Research Topics
Genomes and Genes
Species | Kimberly D DyerSummaryAffiliation: National Institutes of Health Country: USA Publications
| Collaborators
|
Detail Information
Publications
The Pneumonia Virus of Mice (PVM) model of acute respiratory infectionKimberly D Dyer
Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Viruses 4:3494-510. 2012....- Interferon-gamma coordinates CCL3-mediated neutrophil recruitment in vivoCynthia A Bonville
SUNY Upstate Medical University, Syracuse, New York 13210, USA
BMC Immunol 10:14. 2009.... - Defective eosinophil hematopoiesis ex vivo in inbred Rocky Mountain White (IRW) miceKimberly D Dyer
Eosinophil Biology Section, Laboratory of Allergic Diseases, National Institute of Allergy andInfectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
J Leukoc Biol 90:1101-9. 2011..These results suggest that IRW mice have diminished capacity to generate eosinophils in culture and in vivo, likely as a result of diminished signaling via IL-5Rα... - Antigen profiles for the quantitative assessment of eosinophils in mouse tissues by flow cytometryKimberly D Dyer
Eosinophil Biology Section, Laboratory of Allergic Diseases, NIAID, NIH Bethesda, MD, United States
J Immunol Methods 369:91-7. 2011.... - Mouse and human eosinophils degranulate in response to platelet-activating factor (PAF) and lysoPAF via a PAF-receptor-independent mechanism: evidence for a novel receptorKimberly D Dyer
Section of Eosinophil Biology, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1883, USA
J Immunol 184:6327-34. 2010.... - Pneumoviruses infect eosinophils and elicit MyD88-dependent release of chemoattractant cytokines and interleukin-6Kimberly D Dyer
Eosinophil Biology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, Bethesda, MD, USA
Blood 114:2649-56. 2009..Taken together, our findings suggest that eosinophils are targets of virus infection and may have varied and complex contributions to the pathogenesis and resolution of pneumovirus disease... - Functionally competent eosinophils differentiated ex vivo in high purity from normal mouse bone marrowKimberly D Dyer
Eosinophil Biology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 181:4004-9. 2008..Finally, differentiating bmEos are readily transfected with lentiviral vectors, suggesting a means for rapid production of genetically manipulated cells... 
Eosinophils from lineage-ablated Delta dblGATA bone marrow progenitors: the dblGATA enhancer in the promoter of GATA-1 is not essential for differentiation ex vivoKimberly D Dyer
Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases National Institutes of Health NIAID NIH, Bethesda, MD 20892, USA
J Immunol 179:1693-9. 2007....
Efficient replication of pneumonia virus of mice (PVM) in a mouse macrophage cell lineKimberly D Dyer
Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Virol J 4:48. 2007....- Receptor-bound uPA is reversibly protected from inhibition by low molecular weight inhibitorsKimberly D Dyer
Laboratory of Host Defenses, NIAID, Bethesda, MD 20892 1886, USA
Cell Biol Int 26:327-35. 2002.... - Identification of a purine-rich intronic enhancer element in the mouse eosinophil-associated ribonuclease 2 (mEar 2) geneKimberly D Dyer
Eosinophil Pathophysiology Section, LHD, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
Mamm Genome 15:126-34. 2004..Similar intronic enhancers have been described as regulating transcription of the human EDN gene, suggesting an overall conservation of an important regulatory strategy... - Isolation, characterization, and evolutionary divergence of mouse RNase 6: evidence for unusual evolution in rodentsKimberly D Dyer
Eosinophil Biology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Mol Evol 59:657-65. 2004..66. These data suggest that the ancestral rodent RNase 6 was subject to accelerated evolution, resulting in the conserved modern gene, which most likely plays an important role in mouse physiology... - The mouse RNase 4 and RNase 5/ang 1 locus utilizes dual promoters for tissue-specific expressionKimberly D Dyer
Laboratory of Allergic Diseases NIAID, NIH, Bethesda, MD 20892, USA
Nucleic Acids Res 33:1077-86. 2005.... - Interleukin-5 does not influence differential transcription of transmembrane and soluble isoforms of IL-5R alpha in vivoJonas Bystrom
Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1883, USA
Eur J Haematol 77:181-90. 2006..Two variants encoding soluble forms of the alpha subunit (sIL-5R alpha) have been described, although the signals promoting and/or limiting differential transcription remain to be clarified... - Schistosoma mansoni infection in eosinophil lineage-ablated miceJonathan M Swartz
Laboratory of Allergic Diseases, NIAID, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892 1883, USA
Blood 108:2420-7. 2006..However, eosinophils may have unexplored immunomodulatory contributions to this disease process... - Inflammatory responses to pneumovirus infection in IFN-alpha beta R gene-deleted miceTara L Garvey
Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 175:4735-44. 2005.... - Diminished expression of an antiviral ribonuclease in response to pneumovirus infection in vivoJoanne M Moreau
Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10, Room 11N104, 9000 Rockville Pike, Bethesda, MD 20892, USA
