Kimberly D Dyer

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc IL-33 promotes eosinophilia in vivo and antagonizes IL-5-dependent eosinophil hematopoiesis ex vivo
    Kimberly D Dyer
    Inflammation Immunobiology Section of the Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1883, USA
    Immunol Lett 150:41-7. 2013
  2. pmc The Pneumonia Virus of Mice (PVM) model of acute respiratory infection
    Kimberly D Dyer
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Viruses 4:3494-510. 2012
  3. pmc Interferon-gamma coordinates CCL3-mediated neutrophil recruitment in vivo
    Cynthia A Bonville
    SUNY Upstate Medical University, Syracuse, New York 13210, USA
    BMC Immunol 10:14. 2009
  4. ncbi request reprint Eosinophils from lineage-ablated Delta dblGATA bone marrow progenitors: the dblGATA enhancer in the promoter of GATA-1 is not essential for differentiation ex vivo
    Kimberly D Dyer
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases National Institutes of Health NIAID NIH, Bethesda, MD 20892, USA
    J Immunol 179:1693-9. 2007
  5. pmc Efficient replication of pneumonia virus of mice (PVM) in a mouse macrophage cell line
    Kimberly D Dyer
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Virol J 4:48. 2007
  6. pmc Functionally competent eosinophils differentiated ex vivo in high purity from normal mouse bone marrow
    Kimberly D Dyer
    Eosinophil Biology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 181:4004-9. 2008
  7. pmc Pneumoviruses infect eosinophils and elicit MyD88-dependent release of chemoattractant cytokines and interleukin-6
    Kimberly D Dyer
    Eosinophil Biology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, Bethesda, MD, USA
    Blood 114:2649-56. 2009
  8. pmc Antigen profiles for the quantitative assessment of eosinophils in mouse tissues by flow cytometry
    Kimberly D Dyer
    Eosinophil Biology Section, Laboratory of Allergic Diseases, NIAID, NIH Bethesda, MD, United States
    J Immunol Methods 369:91-7. 2011
  9. pmc Defective eosinophil hematopoiesis ex vivo in inbred Rocky Mountain White (IRW) mice
    Kimberly D Dyer
    Eosinophil Biology Section, Laboratory of Allergic Diseases, National Institute of Allergy andInfectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    J Leukoc Biol 90:1101-9. 2011
  10. pmc Mouse and human eosinophils degranulate in response to platelet-activating factor (PAF) and lysoPAF via a PAF-receptor-independent mechanism: evidence for a novel receptor
    Kimberly D Dyer
    Section of Eosinophil Biology, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1883, USA
    J Immunol 184:6327-34. 2010

Collaborators

Detail Information

Publications42

  1. pmc IL-33 promotes eosinophilia in vivo and antagonizes IL-5-dependent eosinophil hematopoiesis ex vivo
    Kimberly D Dyer
    Inflammation Immunobiology Section of the Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1883, USA
    Immunol Lett 150:41-7. 2013
    ..These findings suggest that the direct actions of IL-33 on bone marrow progenitors primed with SCF and Flt3L are antagonistic to the actions of IL-5 and are mediated in part by GM-CSF...
  2. pmc The Pneumonia Virus of Mice (PVM) model of acute respiratory infection
    Kimberly D Dyer
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Viruses 4:3494-510. 2012
    ....
  3. pmc Interferon-gamma coordinates CCL3-mediated neutrophil recruitment in vivo
    Cynthia A Bonville
    SUNY Upstate Medical University, Syracuse, New York 13210, USA
    BMC Immunol 10:14. 2009
    ....
  4. ncbi request reprint Eosinophils from lineage-ablated Delta dblGATA bone marrow progenitors: the dblGATA enhancer in the promoter of GATA-1 is not essential for differentiation ex vivo
    Kimberly D Dyer
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases National Institutes of Health NIAID NIH, Bethesda, MD 20892, USA
    J Immunol 179:1693-9. 2007
    ....
  5. pmc Efficient replication of pneumonia virus of mice (PVM) in a mouse macrophage cell line
    Kimberly D Dyer
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Virol J 4:48. 2007
    ....
