Wayne C Drevets

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Antidepressant efficacy of the antimuscarinic drug scopolamine: a randomized, placebo-controlled clinical trial
    Maura L Furey
    Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 63:1121-9. 2006
  2. pmc The subgenual anterior cingulate cortex in mood disorders
    Wayne C Drevets
    Section on Neuroimaging in Mood and Anxiety Disorders, Molecular Imaging Branch, National Institute of Mental Health, Bethesda, MD, USA
    CNS Spectr 13:663-81. 2008
  3. pmc Brain structural and functional abnormalities in mood disorders: implications for neurocircuitry models of depression
    Wayne C Drevets
    Section on Neuroimaging in Mood and Anxiety Disorders, National Institute of Mental Health, National Institutes of Health NIH NIMH DIRP, 15K North Dr, Room 210, Bethesda, MD 20892, USA
    Brain Struct Funct 213:93-118. 2008
  4. pmc Serotonin-1A receptor imaging in recurrent depression: replication and literature review
    Wayne C Drevets
    Mood and Anxiety Disorders Program, MINH Molecular Imaging Branch, Bethesda, MD 20892, USA
    Nucl Med Biol 34:865-77. 2007
  5. ncbi request reprint Elevated serotonin transporter binding in major depressive disorder assessed using positron emission tomography and [11C]DASB; comparison with bipolar disorder
    Dara M Cannon
    Molecular Imaging Branch, Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
    Biol Psychiatry 62:870-7. 2007
  6. pmc Reduced post-synaptic serotonin type 1A receptor binding in bipolar depression
    Allison C Nugent
    National Institute of Mental Health, Experimental Therapeutics and Pathophysiology Branch, NIMH, NIH, Bethesda, MD 20892 1030, USA
    Eur Neuropsychopharmacol 23:822-9. 2013
  7. pmc Habenula volume in bipolar disorder and major depressive disorder: a high-resolution magnetic resonance imaging study
    Jonathan B Savitz
    Mood and Anxiety Disorders Program, National Institutes of Health National Institute of Mental Health, Bethesda, Maryland, USA
    Biol Psychiatry 69:336-43. 2011
  8. ncbi request reprint Changes in the neural correlates of implicit emotional face processing during antidepressant treatment in major depressive disorder
    Teresa A Victor
    National Institutes of Health, National Institute of Mental Health, Bethesda, MD, USA
    Int J Neuropsychopharmacol 16:2195-208. 2013
  9. pmc Serotonin transporter genotype and depressive phenotype determination by discriminant analysis of glucose metabolism under acute tryptophan depletion
    Allison C Nugent
    Section on Neuroimaging in Mood and Anxiety Disorders, National Institute of Mental Health, NIH, Bethesda, MD 20892 0940, USA
    Neuroimage 43:764-74. 2008
  10. pmc A comparison of cognitive functioning in medicated and unmedicated subjects with bipolar depression
    M Kathleen Holmes
    Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Bipolar Disord 10:806-15. 2008

Collaborators

Detail Information

Publications98

  1. pmc Antidepressant efficacy of the antimuscarinic drug scopolamine: a randomized, placebo-controlled clinical trial
    Maura L Furey
    Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 63:1121-9. 2006
    ..002). Subsequently a clinical trial was designed to assess more specifically the antidepressant efficacy of scopolamine...
  2. pmc The subgenual anterior cingulate cortex in mood disorders
    Wayne C Drevets
    Section on Neuroimaging in Mood and Anxiety Disorders, Molecular Imaging Branch, National Institute of Mental Health, Bethesda, MD, USA
    CNS Spectr 13:663-81. 2008
    ..These data thus hold important implications for the development of neural models of depression that can account for the abnormal motivational, neuroendocrine, autonomic, and emotional manifestations evident in human mood disorders...
  3. pmc Brain structural and functional abnormalities in mood disorders: implications for neurocircuitry models of depression
    Wayne C Drevets
    Section on Neuroimaging in Mood and Anxiety Disorders, National Institute of Mental Health, National Institutes of Health NIH NIMH DIRP, 15K North Dr, Room 210, Bethesda, MD 20892, USA
    Brain Struct Funct 213:93-118. 2008
    ..This paper discusses these systems together with the neurochemical systems that impinge on them and form the basis for most pharmacological therapies...
  4. pmc Serotonin-1A receptor imaging in recurrent depression: replication and literature review
    Wayne C Drevets
    Mood and Anxiety Disorders Program, MINH Molecular Imaging Branch, Bethesda, MD 20892, USA
    Nucl Med Biol 34:865-77. 2007
    ..In the current study, we attempted to replicate our previous findings in an independent sample of subjects selected according to the criteria for primary recurrent depression applied in our prior study...
  5. ncbi request reprint Elevated serotonin transporter binding in major depressive disorder assessed using positron emission tomography and [11C]DASB; comparison with bipolar disorder
    Dara M Cannon
    Molecular Imaging Branch, Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
    Biol Psychiatry 62:870-7. 2007
    ....
