Research Topics
Genomes and GenesSpecies | W C DrevetsSummaryAffiliation: National Institutes of Health Country: USA Publications
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Publications
Neuroimaging and neuropathological studies of depression: implications for the cognitive-emotional features of mood disordersW C Drevets
Mood and Anxiety Disorders Program, National Institutes of Mental Health, 1 Center Drive, Room B3 07 MSC 0135, Bethesda, MD 20892 0135, USA
Curr Opin Neurobiol 11:240-9. 2001....- Orbitofrontal cortex function and structure in depressionWayne C Drevets
Section on Neuroimaging in Mood and Anxiety Disorders, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 2670, USA
Ann N Y Acad Sci 1121:499-527. 2007.... - Neuroimaging abnormalities in the amygdala in mood disordersWayne C Drevets
Mood and Anxiety Disorders Program, Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 2670, USA
Ann N Y Acad Sci 985:420-44. 2003.... - Glucose metabolism in the amygdala in depression: relationship to diagnostic subtype and plasma cortisol levelsWayne C Drevets
Section on Neuroimaging of Mood and Anxiety Disorders, Molecular Imaging Branch, NIH National Institute of Mental Health, Building 1, Room B3 10, 1 Center Drive, MSC 0135, Bethesda, MD 20892 0135, USA
Pharmacol Biochem Behav 71:431-47. 2002.... - Elevated serotonin transporter binding in major depressive disorder assessed using positron emission tomography and [11C]DASB; comparison with bipolar disorderDara M Cannon
Molecular Imaging Branch, Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
Biol Psychiatry 62:870-7. 2007.... - Discovering endophenotypes for major depressionGregor Hasler
Mood and Anxiety Disorders Program, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, USA
Neuropsychopharmacology 29:1765-81. 2004.... - New insights into the role of cortisol and the glucocorticoid receptor in severe depressionPhilip W Gold
National Institutes of Health, National Institute of Mental Health, Clinical Neuroendocrinology Branch, Intramural Research Program, 20852, Bethesda, MD, USA
Biol Psychiatry 52:381-5. 2002 
A comparison of cognitive functioning in medicated and unmedicated subjects with bipolar depressionM Kathleen Holmes
Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
Bipolar Disord 10:806-15. 2008..The present study aims to compare the cognitive performance of medicated and unmedicated subjects with bipolar depression to healthy control subjects...- Prefrontal cortical abnormalities in currently depressed versus currently remitted patients with major depressive disorderGiacomo Salvadore
Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
Neuroimage 54:2643-51. 2011..Consistent with other neuroimaging and post-mortem neuropathological studies of MDD, we also found evidence of decreased white matter in patients with dMDD and rMDD... - Serotonin-1A receptor imaging in recurrent depression: replication and literature reviewWayne C Drevets
Mood and Anxiety Disorders Program, MINH Molecular Imaging Branch, Bethesda, MD 20892, USA
Nucl Med Biol 34:865-77. 2007..In the current study, we attempted to replicate our previous findings in an independent sample of subjects selected according to the criteria for primary recurrent depression applied in our prior study... - Reduced muscarinic type 2 receptor binding in subjects with bipolar disorderDara M Cannon
Mood and Anxiety Disorders Program, Molecular Imaging Branch, National Institutes of Mental Health, National Institutes of Health, Bethesda, MD 20892 2670, USA
Arch Gen Psychiatry 63:741-7. 2006.... - Serotonin transporter binding in bipolar disorder assessed using [11C]DASB and positron emission tomographyDara M Cannon
Mood and Anxiety Disorders Program, Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 2670, USA
Biol Psychiatry 60:207-17. 2006..This study used PET and [(11)C]DASB, a radioligand that afforded higher sensitivity and specificity for the 5-HTT than previously available radioligands, to compare 5-HTT binding between BD and control subjects... - Antidepressant efficacy of the antimuscarinic drug scopolamine: a randomized, placebo-controlled clinical trialMaura L Furey
Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
