Kirk M Druey

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Heterotrimeric G protein signaling: role in asthma and allergic inflammation
    Eric N Johnson
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    J Allergy Clin Immunol 109:592-602. 2002
  2. ncbi request reprint Regulators of G protein signalling: potential targets for treatment of allergic inflammatory diseases such as asthma
    Kirk M Druey
    Molecular Signal Transduction Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 2441 Parklawn Drive, Rockville, MD 20852, USA
    Expert Opin Ther Targets 7:475-84. 2003
  3. pmc Regulation of G-protein-coupled signaling pathways in allergic inflammation
    Kirk M Druey
    Molecular Signal Transduction Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Disease, National Institutes of Health, 10 Center Drive Room 11N242, Bethesda, MD 20892, USA
    Immunol Res 43:62-76. 2009
  4. pmc Extracellular volume fraction mapping in the myocardium, part 2: initial clinical experience
    Peter Kellman
    National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA
    J Cardiovasc Magn Reson 14:64. 2012
  5. pmc Regulator of G-protein signaling-5 inhibits bronchial smooth muscle contraction in severe asthma
    Zhao Yang
    Molecular Signal Transduction Section, Laboratory of Allergic Diseases, National Insitute of Allergy and Infectious Diseases NIH, 10 Center Drive, Bethesda, MD 20982, USA
    Am J Respir Cell Mol Biol 46:823-32. 2012
  6. pmc Narrative review: the systemic capillary leak syndrome
    Kirk M Druey
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, and Mayo Clinic College of Medicine, Rochester, Minnesota 20892, USA
    Ann Intern Med 153:90-8. 2010
  7. ncbi request reprint Palmitoylation regulates regulators of G-protein signaling (RGS) 16 function. I. Mutation of amino-terminal cysteine residues on RGS16 prevents its targeting to lipid rafts and palmitoylation of an internal cysteine residue
    Abel Hiol
    Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 278:19301-8. 2003
  8. pmc RGS13 controls g protein-coupled receptor-evoked responses of human mast cells
    Geetanjali Bansal
    Molecular Signal Transduction Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 181:7882-90. 2008
  9. pmc RGS13 acts as a nuclear repressor of CREB
    Zhihui Xie
    Molecular Signal Transduction Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Cell 31:660-70. 2008
  10. pmc Beta-agonist-associated reduction in RGS5 expression promotes airway smooth muscle hyper-responsiveness
    Zhao Yang
    Molecular Signal Transduction Section, Laboratory of Allergic Diseases, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 286:11444-55. 2011

Collaborators

Detail Information

Publications31

  1. ncbi request reprint Heterotrimeric G protein signaling: role in asthma and allergic inflammation
    Eric N Johnson
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    J Allergy Clin Immunol 109:592-602. 2002
    ....
  2. ncbi request reprint Regulators of G protein signalling: potential targets for treatment of allergic inflammatory diseases such as asthma
    Kirk M Druey
    Molecular Signal Transduction Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 2441 Parklawn Drive, Rockville, MD 20852, USA
    Expert Opin Ther Targets 7:475-84. 2003
    ..This review discusses the emerging functions of RGS proteins in immune processes and inflammatory states such as asthma, and their potential value as therapeutic targets for the treatment of allergic disease...
  3. pmc Regulation of G-protein-coupled signaling pathways in allergic inflammation
    Kirk M Druey
    Molecular Signal Transduction Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Disease, National Institutes of Health, 10 Center Drive Room 11N242, Bethesda, MD 20892, USA
    Immunol Res 43:62-76. 2009
    ..In this review, we focus on some of the new regulatory elements that control the duration and amplitude of GPCR signal transduction pathways in immune effector cells and end-organ structural cells affected by allergic inflammation...