  6. pmc Reduced post-synaptic serotonin type 1A receptor binding in bipolar depression
    Allison C Nugent
    National Institute of Mental Health, Experimental Therapeutics and Pathophysiology Branch, NIMH, NIH, Bethesda, MD 20892 1030, USA
    Eur Neuropsychopharmacol 23:822-9. 2013
    ..These findings suggest that 5-HT(1A) receptor binding is abnormally reduced in BD, and this abnormality may particularly involve the postsynaptic 5-HT(1A) receptor system of individuals with a tendency toward cortisol hypersecretion...
  7. pmc Habenula volume in bipolar disorder and major depressive disorder: a high-resolution magnetic resonance imaging study
    Jonathan B Savitz
    Mood and Anxiety Disorders Program, National Institutes of Health National Institute of Mental Health, Bethesda, Maryland, USA
    Biol Psychiatry 69:336-43. 2011
    ..We conducted the first magnetic resonance imaging analysis of habenula volume in MDD and bipolar disorder (BD)...
  8. ncbi request reprint Changes in the neural correlates of implicit emotional face processing during antidepressant treatment in major depressive disorder
    Teresa A Victor
    National Institutes of Health, National Institute of Mental Health, Bethesda, MD, USA
    Int J Neuropsychopharmacol 16:2195-208. 2013
    ..Treatment-associated functional changes in this limbic network may influence the non-conscious processing of such stimuli by reversing the negative processing bias extant in MDD...
  9. pmc Serotonin transporter genotype and depressive phenotype determination by discriminant analysis of glucose metabolism under acute tryptophan depletion
    Allison C Nugent
    Section on Neuroimaging in Mood and Anxiety Disorders, National Institute of Mental Health, NIH, Bethesda, MD 20892 0940, USA
    Neuroimage 43:764-74. 2008
    ..The robust nature of the classification results indicates that much of the variance in metabolic response to ATD is accounted for by genotypic and phenotypic category...
  10. pmc A comparison of cognitive functioning in medicated and unmedicated subjects with bipolar depression
    M Kathleen Holmes
    Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Bipolar Disord 10:806-15. 2008
    ..The present study aims to compare the cognitive performance of medicated and unmedicated subjects with bipolar depression to healthy control subjects...
  11. pmc Population-based input function and image-derived input function for [¹¹C](R)-rolipram PET imaging: methodology, validation and application to the study of major depressive disorder
    Paolo Zanotti-Fregonara
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
    Neuroimage 63:1532-41. 2012
    ....
  12. pmc An investigation of amino-acid neurotransmitters as potential predictors of clinical improvement to ketamine in depression
    Giacomo Salvadore
    Experimental Therapeutics and Pathophysiology Branch, Division of Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
    Int J Neuropsychopharmacol 15:1063-72. 2012
    ....
  13. ncbi request reprint Regional cerebral glucose metabolic abnormalities in bipolar II depression
    Linda Mah
    Section on Neuroimaging in Mood and Anxiety Disorders, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
    Biol Psychiatry 61:765-75. 2007
    ..This study investigated whether cerebral metabolic abnormalities previously reported in unmedicated BD subjects are evident in depressed bipolar disorder type II (BD II) subjects receiving lithium or divalproex...
  14. pmc Selective effects of cholinergic modulation on task performance during selective attention
    Maura L Furey
    Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Neuropsychopharmacology 33:913-23. 2008
    ..The findings are discussed within the context of the role of acetylcholine both in stimulus processing and stimulus salience, and in establishing attention biases through top-down and bottom-up mechanisms of attention...
  15. pmc Association between subcortical volumes and verbal memory in unmedicated depressed patients and healthy controls
    Arlener D Turner
    National Institutes of Mental Health Experimental and Pathophysiology Branch, NIMH, CRC, Bethesda, MD 20892, USA
    Neuropsychologia 50:2348-55. 2012
    ..This suggests that larger hippocampal volume is related to better memory recall in depression, but specifically with regard to utilizing an inferior memory strategy...
  16. pmc Baseline mood-state measures as predictors of antidepressant response to scopolamine
    Maura L Furey
    Experimental Therapeutics and Pathophysiology Branch, NIMH, NIH, Bethesda, MD 20892, USA
    Psychiatry Res 196:62-7. 2012
    ..These results indicate that self-report mood-ratings obtained before treatment can predict response outcome to scopolamine, and suggest that a constellation of mood-state features may be related to clinical response...
  17. ncbi request reprint Reduced muscarinic type 2 receptor binding in subjects with bipolar disorder
    Dara M Cannon
    Mood and Anxiety Disorders Program, Molecular Imaging Branch, National Institutes of Mental Health, National Institutes of Health, Bethesda, MD 20892 2670, USA
    Arch Gen Psychiatry 63:741-7. 2006
    ....
  18. ncbi request reprint No change in serotonin type 1A receptor binding in patients with posttraumatic stress disorder
    Omer Bonne
    Section of Experimental Therapeutics, NIMH Mood and Anxiety Disorders Program, Bethesda, MD 20892 2670, USA
    Am J Psychiatry 162:383-5. 2005
    ..In the present study, the authors sought an association between 5HT1AR binding and posttraumatic stress disorder (PTSD)...
  19. pmc Genetic variation in HTR2A influences serotonin transporter binding potential as measured using PET and [11C]DASB
    Gonzalo Laje
    Unit on the Genetic Basis of Mood and Anxiety Disorders, National Institute of Mental Health, Bethesda, MD 20892 3719, USA
    Int J Neuropsychopharmacol 13:715-24. 2010
    ....