Arch Gen Psychiatry 63:1121-9. 2006..002). Subsequently a clinical trial was designed to assess more specifically the antidepressant efficacy of scopolamine... - Selective effects of cholinergic modulation on task performance during selective attentionMaura L Furey
Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
Neuropsychopharmacology 33:913-23. 2008..The findings are discussed within the context of the role of acetylcholine both in stimulus processing and stimulus salience, and in establishing attention biases through top-down and bottom-up mechanisms of attention... - Regional cerebral glucose metabolic abnormalities in bipolar II depressionLinda Mah
Section on Neuroimaging in Mood and Anxiety Disorders, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
Biol Psychiatry 61:765-75. 2007..This study investigated whether cerebral metabolic abnormalities previously reported in unmedicated BD subjects are evident in depressed bipolar disorder type II (BD II) subjects receiving lithium or divalproex... - Choosing the lesser of two evils, the better of two goods: specifying the roles of ventromedial prefrontal cortex and dorsal anterior cingulate in object choiceKarina Blair
Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 2670, USA
J Neurosci 26:11379-86. 2006..These data are interpreted with reference to models of ACd and vmPFC functioning... - Sustained low-grade pro-inflammatory state in unmedicated, remitted women with major depressive disorder as evidenced by elevated serum levels of the acute phase proteins C-reactive protein and serum amyloid AMitchel A Kling
Clinical Neuroendocrinology Branch, Division of Intramural Research Programs, National Institute of Mental Health, Bethesda, MD 20892 1284, USA
Biol Psychiatry 62:309-13. 2007..Elevations of the inflammatory markers C-reactive protein (CRP) and serum amyloid A (SAA) predict increased CAD risk in populations; few data on these markers exist in MDD, particularly in remitted patients... - The subgenual anterior cingulate cortex in mood disordersWayne C Drevets
Section on Neuroimaging in Mood and Anxiety Disorders, Molecular Imaging Branch, National Institute of Mental Health, Bethesda, MD, USA
CNS Spectr 13:663-81. 2008..These data thus hold important implications for the development of neural models of depression that can account for the abnormal motivational, neuroendocrine, autonomic, and emotional manifestations evident in human mood disorders... - Relationship between amygdala responses to masked faces and mood state and treatment in major depressive disorderTeresa A Victor
National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
Arch Gen Psychiatry 67:1128-38. 2010..However, few studies have investigated such biases toward implicitly presented stimuli... - Scopolamine produces larger antidepressant and antianxiety effects in women than in menMaura L Furey
Mood and Anxiety Disorders Program, National Institute of Mental Health, NIH, Bethesda, MD 20892, USA
Neuropsychopharmacology 35:2479-88. 2010..6, p=0.001) showed that the antianxiety response was greater in women. Men and women show a rapid antidepressant response following scopolamine, but the magnitude of response is larger in women than in men... - Anterior cingulate desynchronization and functional connectivity with the amygdala during a working memory task predict rapid antidepressant response to ketamineGiacomo Salvadore
Experimental Therapeutics, Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
Neuropsychopharmacology 35:1415-22. 2010..73, p=0.0021, FDR <0.05).These data implicate the pgACC and its putative interaction with the amygdala in predicting antidepressant response to ketamine in a working memory task context... - High levels of Anti-GAD65 and Anti-Ro52 autoantibodies in a patient with major depressive disorder showing psychomotor disturbanceKathryn H Ching
Neurobiology and Pain Therapeutics Section, Laboratory of Sensory Biology, National Institute of Dental and Craniofacial Research, 49 Convent Drive, Bldg 49, 1C20, Bethesda, Maryland, 20892 4410, United States
J Neuroimmunol 222:87-9. 2010..These results suggest the possibility that CNS autoimmunity may be responsible for the psychomotor impairment in this MDD patient... 
