E M Eddy

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Spermatogenic cell-specific type 1 hexokinase is the predominant hexokinase in sperm
    Noriko Nakamura
    Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA
    Mol Reprod Dev 75:632-40. 2008
  2. pmc Calpain 11 is unique to mouse spermatogenic cells
    Irit Ben-Aharon
    Department of Cell and Developmental Biology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Mol Reprod Dev 73:767-73. 2006
  3. ncbi request reprint The scaffold role of the fibrous sheath
    E M Eddy
    Gamete Biology Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, 111 T W Alexander Drive, Research Triangle Park, NC 27709, USA
    Soc Reprod Fertil Suppl 65:45-62. 2007
  4. pmc Characterization of eight novel proteins with male germ cell-specific expression in mouse
    Namhoe Baek
    Department of Life Science and Research Center for Biomolecular Nanotechnology, Gwangju Institute of Science and Technology, Gwangju 500 712, Korea
    Reprod Biol Endocrinol 6:32. 2008
  5. pmc Integrative characterization of germ cell-specific genes from mouse spermatocyte UniGene library
    Eunyoung Choi
    Department of Life Science and Research Center for BiomolecularNanotechnology, Gwangju Institute of Science and Technology, Gwangju, Korea
    BMC Genomics 8:256. 2007
  6. ncbi request reprint Fibrous sheath of mammalian spermatozoa
    Edward M Eddy
    Gamete Biology Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA
    Microsc Res Tech 61:103-15. 2003
  7. ncbi request reprint Targeted disruption of the estrogen receptor gene in male mice causes alteration of spermatogenesis and infertility
    E M Eddy
    Gamete Biology Section, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709 2233, USA
    Endocrinology 137:4796-805. 1996
  8. ncbi request reprint Male germ cell gene expression
    Edward M Eddy
    Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709 2233, USA
    Recent Prog Horm Res 57:103-28. 2002
  9. ncbi request reprint HSP70-2 is required for desynapsis of synaptonemal complexes during meiotic prophase in juvenile and adult mouse spermatocytes
    D J Dix
    Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Development 124:4595-603. 1997
  10. pmc Targeted gene disruption of Hsp70-2 results in failed meiosis, germ cell apoptosis, and male infertility
    D J Dix
    Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Proc Natl Acad Sci U S A 93:3264-8. 1996

Collaborators

Detail Information

Publications58

  1. pmc Spermatogenic cell-specific type 1 hexokinase is the predominant hexokinase in sperm
    Noriko Nakamura
    Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA
    Mol Reprod Dev 75:632-40. 2008
    ..These results strongly suggest that HK1, HK2, HK3, and GCK are unlikely to have a role in glycolysis in sperm and that HK1S encoded by Hk1_v2 and Hk1_v3 serves this role...
  2. pmc Calpain 11 is unique to mouse spermatogenic cells
    Irit Ben-Aharon
    Department of Cell and Developmental Biology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Mol Reprod Dev 73:767-73. 2006
    ..The expression of calpain 11 during spermatogenesis and its localization in spermatozoa suggest that it is involved in regulating calcium-dependent signal transduction events during meiosis and sperm functional processes...
  3. ncbi request reprint The scaffold role of the fibrous sheath
    E M Eddy
    Gamete Biology Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, 111 T W Alexander Drive, Research Triangle Park, NC 27709, USA
    Soc Reprod Fertil Suppl 65:45-62. 2007
    ..However, the nature of the protein-protein interactions involved in assembly and maintenance of FS are known for only a few of the component proteins...
  4. pmc Characterization of eight novel proteins with male germ cell-specific expression in mouse
    Namhoe Baek
    Department of Life Science and Research Center for Biomolecular Nanotechnology, Gwangju Institute of Science and Technology, Gwangju 500 712, Korea
    Reprod Biol Endocrinol 6:32. 2008
    ..We investigated eight proteins encoded by novel spermatogenic cell-specific genes previously identified from the mouse round spermatid UniGene library...