  20. pmc Amygdala volume in depressed patients with bipolar disorder assessed using high resolution 3T MRI: the impact of medication
    Jonathan Savitz
    Section on Neuroimaging in Mood and Anxiety Disorders, NIH NIMH MAP, Bethesda, MD 20892, USA
    Neuroimage 49:2966-76. 2010
    ..Here we extend these results to the amygdala. We raise the possibility that neuroplastic changes in the amygdala associated with BD are moderated by some mood stabilizing medications...
  21. ncbi request reprint Differential performance on tasks of affective processing and decision-making in patients with Panic Disorder and Panic Disorder with comorbid Major Depressive Disorder
    Johanna S Kaplan
    Mood and Anxiety Disorders Program, National Institute of Mental Health, NIH, DHHS, Bethesda MD, USA
    J Affect Disord 95:165-71. 2006
    ..The present study investigated neuropsychological functioning in patients with PD and PD + MDD by focusing on tasks that assess attention, psychomotor speed, executive function, decision-making, and affective processing...
  22. ncbi request reprint Serotonin transporter binding in bipolar disorder assessed using [11C]DASB and positron emission tomography
    Dara M Cannon
    Mood and Anxiety Disorders Program, Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 2670, USA
    Biol Psychiatry 60:207-17. 2006
    ..This study used PET and [(11)C]DASB, a radioligand that afforded higher sensitivity and specificity for the 5-HTT than previously available radioligands, to compare 5-HTT binding between BD and control subjects...
  23. pmc Early intervention in bipolar disorder, part II: therapeutics
    Giacomo Salvadore
    Mood and Anxiety Disorders Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Early Interv Psychiatry 2:136-46. 2008
    ..We also discuss their potential use as early intervention strategies for improving symptoms and functioning in patients in the earliest stages of BPD, as well as high-risk individuals...
  24. pmc Potential of pretreatment neural activity in the visual cortex during emotional processing to predict treatment response to scopolamine in major depressive disorder
    Maura L Furey
    Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    JAMA Psychiatry 70:280-90. 2013
    ..Scopolamine produces rapid antidepressant effects and thus offers the opportunity to characterize potential biomarkers of treatment response within short periods...
  25. pmc Bcl-2 polymorphism influences gray matter volume in the ventral striatum in healthy humans
    Giacomo Salvadore
    Mood and Anxiety Disorders Program, National Institute of Mental Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    Biol Psychiatry 66:804-7. 2009
    ..We tested the hypothesis that this SNP would modulate gray matter (GM) volume in the limbic-cortical-striatal-pallidal-thalamic circuitry that plays major roles in mood regulation...
  26. ncbi request reprint Mood-congruent bias in affective go/no-go performance of unmedicated patients with major depressive disorder
    Kristine Erickson
    Mood and Anxiety Disorders Program, National Institute of Mental Health, MD 20814 9692, USA
    Am J Psychiatry 162:2171-3. 2005
    ..This study investigated performance of unmedicated depressed patients on the Affective Go/No-Go Task...
  27. pmc Relationship between amygdala responses to masked faces and mood state and treatment in major depressive disorder
    Teresa A Victor
    National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
    Arch Gen Psychiatry 67:1128-38. 2010
    ..However, few studies have investigated such biases toward implicitly presented stimuli...
  28. pmc Anterior cingulate desynchronization and functional connectivity with the amygdala during a working memory task predict rapid antidepressant response to ketamine
    Giacomo Salvadore
    Experimental Therapeutics, Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Neuropsychopharmacology 35:1415-22. 2010
    ..73, p=0.0021, FDR <0.05).These data implicate the pgACC and its putative interaction with the amygdala in predicting antidepressant response to ketamine in a working memory task context...
  29. ncbi request reprint Neural and behavioral responses to tryptophan depletion in unmedicated patients with remitted major depressive disorder and controls
    Alexander Neumeister
    Section on Experimental Therapeutics, Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, MD 20892 2670, USA
    Arch Gen Psychiatry 61:765-73. 2004
    ....
  30. ncbi request reprint Reduced hippocampal volume in unmedicated, remitted patients with major depression versus control subjects
    Alexander Neumeister
    Section on Experimental Therapeutics and Pathophysiology, Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, Maryland, USA
    Biol Psychiatry 57:935-7. 2005
    ..Hippocampal volumes obtained from a group of medication-free, remitted subjects with recurrent major depressive disorder (MDD) were compared against corresponding measures from healthy controls...
  31. pmc Prefrontal cortical abnormalities in currently depressed versus currently remitted patients with major depressive disorder
    Giacomo Salvadore
    Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Neuroimage 54:2643-51. 2011
    ..Consistent with other neuroimaging and post-mortem neuropathological studies of MDD, we also found evidence of decreased white matter in patients with dMDD and rMDD...
  32. pmc Effects of arterial cannulation stress on regional cerebral blood flow in major depressive disorder
    Jonathan Savitz
    Section on Neuroimaging in Mood and Anxiety Disorders, Mood and Anxiety Disorders Program, NIH NIMH, Bethesda, MD
    Sci Rep 2:308. 2012
    ..The rCBF in the right amygdala was significantly correlated with depression severity. Conceivably, the limbic response to invasive physical stress is greater in MDD subjects than in HCs...