  4. pmc Extracellular volume fraction mapping in the myocardium, part 2: initial clinical experience
    Peter Kellman
    National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA
    J Cardiovasc Magn Reson 14:64. 2012
    ..We hypothesized that quantitative assessment of myocardial ECV would be clinically useful for detecting both focal and diffuse myocardial abnormalities in a variety of common and uncommon heart diseases...
  5. pmc Regulator of G-protein signaling-5 inhibits bronchial smooth muscle contraction in severe asthma
    Zhao Yang
    Molecular Signal Transduction Section, Laboratory of Allergic Diseases, National Insitute of Allergy and Infectious Diseases NIH, 10 Center Drive, Bethesda, MD 20982, USA
    Am J Respir Cell Mol Biol 46:823-32. 2012
    ..These results suggest that increased RGS5 expression contributes to decreased myocyte shortening in severe and fatal asthma...
  6. pmc Narrative review: the systemic capillary leak syndrome
    Kirk M Druey
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, and Mayo Clinic College of Medicine, Rochester, Minnesota 20892, USA
    Ann Intern Med 153:90-8. 2010
    ..Much remains to be learned about SCLS, and clinicians should consider the diagnosis in patients with unexplained edema, increased hematocrit, and hypotension...
  7. ncbi request reprint Palmitoylation regulates regulators of G-protein signaling (RGS) 16 function. I. Mutation of amino-terminal cysteine residues on RGS16 prevents its targeting to lipid rafts and palmitoylation of an internal cysteine residue
    Abel Hiol
    Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 278:19301-8. 2003
    ..L., Waheed, A. A., Hiol, A., Ward, R. J., Davey, P. C., Nini, L., Wang, J., Milligan, G., Jones, T. L. Z., and Druey, K. M. (2003) J. Biol. Chem. 278, 19309-19316) was critical for RGS16 and RGS4 GAP activity...
  8. pmc RGS13 controls g protein-coupled receptor-evoked responses of human mast cells
    Geetanjali Bansal
    Molecular Signal Transduction Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 181:7882-90. 2008
    ..RGS13 overexpression inhibited CXCL12-evoked Ca(2+) mobilization, Akt phosphorylation and chemotaxis. These results suggest that RGS13 restricts certain GPCR-mediated biological responses of human mast cells...
  9. pmc RGS13 acts as a nuclear repressor of CREB
    Zhihui Xie
    Molecular Signal Transduction Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Cell 31:660-70. 2008
    ..B lymphocytes from Rgs13(-/-) mice had more beta(2)-agonist-induced OCA-B expression. Thus, RGS13 inhibits CREB-dependent transcription of target genes through disruption of complexes formed at the promoter...
  10. pmc Beta-agonist-associated reduction in RGS5 expression promotes airway smooth muscle hyper-responsiveness
    Zhao Yang
    Molecular Signal Transduction Section, Laboratory of Allergic Diseases, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 286:11444-55. 2011
    ..Repetitive β(2)-agonist use may not only lead to reduced bronchoprotection but also to sensitization of excitation-contraction signaling pathways as a result of reduced RGS5 expression...
  11. ncbi request reprint RGS16 inhibits signalling through the G alpha 13-Rho axis
    Eric N Johnson
    Molecular Signal Transduction Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases National Institute of Health, Rockville, MD 20852, USA
    Nat Cell Biol 5:1095-103. 2003
    ..These results elucidate a new mechanism whereby a classical RGS protein regulates G alpha 13-mediated signal transduction independently of the RGS box...
  12. ncbi request reprint Palmitoylation regulates regulator of G-protein signaling (RGS) 16 function. II. Palmitoylation of a cysteine residue in the RGS box is critical for RGS16 GTPase accelerating activity and regulation of Gi-coupled signalling
    James L Osterhout
    Molecular Signal Transduction Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20892, USA
    J Biol Chem 278:19309-16. 2003
    ..These results suggest that palmitoylation of a Cys residue in the RGS box is critical for RGS16 and RGS4 GAP activity and their ability to regulate Gi-coupled signaling in mammalian cells...
