Marilyn Ehrenshaft

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Hypericin-mediated photooxidative damage of α-crystallin in human lens epithelial cells
    Marilyn Ehrenshaft
    Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 60:347-54. 2013
  2. ncbi request reprint Protein radical formation on thyroid peroxidase during turnover as detected by immuno-spin trapping
    Marilyn Ehrenshaft
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 41:422-30. 2006
  3. pmc Immunological detection of N-formylkynurenine in porphyrin-mediated photooxided lens α-crystallin
    Marilyn Ehrenshaft
    Laboratory of Pharmacology and Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA
    Photochem Photobiol 87:1321-9. 2011
  4. pmc Immunological detection of N-formylkynurenine in oxidized proteins
    Marilyn Ehrenshaft
    Laboratory of Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 46:1260-6. 2009
  5. pmc Partial colocalization of oxidized, N-formylkynurenine-containing proteins in mitochondria and Golgi of keratinocytes
    Marilyn Ehrenshaft
    Laboratory of Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA
    Photochem Photobiol 86:752-6. 2010
  6. pmc Site-specific radical formation in DNA induced by Cu(II)-H₂O₂ oxidizing system, using ESR, immuno-spin trapping, LC-MS, and MS/MS
    Suchandra Bhattacharjee
    Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 50:1536-45. 2011
  7. pmc Procainamide, but not N-acetylprocainamide, induces protein free radical formation on myeloperoxidase: a potential mechanism of agranulocytosis
    Arno G Siraki
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, 111 Alexander Dr, Research Triangle Park, NC 27709, USA
    Chem Res Toxicol 21:1143-53. 2008
  8. pmc Protein Radical Formation Resulting from Eosinophil Peroxidase-catalyzed Oxidation of Sulfite
    Kalina Ranguelova
    Laboratory of Pharmacology, NIEHS, National Institutes of Health, Research Triangle Park, NC 27709, USA
    J Biol Chem 285:24195-205. 2010
  9. pmc Oxidative stress induces protein and DNA radical formation in follicular dendritic cells of the germinal center and modulates its cell death patterns in late sepsis
    Saurabh Chatterjee
    National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 50:988-99. 2011
  10. pmc Immuno-spin trapping of a post-translational carboxypeptidase B1 radical formed by a dual role of xanthine oxidase and endothelial nitric oxide synthase in acute septic mice
    Saurabh Chatterjee
    Free Radical Metabolites Group, Laboratory of Pharmacology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Free Radic Biol Med 46:454-61. 2009

