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| Ezekiel J EmanuelSummaryAffiliation: National Institutes of Health Country: USA Publications
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Publications
What cannot be said on television about health careEzekiel J Emanuel
Department of Clinical Bioethics, The Clinical Center, National Institutes of Health, Bethesda, MD 20892-1156, USA
JAMA 297:2131-3. 2007
Managed care, hospice use, site of death, and medical expenditures in the last year of lifeEzekiel J Emanuel
Department of Clinical Bioethics, Warren G Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892 1156, USA
Arch Intern Med 162:1722-8. 2002..We examined deaths of Medicare beneficiaries in Massachusetts and California to evaluate the effect of managed care on the use of hospice and site of death and to determine how hospice affects the expenditures for the last year of life...
Post-trial access to tested interventions: the views of IRB/REC chair, investigators, and research participants in a multinational HIV/AIDS studyChristine Pace
Department of Clinical Bioethics, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, Mayland 20892, USA
AIDS Res Hum Retroviruses 22:837-41. 2006..IRB/REC chairs and researchers were less expansive both in who and how they thought a drug should be guaranteed...
Informed consent: practices and views of investigators in a multinational clinical trialLindsay Sabik
Department of Clinical Bioethics, National Institutes of Health, Bethesda, MD, USA
IRB 27:13-8. 2005
Patients' decision-making process regarding participation in phase I oncology researchManish Agrawal
Department of Clinical Bioethics, Warren G Magnuson Clinical Center, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 1156, USA
J Clin Oncol 24:4479-84. 2006..This study assesses the decision-making process of patients enrolling in phase I oncology studies...
Factors that influence practitioners' interpretations of evidence from alternative medicine trials: a factorial vignette experiment embedded in a national surveyJon C Tilburt
Department of Bioethics, National Institutes of Health, Bethesda, MD 20892, USA
Med Care 48:341-8. 2010..Clinical trial evidence in controversial areas such as complementary and alternative medicine (CAM) must be approached with an open mind...
Frequency, type, and monetary value of financial conflicts of interest in cancer clinical researchLindsay A Hampson
Department of Bioethics, The Clinical Center, National Institutes of Health, Bethesda, MD 20892 1156, USA
J Clin Oncol 25:3609-14. 2007..Using data from American Society of Clinical Oncology (ASCO) Annual Meetings, we determined the frequency, type, and monetary value of researchers' financial interests...
Patients' views on financial conflicts of interest in cancer research trialsLindsay A Hampson
Department of Clinical Bioethics, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA
N Engl J Med 355:2330-7. 2006..A substantial minority wanted to be informed about the oversight system to protect against financial conflicts of interest and about researchers' financial interests. Copyright 2006 Massachusetts Medical Society...
Undue inducement: nonsense on stilts?Ezekiel J Emanuel
National Institutes of Health, USA
Am J Bioeth 5:9-13; discussion W8-11, W17. 2005
Research with stored biological samples: what do research participants want?Donna T Chen
Department of Clinical Bioethics, Warren G Magnuson Clinical Center, and National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
Arch Intern Med 165:652-5. 2005..Many believe consent for each future use is required to respect individuals. Others worry this approach may block important research...
Why patients continue to participate in clinical researchDavid Wendler
Department of Bioethics, National Institutes of Health, Bldg 10, Room 1C118, Bethesda, MD 20892, USA
Arch Intern Med 168:1294-9. 2008..While some commentators argue that this process inappropriately exploits patient participants, there are few data available to evaluate this claim...
Quality-improvement research and informed consentFranklin G Miller
Department of Bioethics, National Institutes of Health, Bethesda, MD, USA
N Engl J Med 358:765-7. 2008
What is a "minor" increase over minimal risk?David Wendler
Department of Clinical Bioethics, National Institutes of Health Clinical Center, Bethesda, MD 20892, USA
J Pediatr 147:575-8. 2005
Principles for allocation of scarce medical interventionsGovind Persad
Department of Bioethics, The Clinical Center, National Institutes of Health, Bethesda, Maryland, USA
Lancet 373:423-31. 2009..We recommend an alternative system-the complete lives system-which prioritises younger people who have not yet lived a complete life, and also incorporates prognosis, save the most lives, lottery, and instrumental value principles...