  13. pmc RGS16 inhibits breast cancer cell growth by mitigating phosphatidylinositol 3-kinase signaling
    Genqing Liang
    Molecular Signal Transduction Section, Laboratory of Allergic Diseases, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 284:21719-27. 2009
    ..These results suggest that the loss of RGS16 in some breast tumors enhances PI3K signaling elicited by growth factors and thereby promotes proliferation and TKI evasion downstream of HER activation...
  14. pmc Phosphorylation of RGS13 by the cyclic AMP-dependent protein kinase inhibits RGS13 degradation
    Zhihui Xie
    Molecular Signal Transduction Section, Laboratory of Allergic Diseases, NIAID NIH, 10 Center Drive, Room 11N242, Bethesda, MD 20892, USA
    J Mol Cell Biol 2:357-65. 2010
    ..Stabilization of RGS13 through PKA-mediated phosphorylation could enhance RGS13 functions, providing negative feedback regulation that promotes cellular desensitization...
  15. pmc p53 negatively regulates RGS13 protein expression in immune cells
    Shoko Iwaki
    Molecular Signal Transduction Section, Laboratory of Allergic Diseases, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 286:22219-26. 2011
    ..These studies indicate that p53 may modulate immune responses through suppression of RGS13 transcription in MCs and B cells...
  16. pmc RGS16 attenuates pulmonary Th2/Th17 inflammatory responses
    Sucharita P Shankar
    Molecular Signal Transduction Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 188:6347-56. 2012
    ..Thus, RGS16-mediated confinement of T cells to Schistosome granulomas mitigates widespread cytokine-mediated pulmonary inflammation...
  17. pmc Naive T cells sense the cysteine protease allergen papain through protease-activated receptor 2 and propel TH2 immunity
    Genqing Liang
    Molecular Signal Transduction Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    J Allergy Clin Immunol 129:1377-1386.e13. 2012
    ..Basophils have the capacity to present antigen to naive T cells and promote T(H)2 differentiation directly or indirectly through IL-4 production...
  18. pmc Mouse and human eosinophils degranulate in response to platelet-activating factor (PAF) and lysoPAF via a PAF-receptor-independent mechanism: evidence for a novel receptor
    Kimberly D Dyer
    Section of Eosinophil Biology, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1883, USA
    J Immunol 184:6327-34. 2010
    ....
  19. pmc Enhanced effector function of CD8(+) T cells from healthy controls and HIV-infected patients occurs through thrombin activation of protease-activated receptor 1
    Amanda Hurley
    CMRS Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 1360, USA
    J Infect Dis 207:638-50. 2013
    ..These findings suggest that thrombin mediates cross-talk between the coagulation system and the adaptive immune system at sites of vascular injury through increased T-cell motility and production of proinflammatory cytokines...
  20. pmc Vascular endothelial hyperpermeability induces the clinical symptoms of Clarkson disease (the systemic capillary leak syndrome)
    Zhihui Xie
    Molecular Signal Transduction Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 119:4321-32. 2012
    ..Our results support a model of SCLS pathogenesis in which nonimmunoglobulin humoral factors such as VEGF and Ang2 contribute to transient endothelial contraction, suggesting a molecular mechanism for this highly lethal disorder...
  21. pmc Suppression of immunoglobulin E-mediated allergic responses by regulator of G protein signaling 13
    Geetanjali Bansal
    Molecular Signal Transduction Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Immunol 9:73-80. 2008
    ..Thus, RGS13 inhibits the assembly of immune receptor-induced signalosomes in mast cells. Abnormal RGS13 expression or function may contribute to disorders of amplified mast cell activity, such as idiopathic anaphylaxis...
