E J Emanuel

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Money and distorted ethical judgments about research: ethical assessment of the TeGenero TGN1412 trial
    Ezekiel J Emanuel
    Department of Clinical Bioethics, The Clinical Center, National Institutes of Health, Bethesda, MD 20892 1156, USA
    Am J Bioeth 7:76-81. 2007
  2. ncbi request reprint What cannot be said on television about health care
    Ezekiel J Emanuel
    Department of Clinical Bioethics, The Clinical Center, National Institutes of Health, Bethesda, MD 20892 1156, USA
    JAMA 297:2131-3. 2007
  3. ncbi request reprint Oversight of human participants research: identifying problems to evaluate reform proposals
    Ezekiel J Emanuel
    Department of Clinical Bioethics, Warren G Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland 20892 1156, USA
    Ann Intern Med 141:282-91. 2004
  4. ncbi request reprint Changing premed requirements and the medical curriculum
    Ezekiel J Emanuel
    Department of Clinical Bioethics, The Clinical Center, National Institutes of Health, Bethesda, MD 20892 1156, USA
    JAMA 296:1128-31. 2006
  5. ncbi request reprint What makes clinical research in developing countries ethical? The benchmarks of ethical research
    Ezekiel J Emanuel
    Department of Clinical Bioethics, Warren G Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland 20892 1156, USA
    J Infect Dis 189:930-7. 2004
  6. ncbi request reprint Undue inducement in clinical research in developing countries: is it a worry?
    Ezekiel J Emanuel
    Department of Clinical Bioethics, Warren G Magnuson Clinical Center, National Institutes of Health, Building 10 Room 1C118, Bethesda, MD 20892 1156, USA
    Lancet 366:336-40. 2005
  7. ncbi request reprint Who really pays for health care? The myth of "shared responsibility"
    Ezekiel J Emanuel
    Department of Bioethics, Clinical Center, National Institutes of Health, Bethesda, Maryland 20892, USA
    JAMA 299:1057-9. 2008
  8. ncbi request reprint Public health. Who should get influenza vaccine when not all can?
    Ezekiel J Emanuel
    Department of Clinical Bioethics, Clinical Center, National Institutes of Health, Bethesda, MD 20892 1156, USA
    Science 312:854-5. 2006
  9. doi request reprint The perfect storm of overutilization
    Ezekiel J Emanuel
    Department of Bioethics, Bldg 10, Room 1C118, National Institutes of Health, Bethesda, MD 20892 1156, USA
    JAMA 299:2789-91. 2008
  10. ncbi request reprint Understanding the experience of pain in terminally ill patients
    S C Weiss
    Department of Clinical Bioethics, Warren G Magnuson Clinical Center, National Institutes of Health, Building 10, Room 1C118, Bethesda, MD 20892, USA
    Lancet 357:1311-5. 2001

Detail Information

Publications63

  1. ncbi request reprint Money and distorted ethical judgments about research: ethical assessment of the TeGenero TGN1412 trial
    Ezekiel J Emanuel
    Department of Clinical Bioethics, The Clinical Center, National Institutes of Health, Bethesda, MD 20892 1156, USA
    Am J Bioeth 7:76-81. 2007
    ....
  2. ncbi request reprint What cannot be said on television about health care
    Ezekiel J Emanuel
    Department of Clinical Bioethics, The Clinical Center, National Institutes of Health, Bethesda, MD 20892 1156, USA
    JAMA 297:2131-3. 2007
  3. ncbi request reprint Oversight of human participants research: identifying problems to evaluate reform proposals
    Ezekiel J Emanuel
    Department of Clinical Bioethics, Warren G Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland 20892 1156, USA
    Ann Intern Med 141:282-91. 2004
    ....
  4. ncbi request reprint Changing premed requirements and the medical curriculum
    Ezekiel J Emanuel
    Department of Clinical Bioethics, The Clinical Center, National Institutes of Health, Bethesda, MD 20892 1156, USA
    JAMA 296:1128-31. 2006
  5. ncbi request reprint What makes clinical research in developing countries ethical? The benchmarks of ethical research
    Ezekiel J Emanuel
    Department of Clinical Bioethics, Warren G Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland 20892 1156, USA
    J Infect Dis 189:930-7. 2004
  6. ncbi request reprint Undue inducement in clinical research in developing countries: is it a worry?