  33. ncbi request reprint Ventral striatum response during reward and punishment reversal learning in unmedicated major depressive disorder
    Oliver J Robinson
    Section on Neuroimaging in Mood and Anxiety Disorders, NIMH, Bethesda, MD, USA
    Am J Psychiatry 169:152-9. 2012
    ....
  34. pmc Sustained low-grade pro-inflammatory state in unmedicated, remitted women with major depressive disorder as evidenced by elevated serum levels of the acute phase proteins C-reactive protein and serum amyloid A
    Mitchel A Kling
    Clinical Neuroendocrinology Branch, Division of Intramural Research Programs, National Institute of Mental Health, Bethesda, MD 20892 1284, USA
    Biol Psychiatry 62:309-13. 2007
    ..Elevations of the inflammatory markers C-reactive protein (CRP) and serum amyloid A (SAA) predict increased CAD risk in populations; few data on these markers exist in MDD, particularly in remitted patients...
  35. ncbi request reprint Normal prefrontal gamma-aminobutyric acid levels in remitted depressed subjects determined by proton magnetic resonance spectroscopy
    Gregor Hasler
    Mood and Anxiety Disorders Program, Section on Experimental Therapeutics, National Institutes of Health, Bethesda, MD 20892 2670, USA
    Biol Psychiatry 58:969-73. 2005
    ..As a result, the current study investigates whether GABA levels in the prefrontal cortex differ between unmedicated subjects with remitted major depressive disorder (rMDD) and healthy control subjects...
  36. ncbi request reprint Choosing the lesser of two evils, the better of two goods: specifying the roles of ventromedial prefrontal cortex and dorsal anterior cingulate in object choice
    Karina Blair
    Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 2670, USA
    J Neurosci 26:11379-86. 2006
    ..These data are interpreted with reference to models of ACd and vmPFC functioning...
  37. pmc Response to emotional expressions in generalized social phobia and generalized anxiety disorder: evidence for separate disorders
    Karina Blair
    Mood and Anxiety Program, NIMH, NIH, 15K North Dr, MSC 2670, Bethesda, MD 20892, USA
    Am J Psychiatry 165:1193-202. 2008
    ..Functional magnetic resonance imaging assessed the neural response to facial expressions in generalized social phobia and generalized anxiety disorder...
  38. pmc Sex differences in the neural correlates of autonomic arousal: a pilot PET study
    Allison C Nugent
    Section on Neuroimaging in Mood and Anxiety Disorders, NIMH NIH, 9 Memorial Drive, MSC 0940, Bethesda, MD 20892 0940, United States
    Int J Psychophysiol 80:182-91. 2011
    ....
  39. ncbi request reprint Cortical abnormalities in bipolar disorder investigated with MRI and voxel-based morphometry
    Allison C Nugent
    Section on Neuroimaging in Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, 1 Center Drive, MSC 0135, Bethesda, MD 20892 0135, USA
    Neuroimage 30:485-97. 2006
    ....
  40. pmc Neural correlates of rapid antidepressant response to ketamine in bipolar disorder
    Allison C Nugent
    Experimental Therapeutics and Pathophysiology Branch, NIMH, NIH, Bethesda, MD, USA
    Bipolar Disord 16:119-28. 2014
    ..Evidence supports a role for the glutamatergic system in the pathophysiology of BD. This double-blind, randomized, cross-over study sought to determine cerebral metabolic correlates of antidepressant response to ketamine...
  41. pmc Mood stabilizer treatment increases serotonin type 1A receptor binding in bipolar depression
    Allison C Nugent
    1Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, Bethesda, USA
    J Psychopharmacol 27:894-902. 2013
    ..These preliminary findings are consistent with the hypothesis that these mood stabilizers enhance 5-HT1A receptor expression in BD, which may underscore an important component of these agents' mechanism of action. ..
  42. pmc The extended functional neuroanatomy of emotional processing biases for masked faces in major depressive disorder
    Teresa A Victor
    National Institutes of Health, National Institute of Mental Health, Bethesda, Maryland, USA
    PLoS ONE 7:e46439. 2012
    ..The extended functional anatomical network that maintains this response bias has not been established, however...
  43. doi request reprint Avoidant coping in panic disorder: a yohimbine biological challenge study
    Johanna S Kaplan
    Mood and Anxiety Disorders Program, National Institute of Mental Health, NIH, DHHS, Bethesda, MD, USA
    Anxiety Stress Coping 25:425-42. 2012
    ....
  44. pmc Habenula volume in post-traumatic stress disorder measured with high-resolution MRI
    Jonathan B Savitz
    Section on Neuroimaging in Mood and Anxiety Disorders, NIH NIMH, Bethesda, MD, USA
    Biol Mood Anxiety Disord 1:7. 2011
    ..abstract:..
  45. doi request reprint Unmedicated, remitted patients with major depression have decreased serum immunoglobulin A
    Philip W Gold
    Clinical Neuroendocrinology Branch, NIH NIMH, 10 Center Drive, Bethesda, MD 20892, USA
    Neurosci Lett 520:1-5. 2012
    ..In the light of the fact that IgA serves many immunomodulatory, anti-inflammatory roles, this finding supports the concept that major depressive illness represents a proinflammatory state...
