J K Dunnick

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. doi request reprint The toxicity and pathology of selected dietary herbal medicines
    June K Dunnick
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 41:374-86. 2013
  2. doi request reprint Characterization of polybrominated diphenyl ether toxicity in Wistar Han rats and use of liver microarray data for predicting disease susceptibilities
    June K Dunnick
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 40:93-106. 2012
  3. ncbi request reprint Bis(2-chloroethoxy)methane-induced mitochondrial and myofibrillar damage: short-term time-course study
    June Dunnick
    Environmental Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Toxicol Sci 81:243-52. 2004
  4. ncbi request reprint Cardiac damage in rodents after exposure to bis(2-chloroethoxy)methane
    June K Dunnick
    Environmental Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 32:309-17. 2004
  5. ncbi request reprint Critical pathways in heart function: bis(2-chloroethoxy)methane-induced heart gene transcript change in F344 rats
    J Dunnick
    National Institutes of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Toxicol Pathol 34:348-56. 2006
  6. pmc Inclusion of biomarkers for detecting perturbations in the heart and lung and lipid/carbohydrate metabolism in National Toxicology Program studies
    June K Dunnick
    National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 100:29-35. 2007
  7. pmc Cardiotoxicity of Ma Huang/caffeine or ephedrine/caffeine in a rodent model system
    J K Dunnick
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 35:657-64. 2007
  8. pmc Characterization of liver toxicity in F344/N rats and B6C3F1 mice after exposure to a flame retardant containing lower molecular weight polybrominated diphenyl ethers
    June K Dunnick
    National Institute of Environmental Health Sciences, Research Triangle Park, P O Box 12233, NC 27709, USA
    Exp Toxicol Pathol 61:1-12. 2009
  9. doi request reprint Investigating the potential for toxicity from long-term use of the herbal products, goldenseal and milk thistle
    June K Dunnick
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
    Toxicol Pathol 39:398-409. 2011
  10. ncbi request reprint Carcinogenic potential of o-nitrotoluene and p-nitrotoluene
    June K Dunnick
    National Institute of Environmental Health Sciences, National Institutes of Health, 111 T W Alexander Drive, P O Box 12233, Research Triangle Park, NC 27709, USA
    Toxicology 183:221-34. 2003

Detail Information

Publications27

  1. doi request reprint The toxicity and pathology of selected dietary herbal medicines
    June K Dunnick
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 41:374-86. 2013
    ....
  2. doi request reprint Characterization of polybrominated diphenyl ether toxicity in Wistar Han rats and use of liver microarray data for predicting disease susceptibilities
    June K Dunnick
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 40:93-106. 2012
    ....
  3. ncbi request reprint Bis(2-chloroethoxy)methane-induced mitochondrial and myofibrillar damage: short-term time-course study
    June Dunnick
    Environmental Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Toxicol Sci 81:243-52. 2004
    ....
  4. ncbi request reprint Cardiac damage in rodents after exposure to bis(2-chloroethoxy)methane
    June K Dunnick
    Environmental Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 32:309-17. 2004
    ..CEM is metabolized to thiodiglycolic acid, a chemical that causes mitochondrial dysfunction. It is hypothesized that mitochondrial damage leads to the heart toxicity from bis(2-chloroethoxy)methane...
  5. ncbi request reprint Critical pathways in heart function: bis(2-chloroethoxy)methane-induced heart gene transcript change in F344 rats
    J Dunnick
    National Institutes of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Toxicol Pathol 34:348-56. 2006
    ..The heart transcript changes suggest that CEM cardiotoxicity activates protective processes associated energy conservation and maintenance of heart function...
  6. pmc Inclusion of biomarkers for detecting perturbations in the heart and lung and lipid/carbohydrate metabolism in National Toxicology Program studies
    June K Dunnick
    National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 100:29-35. 2007
    ..Breakout group reports and additional information on the workshop, including participants, presentations, and background materials, are posted on the NTP Web site http://ntp.niehs.nih.gov/go/20940...
  7. pmc Cardiotoxicity of Ma Huang/caffeine or ephedrine/caffeine in a rodent model system
    J K Dunnick
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 35:657-64. 2007
    ..The combination of Ma Huang or ephedrine with caffeine enhanced the cardiotoxicity over that with the herbal medicine or the active ingredient alone...
