Research Topics
| Laura L ElnitskiSummaryAffiliation: National Institutes of Health Country: USA Publications
| Collaborators
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Detail Information
Publications
Genomic features defining exonic variants that modulate splicingAdam Woolfe
Genomic Functional Analysis Section, National Human Genome Research Institute, National Institutes of Health, Rockville, Maryland 20892, USA
Genome Biol 11:R20. 2010..In addition, little is known about which computational prediction approaches, such as those involving exonic splicing enhancers and exonic splicing silencers, are most informative...- Word-based characterization of promoters involved in human DNA repair pathwaysJens Lichtenberg
Bioinformatics Laboratory, School of Electrical Engineering and Computer Science, Ohio University, Athens, Ohio, USA
BMC Genomics 10:S18. 2009.... - Cross-species mapping of bidirectional promoters enables prediction of unannotated 5' UTRs and identification of species-specific transcriptsHelen Piontkivska
2Department of BiologicalSciences, Kent State University, Kent, Ohio 44242, USA
BMC Genomics 10:189. 2009.... - WordSeeker: concurrent bioinformatics software for discovering genome-wide patterns and word-based genomic signaturesJens Lichtenberg
Bioinformatics Laboratory, School of EECS, Ohio University, Athens, Ohio 45701, USA
BMC Bioinformatics 11:S6. 2010..Although a number of methods have been developed for motif discovery, most of them lack the scalability needed to analyze large genomic data sets... - Comparative analyses of bidirectional promoters in vertebratesMary Qu Yang
Genome Technology Branch, NHGRI, NIH, MD, USA
BMC Bioinformatics 9:S9. 2008..In this report we utilize orthology assignments for pairs of genes co-regulated by bidirectional promoters to map the ancestral history of the promoter regions... 
Locating mammalian transcription factor binding sites: a survey of computational and experimental techniquesLaura Elnitski
Genomic Functional Analysis Section, National Human Genome Research Institute, National Institutes of Health, Rockville, Maryland 20878, USA
Genome Res 16:1455-64. 2006..A variety of techniques useful for localized- and high-throughput analyses are discussed here, with emphasis on aspects of data generation and verification...- Tissue-specific and ubiquitous expression patterns from alternative promoters of human genesEdwin Jacox
National Human Genome Research Institute, National Institutes of Health, Rockville, Maryland, United States of America
PLoS ONE 5:e12274. 2010..We show that annotation of alternative promoters regulating expression of transcripts with distinct first exons enables a novel methodology to quantify expression levels and tissue specificity of mRNA isoforms... - Prediction-based approaches to characterize bidirectional promoters in the mammalian genomeMary Qu Yang
National Human Genome Research Institute, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892, USA
BMC Genomics 9:S2. 2008..We proposed that knowledge gleaned from those methods could be further refined using a multiple class predictor to separate classes of promoter elements from enhancers or nonfunctional DNA... - Diversity of core promoter elements comprising human bidirectional promotersMary Qu Yang
National Human Genome Research Institute, National Institutes Health, Rockville, MD 20852, USA
BMC Genomics 9:S3. 2008..To define the core promoter elements of bidirectional promoters in human, we mapped motifs for TATA, INR, BRE, DPE, INR, as well as CpG-islands... - The ENCODEdb portal: simplified access to ENCODE Consortium dataLaura L Elnitski
Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Genome Res 17:954-9. 2007..The ENCODEdb portal is freely accessible at http://research.nhgri.nih.gov/ENCODEdb... - Comprehensive annotation of bidirectional promoters identifies co-regulation among breast and ovarian cancer genesMary Q Yang
Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Rockville, Maryland, United States of America
PLoS Comput Biol 3:e72. 2007..Interpreting the regulation of genes involved in co-expression networks, especially those involved in cancer, will be an important step toward defining molecular events that may contribute to disease... - Computational prediction of cis-regulatory modules from multispecies alignments using Galaxy, Table Browser, and GALALaura Elnitski
Genome Technology Branch, National Institutes of Health, Rockville, MD, USA
Methods Mol Biol 338:91-103. 2006..Links to these servers can be accessed at http://www.bx.psu.edu/ and http://genome.ucsc.edu/... - Functional analysis of a novel cis-acting regulatory region within the human ankyrin gene (ANK-1) promoterKarina Laflamme
National Institutes of Health, National Human Genome Research Institute, Genetics and Molecular Biology Branch, Bethesda, Maryland 20892, USA
Mol Cell Biol 30:3493-502. 2010..One sequence increased ANK-1 promoter function 5-fold, while randomly chosen sequences decreased ANK-1 promoter function. Our results demonstrate a novel functional motif in the ANK-1 promoter... - Detection and characterization of silencers and enhancer-blockers in the greater CFTR locusHanna M Petrykowska
Genome Technology Branch, National Human Genome Research Institute, NIH, Rockville, MD 20852, USA
Genome Res 18:1238-46. 2008..Overall, we identified 15 novel NREs, which contribute new insights into the prevalence and composition of sequences that negatively regulate gene expression... - Generation and comparative analysis of approximately 3.3 Mb of mouse genomic sequence orthologous to the region of human chromosome 7q11.23 implicated in Williams syndromeUdaya DeSilva
Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Genome Res 12:3-15. 2002....