Hideki Ebihara

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc A Syrian golden hamster model recapitulating ebola hemorrhagic fever
    Hideki Ebihara
    Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NID, Rocky Mountain Laboratories RML, Hamilton, Montana 59840, USA
    J Infect Dis 207:306-18. 2013
  2. pmc Host response dynamics following lethal infection of rhesus macaques with Zaire ebolavirus
    Hideki Ebihara
    Laboratory of Virology, Rocky Mountain Veterinary Branch, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, Montana 59840, USA
    J Infect Dis 204:S991-9. 2011
  3. pmc Pathogenesis and host response in Syrian hamsters following intranasal infection with Andes virus
    David Safronetz
    Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, Montana, United States of America
    PLoS Pathog 7:e1002426. 2011
  4. pmc Protective efficacy of a bivalent recombinant vesicular stomatitis virus vaccine in the Syrian hamster model of lethal Ebola virus infection
    Yoshimi Tsuda
    Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA
    J Infect Dis 204:S1090-7. 2011
  5. pmc In vitro and in vivo activity of ribavirin against Andes virus infection
    David Safronetz
    Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America
    PLoS ONE 6:e23560. 2011
  6. pmc Characterization of the Bhanja serogroup viruses (Bunyaviridae): a novel species of the genus Phlebovirus and its relationship with other emerging tick-borne phleboviruses
    Keita Matsuno
    Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, Montana, USA
    J Virol 87:3719-28. 2013
  7. pmc Lethal Crimean-Congo hemorrhagic fever virus infection in interferon α/β receptor knockout mice is associated with high viral loads, proinflammatory responses, and coagulopathy
    Marko Zivcec
    Laboratory of Virology, Division of Intramural Research, National Institute Allergy and Infectious Disease, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, Montana, USA
    J Infect Dis 207:1909-21. 2013
  8. pmc Hamster-adapted Sin Nombre virus causes disseminated infection and efficiently replicates in pulmonary endothelial cells without signs of disease
    David Safronetz
    Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, Montana, USA
    J Virol 87:4778-82. 2013
  9. pmc The Ebola virus glycoprotein contributes to but is not sufficient for virulence in vivo
    Allison Groseth
    Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA
    PLoS Pathog 8:e1002847. 2012
  10. pmc Clinical outcome of henipavirus infection in hamsters is determined by the route and dose of infection
    Barry Rockx
    Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA
    J Virol 85:7658-71. 2011