Genetic variation in HTR2A influences serotonin transporter binding potential as measured using PET and [11C]DASBGonzalo Laje
Unit on the Genetic Basis of Mood and Anxiety Disorders, National Institute of Mental Health, Bethesda, MD 20892 3719, USA
Int J Neuropsychopharmacol 13:715-24. 2010....- Amygdala volume in depressed patients with bipolar disorder assessed using high resolution 3T MRI: the impact of medicationJonathan Savitz
Section on Neuroimaging in Mood and Anxiety Disorders, NIH NIMH MAP, Bethesda, MD 20892, USA
Neuroimage 49:2966-76. 2010..Here we extend these results to the amygdala. We raise the possibility that neuroplastic changes in the amygdala associated with BD are moderated by some mood stabilizing medications... - Bcl-2 polymorphism influences gray matter volume in the ventral striatum in healthy humansGiacomo Salvadore
Mood and Anxiety Disorders Program, National Institute of Mental Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
Biol Psychiatry 66:804-7. 2009..We tested the hypothesis that this SNP would modulate gray matter (GM) volume in the limbic-cortical-striatal-pallidal-thalamic circuitry that plays major roles in mood regulation... - 5-HT(1A) receptor function in major depressive disorderJonathan Savitz
Section on Neuroimaging in Mood and Anxiety Disorders, Mood and Anxiety Disorders Program, NIH NIMH, Bethesda, MD 20892, United States
Prog Neurobiol 88:17-31. 2009..Conversely, the C allele has been associated with better response to AD drugs. We raise the possibility that 5-HT(1A) receptor dysfunction represents one potential mechanism underpinning MDD and other stress-related disorders... - Bipolar and major depressive disorder: neuroimaging the developmental-degenerative divideJonathan Savitz
Section on Neuroimaging in Mood and Anxiety Disorders, Mood and Anxiety Disorders Program, National Institute of Mental Health NIH, Bethesda, MD 20892, USA
Neurosci Biobehav Rev 33:699-771. 2009..Imaging genetic approaches hold out promise for advancing our understanding of affective illness... - Serotonin transporter genotype and depressive phenotype determination by discriminant analysis of glucose metabolism under acute tryptophan depletionAllison C Nugent
Section on Neuroimaging in Mood and Anxiety Disorders, National Institute of Mental Health, NIH, Bethesda, MD 20892 0940, USA
Neuroimage 43:764-74. 2008..The robust nature of the classification results indicates that much of the variance in metabolic response to ATD is accounted for by genotypic and phenotypic category... - Brain structural and functional abnormalities in mood disorders: implications for neurocircuitry models of depressionWayne C Drevets
Section on Neuroimaging in Mood and Anxiety Disorders, National Institute of Mental Health, National Institutes of Health NIH NIMH DIRP, 15K North Dr, Room 210, Bethesda, MD 20892, USA
Brain Struct Funct 213:93-118. 2008..This paper discusses these systems together with the neurochemical systems that impinge on them and form the basis for most pharmacological therapies... - Differential performance on tasks of affective processing and decision-making in patients with Panic Disorder and Panic Disorder with comorbid Major Depressive DisorderJohanna S Kaplan
Mood and Anxiety Disorders Program, National Institute of Mental Health, NIH, DHHS, Bethesda MD, USA
J Affect Disord 95:165-71. 2006..In addition, patients with comorbid depression provided qualitatively different responses in the areas of affective and decision-making processes... - Functional anatomical correlates of antidepressant drug treatment assessed using PET measures of regional glucose metabolismWayne C Drevets
Neuroimaging in Mood and Anxiety Disorders Section, National Institutes of Health, NIMH MIB, Bethesda, MD 20892, USA
Eur Neuropsychopharmacol 12:527-44. 2002.... - Neural and behavioral responses to tryptophan depletion in unmedicated patients with remitted major depressive disorder and controlsAlexander Neumeister
Section on Experimental Therapeutics, Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, MD 20892 2670, USA
Arch Gen Psychiatry 61:765-73. 2004.... - Reduced serotonin type 1A receptor binding in panic disorderAlexander Neumeister
