Research Topics
Genomes and GenesSpecies | Ira DriscollSummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
The aging hippocampus: navigating between rat and human experimentsIra Driscoll
Canadian Centre for Behavioural Neuroscience, Department of Psychology and Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada
Rev Neurosci 16:87-121. 2005..In addition, studies of the aging hippocampus may have a side-effect in leading to a better understanding of the mechanisms that underlie learning and memory in general...
Midlife obesity and trajectories of brain volume changes in older adultsIra Driscoll
Laboratory of Personality and Cognition, National Institute on Aging, Baltimore, MD 21224, USA
Hum Brain Mapp 33:2204-10. 2012..Moreover, the discrepancies in findings between studies may be in part due to participant sampling and methodological differences...- Lack of association between 11C-PiB and longitudinal brain atrophy in non-demented older individualsIra Driscoll
NIH Biomedical Research Center, 251 Bayview Blvd, Suite 100, Baltimore, MD 21224, USA
Neurobiol Aging 32:2123-30. 2011..Consistent with a threshold model of disease, our findings suggest that Aβ load does not seem to affect brain volume changes in individuals without dementia... - Neurophysiological properties of cells filling the neonatal medial prefrontal cortex lesion cavityIra Driscoll
Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada
Brain Res 1178:38-43. 2007.... - Asymptomatic Alzheimer's disease: a prodrome or a state of resilience?I Driscoll
National Institute on Aging, NIH, Baltimore, MD, USA
Curr Alzheimer Res 8:330-5. 2011.... - Testosterone and cognition in normal aging and Alzheimer's disease: an updateIra Driscoll
Laboratory of Personality and Cognition, National Institute on Aging, Baltimore, MD 21224, USA
Curr Alzheimer Res 4:33-45. 2007..In addition, a number of potential explanations of the discrepancy between data obtained in humans and non-human animals are discussed... - Impact of Alzheimer's pathology on cognitive trajectories in nondemented elderlyIra Driscoll
Laboratory of Personality and Cognition, National Institute on Aging, National Institutes of Health, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Ann Neurol 60:688-95. 2006..We investigated whether cognitive trajectories differ between clinically normal elderly individuals with and without AD neuropathology and how they compare with trajectories of clinically impaired individuals before dementia diagnosis... - FGF-2-induced cell proliferation stimulates anatomical, neurophysiological and functional recovery from neonatal motor cortex injuryMarie H Monfils
Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, Alberta, Canada
Eur J Neurosci 24:739-49. 2006.... - In vivo fibrillar beta-amyloid detected using [11C]PiB positron emission tomography and neuropathologic assessment in older adultsJitka Sojkova
National Institute on Aging, National Institutes of Health, 251 Bayview Blvd, Baltimore, MD 21224, USA
Arch Neurol 68:232-40. 2011..In demented older adults, in vivo amyloid imaging shows agreement with diagnostic neuropathologic assessment of β-amyloid (Aβ). However, the extent of agreement in nondemented older adults remains unclear... - Correspondence between in vivo (11)C-PiB-PET amyloid imaging and postmortem, region-matched assessment of plaquesIra Driscoll
National Institute on Aging, Baltimore, MD, USA
Acta Neuropathol 124:823-31. 2012..The strong associations of PiB retention with region-matched, quantitative analyses of Aβ in postmortem tissue offer support for the validity of (11)C-PiB-PET imaging as a method for evaluation of plaque burden in vivo... - Plasma BDNF is associated with age-related white matter atrophy but not with cognitive function in older, non-demented adultsIra Driscoll
Laboratory of Behavioral Neuroscience, National Institute on Aging, Baltimore, Maryland, United States of America
PLoS ONE 7:e35217. 2012..Together, our findings contribute to furthering the understanding of the relationships between plasma BDNF, structural brain integrity and cognition. Potential mechanisms mediating these relationships merit further investigation... - FGF-2-induced functional improvement from neonatal motor cortex injury via corticospinal projectionsMarie H Monfils
Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, AB, Canada