  5. pmc Integrative characterization of germ cell-specific genes from mouse spermatocyte UniGene library
    Eunyoung Choi
    Department of Life Science and Research Center for BiomolecularNanotechnology, Gwangju Institute of Science and Technology, Gwangju, Korea
    BMC Genomics 8:256. 2007
    ..The primary regulator of spermatogenesis, a highly ordered and tightly regulated developmental process, is an intrinsic genetic program involving male germ cell-specific genes...
  6. ncbi request reprint Fibrous sheath of mammalian spermatozoa
    Edward M Eddy
    Gamete Biology Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA
    Microsc Res Tech 61:103-15. 2003
    ....
  7. ncbi request reprint Targeted disruption of the estrogen receptor gene in male mice causes alteration of spermatogenesis and infertility
    E M Eddy
    Gamete Biology Section, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709 2233, USA
    Endocrinology 137:4796-805. 1996
    ..These results suggest that estrogen action is required for fertility in male mice and that the mutation of the ER in ERKO males leads to reduced mating frequency, low sperm numbers, and defective sperm function...
  8. ncbi request reprint Male germ cell gene expression
    Edward M Eddy
    Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709 2233, USA
    Recent Prog Horm Res 57:103-28. 2002
    ..Nevertheless, an intrinsic evolutionarily conserved genetic program regulates male germ cell gene expression and development...
  9. ncbi request reprint HSP70-2 is required for desynapsis of synaptonemal complexes during meiotic prophase in juvenile and adult mouse spermatocytes
    D J Dix
    Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Development 124:4595-603. 1997
    ....
  10. pmc Targeted gene disruption of Hsp70-2 results in failed meiosis, germ cell apoptosis, and male infertility
    D J Dix
    Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Proc Natl Acad Sci U S A 93:3264-8. 1996
    ..These results suggest that HSP70-2 participates in synaptonemal complex function during meiosis in male germ cells and is linked to mechanisms that inhibit apoptosis...
  11. ncbi request reprint Characterization of Fsc1 cDNA for a mouse sperm fibrous sheath component
    K D Fulcher
    Gamete Biology Section, National Institute of Environmental Health Sciences, National Institutes of Health Research Triangle Park, North Carolina 27709 2233
    Biol Reprod 52:41-9. 1995
    ..abstract truncated at 250 words)..
  12. ncbi request reprint Estrogen receptor-alpha is required by the supporting somatic cells for spermatogenesis
    D Mahato
    Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, MD C4 01, PO Box 12233, Research Triangle Park, NC 27709 2233, USA
    Mol Cell Endocrinol 178:57-63. 2001
    ....
  13. ncbi request reprint Genomic organization of a mouse glyceraldehyde 3-phosphate dehydrogenase gene (Gapd-s) expressed in post-meiotic spermatogenic cells
    J E Welch
    Gamete Biology Section, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Dev Genet 16:179-89. 1995
    ..Since GAPD has been proposed to be a key enzyme regulating glycolysis in spermatogenic cells, GAPD-S may represent a potential target for toxicological or contraceptive agents affecting fertility by interfering with glycolysis...
  14. ncbi request reprint Expression of a glyceraldehyde 3-phosphate dehydrogenase gene specific to mouse spermatogenic cells
    J E Welch
    Gamete Biology Section, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709
    Biol Reprod 46:869-78. 1992
    ..We hypothesize that the GAPD-S enzyme plays an important role in regulating the switch between different pathways for energy production during spermiogenesis and in the spermatozoon...
  15. ncbi request reprint Unique hexokinase messenger ribonucleic acids lacking the porin-binding domain are developmentally expressed in mouse spermatogenic cells
    C Mori
    Gamete Biology Section, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709
    Biol Reprod 49:191-203. 1993
    ..These and other findings suggest that enzymes encoded by Hk1-sa, Hk1-sb, and Hk1-sc are present only in spermatogenic cells...