National Institutes of Health, National Institute of Mental Health, Mood and Anxiety Disorders Program, Bethesda, Maryland 20892 2670, USA
J Neurosci 24:589-91. 2004..These results provide for the first time in vivo evidence for the involvement of 5-HT(1A)Rs in the pathophysiology of PD... - Mood-congruent bias in affective go/no-go performance of unmedicated patients with major depressive disorderKristine Erickson
Mood and Anxiety Disorders Program, National Institute of Mental Health, MD 20814 9692, USA
Am J Psychiatry 162:2171-3. 2005..This study investigated performance of unmedicated depressed patients on the Affective Go/No-Go Task... - Cortical abnormalities in bipolar disorder investigated with MRI and voxel-based morphometryAllison C Nugent
Section on Neuroimaging in Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, 1 Center Drive, MSC 0135, Bethesda, MD 20892 0135, USA
Neuroimage 30:485-97. 2006.... - No change in serotonin type 1A receptor binding in patients with posttraumatic stress disorderOmer Bonne
Section of Experimental Therapeutics, NIMH Mood and Anxiety Disorders Program, Bethesda, MD 20892 2670, USA
Am J Psychiatry 162:383-5. 2005..In the present study, the authors sought an association between 5HT1AR binding and posttraumatic stress disorder (PTSD)... - Normal prefrontal gamma-aminobutyric acid levels in remitted depressed subjects determined by proton magnetic resonance spectroscopyGregor Hasler
Mood and Anxiety Disorders Program, Section on Experimental Therapeutics, National Institutes of Health, Bethesda, MD 20892 2670, USA
Biol Psychiatry 58:969-73. 2005..As a result, the current study investigates whether GABA levels in the prefrontal cortex differ between unmedicated subjects with remitted major depressive disorder (rMDD) and healthy control subjects... - Frontotemporal alterations in pediatric bipolar disorder: results of a voxel-based morphometry studyDaniel P Dickstein
Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, MD 20892, USA
Arch Gen Psychiatry 62:734-41. 2005..While numerous magnetic resonance imaging (MRI) studies have evaluated adults with bipolar disorder (BPD), few have examined MRI changes in children with BPD... - Modulation of emotion by cognition and cognition by emotionK S Blair
Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 2670, USA
Neuroimage 35:430-40. 2007..NeuroImage, 29 (3), 721-733] and negative connectivity with bilateral amygdala. These data suggest that processes involved in emotional regulation are recruited during task performance in the context of emotional distractors... - Neural circuitry and neuroplasticity in mood disorders: insights for novel therapeutic targetsPaul J Carlson
Laboratory of Molecular Pathophysiology, National Institute of Mental Health, Bethesda, Maryland 20892, USA
NeuroRx 3:22-41. 2006.... - Response to emotional expressions in generalized social phobia and generalized anxiety disorder: evidence for separate disordersKarina Blair
Mood and Anxiety Program, NIMH, NIH, 15K North Dr, MSC 2670, Bethesda, MD 20892, USA
Am J Psychiatry 165:1193-202. 2008..Functional magnetic resonance imaging assessed the neural response to facial expressions in generalized social phobia and generalized anxiety disorder... - Toward constructing an endophenotype strategy for bipolar disordersGregor Hasler
Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, Maryland, USA
Biol Psychiatry 60:93-105. 2006..Studies to evaluate candidate endophenotypes with respect to specificity, heritability, temporal stability, and prevalence in unaffected relatives are encouraged... - Reduced hippocampal volume in unmedicated, remitted patients with major depression versus control subjectsAlexander Neumeister
Section on Experimental Therapeutics and Pathophysiology, Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, Maryland, USA
Biol Psychiatry 57:935-7. 2005..Hippocampal volumes obtained from a group of medication-free, remitted subjects with recurrent major depressive disorder (MDD) were compared against corresponding measures from healthy controls... - Replication of scopolamine's antidepressant efficacy in major depressive disorder: a randomized, placebo-controlled clinical trialWayne C Drevets
Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
Biol Psychiatry 67:432-8. 2010..The present study aimed to replicate this finding in an independent sample limited to unipolar depressives... - The cellular neurobiology of depressionH K Manji
Laboratory of Molecular Pathophysiology, National Institute of Mental Health, Bethesda, Maryland, USA
Nat Med 7:541-7. 2001..Agents designed to directly target molecules in these pathways may hold promise as new therapeutics for depression... - Imaging phenotypes of major depressive disorder: genetic correlatesJ B Savitz
Mood and Anxiety Disorders Program, NIH NIMH, Bethesda, MD 20892, USA
Neuroscience 164:300-30. 2009..Further advances are likely as epigenetic, copy-number variant, gene-gene interaction, and genome-wide association (GWA) approaches are brought to bear on imaging data... - The role of 5-HTTLPR in choosing the lesser of two evils, the better of two goods: examining the impact of 5-HTTLPR genotype and tryptophan depletion in object choiceK S Blair
Department of Health and Human Services, Mood and Anxiety Program, National Institute of Mental Health, National Institutes of Health, 15K North Drive, Room 300A, MSC 2670, Bethesda, MD 20892 2670, USA
Psychopharmacology (Berl) 196:29-38. 2008..The serotonin (5-HT) system is considered important for decision-making. However, its role in reward- and punishment-based processing has not yet been clearly determined... - Tryptophan depletion alters the decision-making of healthy volunteers through altered processing of reward cuesRobert D Rogers
University Department of Psychiatry, University of Oxford, UK
Neuropsychopharmacology 28:153-62. 2003..It is possible that such a change in the cognition mediating human choice is one mechanism associated with the onset and maintenance of anhedonia and lowered mood in psychiatric illness... - Volumetric reduction in left subgenual prefrontal cortex in early onset depressionKelly N Botteron
Department of Radiology, School of Medicine, Washington University, 660 South Euclid Avenue, Box 8134, St. Louis, MO 63110, USA
Biol Psychiatry 51:342-4. 2002..CONCLUSIONS: Left subgenual cingulate volume reductions are present in young women with adolescent onset MD... - Neural basis of abnormal response to negative feedback in unmedicated mood disordersJoana V Taylor Tavares
Department of Psychiatry, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
Neuroimage 42:1118-26. 2008..Disrupted top-down control by the prefrontal cortex of the amygdala may underlie this abnormal response to negative feedback in unipolar depression... - Glial reduction in amygdala in major depressive disorder is due to oligodendrocytesMassihullah Hamidi
Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA
Biol Psychiatry 55:563-9. 2004..There was no significant decrease in astrocyte or microglia density in MDD or BD subjects. CONCLUSIONS: The glial cell reduction previously found in the amygdala in MDD is primarily due to oligodendrocytes... - Reduced posterior hippocampal volume in posttraumatic stress disorderOmer Bonne
Department of Psychiatry, Hadassah Hebrew University Medical Center, Jerusalem, Israel
J Clin Psychiatry 69:1087-91. 2008..Hippocampal volume is reduced in posttraumatic stress disorder (PTSD). In the present study, we sought to determine whether volume loss is homogenously distributed or confined to a certain part of the structure... - Widespread increases of cortical serotonin type 2A receptor availability after hormone therapy in euthymic postmenopausal womenEydie L Moses-Kolko
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Fertil Steril 80:554-9. 2003..To use statistical parametric mapping to determine the extent of previously reported serotonin type 2A (5HT(2A)) receptor binding potential (BP) increases in postmenopausal women following hormone therapy... - Altered cerebral gamma-aminobutyric acid type A-benzodiazepine receptor binding in panic disorder determined by [11C]flumazenil positron emission tomographyGregor Hasler
Department of Psychiatry, University Hospital, Culmannstrasse 8, 8091 Zurich, Switzerland