Detail Information

Publications14

  1. pmc Hypericin-mediated photooxidative damage of α-crystallin in human lens epithelial cells
    Marilyn Ehrenshaft
    Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 60:347-54. 2013
    ..John's wort cannot adequately shield their lenses from hypericin-mediated photosensitized damage...
  2. ncbi request reprint Protein radical formation on thyroid peroxidase during turnover as detected by immuno-spin trapping
    Marilyn Ehrenshaft
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 41:422-30. 2006
    ..Evidence that correlates iodine deficiencies with development of thyroid autoimmune disorders supports this conjecture...
  3. pmc Immunological detection of N-formylkynurenine in porphyrin-mediated photooxided lens α-crystallin
    Marilyn Ehrenshaft
    Laboratory of Pharmacology and Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA
    Photochem Photobiol 87:1321-9. 2011
    ..Confocal microscopy of cultured human lens epithelial cells indicates that while all four porphyrins photosensitize cellular proteins, not all oxidize the tryptophans of cellular α-crystallin to NFK...
  4. pmc Immunological detection of N-formylkynurenine in oxidized proteins
    Marilyn Ehrenshaft
    Laboratory of Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 46:1260-6. 2009
    ..Results from mass spectrometric analysis of photooxidized myoglobin samples corroborate the immunological data, detecting an increase in NFK content as the extent of photooxidation increases...
  5. pmc Partial colocalization of oxidized, N-formylkynurenine-containing proteins in mitochondria and Golgi of keratinocytes
    Marilyn Ehrenshaft
    Laboratory of Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA
    Photochem Photobiol 86:752-6. 2010
    ..These experiments demonstrate that we have developed a tool for the specific detection of oxidized tryptophan residues in cells and suggest that this tool could be useful in tracking the fate of these oxidized proteins...
  6. pmc Site-specific radical formation in DNA induced by Cu(II)-H₂O₂ oxidizing system, using ESR, immuno-spin trapping, LC-MS, and MS/MS
    Suchandra Bhattacharjee
    Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 50:1536-45. 2011
    ..The DMPO adduct formed is initially EPR active but subsequently is oxidized to the stable nitrone, which can then be detected by IST and further characterized by MS and MS/MS...
  7. pmc Procainamide, but not N-acetylprocainamide, induces protein free radical formation on myeloperoxidase: a potential mechanism of agranulocytosis
    Arno G Siraki
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, 111 Alexander Dr, Research Triangle Park, NC 27709, USA
    Chem Res Toxicol 21:1143-53. 2008
    ..We propose that drug-induced free radical formation on MPO may play a role in the origin of agranulocytosis...
  8. pmc Protein Radical Formation Resulting from Eosinophil Peroxidase-catalyzed Oxidation of Sulfite
    Kalina Ranguelova
    Laboratory of Pharmacology, NIEHS, National Institutes of Health, Research Triangle Park, NC 27709, USA
    J Biol Chem 285:24195-205. 2010
    ..These studies suggest that EPO-dependent oxidative damage may play a role in tissue injury in bisulfite-exacerbated eosinophilic inflammatory disorders...
  9. pmc Oxidative stress induces protein and DNA radical formation in follicular dendritic cells of the germinal center and modulates its cell death patterns in late sepsis
    Saurabh Chatterjee
    National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 50:988-99. 2011
    ..In one such mechanism, radical formation initiated by xanthine oxidase formed protein and DNA radicals, which may lead to cell death of germinal center FDCs...
  10. pmc Immuno-spin trapping of a post-translational carboxypeptidase B1 radical formed by a dual role of xanthine oxidase and endothelial nitric oxide synthase in acute septic mice
    Saurabh Chatterjee
    Free Radical Metabolites Group, Laboratory of Pharmacology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Free Radic Biol Med 46:454-61. 2009
    ..This suggests the presence of a possible mechanism for CPB1 activity loss with compensatory protein production...
  11. pmc Targeted oxidation of Torpedo californica acetylcholinesterase by singlet oxygen: identification of N-formylkynurenine tryptophan derivatives within the active-site gorge of its complex with the photosensitizer methylene blue
    Mathilde M Triquigneaux
    Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, DHHS, PO Box 12233 MD F0 03, Research Triangle Park, NC 27709, USA
    Biochem J 448:83-91. 2012
    ....
  12. pmc Aminoglutethimide-induced protein free radical formation on myeloperoxidase: a potential mechanism of agranulocytosis
    Arno G Siraki
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, 111 Alexander Drive, Research Triangle Park, North Carolina 27709, USA
    Chem Res Toxicol 20:1038-45. 2007
    ..We propose that drug-dependent free radical formation on MPO may play a role in the origin of agranulocytosis...
  13. pmc Development of immunoblotting techniques for DNA radical detection
    Fiona A Summers
    Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 56:64-71. 2013
    ..Moreover, we have determined that denaturation of samples into single-stranded DNA enhances the detection of DNA-DMPO adducts in our new blotting methods and also in ELISA...
  14. ncbi request reprint Functional expression and cellular localization of cercosporin-resistance proteins fused with the GFP in Cercospora nicotianae
    Kuang Ren Chung
    Department of Plant Pathology, North Carolina State University, Raleigh 27695 7616, USA
    Curr Genet 41:159-67. 2002
    ....