  16. ncbi request reprint Estrogen receptor gene disruption: molecular characterization and experimental and clinical phenotypes
    K S Korach
    Receptor Biology Section, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Recent Prog Horm Res 51:159-86; discussion 186-8. 1996
    ..Mutation in the ER gene is present in the human population. Further characterization of the mice and identification of additional patients will be required to more fully understand the consequences of ER gene mutations...
  17. ncbi request reprint Human glyceraldehyde 3-phosphate dehydrogenase-2 gene is expressed specifically in spermatogenic cells
    J E Welch
    Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709 2233, USA
    J Androl 21:328-38. 2000
    ..The conserved nature of the mouse, rat, and human enzymes suggests that they serve similar roles in these and other mammalian species...
  18. ncbi request reprint Spermatogenic cells do not require estrogen receptor-alpha for development or function
    D Mahato
    Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Endocrinology 141:1273-6. 2000
    ....
  19. ncbi request reprint Developmentally regulated expression of Hsp70-2 and a Hsp70-2/lacZ transgene during spermatogenesis
    D J Dix
    National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Dev Biol 174:310-21. 1996
    ....
  20. ncbi request reprint Studies using the estrogen receptor alpha knockout uterus demonstrate that implantation but not decidualization-associated signaling is estrogen dependent
    Sylvia Curtis Hewitt
    Laboratory of Reproductive and Developmental Toxicology, NIEHS, NIH, Research Triangle Park, North Carolina 27709, USA
    Biol Reprod 67:1268-77. 2002
    ....
  21. ncbi request reprint Disruption of the mouse oestrogen receptor gene: resulting phenotypes and experimental findings
    J F Couse
    Receptor Biology Section, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Biochem Soc Trans 23:929-35. 1995
  22. ncbi request reprint Characterization of laminin receptor messenger ribonucleic acid and protein expression in mouse spermatogenic cells
    K D Fulcher
    Gamete Biology Section, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709
    Biol Reprod 48:674-82. 1993
    ..However, spermatocytes and spermatids are spatially isolated from laminin in the testes, and MLR may have other functions in these cells...
  23. ncbi request reprint HSP70-2 is required for CDC2 kinase activity in meiosis I of mouse spermatocytes
    D Zhu
    Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Development 124:3007-14. 1997
    ..These studies provide novel in vivo evidence for a link between an HSP70 molecular chaperone and CDC2 kinase activity essential for the meiotic cell cycle in spermatogenesis...
  24. ncbi request reprint Identification of a unique mu-class glutathione S-transferase in mouse spermatogenic cells
    K D Fulcher
    Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Mol Reprod Dev 42:415-24. 1995
    ..Immunoblot analysis indicated that a mu-class GST protein is associated with the fibrous sheath, suggesting that it becomes an integral part of the mouse sperm cytoskeleton...
  25. ncbi request reprint Molecular mechanism of estrogen action in the male: insights from the estrogen receptor null mice
    J E Couse
    Receptor Biology Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Reprod Fertil Dev 13:211-9. 2001
    ..This brief review will discuss the roles of estrogen action in male reproduction as revealed by mice lacking both known forms of the ER. A brief review of the estrogen signaling system is also included...
  26. ncbi request reprint Glyceraldehyde 3-phosphate dehydrogenase-S protein distribution during mouse spermatogenesis
    D O Bunch
    Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Biol Reprod 58:834-41. 1998
    ..Western blot analysis indicated that GAPD-S is tightly associated with the fibrous sheath of the flagellum, consistent with a potential role in regulating sperm motility...
  27. ncbi request reprint Identification of tethering domains for protein kinase A type Ialpha regulatory subunits on sperm fibrous sheath protein FSC1
    K Miki
    Gamete Biology Group, Laboratory of Reproductive and Developmental Toxicology, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 273:34384-90. 1998
    ..This was supported by the finding that site-directed mutagenesis to disrupt the amphipathic helix eliminated RIalpha binding. This is apparently the first report of an RIalpha-specific protein kinase A anchoring protein tethering domain...
