Lee E Eiden
Affiliation: National Institutes of Health
Emery A, Liu X, Xu W, Eiden M, Eiden L. Cyclic Adenosine 3',5'-Monophosphate Elevation and Biological Signaling through a Secretin Family Gs-Coupled G Protein-Coupled Receptor Are Restricted to a Single Adenylate Cyclase Isoform. Mol Pharmacol. 2015;87:928-35 pubmed publisher
Zhang L, Eiden L. Two ancient neuropeptides, PACAP and AVP, modulate motivated behavior at synapses in the extrahypothalamic brain: a study in contrast. Cell Tissue Res. 2019;375:103-122 pubmed publisher
..There is paradigmatic value in the discussion of these two particular ancient neuropeptides, for peptide-centric translational neuroendocrinology and peptide GPCR-based neurotherapeutics. ..
Eiden L, Weihe E. VMAT2: a dynamic regulator of brain monoaminergic neuronal function interacting with drugs of abuse. Ann N Y Acad Sci. 2011;1216:86-98 pubmed publisher
..The presence of VMAT2 in noradrenergic, serotoninergic, histaminergic, and potentially trace aminergic neurons invites consideration of a wider role for aminergic neurotransmission in AMPH and COC abuse and addiction. ..
Eiden L. Neuropeptide-catecholamine interactions in stress. Adv Pharmacol. 2013;68:399-404 pubmed publisher
..The interactions between catecholamines and neuropeptides within some of these circuits are summarized in this chapter and described in detail in the three chapters following. ..
Almeida Suhett C, Prager E, Pidoplichko V, Figueiredo T, Marini A, Li Z, et al
. GABAergic interneuronal loss and reduced inhibitory synaptic transmission in the hippocampal CA1 region after mild traumatic brain injury. Exp Neurol. 2015;273:11-23 pubmed publisher
Samal B, Waites C, Almeida Suhett C, Li Z, Marini A, Samal N, et al
. Acute Response of the Hippocampal Transcriptome Following Mild Traumatic Brain Injury After Controlled Cortical Impact in the Rat. J Mol Neurosci. 2015;57:282-303 pubmed publisher
Emery A, Alvarez R, Abboud P, Xu W, Westover C, Eiden M, et al
. C-terminal amidation of PACAP-38 and PACAP-27 is dispensable for biological activity at the PAC1 receptor. Peptides. 2016;79:39-48 pubmed publisher
..The specific implications for the role of amidation in arming of secretin-related neuropeptides for biological function, and the general implications for neuropeptide-based delivery in the context of gene therapy, are discussed. ..
Emery A, Xu W, Eiden M, Eiden L. Guanine nucleotide exchange factor Epac2-dependent activation of the GTP-binding protein Rap2A mediates cAMP-dependent growth arrest in neuroendocrine cells. J Biol Chem. 2017;292:12220-12231 pubmed publisher
Eiden L, Emery A, Zhang L, SMITH C. PACAP signaling in stress: insights from the chromaffin cell. Pflugers Arch. 2018;470:79-88 pubmed publisher
..Experimental elucidation of PACAP action at this synapse remains at the forefront of understanding PACAP's role in stress signaling throughout the nervous system. ..