    Ezekiel J Emanuel
    Department of Clinical Bioethics, Warren G Magnuson Clinical Center, National Institutes of Health, Building 10 Room 1C118, Bethesda, MD 20892 1156, USA
    Lancet 366:336-40. 2005
  7. ncbi request reprint Who really pays for health care? The myth of "shared responsibility"
    Ezekiel J Emanuel
    Department of Bioethics, Clinical Center, National Institutes of Health, Bethesda, Maryland 20892, USA
    JAMA 299:1057-9. 2008
  8. ncbi request reprint Public health. Who should get influenza vaccine when not all can?
    Ezekiel J Emanuel
    Department of Clinical Bioethics, Clinical Center, National Institutes of Health, Bethesda, MD 20892 1156, USA
    Science 312:854-5. 2006
  9. doi request reprint The perfect storm of overutilization
    Ezekiel J Emanuel
    Department of Bioethics, Bldg 10, Room 1C118, National Institutes of Health, Bethesda, MD 20892 1156, USA
    JAMA 299:2789-91. 2008
  10. ncbi request reprint Understanding the experience of pain in terminally ill patients
    S C Weiss
    Department of Clinical Bioethics, Warren G Magnuson Clinical Center, National Institutes of Health, Building 10, Room 1C118, Bethesda, MD 20892, USA
    Lancet 357:1311-5. 2001
    ..Unresolved pain has been cited as evidence that end-of-life care is of poor quality. However, the data on which that conclusion is based are limited. We aimed to provide additional data on the experience of pain in such patients...
  11. ncbi request reprint Who's caring for whom? Differing perspectives between seriously ill patients and their family caregivers
    Joshua M Hauser
    Buehler Center on Aging, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    Am J Hosp Palliat Care 23:105-12. 2006
    ..Consistent sociodemographic or clinical predictors of nonconcordant responses were not found. These data suggest important ways that patient and caregiver reports of the same experience vary...
  12. ncbi request reprint Post-trial access to tested interventions: the views of IRB/REC chair, investigators, and research participants in a multinational HIV/AIDS study
    Christine Pace
    Department of Clinical Bioethics, Warren G Magnuson Clinical Center, National Institutes of Health, Bethesda, Mayland 20892, USA
    AIDS Res Hum Retroviruses 22:837-41. 2006
    ..IRB/REC chairs and researchers were less expansive both in who and how they thought a drug should be guaranteed...
  13. ncbi request reprint Patients' decision-making process regarding participation in phase I oncology research
    Manish Agrawal
    Department of Clinical Bioethics, Warren G Magnuson Clinical Center, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 1156, USA
    J Clin Oncol 24:4479-84. 2006
    ..This study assesses the decision-making process of patients enrolling in phase I oncology studies...
  14. ncbi request reprint "Physician-assisted suicide among Oregon cancer patients": a fading issue
    Colleen C Denny
    Department of Clinical Bioethics at the National Institutes of Health, Bethesda, USA
    J Clin Ethics 17:39-42; discussion 43-5. 2006
  15. ncbi request reprint Medicare's requirement for research participation as a condition of coverage: is it ethical?
    Steven D Pearson
    Department of Clinical Bioethics, National Institutes of Health, Bethesda, MD 20892, USA
    JAMA 296:988-91. 2006
  16. ncbi request reprint Circumcision and HIV prevention research: an ethical analysis
    Reidar K Lie
    Department of Clinical Bioethics, Clinical Center, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Lancet 368:522-5. 2006
  17. pmc Should society allow research ethics boards to be run as for-profit enterprises?
    Ezekiel J Emanuel
    Department of Clinical Bioethics, Clinical Center, National Institutes of Health, Bethesda, Maryland, United States
    PLoS Med 3:e309. 2006
    ..Critics argue that for-profit IRBs have a conflict of interest because they generate their income from clients who have a direct financial interest in obtaining approval...
  18. pmc Does random treatment assignment cause harm to research participants?
    Cary P Gross
    Section of General Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA
    PLoS Med 3:e188. 2006
    ..We therefore performed a systematic review to quantify the differences in health outcomes between randomized trial participants and eligible non-participants...
  19. ncbi request reprint Patients' views on financial conflicts of interest in cancer research trials
    Lindsay A Hampson
    Department of Clinical Bioethics, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA
    N Engl J Med 355:2330-7. 2006
    ..Financial ties between researchers or medical centers and companies whose drugs are being tested have come under increasing scrutiny...