  28. ncbi request reprint Role of heat shock protein HSP70-2 in spermatogenesis
    E M Eddy
    Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Rev Reprod 4:23-30. 1999
    ..Homologues of HSP70-2 are present in the testes of many animals, suggesting that the role of this spermatogenic cell chaperone is conserved across phyla...
  29. pmc Expression of a dominant negative estrogen receptor alpha variant in transgenic mice accelerates uterine cancer induced by the potent estrogen diethylstilbestrol
    Vicki L Davis
    Receptor Biology Group, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, United States
    Reprod Toxicol 34:512-21. 2012
    ..These findings indicate that expression of this ERα variant can influence determining events in uterine cancer development and its natural occurrence in the human uterus would unlikely be protective...
  30. ncbi request reprint HSP70-2 heat-shock protein of mouse spermatogenic cells
    E M Eddy
    Gamete Biology Section, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Exp Zool 282:261-71. 1998
    ..This appears to be the first demonstration that interaction between an HSP70 protein and a cyclin-dependent kinase is necessary for progression of the cell cycle...
  31. ncbi request reprint Aberrant reproductive phenotypes evident in transgenic mice expressing the wild-type mouse estrogen receptor
    V L Davis
    Receptor Biology Section, National Institute of Environmental Health Sciences, National Institute of Health, Research Triangle Park, North Carolina 27709
    Endocrinology 135:379-86. 1994
    ....
  32. pmc A novel hsp70-like protein (P70) is present in mouse spermatogenic cells
    R L Allen
    Gamete Biology Section, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709
    Mol Cell Biol 8:828-32. 1988
    ..P70 appears to be a novel heat shock protein of spermatogenic cells which is synthesized in association with germ cell differentiation...
  33. ncbi request reprint BRCA2-null embryonic survival is prolonged on the BALB/c genetic background
    L M Bennett
    Laboratory of Molecular Carcinogenesis, National Institutes of Health, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
    Mol Carcinog 28:174-83. 2000
    ..5 BALB/c(B2-/-) embryos that was comparable to Brca2-heterozygous littermates. Thus, the Brca1 and Brca2 transcripts are expressed independently of one another in Brca1- and Brca2-null embryos. Mol. Carcinog. 28:174-183, 2000...
  34. pmc Speriolin is a novel human and mouse sperm centrosome protein
    M Goto
    Gamete Biology Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, 111 T W Alexander Drive, NC 27709, USA
    Hum Reprod 25:1884-94. 2010
    ..We previously identified speriolin as a spermatogenic cell-specific binding partner of Cdc20 that co-localizes with pericentrin in mouse spermatocytes and is present in the centrosome in round spermatids...
  35. ncbi request reprint Heat-shock cognate protein (hsc71) and related proteins in mouse spermatogenic cells
    M Maekawa
    Gamete Biology Section, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709
    Biol Reprod 40:843-52. 1989
    ..Although [35S]methionine was incorporated into the new proteins in condensing spermatids, hsc71, hsc74, and P70 were not labeled. These results suggest that unique heat-shock proteins are synthesized late in spermatogenesis...
  36. ncbi request reprint In situ localization of spermatogenic cell-specific glyceraldehyde 3-phosphate dehydrogenase (Gapd-s) messenger ribonucleic acid in mice
    C Mori
    Gamete Biology Section, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709
    Biol Reprod 46:859-68. 1992
    ....
  37. ncbi request reprint Haploinsufficiency of protamine-1 or -2 causes infertility in mice
    C Cho
    Gamete Biology Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA
    Nat Genet 28:82-6. 2001
    ..Our studies show that both protamines are essential and that haploinsufficiency caused by a mutation in one allele of Prm1 or Prm2 prevents genetic transmission of both mutant and wild-type alleles...