  6. pmc Functionally competent eosinophils differentiated ex vivo in high purity from normal mouse bone marrow
    Kimberly D Dyer
    Eosinophil Biology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 181:4004-9. 2008
    ..Finally, differentiating bmEos are readily transfected with lentiviral vectors, suggesting a means for rapid production of genetically manipulated cells...
  7. pmc Pneumoviruses infect eosinophils and elicit MyD88-dependent release of chemoattractant cytokines and interleukin-6
    Kimberly D Dyer
    Eosinophil Biology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, Bethesda, MD, USA
    Blood 114:2649-56. 2009
    ..Taken together, our findings suggest that eosinophils are targets of virus infection and may have varied and complex contributions to the pathogenesis and resolution of pneumovirus disease...
  8. pmc Antigen profiles for the quantitative assessment of eosinophils in mouse tissues by flow cytometry
    Kimberly D Dyer
    Eosinophil Biology Section, Laboratory of Allergic Diseases, NIAID, NIH Bethesda, MD, United States
    J Immunol Methods 369:91-7. 2011
    ....
  9. pmc Defective eosinophil hematopoiesis ex vivo in inbred Rocky Mountain White (IRW) mice
    Kimberly D Dyer
    Eosinophil Biology Section, Laboratory of Allergic Diseases, National Institute of Allergy andInfectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    J Leukoc Biol 90:1101-9. 2011
    ..These results suggest that IRW mice have diminished capacity to generate eosinophils in culture and in vivo, likely as a result of diminished signaling via IL-5Rα...
  10. pmc Mouse and human eosinophils degranulate in response to platelet-activating factor (PAF) and lysoPAF via a PAF-receptor-independent mechanism: evidence for a novel receptor
    Kimberly D Dyer
    Section of Eosinophil Biology, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1883, USA
    J Immunol 184:6327-34. 2010
    ....
  11. pmc The mouse RNase 4 and RNase 5/ang 1 locus utilizes dual promoters for tissue-specific expression
    Kimberly D Dyer
    Laboratory of Allergic Diseases NIAID, NIH, Bethesda, MD 20892, USA
    Nucleic Acids Res 33:1077-86. 2005
    ....
  12. ncbi request reprint Receptor-bound uPA is reversibly protected from inhibition by low molecular weight inhibitors
    Kimberly D Dyer
    Laboratory of Host Defenses, NIAID, Bethesda, MD 20892 1886, USA
    Cell Biol Int 26:327-35. 2002
    ....
  13. ncbi request reprint Identification of a purine-rich intronic enhancer element in the mouse eosinophil-associated ribonuclease 2 (mEar 2) gene
    Kimberly D Dyer
    Eosinophil Pathophysiology Section, LHD, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mamm Genome 15:126-34. 2004
    ..Similar intronic enhancers have been described as regulating transcription of the human EDN gene, suggesting an overall conservation of an important regulatory strategy...
  14. ncbi request reprint Isolation, characterization, and evolutionary divergence of mouse RNase 6: evidence for unusual evolution in rodents
    Kimberly D Dyer
    Eosinophil Biology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Mol Evol 59:657-65. 2004
    ..66. These data suggest that the ancestral rodent RNase 6 was subject to accelerated evolution, resulting in the conserved modern gene, which most likely plays an important role in mouse physiology...
  15. ncbi request reprint Interleukin-5 does not influence differential transcription of transmembrane and soluble isoforms of IL-5R alpha in vivo
    Jonas Bystrom
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1883, USA
    Eur J Haematol 77:181-90. 2006
    ..Two variants encoding soluble forms of the alpha subunit (sIL-5R alpha) have been described, although the signals promoting and/or limiting differential transcription remain to be clarified...
  16. pmc Schistosoma mansoni infection in eosinophil lineage-ablated mice
    Jonathan M Swartz
    Laboratory of Allergic Diseases, NIAID, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892 1883, USA
    Blood 108:2420-7. 2006
    ..However, eosinophils may have unexplored immunomodulatory contributions to this disease process...
  17. pmc Activated mouse eosinophils protect against lethal respiratory virus infection
    Caroline M Percopo
    Inflammation Immunobiology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD
    Blood 123:743-52. 2014
    ..Thus, although activated eosinophils within a Th2-polarized inflammatory response may have pathophysiologic features, they are also efficient and effective mediators of antiviral host defense. ..