Arch Gen Psychiatry 65:1166-75. 2008..However, the results of previous neuroimaging studies are in disagreement, possibly because of experimental design limitations related to sample size, matching between patients and controls, and confounding medication effects... - Low glial numbers in the amygdala in major depressive disorderMichael P Bowley
Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA
Biol Psychiatry 52:404-12. 2002..CONCLUSIONS: Glia are reduced in the amygdala in major depressive disorder, especially on the left side. The results suggest that lithium and valproate may moderate the glial reduction... - Evidence of increased serotonin-1A receptor binding in type 2 diabetes: a positron emission tomography studyJulie C Price
PET Facility, Department of Radiology, University of Pittsburgh School of Medicine, 200 Lothrop St, Rm B938, Pittsburgh, PA 15213, USA
Brain Res 927:97-103. 2002..02). These findings support previous studies that suggest serotonergic underpinnings to the neurobiology of diabetes and have shown diabetes-induced neurological changes in hippocampus... - Neural response to catecholamine depletion in unmedicated subjects with major depressive disorder in remission and healthy subjectsGregor Hasler
Department of Psychiatry, University Hospital, Culmannstrasse 8, 8091 Zurich, Switzerland
Arch Gen Psychiatry 65:521-31. 2008..An instructive paradigm for more directly investigating the relationship between catecholaminergic function and depression has involved the mood response to experimental catecholamine depletion (CD)... - Altered brain serotonin 5-HT1A receptor binding after recovery from anorexia nervosa measured by positron emission tomography and [carbonyl11C]WAY-100635Ursula F Bailer
Department of Psychiatry, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
Arch Gen Psychiatry 62:1032-41. 2005..These psychobiological alterations may be trait related and may contribute to the pathogenesis of AN... - Hippocampus, VI. Depression and the HippocampusAlexander Neumeister
UT Southwestern Medical Center, Department of Psychiatry, Dallas, TX 75390-9070, USA
Am J Psychiatry 162:1057. 2005 - Effects of a alpha 2C-adrenoreceptor gene polymorphism on neural responses to facial expressions in depressionAlexander Neumeister
Department of Psychiatry, Yale University School of Medicine, West Haven, CT 06516, USA
Neuropsychopharmacology 31:1750-6. 2006..These results suggest that the alpha2CDel322-325-AR confers a change in brain function implicating this alpha2-AR subtype into the pathophysiology of MDD... - Reduced prefrontal glutamate/glutamine and gamma-aminobutyric acid levels in major depression determined using proton magnetic resonance spectroscopyGregor Hasler
Department of Psychiatry, University Hospital, Zurich, Switzerland
Arch Gen Psychiatry 64:193-200. 2007.... - Measurement of 5-HT1A receptor binding in depressed adults before and after antidepressant drug treatment using positron emission tomography and [11C]WAY-100635Eydie L Moses-Kolko
Departments of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Synapse 61:523-30. 2007..To assess effects of chronic antidepressant drug treatment on serotonin type-1A receptor (5-HT(1A)R) binding potential (BP) in major depressive disorder... - Selective reduction in amygdala volume in pediatric anxiety disorders: a voxel-based morphometry investigationMichael P Milham
Beckman Institute, University of Illinois, Urbana, Illinois, USA
Biol Psychiatry 57:961-6. 2005..We examine the neural correlates of pediatric anxiety disorders, to consider the validity of the categorization scheme used in recent treatment studies... - Serotonin 1A receptor reductions in postpartum depression: a positron emission tomography studyEydie L Moses-Kolko
Department of Psychiatry, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania, USA
Fertil Steril 89:685-92. 2008..To measure brain serotonin-1A (5HT1A) receptor binding potential (BP) in healthy and depressed postpartum women... - The effect of acute tryptophan depletion on the neural correlates of emotional processing in healthy volunteersJonathan P Roiser