US health aid beyond PEPFAR: the Mother & Child CampaignColleen C Denny
Department of Bioethics, The Clinical Center, National Institutes of Health, Bethesda, MD 20892-1156, USA
JAMA 300:2048-51. 2008
Participants in phase 1 oncology research trials: are they vulnerable?Justine Seidenfeld
Department of Bioethics, Clinical Center, National Institutes of Health, Bethesda, MD 20892 1156, USA
Arch Intern Med 168:16-20. 2008....
Research benefits for hypothetical HIV vaccine trials: The views of Ugandans in the Rakai DistrictChristine Grady
Department of Bioethics, Clinical Center, National Institutes of Health, Bethesda, MD, USA
IRB 30:1-7. 2008
Quantifying the federal minimal risk standard: implications for pediatric research without a prospect of direct benefitDavid Wendler
Department of Clinical Bioethics, NIH Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA
JAMA 294:826-32. 2005..These data also raise the question of whether the federal minimal risk standard may sometimes fail to provide sufficient protection for children, prompting the need to consider alternative standards...
Circumcision and HIV prevention research: an ethical analysisReidar K Lie
Department of Clinical Bioethics, Clinical Center, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
Lancet 368:522-5. 2006
Undue inducement in clinical research in developing countries: is it a worry?Ezekiel J Emanuel
Department of Clinical Bioethics, Warren G Magnuson Clinical Center, National Institutes of Health, Building 10 Room 1C118, Bethesda, MD 20892 1156, USA
Lancet 366:336-40. 2005
Money and distorted ethical judgments about research: ethical assessment of the TeGenero TGN1412 trialEzekiel J Emanuel
Department of Clinical Bioethics, The Clinical Center, National Institutes of Health, Bethesda, MD 20892 1156, USA
Am J Bioeth 7:76-81. 2007....
Risks and benefits of phase 1 oncology trials, 1991 through 2002Elizabeth Horstmann
Department of Clinical Bioethics, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892-1156, USA
N Engl J Med 352:895-904. 2005..Rates of response and toxicity vary, however, among the various types of phase 1 oncology trials...
The obligation to participate in biomedical researchG Owen Schaefer
Department of Bioethics, The Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA
JAMA 302:67-72. 2009..Such a shift would be of great aid to the progress of biomedical research, eventually making society significantly healthier and longer lived...
Chemotherapy use among Medicare beneficiaries at the end of lifeEzekiel J Emanuel
Department of Clinical Bioethics, Warren G. Magnuson Clinical Center, National Institutes of Health, Building 10, Room 1C118, Bethesda, Maryland 20892-1156, USA
Ann Intern Med 138:639-43. 2003..The cancer's responsiveness to chemotherapy does not seem to influence whether dying patients receive chemotherapy at the end of life...
The perfect storm of overutilizationEzekiel J Emanuel
Department of Bioethics, Bldg 10, Room 1C118, National Institutes of Health, Bethesda, MD 20892-1156, USA
JAMA 299:2789-91. 2008
The ethics of research on enhancement interventionsOri Lev
Department of Bioethics, Warren G Magnuson Clinical Center, National Institutes of Health, Bethesda, MD, USA
Kennedy Inst Ethics J 20:101-13. 2010..Instead, like any other clinical research, each proposed enhancement study should be reviewed individually to assess whether it fulfills the ethical requirements that make a clinical study permissible...
Should society allow research ethics boards to be run as for-profit enterprises?Ezekiel J Emanuel
Department of Clinical Bioethics, Clinical Center, National Institutes of Health, Bethesda, Maryland, United States
PLoS Med 3:e309. 2006..Critics argue that for-profit IRBs have a conflict of interest because they generate their income from clients who have a direct financial interest in obtaining approval...
