P C Elwood

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint The divergent 5' termini of the alpha human folate receptor (hFR) mRNAs originate from two tissue-specific promoters and alternative splicing: characterization of the alpha hFR gene structure
    P C Elwood
    Medicine Branch, National Cancer Institute, Bethesda, Maryland 20892, USA
    Biochemistry 36:1467-78. 1997
  2. ncbi request reprint Expression of the human placental folate receptor transcript is regulated in human tissues. Organization and full nucleotide sequence of the gene
    S T Page
    Medicine Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892
    J Mol Biol 229:1175-83. 1993
  3. pmc Tissue-specific promoters of the alpha human folate receptor gene yield transcripts with divergent 5' leader sequences and different translational efficiencies
    S J Roberts
    Medicine Branch, Division of Clinical Sciences, National Cancer Institute, Bethesda, MD 20892, USA
    Biochem J 326:439-47. 1997
  4. ncbi request reprint Structural and functional analysis of the human KB cell folate receptor gene P4 promoter: cooperation of three clustered Sp1-binding sites with initiator region for basal promoter activity
    Y Saikawa
    Medicine Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biochemistry 34:9951-61. 1995
  5. ncbi request reprint Molecular cloning and characterization of the human folate-binding protein cDNA from placenta and malignant tissue culture (KB) cells
    P C Elwood
    Medicine Branch, National Cancer Institute, Bethesda, Maryland 20892
    J Biol Chem 264:14893-901. 1989
  6. ncbi request reprint Exon 3 of the alpha folate receptor gene contains a 5' splice site which confers enhanced ovarian carcinoma specific expression
    E Galmozzi
    Unit of Molecular Therapies, Department of Experimental Oncology, Istituto Nazionale Tumori, Milan, Italy
    FEBS Lett 502:31-4. 2001
  7. ncbi request reprint Sorting of the human folate receptor in MDCK cells
    Chong Ho Kim
    Department of Clinical Pathology, Wonkwang Health Science College, Iksan 570 750, Korea
    J Biochem Mol Biol 37:362-9. 2004

Collaborators

Detail Information

Publications7

  1. ncbi request reprint The divergent 5' termini of the alpha human folate receptor (hFR) mRNAs originate from two tissue-specific promoters and alternative splicing: characterization of the alpha hFR gene structure
    P C Elwood
    Medicine Branch, National Cancer Institute, Bethesda, Maryland 20892, USA
    Biochemistry 36:1467-78. 1997
    ..These data demonstrate that a single gene encodes the divergent 5' termini of the alpha hFR cDNAs and that the alpha hFR transcripts are transcribed from two promoters that are activated in a tissue-specific manner...
  2. ncbi request reprint Expression of the human placental folate receptor transcript is regulated in human tissues. Organization and full nucleotide sequence of the gene
    S T Page
    Medicine Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892
    J Mol Biol 229:1175-83. 1993
    ..The isolation of the FR-P3 gene will permit functional analysis of the cis and trans regulatory elements of the FR-P3 gene and the mechanisms involved in tissue-specific FR gene expression...
  3. pmc Tissue-specific promoters of the alpha human folate receptor gene yield transcripts with divergent 5' leader sequences and different translational efficiencies
    S J Roberts
    Medicine Branch, Division of Clinical Sciences, National Cancer Institute, Bethesda, MD 20892, USA
    Biochem J 326:439-47. 1997
    ..Hence, one consequence of tissue-specific promoter usage is the production of alphahFR transcripts with different 5' non-coding regions that affect translational efficiency...
  4. ncbi request reprint Structural and functional analysis of the human KB cell folate receptor gene P4 promoter: cooperation of three clustered Sp1-binding sites with initiator region for basal promoter activity
    Y Saikawa
    Medicine Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biochemistry 34:9951-61. 1995
    ....
  5. ncbi request reprint Molecular cloning and characterization of the human folate-binding protein cDNA from placenta and malignant tissue culture (KB) cells
    P C Elwood
    Medicine Branch, National Cancer Institute, Bethesda, Maryland 20892
    J Biol Chem 264:14893-901. 1989
    ..In vitro translation of RNA transcripts from the FBP cDNA inserts yields a 30-kDa and a 42-kDa polypeptide in the absence and presence of microsomal membranes, respectively...
  6. ncbi request reprint Exon 3 of the alpha folate receptor gene contains a 5' splice site which confers enhanced ovarian carcinoma specific expression
    E Galmozzi
    Unit of Molecular Therapies, Department of Experimental Oncology, Istituto Nazionale Tumori, Milan, Italy
    FEBS Lett 502:31-4. 2001
    ..A 5' splice site and 35 bp downstream intronic region of exon 3 appeared to regulate enhanced FR expression in ovarian carcinoma...
  7. ncbi request reprint Sorting of the human folate receptor in MDCK cells
    Chong Ho Kim
    Department of Clinical Pathology, Wonkwang Health Science College, Iksan 570 750, Korea
    J Biochem Mol Biol 37:362-9. 2004
    ..The results suggest the hypothesis that there may be multiple mechanisms for targeting hFR to the plasma membrane...