  20. ncbi request reprint Why well-insured patients should demand value-based insurance benefits
    Colleen C Denny
    Department of Bioethics, The NIH Clinical Center, National Institutes of Health, Bethesda, MD 20892 1156, USA
    JAMA 297:2515-8. 2007
  21. doi request reprint Why patients continue to participate in clinical research
    David Wendler
    Department of Bioethics, National Institutes of Health, Bldg 10, Room 1C118, Bethesda, MD 20892, USA
    Arch Intern Med 168:1294-9. 2008
    ..While some commentators argue that this process inappropriately exploits patient participants, there are few data available to evaluate this claim...
  22. doi request reprint Legal reforms necessary to promote delivery system innovation
    Timothy Stoltzfus Jost
    Washington and Lee School of Law, Lexington, Virginia, USA
    JAMA 299:2561-3. 2008
  23. ncbi request reprint What are bioethicists doing about health care reform?
    Ezekiel J Emanuel
    Hastings Cent Rep 38:12-3. 2008
  24. ncbi request reprint The problem with single-payer plans
    Ezekiel J Emanuel
    Department of Bioethics, Clinical Center, National Institutes of Health, USA
    Hastings Cent Rep 38:38-41. 2008
  25. doi request reprint The cost-coverage trade-off: "it's health care costs, stupid"
    Ezekiel J Emanuel
    Department of Bioethics, The Clinical Center, National Institutes of Health, Bethesda, Maryland 20892 1156, USA
    JAMA 299:947-9. 2008
  26. doi request reprint Quality-improvement research and informed consent
    Franklin G Miller
    Department of Bioethics, National Institutes of Health, Bethesda, MD, USA
    N Engl J Med 358:765-7. 2008
  27. doi request reprint Participants in phase 1 oncology research trials: are they vulnerable?
    Justine Seidenfeld
    Department of Bioethics, Clinical Center, National Institutes of Health, Bethesda, MD 20892 1156, USA
    Arch Intern Med 168:16-20. 2008
    ....
  28. ncbi request reprint Essential elements of a technology and outcomes assessment initiative
    Ezekiel J Emanuel
    Department of Bioethics, Clinical Center, National Institutes of Health, Bethesda, Maryland 20892, USA
    JAMA 298:1323-5. 2007
  29. doi request reprint US health aid beyond PEPFAR: the Mother & Child Campaign
    Colleen C Denny
    Department of Bioethics, The Clinical Center, National Institutes of Health, Bethesda, MD 20892 1156, USA
    JAMA 300:2048-51. 2008
  30. ncbi request reprint Risks and benefits associated with novel phase 1 oncology trial designs
    Shlomo A Koyfman
    Department of Radiation Oncology, Cleveland Clinic, Cleveland, OH, USA
    Cancer 110:1115-24. 2007
    ..The prevalence of several novel trial designs and their association with a variety of clinical endpoints was evaluated...
  31. ncbi request reprint Informed consent: practices and views of investigators in a multinational clinical trial
    Lindsay Sabik
    Department of Clinical Bioethics, National Institutes of Health, Bethesda, MD, USA
    IRB 27:13-8. 2005
  32. ncbi request reprint Chemotherapy use among Medicare beneficiaries at the end of life
    Ezekiel J Emanuel
    Department of Clinical Bioethics, Warren G Magnuson Clinical Center, National Institutes of Health, Building 10, Room 1C118, Bethesda, Maryland 20892 1156, USA
    Ann Intern Med 138:639-43. 2003
    ..Although many observers believe that cancer chemotherapy is overused at the end of life, there are no published data on this...
  33. ncbi request reprint Risks and benefits of phase 1 oncology trials, 1991 through 2002
    Elizabeth Horstmann
    Department of Clinical Bioethics, Warren G Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892 1156, USA
    N Engl J Med 352:895-904. 2005
    ..Previous reviews of phase 1 oncology trials reported a rate of response to treatment of 4 to 6 percent and a toxicity-related death rate of 0.5 percent. These results may not reflect the rates in current phase 1 oncology trials...
  34. ncbi request reprint The ethics of research in developing countries: assessing voluntariness
    Christine A Pace
    Harvard Medical School, Boston, Massachusetts, USA
    Lancet 365:11-2. 2005
  35. ncbi request reprint Regional ethics organizations for protection of human research participants
    Anne Wood
    School of Law, University of California, Berkeley, Berkeley, California 94720 7200, USA
    Nat Med 10:1283-8. 2004
  36. pmc The standard of care debate: can research in developing countries be both ethical and responsive to those countries' health needs?