Medicare's requirement for research participation as a condition of coverage: is it ethical?Steven D Pearson
Department of Clinical Bioethics, National Institutes of Health, Bethesda, MD 20892, USA
JAMA 296:988-91. 2006
Why well-insured patients should demand value-based insurance benefitsColleen C Denny
Department of Bioethics, The NIH Clinical Center, National Institutes of Health, Bethesda, MD 20892-1156, USA
JAMA 297:2515-8. 2007
Conflict of interest in industry-sponsored drug developmentEzekiel J Emanuel
Department of Clinical Bioethics, The Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA
Clin Adv Hematol Oncol 5:265-7. 2007
Prescribing "placebo treatments": results of national survey of US internists and rheumatologistsJon C Tilburt
Department of Bioethics, National Institutes of Health, Bethesda, MD 20892, USA
BMJ 337:a1938. 2008..To describe the attitudes and behaviours regarding placebo treatments, defined as a treatment whose benefits derive from positive patient expectations and not from the physiological mechanism of the treatment itself...
Case study. Is longer always better? CommentaryEzekiel J Emanuel
Bioethics Department, Clinical Center, National Institutes of Health, USA
Hastings Cent Rep 38:10-1. 2008
The quality of informed consent in a clinical research study in ThailandChristine Pace
Department of Clinical Bioethics, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, MD, USA
IRB 27:9-17. 2005
Who really pays for health care? The myth of "shared responsibility"Ezekiel J Emanuel
Department of Bioethics, Clinical Center, National Institutes of Health, Bethesda, Maryland 20892, USA
JAMA 299:1057-9. 2008
The problem with single-payer plansEzekiel J Emanuel
Department of Bioethics, Clinical Center, National Institutes of Health, USA
Hastings Cent Rep 38:38-41. 2008
Descriptions of benefits and risks in consent forms for phase 1 oncology trialsSam Horng
Department of Clinical Bioethics, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892-1156, USA
N Engl J Med 347:2134-40. 2002..Although there is room for improvement, the substance of these forms is unlikely to be the primary source of misunderstanding by subjects in phase 1 oncology trials...
Changing premed requirements and the medical curriculumEzekiel J Emanuel
Department of Clinical Bioethics, The Clinical Center, National Institutes of Health, Bethesda, MD 20892-1156, USA
JAMA 296:1128-31. 2006
Essential elements of a technology and outcomes assessment initiativeEzekiel J Emanuel
Department of Bioethics, Clinical Center, National Institutes of Health, Bethesda, Maryland 20892, USA
JAMA 298:1323-5. 2007
Evaluating the risks of clinical researchAnnette Rid
Department of Bioethics, NIH Clinical Center, Bethesda, MD 20892, USA
JAMA 304:1472-9. 2010....
The standard of care debate: can research in developing countries be both ethical and responsive to those countries' health needs?David Wendler
Department of Clinical Bioethics, National Institutes of Health, Building 10, Room 1C118, Bethesda, MD 20892
Am J Public Health 94:923-8. 2004....
"Physician-assisted suicide among Oregon cancer patients": a fading issueColleen C Denny
Department of Clinical Bioethics at the National Institutes of Health, Bethesda, USA
J Clin Ethics 17:39-42; discussion 43-5. 2006
The cost-coverage trade-off: "it's health care costs, stupid"Ezekiel J Emanuel
Department of Bioethics, The Clinical Center, National Institutes of Health, Bethesda, Maryland 20892-1156, USA
JAMA 299:947-9. 2008
Technology licensing: lessons from the US experienceGregory K Sobolski
Department of Clinical Bioethics, National Institutes of Health, Bethesda, MD 20892, USA
JAMA 294:3137-40. 2005
Ethics. The ethics of international research with abandoned childrenJoseph Millum
Department of Bioethics, Clinical Center, National Institutes of Health, Bethesda, MD 20892-1156, USA
Science 318:1874-5. 2007
Ethical issues concerning research in complementary and alternative medicineFranklin G Miller
Department of Clinical Bioethics, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA
JAMA 291:599-604. 2004..In addition, we explore the legitimacy of providing CAM and conventional therapies that have been demonstrated to be effective only by virtue of the placebo effect...