  46. pmc Localization of dysfunction in major depressive disorder: prefrontal cortex and amygdala
    Elisabeth A Murray
    Section on the Neurobiology of Learning and Memory, Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 4415, USA
    Biol Psychiatry 69:e43-54. 2011
    ....
  47. pmc The Bcl-2 gene polymorphism rs956572AA increases inositol 1,4,5-trisphosphate receptor-mediated endoplasmic reticulum calcium release in subjects with bipolar disorder
    Rodrigo Machado-Vieira
    Laboratory of Molecular Pathophysiology and Experimental Therapeutics, Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, Maryland, USA
    Biol Psychiatry 69:344-52. 2011
    ..Here, we examined the effects of the Bcl-2 gene single nucleotide polymorphism (SNP) rs956572 on intracellular Ca(2+) dynamics in patients with BPD...
  48. pmc Scopolamine produces larger antidepressant and antianxiety effects in women than in men
    Maura L Furey
    Mood and Anxiety Disorders Program, National Institute of Mental Health, NIH, Bethesda, MD 20892, USA
    Neuropsychopharmacology 35:2479-88. 2010
    ..6, p=0.001) showed that the antianxiety response was greater in women. Men and women show a rapid antidepressant response following scopolamine, but the magnitude of response is larger in women than in men...
  49. pmc Neural circuitry and neuroplasticity in mood disorders: insights for novel therapeutic targets
    Paul J Carlson
    Laboratory of Molecular Pathophysiology, National Institute of Mental Health, Bethesda, Maryland 20892, USA
    NeuroRx 3:22-41. 2006
    ....
  50. pmc Automated subcortical segmentation using FIRST: test-retest reliability, interscanner reliability, and comparison to manual segmentation
    Allison C Nugent
    Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    Hum Brain Mapp 34:2313-29. 2013
    ..In addition, the inclusion of psychiatric patients establishes reliability in subjects exhibiting volumetric abnormalities, validating patient studies...
  51. ncbi request reprint Match between cue and memory valence during autobiographical memory recall in depression
    Kymberly D Young
    National Institutes of Health, National Institute of Mental Health, Bethesda, Maryland, USA
    Psychol Rep 111:129-48. 2012
    ....
  52. pmc Neural correlates of sleepiness induced by catecholamine depletion
    Noah Meyers
    National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Psychiatry Res 194:73-8. 2011
    ..The visceromotor system, the cingulate motor area, the periaqueductal gray and the caudal hypothalamus may mediate the impact of the dopaminergic system on regulation of wakefulness and sleep...
  53. ncbi request reprint Reduced serotonin type 1A receptor binding in panic disorder
    Alexander Neumeister
    National Institutes of Health, National Institute of Mental Health, Mood and Anxiety Disorders Program, Bethesda, Maryland 20892 2670, USA
    J Neurosci 24:589-91. 2004
    ..These results provide for the first time in vivo evidence for the involvement of 5-HT(1A)Rs in the pathophysiology of PD...
  54. pmc Bipolar and major depressive disorder: neuroimaging the developmental-degenerative divide
    Jonathan Savitz
    Section on Neuroimaging in Mood and Anxiety Disorders, Mood and Anxiety Disorders Program, National Institute of Mental Health NIH, Bethesda, MD 20892, USA
    Neurosci Biobehav Rev 33:699-771. 2009
    ..Imaging genetic approaches hold out promise for advancing our understanding of affective illness...
  55. ncbi request reprint Frontotemporal alterations in pediatric bipolar disorder: results of a voxel-based morphometry study
    Daniel P Dickstein
    Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 62:734-41. 2005
    ..While numerous magnetic resonance imaging (MRI) studies have evaluated adults with bipolar disorder (BPD), few have examined MRI changes in children with BPD...
  56. ncbi request reprint New insights into the role of cortisol and the glucocorticoid receptor in severe depression
    Philip W Gold
    National Institutes of Health, National Institute of Mental Health, Clinical Neuroendocrinology Branch, Intramural Research Program, 20852, Bethesda, MD, USA
    Biol Psychiatry 52:381-5. 2002
  57. pmc Early intervention in bipolar disorder, part I: clinical and imaging findings
    Giacomo Salvadore
    Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    Early Interv Psychiatry 2:122-35. 2008
    ..A companion paper discusses the cellular and molecular mechanisms of action of agents with neurotrophic and neuroplastic properties, with a particular emphasis on lithium and valproate...
  58. pmc Replication of scopolamine's antidepressant efficacy in major depressive disorder: a randomized, placebo-controlled clinical trial
    Wayne C Drevets
    Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biol Psychiatry 67:432-8. 2010
    ..The present study aimed to replicate this finding in an independent sample limited to unipolar depressives...
  59. ncbi request reprint Toward constructing an endophenotype strategy for bipolar disorders
    Gregor Hasler
    Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, Maryland, USA
    Biol Psychiatry 60:93-105. 2006
    ..Studies to evaluate candidate endophenotypes with respect to specificity, heritability, temporal stability, and prevalence in unaffected relatives are encouraged...