    David Wendler
    Department of Clinical Bioethics, National Institutes of Health, Building 10, Room 1C118, Bethesda, MD 20892
    Am J Public Health 94:923-8. 2004
    ....
  37. ncbi request reprint Ending concerns about undue inducement
    Ezekiel J Emanuel
    J Law Med Ethics 32:100-5. 2004
  38. ncbi request reprint Descriptions of benefits and risks in consent forms for phase 1 oncology trials
    Sam Horng
    Department of Clinical Bioethics, Warren G Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892 1156, USA
    N Engl J Med 347:2134-40. 2002
    ..Ethicists have suggested that written consent forms encourage participants in phase 1 cancer trials to expect benefit from the experimental agent and to overlook serious risks...
  39. ncbi request reprint Ethical issues concerning research in complementary and alternative medicine
    Franklin G Miller
    Department of Clinical Bioethics, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA
    JAMA 291:599-604. 2004
    ..In addition, we explore the legitimacy of providing CAM and conventional therapies that have been demonstrated to be effective only by virtue of the placebo effect...
  40. ncbi request reprint The costs of conducting clinical research
    Ezekiel J Emanuel
    Department of Clinical Bioethics, Warren G Magnuson Clinical Center, National Institutes of Health, Bethesda, MD, USA
    J Clin Oncol 21:4145-50. 2003
    ..Others contend that these payments are necessary reimbursements for conducting clinical research. We evaluated the clinical and nonclinical hours and costs associated with conducting a mock phase III clinical research trial...
  41. ncbi request reprint Talking with terminally ill patients and their caregivers about death, dying, and bereavement: is it stressful? Is it helpful?
    Ezekiel J Emanuel
    Department of Clinical Bioethics, Warren G Magnuson Clinical Center, National Institutes of Health, Bethesda, MD, USA
    Arch Intern Med 164:1999-2004. 2004
    ..This study was conducted to assess whether interviewing terminally ill patients and their caregivers about death, dying, and bereavement is stressful and/or helpful...
  42. ncbi request reprint Ethics of phase 1 oncology studies: reexamining the arguments and data
    Manish Agrawal
    Department of Clinical Bioethics, Warren G Magnuson Clinical Center and National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 1156, USA
    JAMA 290:1075-82. 2003
    ..Overall, it appears that phase 1 oncology trials satisfy the requirement for a favorable risk-benefit ratio and that patients who enroll provide adequate informed consent...
  43. ncbi request reprint Managing end-of-life care: comparing the experiences of terminally Ill patients in managed care and fee for service
    Julia Slutsman
    Department of Health Policy and Management, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA
    J Am Geriatr Soc 50:2077-83. 2002
    ..Finally, terminally ill patients in MCOs did not show better experiences than those in FFS on any outcome measure. Additional research is required to explore how MCOs may improve upon the care available to dying patients...
  44. ncbi request reprint Health care vouchers--a proposal for universal coverage
    Ezekiel J Emanuel
    Posterity Project, Chicago, USA
    N Engl J Med 352:1255-60. 2005
  45. ncbi request reprint Clarifying confusions about coercion
    Jennifer S Hawkins
    University of Toronto
    Hastings Cent Rep 35:16-9. 2005
  46. ncbi request reprint What is a "minor" increase over minimal risk?
    David Wendler
    Department of Clinical Bioethics, National Institutes of Health Clinical Center, Bethesda, MD 20892, USA
    J Pediatr 147:575-8. 2005
  47. ncbi request reprint Euthanasia and physician-assisted suicide: a review of the empirical data from the United States
    Ezekiel J Emanuel
    Department of Clinical Bioethics, Warren G Magnuson Clinical Center, Bldg 10, Room 1C118, National Institutes of Health, Bethesda, MD 20892 1156, USA
    Arch Intern Med 162:142-52. 2002
  48. ncbi request reprint Undue inducement: nonsense on stilts?
    Ezekiel J Emanuel
    National Institutes of Health, USA
    Am J Bioeth 5:9-13; discussion W8-11, W17. 2005
  49. ncbi request reprint Depression, euthanasia, and improving end-of-life care
    Ezekiel J Emanuel
    J Clin Oncol 23:6456-8. 2005
  50. ncbi request reprint Quantifying the federal minimal risk standard: implications for pediatric research without a prospect of direct benefit
    David Wendler
    Department of Clinical Bioethics, NIH Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA
    JAMA 294:826-32. 2005
    ..These data also raise the question of whether the federal minimal risk standard may sometimes fail to provide sufficient protection for children, prompting the need to consider alternative standards...
