fishers Lane, Room 3S32, MSC 9412, Bethesda, MD 20892 9412, USA
    Psychopharmacology (Berl) 214:17-31. 2011
    ..Exposure to early life stress, that is unfortunately common in the general population, has been shown to predict a wide range of psychopathology, including addiction...
  41. ncbi request reprint How can I help my patient stop drinking?
    MARY ANNE ENOCH
    National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland, USA
    Am Fam Physician 65:1475-6. 2002
  42. pmc The influence of gene-environment interactions on the development of alcoholism and drug dependence
    MARY ANNE ENOCH
    NIH NIAAA DICBR LNG, 5625 Fishers Lane, Room 3S32, MSC 9412, Bethesda, MD 20892 9412, USA
    Curr Psychiatry Rep 14:150-8. 2012
    ..In this article, the current state of the field is critically reviewed and suggestions are put forth for future research...
  43. pmc Association of galanin haplotypes with alcoholism and anxiety in two ethnically distinct populations
    I Belfer
    Pain and Neurosensory Mechanisms Branch, National Institute of Dental and Craniofacial Research, Bethesda, MD 20892, USA
    Mol Psychiatry 11:301-11. 2006
    ..Our results from two independent populations suggest that GAL may contribute to vulnerability to alcoholism, perhaps mediated by dimensional anxiety...
  44. ncbi request reprint Neurocognitive impairment due to chronic alcohol consumption in an American Indian community
    C R Harris
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892 8110, USA
    J Stud Alcohol 64:458-66. 2003
    ....
  45. ncbi request reprint Alcoholism is associated with GALR3 but not two other galanin receptor genes
    I Belfer
    Pain and Neurosensory Mechanisms Branch, National Institute of Dental and Craniofacial Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, DHHS, Bethesda, MD 20892, USA
    Genes Brain Behav 6:473-81. 2007
    ..6) as compared with the effect of either GAL (2.0) or GALR3 alone (1.6). There was no effect of GALR1 or GALR2 on alcoholism risk. This evidence suggests that GALR3 mediates the alcoholism-related actions of galanin...
  46. ncbi request reprint Sexually dimorphic relationship of a 5-HT2A promoter polymorphism with obsessive-compulsive disorder
    M A Enoch
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland 20892 8110, USA
    Biol Psychiatry 49:385-8. 2001
    ..We hypothesized that the 5-HT2A promoter polymorphism, -1438G>A, previously associated with anorexia nervosa, would be more abundant in women with obsessive-compulsive disorder...
  47. ncbi request reprint 5-HT2A promoter polymorphism -1438G/A, anorexia nervosa, and obsessive-compulsive disorder
    M A Enoch
    Lancet 351:1785-6. 1998