  60. ncbi request reprint Functional anatomical correlates of antidepressant drug treatment assessed using PET measures of regional glucose metabolism
    Wayne C Drevets
    Neuroimaging in Mood and Anxiety Disorders Section, National Institutes of Health, NIMH MIB, Bethesda, MD 20892, USA
    Eur Neuropsychopharmacol 12:527-44. 2002
    ....
  61. ncbi request reprint Glucose metabolism in the amygdala in depression: relationship to diagnostic subtype and plasma cortisol levels
    Wayne C Drevets
    Section on Neuroimaging of Mood and Anxiety Disorders, Molecular Imaging Branch, NIH National Institute of Mental Health, Building 1, Room B3 10, 1 Center Drive, MSC 0135, Bethesda, MD 20892 0135, USA
    Pharmacol Biochem Behav 71:431-47. 2002
    ....
  62. pmc High levels of Anti-GAD65 and Anti-Ro52 autoantibodies in a patient with major depressive disorder showing psychomotor disturbance
    Kathryn H Ching
    Neurobiology and Pain Therapeutics Section, Laboratory of Sensory Biology, National Institute of Dental and Craniofacial Research, 49 Convent Drive, Bldg 49, 1C20, Bethesda, Maryland, 20892 4410, United States
    J Neuroimmunol 222:87-9. 2010
    ..These results suggest the possibility that CNS autoimmunity may be responsible for the psychomotor impairment in this MDD patient...
  63. pmc In vivo evaluation of the effect of stimulus distribution on FIR statistical efficiency in event-related fMRI
    J Martijn Jansma
    Mood and Anxiety Disorders Program, Molecular Imaging Branch, Section on Neuroimaging in Mood and Anxiety Disorders, NIMH, NIH, United States
    J Neurosci Methods 215:190-5. 2013
    ..Our in vivo measurements can be used to aid in making an informed decision between freedom in protocol design and statistical efficiency...
  64. ncbi request reprint Orbitofrontal cortex function and structure in depression
    Wayne C Drevets
    Section on Neuroimaging in Mood and Anxiety Disorders, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 2670, USA
    Ann N Y Acad Sci 1121:499-527. 2007
    ....
  65. ncbi request reprint Discovering endophenotypes for major depression
    Gregor Hasler
    Mood and Anxiety Disorders Program, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, USA
    Neuropsychopharmacology 29:1765-81. 2004
    ....
  66. pmc Downregulation of brain phosphodiesterase type IV measured with 11C-(R)-rolipram positron emission tomography in major depressive disorder
    Masahiro Fujita
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 1026, USA
    Biol Psychiatry 72:548-54. 2012
    ..This study sought to quantify the binding of 11C-(R)-rolipram, a PDE4 inhibitor, as an indirect measure of this enzyme's activity in the brain of individuals with major depressive disorder (MDD) compared with healthy control subjects...
  67. pmc Differential effects of emotionally versus neutrally cued autobiographical memories on performance of a subsequent cognitive task: effects of task difficulty
    Kymberly D Young
    Section on Neuroimaging in Mood and Anxiety Disorders, National Institute of Mental Health, National Institutes of Health Bethesda, MD, USA Laureate Institute for Brain Research, Tulsa OK, USA
    Front Psychol 3:299. 2012
    ..Our results have implications for patients with major depressive disorder (MDD), as performing cognitively demanding tasks may allow them to attenuate the impairing effects of negative rumination on cognition...
  68. pmc 5-HT(1A) receptor function in major depressive disorder
    Jonathan Savitz
    Section on Neuroimaging in Mood and Anxiety Disorders, Mood and Anxiety Disorders Program, NIH NIMH, Bethesda, MD 20892, United States
    Prog Neurobiol 88:17-31. 2009
    ..Conversely, the C allele has been associated with better response to AD drugs. We raise the possibility that 5-HT(1A) receptor dysfunction represents one potential mechanism underpinning MDD and other stress-related disorders...
  69. ncbi request reprint Neuroimaging abnormalities in the amygdala in mood disorders
    Wayne C Drevets
    Mood and Anxiety Disorders Program, Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 2670, USA
    Ann N Y Acad Sci 985:420-44. 2003
    ....
  70. pmc Dose-dependent effects of hydrocortisone infusion on autobiographical memory recall
    Kymberly Young
    Section on Neuroimaging in Mood and Anxiety Disorders, National Institute of Mental Health NIMH, National Institutes of Health NIH, USA
    Behav Neurosci 125:735-41. 2011
    ..Specifically, administration of hydrocortisone at doses analogous to those achieved under severe psychosocial stress impaired the specificity and speed of retrieval of autobiographical memories...
  71. ncbi request reprint Estradiol effects on the postmenopausal brain
    Eydie L Moses-Kolko
    Am J Psychiatry 161:2136; author reply 2136. 2004
  72. ncbi request reprint Measurement of 5-HT1A receptor binding in depressed adults before and after antidepressant drug treatment using positron emission tomography and [11C]WAY-100635
    Eydie L Moses-Kolko
    Departments of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Synapse 61:523-30. 2007
    ..To assess effects of chronic antidepressant drug treatment on serotonin type-1A receptor (5-HT(1A)R) binding potential (BP) in major depressive disorder...