  51. ncbi request reprint The prognosis for changes in end-of-life care after the Schiavo case
    Lindsay A Hampson
    Warren G Magnuson Clinical Center, National Institutes of Health, in Bethesda, Maryland, USA
    Health Aff (Millwood) 24:972-5. 2005
    ..But despite court cases and national consensus that these are private and not legislative matters, the Schiavo case is unlikely to change practices except to increase the number of Americans who complete living wills...
  52. ncbi request reprint Managed care, hospice use, site of death, and medical expenditures in the last year of life
    Ezekiel J Emanuel
    Department of Clinical Bioethics, Warren G Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892 1156, USA
    Arch Intern Med 162:1722-8. 2002
    ..We examined deaths of Medicare beneficiaries in Massachusetts and California to evaluate the effect of managed care on the use of hospice and site of death and to determine how hospice affects the expenditures for the last year of life...
  53. ncbi request reprint The quality of informed consent in a clinical research study in Thailand
    Christine Pace
    Department of Clinical Bioethics, Warren G Magnuson Clinical Center, National Institutes of Health, Bethesda, MD, USA
    IRB 27:9-17. 2005
  54. ncbi request reprint Research with stored biological samples: what do research participants want?
    Donna T Chen
    Department of Clinical Bioethics, Warren G Magnuson Clinical Center, and National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Arch Intern Med 165:652-5. 2005
    ..Many believe consent for each future use is required to respect individuals. Others worry this approach may block important research...
  55. ncbi request reprint Research benefits for hypothetical HIV vaccine trials: The views of Ugandans in the Rakai District
    Christine Grady
    Department of Bioethics, Clinical Center, National Institutes of Health, Bethesda, MD, USA
    IRB 30:1-7. 2008
  56. ncbi request reprint Technology licensing: lessons from the US experience
    Gregory K Sobolski
    Department of Clinical Bioethics, National Institutes of Health, Bethesda, MD 20892, USA
    JAMA 294:3137-40. 2005
  57. doi request reprint The current state of medical school education in bioethics, health law, and health economics
    Govind C Persad
    Department of Bioethics, National Institutes of Health, USA
    J Law Med Ethics 36:89-94, 4. 2008
    ..This suggests that medical schools should reevaluate their curricula and instructors in bioethics, health law, and health economics...
  58. ncbi request reprint Ethics. The ethics of international research with abandoned children
    Joseph Millum
    Department of Bioethics, Clinical Center, National Institutes of Health, Bethesda, MD 20892 1156, USA
    Science 318:1874-5. 2007
  59. ncbi request reprint The lessons of SARS
    Ezekiel J Emanuel
    Department of Clinical Bioethics, Warren G Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland 20892 1156, USA
    Ann Intern Med 139:589-91. 2003
    ..These lessons will be valuable far beyond the SARS episode...
  60. ncbi request reprint Access and ability to pay: the ethics of a tiered health care system
    Benjamin J Krohmal
    Department of Clinical Bioethics at the Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA
    Arch Intern Med 167:433-7. 2007
  61. ncbi request reprint Community permission for medical research in developing countries
    Dapa A Diallo
    Department of Hematology, Malaria Research and Training Center, Faculty of Medicine, Pharmacy and Dentistry, University of Bamako, Mali
    Clin Infect Dis 41:255-9. 2005
    ..Far from competing with the individual informed consent process, the process of obtaining community permission both initiated and facilitated the process of disclosure for individual informed consent...
  62. ncbi request reprint End-of-life care: the authors respond
    Lindsay A Hampson
    University of Michigan School of Medicine, Ann Arbor, MichiganNational Institutes of Health, Bethesda, Maryland
    Health Aff (Millwood) 24:1687-8. 2005
  63. ncbi request reprint Frequency, type, and monetary value of financial conflicts of interest in cancer clinical research
    Lindsay A Hampson
    Department of Bioethics, The Clinical Center, National Institutes of Health, Bethesda, MD 20892 1156, USA
    J Clin Oncol 25:3609-14. 2007
    ..Using data from American Society of Clinical Oncology (ASCO) Annual Meetings, we determined the frequency, type, and monetary value of researchers' financial interests...