  8. pmc Characterization of liver toxicity in F344/N rats and B6C3F1 mice after exposure to a flame retardant containing lower molecular weight polybrominated diphenyl ethers
    June K Dunnick
    National Institute of Environmental Health Sciences, Research Triangle Park, P O Box 12233, NC 27709, USA
    Exp Toxicol Pathol 61:1-12. 2009
    ..These results suggest that liver may be a target organ for carcinogenesis processes after long-term administration of PBDEs. A chronic PBDE study is currently being conducted by the National Toxicology Program...
  9. doi request reprint Investigating the potential for toxicity from long-term use of the herbal products, goldenseal and milk thistle
    June K Dunnick
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
    Toxicol Pathol 39:398-409. 2011
    ..The fate of the active constituents of goldenseal and milk thistle is similar in humans and rodents; therefore, the modes of action may translate across species. Further studies are needed to extrapolate the findings to humans...
  10. ncbi request reprint Carcinogenic potential of o-nitrotoluene and p-nitrotoluene
    June K Dunnick
    National Institute of Environmental Health Sciences, National Institutes of Health, 111 T W Alexander Drive, P O Box 12233, Research Triangle Park, NC 27709, USA
    Toxicology 183:221-34. 2003
    ..Differences in the o-nitrotoluene and p-nitrotoluene carcinogenic activity may be due to differences in the metabolism of the parent compound to carcinogenic metabolites...
  11. ncbi request reprint Phenolphthalein induces thymic lymphomas accompanied by loss of the p53 wild type allele in heterozygous p53-deficient (+/-) mice
    J K Dunnick
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 25:533-40. 1997
    ..Our studies show that exposure to phenolphthalein combined with a genetic predisposition to cancer can potentiate the carcinogenic process and cause p53 gene alterations, a gene alteration found in many human cancers...
  12. ncbi request reprint Measurement of micronucleated erythrocytes and DNA damage during chronic ingestion of phenolphthalein in transgenic female mice heterozygous for the p53 gene
    R R Tice
    Integrated Laboratory Systems, Research Triangle Park, North Carolina, USA
    Environ Mol Mutagen 31:113-24. 1998
    ..e., the induction of MN-NCE) was detected was 200 ppm, the lowest dose tested in this study. This dose in mice is comparable to doses (on a mg/m2 basis) experienced by humans...
  13. ncbi request reprint Phenolphthalein exposure causes multiple carcinogenic effects in experimental model systems
    J K Dunnick
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Cancer Res 56:4922-6. 1996
    ..One of the sites for neoplasm that is of particular concern is the ovary, and epidemiology studies are under way to identify any potential effects of phenolphthalein exposure at this site in humans...
  14. ncbi request reprint Subchronic toxicity of propantheline bromide administered in the feed to Fischer 344/N rats and B6C3F1 mice
    J K Dunnick
    National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709
    Fundam Appl Toxicol 9:496-503. 1987
    ..Hyperplasia of the transitional epithelium of the urinary bladder was seen in high-dose male rats at the end of 13 weeks...
  15. ncbi request reprint Regenerative hyperplasia is not required for liver tumor induction in female B6C3F1 mice exposed to trihalomethanes
    R L Melnick
    Environmental Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Appl Pharmacol 148:137-47. 1998
    ..The possible contributions from other activation pathways, including GSH conjugation and reductive metabolism, need to be considered in assessments of the carcinogenicity of the trihalomethanes...
  16. doi request reprint Toxicokinetics of bis(2-chloroethoxy)methane following intravenous administration and dermal application in male and female F344/N rats and B6C3F1 mice
    S Waidyanatha
    National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Toxicol Lett 205:215-26. 2011
    ..This animal study suggests that toxicologically significant concentrations of CEM and TDGA could possibly be achieved in the systemic circulation and/or target tissues in humans as a result of dermal exposure to CEM...
