Patrick Emmet Duffy
Affiliation: National Institutes of Health
- Using infective mosquitoes to challenge monkeys with Plasmodium knowlesi in malaria vaccine studiesJittawadee R Murphy
Naval Medical Research Center, Silver Spring, MD, USA
Malar J 13:215. 2014..Thus, intravenous injection may not fairly assess humoral immunity from anti-sporozoite malaria vaccines. To better assess malaria vaccines in rhesus, a method to challenge large numbers of monkeys by mosquito bite was developed...
- Implications of malaria on iron deficiency control strategiesNatasha Spottiswoode
Laboratory of Malaria Immunology and Vaccinology, NIAID, National Institutes of Health, Bethesda, MD, USA
Adv Nutr 3:570-8. 2012..Malaria surveillance and control are necessary components of programs to control iron deficiency and may enhance the efficacy of iron supplementation...
- Intermittent preventive treatment in pregnant women is associated with increased risk of severe malaria in their offspringWhitney E Harrington
Department of Pediatrics, Seattle Children s Hospital University of Washington School of Medicine, Seattle, Washington, United States of America
PLoS ONE 8:e56183. 2013..Because PM predicts increased susceptibility to parasitemia during infancy, we hypothesized that IPTp would also increase susceptibility to malaria infection and disease in the offspring...
- Cytokine profiles at birth predict malaria severity during infancyEdward Kabyemela
MOMS Project, Seattle Biomedical Research Institute, Seattle, Washington, United States of America, and Muheza Designated District Hospital, Muheza, Tanzania
PLoS ONE 8:e77214. 2013..Here, we examined the hypothesis that cytokine profiles at birth reflect inter-individual differences that persist and influence malaria parasite density and disease severity throughout early childhood...
- Pre-erythrocytic malaria vaccines: identifying the targetsPatrick E Duffy
Laboratory of Malaria Immunology and Vaccinology, Division of Intramural Research, NIAID, NIH, Rockville, MD, USA
Expert Rev Vaccines 11:1261-80. 2012..Future advances require human trials of additional antigens, as well as platforms to induce the durable antibody and cellular responses including CD8(+) T cells that contribute to sterile protection...
- Early and extensive CD55 loss from red blood cells supports a causal role in malarial anaemiaMoses Gwamaka
Mother Offspring Malaria Studies Project, Muheza Designated District Hospital, Muheza, Tanzania
Malar J 10:386. 2011..It remains unclear whether CrP changes seen during malaria contribute to the development of anaemia, or result from an altered RBC age distribution due to suppressive effects of malaria on erythropoiesis...
- The relevance of non-human primate and rodent malaria models for humansJean Langhorne
Division of Parasitology, MRC National Institute for Medical Research, The Ridgeway, London NW7 1AA, UK
Malar J 10:23. 2011..The major conclusions of the session were that experimental and human studies should be more closely linked so that they inform each other, and that there should be wider access to relevant clinical material...
- Pregnancy malaria: cryptic disease, apparent solutionPatrick Emmet Duffy
Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA
Mem Inst Oswaldo Cruz 106:64-9. 2011..A vaccine that prevents P. falciparum malaria in pregnant mothers is feasible and would potentially save hundreds of thousands of lives each year...