The costs of conducting clinical researchEzekiel J Emanuel
Department of Clinical Bioethics, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, MD, USA
J Clin Oncol 21:4145-50. 2003..CONCLUSION: Based on the results of our mock trial, the time required for nontreatment trial activities is considerable, and the associated costs are substantial...
Comparing the understanding of subjects receiving a candidate malaria vaccine in the United States and MaliRuth D Ellis
Malaria Vaccine Development Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20892, USA
Am J Trop Med Hyg 83:868-72. 2010....
Four paradigms of clinical research and research oversightEzekiel J Emanuel
Department of Clinical Bioethics, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland, USA
Camb Q Healthc Ethics 16:82-96. 2007
Access and ability to pay: the ethics of a tiered health care systemBenjamin J Krohmal
Department of Clinical Bioethics at the Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA
Arch Intern Med 167:433-7. 2007
Talking with terminally ill patients and their caregivers about death, dying, and bereavement: is it stressful? Is it helpful?Ezekiel J Emanuel
Department of Clinical Bioethics, Warren G Magnuson Clinical Center, National Institutes of Health, Bethesda, MD, USA
Arch Intern Med 164:1999-2004. 2004..This study was conducted to assess whether interviewing terminally ill patients and their caregivers about death, dying, and bereavement is stressful and/or helpful...
Public health. Who should get influenza vaccine when not all can?Ezekiel J Emanuel
Department of Clinical Bioethics, Clinical Center, National Institutes of Health, Bethesda, MD 20892 1156, USA
Science 312:854-5. 2006
Does the evidence make a difference in consumer behavior? Sales of supplements before and after publication of negative research resultsJon C Tilburt
Department of Bioethics, National Institutes of Health, Bethesda, MD, USA
J Gen Intern Med 23:1495-8. 2008..To determine if the public consumption of herbs, vitamins, and supplements changes in light of emerging negative evidence...
Euthanasia and physician-assisted suicide: a review of the empirical data from the United StatesEzekiel J Emanuel
Department of Clinical Bioethics, Warren G. Magnuson Clinical Center, Bldg 10, Room 1C118, National Institutes of Health, Bethesda, MD 20892-1156, USA
Arch Intern Med 162:142-52. 2002
The prognosis for changes in end-of-life care after the Schiavo caseLindsay A Hampson
Warren G. Magnuson Clinical Center, National Institutes of Health, in Bethesda, Maryland, USA
Health Aff (Millwood) 24:972-5. 2005..But despite court cases and national consensus that these are private and not legislative matters, the Schiavo case is unlikely to change practices except to increase the number of Americans who complete living wills...
The patents-based pharmaceutical development process: rationale, problems, and potential reformsJohn H Barton
Department of Clinical Bioethics, National Institutes of Health, Bethesda, MD 20892-1156, USA
JAMA 294:2075-82. 2005....
Ethics of phase 1 oncology studies: reexamining the arguments and dataManish Agrawal
Department of Clinical Bioethics, Warren G Magnuson Clinical Center and National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 1156, USA
JAMA 290:1075-82. 2003..Overall, it appears that phase 1 oncology trials satisfy the requirement for a favorable risk-benefit ratio and that patients who enroll provide adequate informed consent...
Oversight of human participants research: identifying problems to evaluate reform proposalsEzekiel J Emanuel
Department of Clinical Bioethics, Warren G Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland 20892 1156, USA
Ann Intern Med 141:282-91. 2004....
What makes clinical research in developing countries ethical? The benchmarks of ethical researchEzekiel J Emanuel
Department of Clinical Bioethics, Warren G Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland 20892 1156, USA
J Infect Dis 189:930-7. 2004
The current state of medical school education in bioethics, health law, and health economicsGovind C Persad
Department of Bioethics, National Institutes of Health, USA
J Law Med Ethics 36:89-94, 4. 2008..This suggests that medical schools should reevaluate their curricula and instructors in bioethics, health law, and health economics...