  73. pmc Neural basis of abnormal response to negative feedback in unmedicated mood disorders
    Joana V Taylor Tavares
    Department of Psychiatry, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Neuroimage 42:1118-26. 2008
    ..Disrupted top-down control by the prefrontal cortex of the amygdala may underlie this abnormal response to negative feedback in unipolar depression...
  74. pmc Reduced posterior hippocampal volume in posttraumatic stress disorder
    Omer Bonne
    Department of Psychiatry, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    J Clin Psychiatry 69:1087-91. 2008
    ..Hippocampal volume is reduced in posttraumatic stress disorder (PTSD). In the present study, we sought to determine whether volume loss is homogenously distributed or confined to a certain part of the structure...
  75. ncbi request reprint Effects of a alpha 2C-adrenoreceptor gene polymorphism on neural responses to facial expressions in depression
    Alexander Neumeister
    Department of Psychiatry, Yale University School of Medicine, West Haven, CT 06516, USA
    Neuropsychopharmacology 31:1750-6. 2006
    ..These results suggest that the alpha2CDel322-325-AR confers a change in brain function implicating this alpha2-AR subtype into the pathophysiology of MDD...
  76. pmc The effect of acute tryptophan depletion on the neural correlates of emotional processing in healthy volunteers
    Jonathan P Roiser
    Department of Imaging Neuroscience, Institute of Neurology, London, UK
    Neuropsychopharmacology 33:1992-2006. 2008
    ..These data suggest that 5-HT may play an important role in mediating automatic negative attentional biases in major depression, as well as resilience against negative distracting stimuli in never-depressed individuals...
  77. ncbi request reprint Altered brain serotonin 5-HT1A receptor binding after recovery from anorexia nervosa measured by positron emission tomography and [carbonyl11C]WAY-100635
    Ursula F Bailer
    Department of Psychiatry, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Arch Gen Psychiatry 62:1032-41. 2005
    ..Previous studies have shown that women with anorexia nervosa (AN), when ill and after recovery, have alterations of serotonin (5-HT) neuronal activity and core eating disorder symptoms, such as anxiety...
  78. ncbi request reprint Volumetric reduction in left subgenual prefrontal cortex in early onset depression
    Kelly N Botteron
    Department of Radiology, School of Medicine, Washington University, 660 South Euclid Avenue, Box 8134, St Louis, MO 63110, USA
    Biol Psychiatry 51:342-4. 2002
    ..In this study, the authors test the hypothesis that SGPFC reduction is present in adolescent onset MD, and examine differences in the magnitude of reduction in younger versus older women...
  79. pmc Neural response to catecholamine depletion in unmedicated subjects with major depressive disorder in remission and healthy subjects
    Gregor Hasler
    Department of Psychiatry, University Hospital, Culmannstrasse 8, 8091 Zurich, Switzerland
    Arch Gen Psychiatry 65:521-31. 2008
    ..An instructive paradigm for more directly investigating the relationship between catecholaminergic function and depression has involved the mood response to experimental catecholamine depletion (CD)...
  80. ncbi request reprint Differential effects of 5-HTTLPR genotypes on the behavioral and neural responses to tryptophan depletion in patients with major depression and controls
    Alexander Neumeister
    Molecular Imaging Program of the Clinical Neuroscience Division, Department of Psychiatry, Yale University School of Medicine, 950 Campbell Avenue, West Haven, CT 06516, USA
    Arch Gen Psychiatry 63:978-86. 2006
    ....
  81. ncbi request reprint Evidence of increased serotonin-1A receptor binding in type 2 diabetes: a positron emission tomography study
    Julie C Price
    PET Facility, Department of Radiology, University of Pittsburgh School of Medicine, 200 Lothrop St, Rm B938, Pittsburgh, PA 15213, USA
    Brain Res 927:97-103. 2002
    ..02). These findings support previous studies that suggest serotonergic underpinnings to the neurobiology of diabetes and have shown diabetes-induced neurological changes in hippocampus...
  82. pmc Serotonin 1A receptor reductions in postpartum depression: a positron emission tomography study
    Eydie L Moses-Kolko
    Department of Psychiatry, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania, USA
    Fertil Steril 89:685-92. 2008
    ..To measure brain serotonin-1A (5HT1A) receptor binding potential (BP) in healthy and depressed postpartum women...
  83. pmc 5-HT1A receptor binding in temporal lobe epilepsy patients with and without major depression
    Gregor Hasler
    Department of Psychiatry, University Hospital, Culmannstrasse 8, Zurich, Switzerland
    Biol Psychiatry 62:1258-64. 2007
    ..For the first time, 5-HT(1A) receptor binding was measured in a sample large enough to permit sensitive comparisons between TLE patients with and without comorbid MDD diagnosed by clinical and structured psychiatric interviews...
  84. doi request reprint Altered cerebral gamma-aminobutyric acid type A-benzodiazepine receptor binding in panic disorder determined by [11C]flumazenil positron emission tomography
    Gregor Hasler
    Department of Psychiatry, University Hospital, Culmannstrasse 8, 8091 Zurich, Switzerland
    Arch Gen Psychiatry 65:1166-75. 2008
    ..However, the results of previous neuroimaging studies are in disagreement, possibly because of experimental design limitations related to sample size, matching between patients and controls, and confounding medication effects...