Department of Imaging Neuroscience, Institute of Neurology, London, UK
Neuropsychopharmacology 33:1992-2006. 2008..These data suggest that 5-HT may play an important role in mediating automatic negative attentional biases in major depression, as well as resilience against negative distracting stimuli in never-depressed individuals... - 5-HT1A receptor binding in temporal lobe epilepsy patients with and without major depressionGregor Hasler
Department of Psychiatry, University Hospital, Culmannstrasse 8, Zurich, Switzerland
Biol Psychiatry 62:1258-64. 2007..For the first time, 5-HT(1A) receptor binding was measured in a sample large enough to permit sensitive comparisons between TLE patients with and without comorbid MDD diagnosed by clinical and structured psychiatric interviews... - Neurophysiological responses to traumatic reminders in the acute aftermath of serious motor vehicle collisions using [15O]-H2O positron emission tomographyElizabeth A Osuch
Department of Psychiatry, University of Western Ontario, London, Ontario, Canada
Biol Psychiatry 64:327-35. 2008..However, neural responses arising in the early aftermath of a traumatic event have not been studied... - Differential effects of 5-HTTLPR genotypes on the behavioral and neural responses to tryptophan depletion in patients with major depression and controlsAlexander Neumeister
Molecular Imaging Program of the Clinical Neuroscience Division, Department of Psychiatry, Yale University School of Medicine, 950 Campbell Avenue, West Haven, CT 06516, USA
Arch Gen Psychiatry 63:978-86. 2006.... - Distinct profiles of neurocognitive function in unmedicated unipolar depression and bipolar II depressionJoana V Taylor Tavares
Department of Psychiatry, Addenbrooke s Hospital, University of Cambridge, United Kingdom
Biol Psychiatry 62:917-24. 2007..In this study, we compared the performance of unmedicated currently depressed MDD and BD groups on a battery of neuropsychological tests that included measures of risk taking and reflection impulsivity... - Estradiol effects on the postmenopausal brainEydie L Moses-Kolko
Am J Psychiatry 161:2136; author reply 2136. 2004 - Sequential H(2)(15)O PET studies in baboons: before and after amphetamineJulie C Price
Department of Radiology, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA
J Nucl Med 43:1090-100. 2002..A common assumption in bolus injection PET studies of this type is that cerebral blood flow (CBF) does not vary during the scan. The goal of this work was to examine the effect of AMPH administration on sequential PET measures of CBF... - Cerebral blood flow in immediate and sustained anxietyGregor Hasler
Psychiatric University Hospital, 8091 Zurich, Switzerland
J Neurosci 27:6313-9. 2007..This study showed distinct neuronal networks involved in cued fear and contextual anxiety underlying the importance of this distinction for studies on the pathophysiology of anxiety disorders... - Neural and behavioral substrates of mood and mood regulationRichard J Davidson
Department of Psychology, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA
Biol Psychiatry 52:478-502. 2002..Training interdisciplinary clinical scientists who meaningfully draw upon both behavioral and neuroscientific literatures and methods is critically required for the realization of these goals... - Neurobiology of emotion perception II: Implications for major psychiatric disordersMary L Phillips
Division of Psychological Medicine, Institute of Psychiatry, London, United Kingdom
Biol Psychiatry 54:515-28. 2003..We suggest that distinct patterns of structural and functional abnormalities in neural systems important for emotion processing are associated with specific symptoms of schizophrenia and bipolar and major depressive disorder... - Neurobiology of emotion perception I: The neural basis of normal emotion perceptionMary L Phillips
Division of Psychological Medicine, Institute of Psychiatry, London, United Kingdom
Biol Psychiatry 54:504-14. 2003..We suggest that the extent to which a stimulus is identified as emotive and is associated with the production of an affective state may be dependent upon levels of activity within these two neural systems...