  18. ncbi request reprint Inflammatory responses to pneumovirus infection in IFN-alpha beta R gene-deleted mice
    Tara L Garvey
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 175:4735-44. 2005
    ....
  19. pmc B cells are not essential for Lactobacillus-mediated protection against lethal pneumovirus infection
    Caroline M Percopo
    Inflammation Immunobiology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892
    J Immunol 192:5265-72. 2014
    ..We conclude that B cells are dispensable for Lactobacillus-mediated heterologous immunity and were not crucial for promoting survival in response to an otherwise lethal pneumovirus infection. ..
  20. pmc Novel pneumoviruses (PnVs): Evolution and inflammatory pathology
    Stephanie F Glineur
    Inflammation Immunobiology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1883, USA
    Virology 443:257-64. 2013
    ....
  21. pmc Lactobacillus-mediated priming of the respiratory mucosa protects against lethal pneumovirus infection
    Stanislaw J Gabryszewski
    Eosinophil Biology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 186:1151-61. 2011
    ..In summary, we have identified and characterized an effective Lactobacillus-mediated innate immune shield, which may ultimately serve as critical and long-term protection against infection in the absence of specific antiviral vaccines...
  22. ncbi request reprint Evolution and function of leukocyte RNase A ribonucleases of the avian species, Gallus gallus
    Takeaki Nitto
    Laboratory of Allergic Diseases and Research Technologies Branch, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 281:25622-34. 2006
    ....
  23. ncbi request reprint Diminished expression of an antiviral ribonuclease in response to pneumovirus infection in vivo
    Joanne M Moreau
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10, Room 11N104, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Antiviral Res 59:181-91. 2003
    ..We propose that this mechanism may represent a novel virus-mediated evasion strategy, with a mechanism that is linked in some fashion to virus-specific pathogenicity...
  24. pmc Lactobacillus priming of the respiratory tract: Heterologous immunity and protection against lethal pneumovirus infection
    Katia E Garcia-Crespo
    Inflammation Immunobiology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Antiviral Res 97:270-9. 2013
    ..Overall, further evaluation of the responses leading to Lactobacillus-mediated heterologous immunity may provide insight into novel antiviral preventive modalities...
  25. pmc Canine pneumovirus replicates in mouse lung tissue and elicits inflammatory pathology
    Caroline M Percopo
    Laboratory of Allergic Diseases, NIAID, NIH, Bethesda, MD 20892, USA
    Virology 416:26-31. 2011
    ..Given these findings, it will be intriguing to determine the relative role(s) of CnPnV and PVM in eliciting respiratory symptoms in susceptible canine species...
  26. doi request reprint Protocols for identifying, enumerating, and assessing mouse eosinophils
    Kimberly D Dyer
    Inflammation Immunobiology Section, Laboratory of Allergic Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Methods Mol Biol 1032:59-77. 2013
    ..Overall, these protocols provide a scaffold on which the relative contributions of mouse eosinophils can be evaluated. ..
  27. pmc RNase 1 genes from the family Sciuridae define a novel rodent ribonuclease cluster
    Steven J Siegel
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA
    Mamm Genome 20:749-57. 2009
    ..The full significance of these findings awaits a more complete understanding of biological role of mammalian RNase 1s...
  28. ncbi request reprint The RNase a superfamily: generation of diversity and innate host defense
    Kimberly D Dyer
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Divers 10:585-97. 2006
    ..190 words)...
  29. doi request reprint Eosinophils: changing perspectives in health and disease
    Helene F Rosenberg
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Rev Immunol 13:9-22. 2013
    ....
  30. pmc Eosinophils and their interactions with respiratory virus pathogens
    Helene F Rosenberg
    Eosinophil Biology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10, Room 11C215, Bethesda, MD 20892, USA
    Immunol Res 43:128-37. 2009
    ..Interestingly, PVM replicates in eosinophils and promotes cytokine release. The molecular basis of virus infection in eosinophils and its relationship to disease outcome is currently under study...
  31. pmc Chemotaxis of bone marrow derived eosinophils in vivo: a novel method to explore receptor-dependent trafficking in the mouse
    Eva M Sturm
    Inflammation Immunobiology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Eur J Immunol 43:2217-28. 2013
    ..Thus, this chemotaxis model represents a novel and robust tool for pharmacological studies in vivo. ..