  85. ncbi request reprint Glial reduction in amygdala in major depressive disorder is due to oligodendrocytes
    Massihullah Hamidi
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Biol Psychiatry 55:563-9. 2004
    ..It is not known, however, whether this glial loss is due to astrocytes, oligodendrocytes, or microglia...
  86. ncbi request reprint Distinct profiles of neurocognitive function in unmedicated unipolar depression and bipolar II depression
    Joana V Taylor Tavares
    Department of Psychiatry, Addenbrooke s Hospital, University of Cambridge, United Kingdom
    Biol Psychiatry 62:917-24. 2007
    ..In this study, we compared the performance of unmedicated currently depressed MDD and BD groups on a battery of neuropsychological tests that included measures of risk taking and reflection impulsivity...
  87. ncbi request reprint Selective reduction in amygdala volume in pediatric anxiety disorders: a voxel-based morphometry investigation
    Michael P Milham
    Beckman Institute, University of Illinois, Urbana, Illinois, USA
    Biol Psychiatry 57:961-6. 2005
    ..We examine the neural correlates of pediatric anxiety disorders, to consider the validity of the categorization scheme used in recent treatment studies...
  88. pmc Neurophysiological responses to traumatic reminders in the acute aftermath of serious motor vehicle collisions using [15O]-H2O positron emission tomography
    Elizabeth A Osuch
    Department of Psychiatry, University of Western Ontario, London, Ontario, Canada
    Biol Psychiatry 64:327-35. 2008
    ..However, neural responses arising in the early aftermath of a traumatic event have not been studied...
  89. ncbi request reprint Reduced prefrontal glutamate/glutamine and gamma-aminobutyric acid levels in major depression determined using proton magnetic resonance spectroscopy
    Gregor Hasler
    Department of Psychiatry, University Hospital, Zurich, Switzerland
    Arch Gen Psychiatry 64:193-200. 2007
    ....
  90. ncbi request reprint Tryptophan depletion alters the decision-making of healthy volunteers through altered processing of reward cues
    Robert D Rogers
    University Department of Psychiatry, University of Oxford, UK
    Neuropsychopharmacology 28:153-62. 2003
    ..It is possible that such a change in the cognition mediating human choice is one mechanism associated with the onset and maintenance of anhedonia and lowered mood in psychiatric illness...
  91. ncbi request reprint Hippocampus, VI. Depression and the Hippocampus
    Alexander Neumeister
    UT Southwestern Medical Center, Department of Psychiatry, Dallas, TX 75390 9070, USA
    Am J Psychiatry 162:1057. 2005
  92. ncbi request reprint Low glial numbers in the amygdala in major depressive disorder
    Michael P Bowley
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Biol Psychiatry 52:404-12. 2002
    ..Here, glia and neurons were counted in the amygdala and entorhinal cortex in major depressive disorder, bipolar disorder, and control cases...
  93. ncbi request reprint Widespread increases of cortical serotonin type 2A receptor availability after hormone therapy in euthymic postmenopausal women
    Eydie L Moses-Kolko
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Fertil Steril 80:554-9. 2003
    ..To use statistical parametric mapping to determine the extent of previously reported serotonin type 2A (5HT(2A)) receptor binding potential (BP) increases in postmenopausal women following hormone therapy...
  94. ncbi request reprint Sequential H(2)(15)O PET studies in baboons: before and after amphetamine
    Julie C Price
    Department of Radiology, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA
    J Nucl Med 43:1090-100. 2002
    ..A common assumption in bolus injection PET studies of this type is that cerebral blood flow (CBF) does not vary during the scan. The goal of this work was to examine the effect of AMPH administration on sequential PET measures of CBF...
  95. ncbi request reprint Neurobiology of emotion perception I: The neural basis of normal emotion perception
    Mary L Phillips
    Division of Psychological Medicine, Institute of Psychiatry, London, United Kingdom
    Biol Psychiatry 54:504-14. 2003
    ..We suggest that the extent to which a stimulus is identified as emotive and is associated with the production of an affective state may be dependent upon levels of activity within these two neural systems...
  96. ncbi request reprint Neurobiology of emotion perception II: Implications for major psychiatric disorders
    Mary L Phillips
    Division of Psychological Medicine, Institute of Psychiatry, London, United Kingdom
    Biol Psychiatry 54:515-28. 2003
    ..We suggest that distinct patterns of structural and functional abnormalities in neural systems important for emotion processing are associated with specific symptoms of schizophrenia and bipolar and major depressive disorder...
  97. pmc Cerebral blood flow in immediate and sustained anxiety
    Gregor Hasler
    Psychiatric University Hospital, 8091 Zurich, Switzerland
    J Neurosci 27:6313-9. 2007
    ..This study showed distinct neuronal networks involved in cued fear and contextual anxiety underlying the importance of this distinction for studies on the pathophysiology of anxiety disorders...
  98. ncbi request reprint Neural and behavioral substrates of mood and mood regulation
    Richard J Davidson
    Department of Psychology, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Biol Psychiatry 52:478-502. 2002
    ..Training interdisciplinary clinical scientists who meaningfully draw upon both behavioral and neuroscientific literatures and methods is critically required for the realization of these goals...