The lessons of SARSEzekiel J Emanuel
Department of Clinical Bioethics, Warren G Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland 20892 1156, USA
Ann Intern Med 139:589-91. 2003..These lessons will be valuable far beyond the SARS episode...
The ethics of paying for children's participation in researchDavid Wendler
Department of Clinical Bioethics, National Institutes of Health, Bethesda, Maryland, 20892, USA
J Pediatr 141:166-71. 2002
The general agreement on trade in services: implications for health policymakersLeah Belsky
Department of Clinical Bioethics, National Institutes of Health, Bethesda, Maryland, USA
Health Aff (Millwood) 23:137-45. 2004..We explain the rationale behind the agreement and discuss its scope. We also address the major controversies surrounding the GATS and their implications for the U.S. health care system...
Evaluating community-based health initiatives: identifying the characteristics of successful initiatives and evaluationsEzekiel J Emanuel
Department of Clinical Bioethics, Warren G. Magnuson Clinical Center, National Institutes of Health, USA
J Health Polit Policy Law 27:105-8. 2002
Ending concerns about undue inducementEzekiel J Emanuel
J Law Med Ethics 32:100-5. 2004
Managing end-of-life care: comparing the experiences of terminally Ill patients in managed care and fee for serviceJulia Slutsman
Department of Health Policy and Management, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA
J Am Geriatr Soc 50:2077-83. 2002..Finally, terminally ill patients in MCOs did not show better experiences than those in FFS on any outcome measure. Additional research is required to explore how MCOs may improve upon the care available to dying patients...
Regional ethics organizations for protection of human research participantsAnne Wood
School of Law, University of California, Berkeley, Berkeley, California 94720-7200, USA
Nat Med 10:1283-8. 2004
The ethics of research in developing countries: assessing voluntarinessChristine A Pace
Harvard Medical School, Boston, Massachusetts, USA
Lancet 365:11-2. 2005
Does random treatment assignment cause harm to research participants?Cary P Gross
Section of General Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA
PLoS Med 3:e188. 2006..We therefore performed a systematic review to quantify the differences in health outcomes between randomized trial participants and eligible non-participants...
Who's caring for whom? Differing perspectives between seriously ill patients and their family caregiversJoshua M Hauser
Buehler Center on Aging, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
Am J Hosp Palliat Care 23:105-12. 2006..Consistent sociodemographic or clinical predictors of nonconcordant responses were not found. These data suggest important ways that patient and caregiver reports of the same experience vary...
Clarifying confusions about coercionJennifer S Hawkins
University of Toronto
Hastings Cent Rep 35:16-9. 2005
Depression, euthanasia, and improving end-of-life careEzekiel J Emanuel
J Clin Oncol 23:6456-8. 2005
What are bioethicists doing about health care reform?Ezekiel J Emanuel
Hastings Cent Rep 38:12-3. 2008
Health care vouchers--a proposal for universal coverageEzekiel J Emanuel
Posterity Project, Chicago, USA
N Engl J Med 352:1255-60. 2005
Legal reforms necessary to promote delivery system innovationTimothy Stoltzfus Jost
Washington and Lee School of Law, Lexington, Virginia, USA
JAMA 299:2561-3. 2008
Risks and benefits associated with novel phase 1 oncology trial designsShlomo A Koyfman
Department of Radiation Oncology, Cleveland Clinic, Cleveland, OH, USA
Cancer 110:1115-24. 2007..The prevalence of several novel trial designs and their association with a variety of clinical endpoints was evaluated...
Community permission for medical research in developing countriesDapa A Diallo
Department of Hematology, Malaria Research and Training Center, Faculty of Medicine, Pharmacy and Dentistry, University of Bamako, Mali
Clin Infect Dis 41:255-9. 2005..Far from competing with the individual informed consent process, the process of obtaining community permission both initiated and facilitated the process of disclosure for individual informed consent...
End-of-life care: the authors respondLindsay A Hampson
University of Michigan School of Medicine, Ann Arbor, MichiganNational Institutes of Health, Bethesda, Maryland
Health Aff (Millwood) 24:1687-8. 2005