  38. pmc Expression of the gene for mouse lactate dehydrogenase C (Ldhc) is required for male fertility
    Fanny Odet
    Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Biol Reprod 79:26-34. 2008
    ..These studies showed that LDHC plays an essential role in maintenance of the processes of glycolysis and ATP production in the flagellum that are required for male fertility and sperm function...
  39. ncbi request reprint HSP70-2 is part of the synaptonemal complex in mouse and hamster spermatocytes
    J W Allen
    National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Chromosoma 104:414-21. 1996
    ..These findings are suggestive of a previously unsuspected sexual dimorphism in structure and/or function of the synaptonemal complex...
  40. pmc Cleavage of disulfide bonds in mouse spermatogenic cell-specific type 1 hexokinase isozyme is associated with increased hexokinase activity and initiation of sperm motility
    Noriko Nakamura
    Gamete Biology Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Biol Reprod 79:537-45. 2008
    ..These results strongly suggest that cleavage of disulfide bonds in HK1S dimers contributes to the increases in HK activity and motility that occur when mouse sperm become activated...
  41. ncbi request reprint Targeted disruption of the Akap4 gene causes defects in sperm flagellum and motility
    Kiyoshi Miki
    Gamete Biology Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences NIH, Research Triangle Park, NC 27709, USA
    Dev Biol 248:331-42. 2002
    ....
  42. pmc Ex3αERKO male infertility phenotype recapitulates the αERKO male phenotype
    Eugenia H Goulding
    Gamete Biology Group, Laboratory of Reproduction and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Endocrinol 207:281-8. 2010
    ....
  43. pmc Molecular complex of three testis-specific isozymes associated with the mouse sperm fibrous sheath: hexokinase 1, phosphofructokinase M, and glutathione S-transferase mu class 5
    Noriko Nakamura
    Gamete Biology Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Biol Reprod 82:504-15. 2010
    ..These results demonstrated that HK1S is tethered in the principal piece region by PFKMS, which in turn is bound tightly to GSTM5 in the FS...
  44. pmc A missense mutation in the Capza3 gene and disruption of F-actin organization in spermatids of repro32 infertile male mice
    Christopher B Geyer
    Laboratories of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, 111 T W Alexander Drive, Research Triangle Park, NC 27709, USA
    Dev Biol 330:142-52. 2009
    ....
  45. ncbi request reprint Cadmium at a non-toxic dose alters gene expression in mouse testes
    Tong Zhou
    Gamete Biology Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Toxicol Lett 154:191-200. 2004
    ..These results indicate that changes in gene expression occur well before overt effects of Cd-induced testicular toxicity and carcinogenicity are apparent...
  46. ncbi request reprint A-kinase anchoring protein 4 binding proteins in the fibrous sheath of the sperm flagellum
    Paula R Brown
    Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Biol Reprod 68:2241-8. 2003
    ..These results suggest that AKAP3 is involved in organizing the basic structure of the fibrous sheath, whereas AKAP4 has a major role in completing fibrous sheath assembly...
  47. ncbi request reprint Speriolin is a novel spermatogenic cell-specific centrosomal protein associated with the seventh WD motif of Cdc20
    Masuo Goto
    Gamete Biology Section, Laboratory of Reproductive and Developmental Toxicology, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 279:42128-38. 2004
    ....
  48. ncbi request reprint Identification and integrative analysis of 28 novel genes specifically expressed and developmentally regulated in murine spermatogenic cells
    Sungeun Hong
    Department of Life Science, Gwangju Institute of Science and Technology, Gwangju 500 712, Korea
    J Biol Chem 280:7685-93. 2005
    ..Thus, the study establishes on a comprehensive scale a new basis for studies to uncover molecular mechanisms underlying the reproductive process...
  49. ncbi request reprint Deficits in reproduction and pro-gonadotropin-releasing hormone processing in male Cpefat mice
    Sudha Srinivasan
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA
    Endocrinology 145:2023-34. 2004
    ..Together, these findings show that CPE is a key enzyme for pro-GnRH processing in vivo; however, the reproductive deficits in Cpe(fat/fat) males appear to be due primarily to abnormal sexual behavior...