  22. ncbi request reprint Role of regulator of G protein signaling 16 in inflammation-induced T lymphocyte migration and activation
    Eric Lippert
    Molecular Signal Transduction Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    J Immunol 171:1542-55. 2003
    ..These results suggest that RGS16 may regulate T lymphocyte activation in response to inflammatory stimuli and migration induced by CXCR4, CCR3, and CCR5, but not CCR2 or CCR7...
  23. pmc RGS10 exerts a neuroprotective role through the PKA/c-AMP response-element (CREB) pathway in dopaminergic neuron-like cells
    Jae Kyung Lee
    Department of Physiology, Emory University School of Medicine, Atlanta, Georgia, USA
    J Neurochem 122:333-43. 2012
    ....
  24. pmc R4 RGS proteins: regulation of G-protein signaling and beyond
    Geetanjali Bansal
    Molecular Signal Transduction Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, United States
    Pharmacol Ther 116:473-95. 2007
    ....
  25. ncbi request reprint Src-mediated RGS16 tyrosine phosphorylation promotes RGS16 stability
    Alexandrine Derrien
    Laboratory of Allergic Diseases, NIAID National Institutes of Health, 12441 Parklawn Drive, Rockville, MD 20852, USA
    J Biol Chem 278:16107-16. 2003
    ..These results suggest that Src mediates RGS16 tyrosine phosphorylation, which may promote RGS16 stability...
  26. ncbi request reprint Prostaglandin E2 promotes colon cancer cell growth through a Gs-axin-beta-catenin signaling axis
    Maria Domenica Castellone
    Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892 4340, USA
    Science 310:1504-10. 2005
    ..These findings may provide a molecular framework for the future evaluation of chemopreventive strategies for colorectal cancer...
  27. ncbi request reprint Loss of regulator of G protein signaling 5 promotes airway hyperresponsiveness in the absence of allergic inflammation
    Nariman A Balenga
    Molecular Signal Transduction Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases National Institutes of Health, Bethesda, MD
    J Allergy Clin Immunol 134:451-459.e11. 2014
    ..Dysregulation of procontractile G protein-coupled receptor (GPCR) signaling in ASM could mediate enhanced contractility...
  28. ncbi request reprint Functional characterization of the G protein regulator RGS13
    Eric N Johnson
    Molecular Signal Transduction Section, Laboratory of Allergic Diseases, NIAID, National Institutes of Health, Rockville, Maryland 20852, USA
    J Biol Chem 277:16768-74. 2002
    ..Surprisingly, RGS13 inhibits cAMP generation elicited by stimulation of the beta(2)-adrenergic receptor. These data suggest that RGS13 may regulate Galpha(i)-, Galpha(q)-, and Galpha(s)-coupled signaling cascades...
  29. ncbi request reprint Follicular dendritic cell regulation of CXCR4-mediated germinal center CD4 T cell migration
    Jacob D Estes
    Department of Microbiology and Molecular Biology, Brigham Young University, Provo, UT 84602, USA
    J Immunol 173:6169-78. 2004
    ..Thus, FDCs appear to directly affect GC T cell migration within lymphoid follicles...
  30. ncbi request reprint Concerted stimulation and deactivation of pertussis toxin-sensitive G proteins by chimeric G protein-coupled receptor-regulator of G protein signaling 4 fusion proteins: analysis of the contribution of palmitoylated cysteine residues to the GAP activity o
    Daljit S Bahia
    Molecular Pharmacology Group, Division of Biochemistry and Molecular Biology, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow, UK
    J Neurochem 85:1289-98. 2003
    ....
  31. pmc RGS3 interacts with 14-3-3 via the N-terminal region distinct from the RGS (regulator of G-protein signalling) domain
    Jiaxin Niu
    Department of Pharmacology, University of Illinois at Chicago College of Medicine, Chicago, IL 60612, U S A
    Biochem J 365:677-84. 2002
    ..This study describes a new level in the regulation of G-protein signalling, in which the inhibitors of G-proteins, RGS proteins, can themselves be regulated by phosphorylation and binding 14-3-3...