  17. ncbi request reprint Carcinogenic activity of the flame retardant, 2,2-bis(bromomethyl)-1,3-propanediol in rodents, and comparison with the carcinogenicity of other NTP brominated chemicals
    J K Dunnick
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 25:541-8. 1997
    ..BMP is mutagenic in the salmonella test, but it was not determined if the BMP-induced effects that eventually lead to development of neoplasms at multiple sites are the same in both species and in all organ systems affected...
  18. ncbi request reprint Chemicals associated with decreases in the incidence of mononuclear cell leukemia in the Fischer rat
    M R Elwell
    Experimental Toxicology Program, National Institute of Environmental Health Sciences, USA
    Toxicol Pathol 24:238-45. 1996
    ....
  19. ncbi request reprint Chromosome 11 loss from thymic lymphomas induced in heterozygous Trp53 mice by phenolphthalein
    J E Hulla
    University of North Dakota School of Medicine, Grand Forks, ND, USA
    Toxicol Sci 60:264-70. 2001
    ..The mitotic recombination observed may be attributable to p53 haploinsufficiency for normal suppression of mitotic recombination...
  20. ncbi request reprint Chromosome 11 allelotypes reflect a mechanism of chemical carcinogenesis in heterozygous p53-deficient mice
    J E Hulla
    University of North Dakota School of Medicine, Grand Forks, ND, USA
    Carcinogenesis 22:89-98. 2001
    ..If the breeding protocols were carried out as described, the unexpected allelotype patterns observed in histologically normal tissues might be due to mitotic homologous recombination during embryogenesis...
  21. ncbi request reprint Acute hemorrhagic myocardial necrosis and sudden death of rats exposed to a combination of ephedrine and caffeine
    Abraham Nyska
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 83:388-96. 2005
    ..Our work shows the direct relationship between combined ephedrine and caffeine exposure and cardiac pathology...
  22. ncbi request reprint Toxicity studies of amphetamine sulfate, ampicillin trihydrate, codeine, 8-methoxypsoralen, alpha-methyldopa, penicillin VK and propantheline bromide in rats and mice
    J K Dunnick
    National Toxicology Program, National Institutes of Environmental Health Sciences, Research Triangle Park, NC 27709
    Toxicology 56:123-36. 1989
    ..The high doses chosen for subsequent 2-year studies were within 10 times human dose levels when compared on a mg/m2 body surface area...
  23. ncbi request reprint Chemical-specific alterations in ras, p53, and beta-catenin genes in hemangiosarcomas from B6C3F1 mice exposed to o-nitrotoluene or riddelliine for 2 years
    H L Hong
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, P O Box 12233, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 191:227-34. 2003
    ..It also suggests that these mutations play a role in the pathogenesis of the respective hemangiosarcomas in B6C3F1(1) mice...
  24. pmc Genetic pathways and mutation profiles of human cancers: site- and exposure-specific patterns
    I A Lea
    Integrated Laboratory Systems, Inc, Research Triangle Park, NC 27709, USA
    Carcinogenesis 28:1851-8. 2007
    ..05). Furthermore, the TP53 mutational hot spots for lung and laryngeal cancers from smokers included codons 157, 245 and 273, whereas for oral tumors included codons 280 and 281...
  25. ncbi request reprint Loss of heterozygosity frequency at the Trp53 locus in p53-deficient (+/-) mouse tumors is carcinogen-and tissue-dependent
    J E French
    Laboratory of Environmental Mutagenesis and Carcinogenesis, Research Triangle Park, NC 27709, USA
    Carcinogenesis 22:99-106. 2001
    ....
  26. ncbi request reprint Genetic alterations in cancer knowledge system: analysis of gene mutations in mouse and human liver and lung tumors
    Marcus A Jackson
    Integrated Laboratory Systems, Inc, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 90:400-18. 2006
    ....
  27. ncbi request reprint Frequency of Hprt mutant lymphocytes and micronucleated erythrocytes in p53-haplodeficient mice treated perinatally with AZT and AZT in combination with 3TC
    Vasily N Dobrovolsky
    US Food and Drug Administration, Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, Jefferson, Arkansas, USA
    Environ Mol Mutagen 48:270-82. 2007
    ..The data indicate that p53 haplodeficiency affects the genotoxicity of NRTIs; thus, p53(+/-) mice may be a sensitive model for evaluating the carcinogenicity of perinatal exposure to NRTIs...