  50. doi request reprint Bicarbonate-induced phosphorylation of p270 protein in mouse sperm by cAMP-dependent protein kinase
    Masako Kaneto
    Department of Cell and Developmental Biology, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599 7090, USA
    Mol Reprod Dev 75:1045-53. 2008
    ....
  51. ncbi request reprint The expression of calpain 1 and calpain 2 in spermatogenic cells and spermatozoa of the mouse
    Irit Ben-Aharon
    Department of Cell and Developmental Biology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Reproduction 129:435-42. 2005
    ..Thus, calpain, a pluripotential protease with numerous substrates, may serve as an effector in more than one pathway in the complex process of spermatogenesis and in the events preceding fertilization, such as the acrosome reaction...
  52. ncbi request reprint Sperm tail abnormalities in mutant mice with neo(r) gene insertion into an intron of the keratin 9 gene
    Eugene Rivkin
    Department of Cell Biology and Anatomical Sciences, The Sophie Davis School of Biomedical Education, The City University of New York Medical School, 138th Street and Convent Avenue, Harris Hall 306, New York, NY, USA
    Mol Reprod Dev 72:259-71. 2005
    ..Results of this study support the view that intron 6 influences the transcriptional efficiency of the K9 gene by decreasing production of wild-type K9 and changing the expression of K9 proteins...
  53. pmc Glyceraldehyde 3-phosphate dehydrogenase-S, a sperm-specific glycolytic enzyme, is required for sperm motility and male fertility
    Kiyoshi Miki
    Laboratories for Reproductive Biology, and Department of Cell and Developmental Biology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    Proc Natl Acad Sci U S A 101:16501-6. 2004
    ....
  54. ncbi request reprint Changes in intracellular distribution and activity of protein phosphatase PP1gamma2 and its regulating proteins in spermatozoa lacking AKAP4
    Zaohua Huang
    Department of Biological Sciences, Kent State University, Kent, Ohio 44242, USA
    Biol Reprod 72:384-92. 2005
    ..These studies have identified potentially significant new roles for the fibrous sheath in regulating the activity and function of key signaling enzymes...
  55. pmc Identification and characterization of Rhox13, a novel X-linked mouse homeobox gene
    Christopher B Geyer
    Gamete Biology Group, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, NIH, DHHS Research Triangle Park, NC 27709, USA
    Gene 423:194-200. 2008
    ..The Rhox13 gene encodes a 25.3 kDa protein expressed in the adult testis in germ cells at the basal aspect of the seminiferous epithelium...
  56. pmc Impaired sperm fertilizing ability in mice lacking Cysteine-RIch Secretory Protein 1 (CRISP1)
    Vanina G Da Ros
    Instituto de Biologia y Medicina Experimental CONICET, Vuelta de Obligado 2490, Buenos Aires, 1428, Argentina
    Dev Biol 320:12-8. 2008
    ..To our knowledge this is the first knockout mice generated for a CRISP protein. The information obtained might have important functional implications for other members of the widely distributed and evolutionarily conserved CRISP family...
  57. ncbi request reprint Protamine 2 deficiency leads to sperm DNA damage and embryo death in mice
    Chunghee Cho
    Department of Life Science, Kwangju Institute of Science and Technology K JIST, Kwangju 500 712, Republic of Korea
    Biol Reprod 69:211-7. 2003
    ..These findings suggest that development fails because of damage to paternal DNA and that PRM2 is crucial for maintaining the integrity of sperm chromatin...
  58. pmc Post-meiotic shifts in HSPA2/HSP70.2 chaperone activity during mouse spermatogenesis
    Jerome Govin
    INSERM, U309, Institut Albert Bonniot, F 38700 Grenoble, France
    J Biol Chem 281:37888-92. 2006
    ..Hence, HSPA2 is identified here as the first transition protein chaperone, and these data shed a new light on the yet totally unknown process of genome-condensing structure assembly in spermatids...