  32. pmc Genetic diversity of human RNase 8
    Calvin C Chan
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    BMC Genomics 13:40. 2012
    ....
  33. ncbi request reprint Eosinophil-derived neurotoxin (EDN), an antimicrobial protein with chemotactic activities for dendritic cells
    De Yang
    Basic Research Program, SAIC Frederick, Laboratory of Molecular Regulation, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bldg 560, Rm 31 19, Frederick, MD 21702 1201, USA
    Blood 102:3396-403. 2003
    ..Thus, EDN and its mouse ortholog, mEAR2, are eosinophil granule-derived antimicrobial RNases that function as chemoattractants for DCs in vitro and in vivo...
  34. ncbi request reprint Plasminogen activator inhibitor-2 (PAI-2) in eosinophilic leukocytes
    Jonathan M Swartz
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Leukoc Biol 76:812-9. 2004
    ....
  35. pmc GATA transcription factors regulate the expression of the human eosinophil-derived neurotoxin (RNase 2) gene
    Zhijun Qiu
    Laboratory of Allergic Diseases, NIAID, NIH, Bethesda, MD 20892, USA
    J Biol Chem 284:13099-109. 2009
    ..Taken together, our data suggest that GATA-2 functions directly via interactions with the EDN promoter and also indirectly, via its ability to regulate the expression of GATA-1 in differentiating eosinophils and eosinophil cell lines...
  36. pmc Respiratory viruses and eosinophils: exploring the connections
    Helene F Rosenberg
    Eosinophil Biology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Antiviral Res 83:1-9. 2009
    ..Lastly, we consider the data that focus on the role of eosinophils in promoting virus clearance and antiviral host defense, and conclude with a recent study that explores the role of eosinophils themselves as targets of virus infection...
  37. ncbi request reprint Characterization of a ribonuclease gene and encoded protein from the reptile, Iguana iguana
    Takeaki Nitto
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, United States
    Gene 352:36-44. 2005
    ..Further analysis of ribonucleases from non-mammalian vertebrate species is needed in order to define relationships and lineages within the larger RNase A gene superfamily...
  38. ncbi request reprint Eosinophils and Respiratory Virus Infection: A Dual-Standard Curve qRT-PCR-Based Method for Determining Virus Recovery from Mouse Lung Tissue
    Caroline M Percopo
    Inflammation Immunobiology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, 20892, Bethesda, MD, USA
    Methods Mol Biol 1178:257-66. 2014
    ..We have used this assay to evaluate eosinophil-mediated antiviral host defense in mouse models of cytokine and antigen-driven eosinophilic inflammation. ..
  39. pmc KIT GNNK splice variants: expression in systemic mastocytosis and influence on the activating potential of the D816V mutation in mast cells
    Eunice Ching Chan
    Mast Cell Biology Section, Laboratory of Allergic Diseases, Bethesda, MD, USA
    Exp Hematol 41:870-881.e2. 2013
    ..These data suggest that neoplastic mast cells favor a GNNK(-) variant predominance, which in turn enhances the activating potential of the KIT D816V mutation and thus could influence therapeutic sensitivity in systemic mastocytosis. ..
  40. pmc RNase 8, a novel RNase A superfamily ribonuclease expressed uniquely in placenta
    Jianzhi Zhang
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Nucleic Acids Res 30:1169-75. 2002
    ..The rapid evolution, species-limited deactivation and tissue-specific expression of RNase 8 suggest a unique physiological function and reiterates the evolutionary plasticity of the RNase A superfamily...
  41. pmc Isolation of human eosinophils: microbead method has no impact on IL-5 sustained viability
    Caroline M Percopo
    Eosinophil Biology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Exp Dermatol 19:467-9. 2010
    ..No differential survival was observed. While appropriate consideration of methods is always crucial, multi-antibody eosinophil isolation should not be abandoned completely...
  42. pmc Human RNase 7: a new cationic ribonuclease of the RNase A superfamily
    Jianzhi Zhang
    Department of Ecology and Evolutionary Biology, University of Michigan, 3003 Natural Science Building, 830 North University Avenue, Ann Arbor, MI 48109, USA
    Nucleic Acids Res 31:602-7. 2003
    ....