Exp Brain Res 185:453-60. 2008..Our results demonstrate that FGF-2 treatment restores the connectivity of the filled region in neonatal rats. This provides a possible mechanism for FGF-2-induced functional recovery... - Weight change and cognitive function: findings from the Women's Health Initiative Study of Cognitive AgingIra Driscoll
Laboratory of Personality and Cognition, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA
Obesity (Silver Spring) 19:1595-600. 2011..Relationships were largely independent of initial BMI, self-reported caloric intake or dieting. The lack of associations between weight gain and cognition in women is consistent with the existing literature... - Neuropathologic studies of the Baltimore Longitudinal Study of Aging (BLSA)RICHARD J O'BRIEN
Department of Neurology, School of Medicine, Johns Hopkins University, Baltimore, MD 21224, USA
J Alzheimers Dis 18:665-75. 2009..e., neuronal hypertrophy and synaptic plasticity) whereas a failure of compensation may culminate in disease... - A quantitative comparison of synaptic density following perfusion versus immersion fixation in the rat cerebral cortexMarie H Monfils
Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada, T1K 3M4
Microsc Res Tech 67:300-4. 2005..Our results suggest that, despite suboptimal qualitative results, fixation by immersion allows for adequate quantification of synapses... - Enhanced cell death and learning deficits after a mini-stroke in aged hippocampusIra Driscoll
Department of Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, Alta, Canada
Neurobiol Aging 29:1847-58. 2008..Overall, our pattern of results suggest that the aged hippocampus is more vulnerable to the same insult that has little or no effect on the young hippocampus... - Circulating brain-derived neurotrophic factor and indices of metabolic and cardiovascular health: data from the Baltimore Longitudinal Study of AgingErin Golden
Cellular and Molecular Neurosciences Section, National Institute on Aging Intramural Research Program, Baltimore, Maryland, United States of America
PLoS ONE 5:e10099. 2010..Although BDNF is present in the systemic circulation, it is unknown whether plasma BDNF correlates with circulating markers of dysregulated metabolism and an adverse cardiovascular profile... - Vulnerability of the orbitofrontal cortex to age-associated structural and functional brain changesSusan M Resnick
Intramural Research Program, National Institute on Aging, Gerontology Research Center, Baltimore, MD 21224 6825, USA
Ann N Y Acad Sci 1121:562-75. 2007..Future studies using new in vivo imaging probes will help determine whether neuropathologic changes underlie the structural and functional changes... - Seahorse wins all races: hippocampus participates in both linear and non-linear visual discrimination learningIra Driscoll
Canadian Centre for Behavioural Neuroscience, Department of Psychology and Neuroscience, University of Lethbridge, Alta
Behav Brain Res 164:29-35. 2005.... - Virtual navigation in humans: the impact of age, sex, and hormones on place learningIra Driscoll
Department of Psychology and Neuroscience, Canadian Centre for Behavioural Neuroscience, The University of Lethbridge, 4401 University Drive Lethbridge, Alberta, Canada T1H 6P4
Horm Behav 47:326-35. 2005..Our findings indicate that the persistence of male spatial advantage may be related to circulating testosterone, but not cortisol levels, and independent of generalized age-related cognitive decline... - The aging hippocampus: cognitive, biochemical and structural findingsIra Driscoll
Department of Psychology, The University of New Mexico, Albuquerque, New Mexico 87131, USA
Cereb Cortex 13:1344-51. 2003.... - Differential contributions of hippocampus, amygdala and perirhinal cortex to recognition of novel objects, contextual stimuli and stimulus relationshipsSandra N Moses
Rotman Research Institute, Baycrest Centre for Geriatric Care, 3560 Bathurst St, Toronto, Ont, Canada M6A 2E1
Brain Res Bull 67:62-76. 2005..Implications for declarative and conjunctive hippocampal theories are discussed... - Apolipoprotein E and prospective memory in normally aging adultsIra Driscoll
Department of Psychology, University of New Mexico, Albuquerque, NM, USA
Neuropsychology 19:28-34. 2005..The authors found a significant deficit in prospective memory for epsilon4 allele carriers but no effect of association in either group. The results suggest the deficit was due to failure of the prospective component of the task...