Antiviral Res 59:181-91. 2003..We propose that this mechanism may represent a novel virus-mediated evasion strategy, with a mechanism that is linked in some fashion to virus-specific pathogenicity... - Evolution and function of leukocyte RNase A ribonucleases of the avian species, Gallus gallusTakeaki Nitto
Laboratory of Allergic Diseases and Research Technologies Branch, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 281:25622-34. 2006.... - Lactobacillus-mediated priming of the respiratory mucosa protects against lethal pneumovirus infectionStanislaw J Gabryszewski
Eosinophil Biology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 186:1151-61. 2011..In summary, we have identified and characterized an effective Lactobacillus-mediated innate immune shield, which may ultimately serve as critical and long-term protection against infection in the absence of specific antiviral vaccines... - Canine pneumovirus replicates in mouse lung tissue and elicits inflammatory pathologyCaroline M Percopo
Laboratory of Allergic Diseases, NIAID, NIH, Bethesda, MD 20892, USA
Virology 416:26-31. 2011..Given these findings, it will be intriguing to determine the relative role(s) of CnPnV and PVM in eliciting respiratory symptoms in susceptible canine species... - The RNase a superfamily: generation of diversity and innate host defenseKimberly D Dyer
Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Mol Divers 10:585-97. 2006..190 words)... - RNase 1 genes from the family Sciuridae define a novel rodent ribonuclease clusterSteven J Siegel
Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA
Mamm Genome 20:749-57. 2009..The full significance of these findings awaits a more complete understanding of biological role of mammalian RNase 1s... - Eosinophils and their interactions with respiratory virus pathogensHelene F Rosenberg
Eosinophil Biology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10, Room 11C215, Bethesda, MD 20892, USA
Immunol Res 43:128-37. 2009..Interestingly, PVM replicates in eosinophils and promotes cytokine release. The molecular basis of virus infection in eosinophils and its relationship to disease outcome is currently under study... 
Eosinophils: changing perspectives in health and diseaseHelene F Rosenberg
Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Nat Rev Immunol 13:9-22. 2013....- Genetic diversity of human RNase 8Calvin C Chan
Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
BMC Genomics 13:40. 2012.... - Eosinophil-derived neurotoxin (EDN), an antimicrobial protein with chemotactic activities for dendritic cellsDe Yang
Basic Research Program, SAIC Frederick, Laboratory of Molecular Regulation, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bldg 560, Rm 31 19, Frederick, MD 21702 1201, USA
Blood 102:3396-403. 2003..Thus, EDN and its mouse ortholog, mEAR2, are eosinophil granule-derived antimicrobial RNases that function as chemoattractants for DCs in vitro and in vivo... - GATA transcription factors regulate the expression of the human eosinophil-derived neurotoxin (RNase 2) geneZhijun Qiu
Laboratory of Allergic Diseases, NIAID, NIH, Bethesda, MD 20892, USA
J Biol Chem 284:13099-109. 2009..Taken together, our data suggest that GATA-2 functions directly via interactions with the EDN promoter and also indirectly, via its ability to regulate the expression of GATA-1 in differentiating eosinophils and eosinophil cell lines... - Plasminogen activator inhibitor-2 (PAI-2) in eosinophilic leukocytesJonathan M Swartz
Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Leukoc Biol 76:812-9. 2004.... - Characterization of a ribonuclease gene and encoded protein from the reptile, Iguana iguanaTakeaki Nitto
Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, United States
Gene 352:36-44. 2005..Further analysis of ribonucleases from non-mammalian vertebrate species is needed in order to define relationships and lineages within the larger RNase A gene superfamily... - Respiratory viruses and eosinophils: exploring the connectionsHelene F Rosenberg
Eosinophil Biology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Antiviral Res 83:1-9. 2009..Lastly, we consider the data that focus on the role of eosinophils in promoting virus clearance and antiviral host defense, and conclude with a recent study that explores the role of eosinophils themselves as targets of virus infection... - Isolation of human eosinophils: microbead method has no impact on IL-5 sustained viabilityCaroline M Percopo
Eosinophil Biology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
Exp Dermatol 19:467-9. 2010..No differential survival was observed. While appropriate consideration of methods is always crucial, multi-antibody eosinophil isolation should not be abandoned completely... - RNase 8, a novel RNase A superfamily ribonuclease expressed uniquely in placentaJianzhi Zhang
Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Nucleic Acids Res 30:1169-75. 2002..The rapid evolution, species-limited deactivation and tissue-specific expression of RNase 8 suggest a unique physiological function and reiterates the evolutionary plasticity of the RNase A superfamily... - Human RNase 7: a new cationic ribonuclease of the RNase A superfamilyJianzhi Zhang
Department of Ecology and Evolutionary Biology, University of Michigan, 3003 Natural Science Building, 830 North University Avenue, Ann Arbor, MI 48109, USA
Nucleic Acids Res 31:602-7. 2003....