Collaborators

Detail Information

Publications22

  1. pmc A Syrian golden hamster model recapitulating ebola hemorrhagic fever
    Hideki Ebihara
    Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NID, Rocky Mountain Laboratories RML, Hamilton, Montana 59840, USA
    J Infect Dis 207:306-18. 2013
    ....
  2. pmc Host response dynamics following lethal infection of rhesus macaques with Zaire ebolavirus
    Hideki Ebihara
    Laboratory of Virology, Rocky Mountain Veterinary Branch, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, Montana 59840, USA
    J Infect Dis 204:S991-9. 2011
    ..These results highlight the pathological analogies between EHF and severe sepsis and not only contribute to our understanding of the pathogenic process, but will also help to establish novel postexposure treatment modalities...
  3. pmc Pathogenesis and host response in Syrian hamsters following intranasal infection with Andes virus
    David Safronetz
    Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, Montana, United States of America
    PLoS Pathog 7:e1002426. 2011
    ....
  4. pmc Protective efficacy of a bivalent recombinant vesicular stomatitis virus vaccine in the Syrian hamster model of lethal Ebola virus infection
    Yoshimi Tsuda
    Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA
    J Infect Dis 204:S1090-7. 2011
    ..Outbreaks of filoviral hemorrhagic fever occur sporadically and unpredictably across wide regions in central Africa and overlap with the occurrence of other infectious diseases of public health importance...
  5. pmc In vitro and in vivo activity of ribavirin against Andes virus infection
    David Safronetz
    Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America
    PLoS ONE 6:e23560. 2011
    ....
  6. pmc Characterization of the Bhanja serogroup viruses (Bunyaviridae): a novel species of the genus Phlebovirus and its relationship with other emerging tick-borne phleboviruses
    Keita Matsuno
    Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, Montana, USA
    J Virol 87:3719-28. 2013
    ..The results of this study should facilitate epidemiological surveillance for other, similar tick-borne phleboviruses that may represent unrecognized causes of febrile illness in humans...
  7. pmc Lethal Crimean-Congo hemorrhagic fever virus infection in interferon α/β receptor knockout mice is associated with high viral loads, proinflammatory responses, and coagulopathy
    Marko Zivcec
    Laboratory of Virology, Division of Intramural Research, National Institute Allergy and Infectious Disease, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, Montana, USA
    J Infect Dis 207:1909-21. 2013
    ..Disease progression closely mimics hallmarks of human CCHF disease, making IFNAR(-/-) mice an excellent choice to assess medical countermeasures...
  8. pmc Hamster-adapted Sin Nombre virus causes disseminated infection and efficiently replicates in pulmonary endothelial cells without signs of disease
    David Safronetz
    Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, Montana, USA
    J Virol 87:4778-82. 2013
    ..We found that a host-adapted SNV achieves prolonged and disseminated infection in hamsters, including efficient replication in pulmonary endothelial cells, albeit without signs of disease...
  9. pmc The Ebola virus glycoprotein contributes to but is not sufficient for virulence in vivo
    Allison Groseth
    Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA
    PLoS Pathog 8:e1002847. 2012
    ..Thus, while these findings provide direct evidence that GP contributes to filovirus virulence in vivo, they also clearly indicate that other factors are needed for the acquisition of full virulence...
  10. pmc Clinical outcome of henipavirus infection in hamsters is determined by the route and dose of infection
    Barry Rockx
    Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA
    J Virol 85:7658-71. 2011
    ....
  11. pmc Ebola virus RNA editing depends on the primary editing site sequence and an upstream secondary structure
    Masfique Mehedi
    Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada Laboratory of Virology, Rocky Mountain Laboratories, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America
    PLoS Pathog 9:e1003677. 2013
    ..Overall, our results provide novel insights into the RNA editing mechanism of EBOV, further understanding of which might result in novel intervention strategies against this viral pathogen. ..
  12. pmc Validation of assays to monitor immune responses in the Syrian golden hamster (Mesocricetus auratus)
    Marko Zivcec
    Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA
    J Immunol Methods 368:24-35. 2011
    ..Ribosomal protein L18 was identified as the most stable internal reference gene. In conclusion, these new assays will greatly improve the use of the hamster as an important small animal model in infectious disease research...
  13. pmc The Syrian hamster model of hantavirus pulmonary syndrome
    David Safronetz
    Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 South 4th Street, Hamilton, MT 59840, USA
    Antiviral Res 95:282-92. 2012
    ..The purpose of this article is to review the current understanding of HPS disease progression in Syrian hamsters and discuss the suitability of utilizing this model to evaluate potential medical countermeasures against HPS...
  14. pmc Vesicular stomatitis virus-based Ebola vaccines with improved cross-protective efficacy
    Andrea Marzi
    Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institute of Health, Hamilton, Montana 59840, USA
    J Infect Dis 204:S1066-74. 2011
    ..Our data demonstrate that cross-protection between the EBOV species can be achieved, although EBOV-GP alone cannot induce the required immune response...
  15. pmc Pandemic swine-origin H1N1 influenza A virus isolates show heterogeneous virulence in macaques
    David Safronetz
    Laboratory of Virology, Hamilton, Montana, USA
    J Virol 85:1214-23. 2011
    ..Differences in virulence may explain more severe disease, as was seen with certain individuals infected with the emerged pandemic influenza virus. Thus, the nonhuman primate model closely mimics influenza in humans...
  16. pmc New World hantaviruses activate IFNlambda production in type I IFN-deficient vero E6 cells
    Joseph Prescott
    Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Disease, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, Montana, USA
    PLoS ONE 5:e11159. 2010
    ..Interferon lambda, a more recently characterized type III IFN, is transcriptionally controlled much like the type I IFNs, and activates the innate immune system in a similar manner...
  17. pmc Proposal for a revised taxonomy of the family Filoviridae: classification, names of taxa and viruses, and virus abbreviations
    Jens H Kuhn
    Integrated Research Facility at Fort Detrick, Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, National Interagency Biodefense Campus, B 8200 Research Plaza, Fort Detrick, Frederick, MD 21702, USA
    Arch Virol 155:2083-103. 2010
    ..Furthermore, we explain the etymological derivation of individual names, their pronunciation, and their correct use, and we elaborate on demarcation criteria for each taxon and virus...
  18. pmc Use of the Syrian hamster as a new model of ebola virus disease and other viral hemorrhagic fevers
    Victoria Wahl-Jensen
    Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, National Interagency Biodefense Campus, B 8200 Research Plaza, Fort Detrick, Frederick, Maryland 21702, USA
    Viruses 4:3754-84. 2012
    ..Availability of immunological reagents is addressed. Salient features of EVD in hamsters, including relevant pathology and coagulation parameters, are compared directly with the mouse, guinea pig and nonhuman primate models...
  19. pmc Vesicular stomatitis virus-based vaccine protects hamsters against lethal challenge with Andes virus
    Kyle S Brown
    Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada
    J Virol 85:12781-91. 2011
    ..Overall, our data suggest the potential for the use of the VSV platform as a fast-acting and effective prophylaxis/postexposure treatment against lethal hantavirus infections...
  20. pmc Complete genome sequencing of four geographically diverse strains of Batai virus
    Allison Groseth
    Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA
    J Virol 86:13844-5. 2012
    ..Based on these data, we have determined that strain MS50 is in fact unrelated to BATV and likely represents as a novel genotype in the genus Orthobunyavirus...
  21. pmc Antagonism of type I interferon responses by new world hantaviruses
    Jessica R Levine
    Rocky Mountain Laboratories, Hamilton, MT 59840, USA
    J Virol 84:11790-801. 2010
    ..These data suggest that IFN antagonism strategies by hantaviruses are quite variable, even between species with similar disease phenotypes, and may help to better elucidate species-specific pathogenesis...
  22. pmc Complete genome sequencing of mosquito and human isolates of Ngari virus
    Allison Groseth
    Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA
    J Virol 86:13846-7. 2012
    ..Based on an analysis of these sequence data, NRIVs are clearly genetically distinct from all known BUNV and BATV strains but are very closely related to one another regardless of their source...