Dennis T Drayna

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi Founder mutations
    Dennis Drayna
    National Institutes of Health, National Institute on Deafness and Other Communication Disorders, USA
    Sci Am 293:78-85. 2005
  2. ncbi MALS: an efficient strategy for multiple site-directed mutagenesis employing a combination of DNA amplification, ligation and suppression PCR
    Alexey A Fushan
    National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892, USA
    BMC Biotechnol 9:83. 2009
  3. ncbi Genetic approaches to understanding the causes of stuttering
    Dennis Drayna
    National Institute on Deafness and Other Communication Disorders, National Institutes of Health, 5 Research Court, Room 2B 46, Rockville, MD, 20850, USA
    J Neurodev Disord 3:374-80. 2011
  4. ncbi Absolute pitch: a special group of ears
    Dennis T Drayna
    National Institute on Deafness and Other Communication Disorders, National Institutes of Health, 5 Research Court, Rockville, MD 20850, USA
    Proc Natl Acad Sci U S A 104:14549-50. 2007
  5. ncbi Human taste genetics
    Dennis Drayna
    National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Rockville, Maryland 20850, USA
    Annu Rev Genomics Hum Genet 6:217-35. 2005
  6. ncbi Positional cloning of the human quantitative trait locus underlying taste sensitivity to phenylthiocarbamide
    Un Kyung Kim
    National Institute on Deafness and Other Communication Disorders, National Institutes of Health, 5 Research Court, Rockville, MD 20850, USA
    Science 299:1221-5. 2003
  7. ncbi Tune deafness: processing melodic errors outside of conscious awareness as reflected by components of the auditory ERP
    Allen Braun
    Language Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 3:e2349. 2008
  8. ncbi A twin study of auditory processing indicates that dichotic listening ability is a strongly heritable trait
    Robert J Morell
    Laboratory of Molecular Genetics, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, 5 Research Court, Rockville, MD 20850, USA
    Hum Genet 122:103-11. 2007
  9. ncbi Mutant dynactin in motor neuron disease
    Imke Puls
    Neurogenetics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Genet 33:455-6. 2003
  10. ncbi Variation in the human TAS1R taste receptor genes
    Un-Kyung Kim
    National Institute on Deafness and Other Communication Disorders, National Institutes of Health, 5 Research Court, Rockville, MD 20850, USA
    Chem Senses 31:599-611. 2006

Detail Information

Publications16

  1. ncbi Founder mutations
    Dennis Drayna
    National Institutes of Health, National Institute on Deafness and Other Communication Disorders, USA
    Sci Am 293:78-85. 2005
  2. ncbi MALS: an efficient strategy for multiple site-directed mutagenesis employing a combination of DNA amplification, ligation and suppression PCR
    Alexey A Fushan
    National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892, USA
    BMC Biotechnol 9:83. 2009
    ..In addition, many of the existing multiple SDM methods have technical limitations associated with type and number of mutations that can be introduced, or are technically demanding and require special chemical reagents...
  3. ncbi Genetic approaches to understanding the causes of stuttering
    Dennis Drayna
    National Institute on Deafness and Other Communication Disorders, National Institutes of Health, 5 Research Court, Room 2B 46, Rockville, MD, 20850, USA
    J Neurodev Disord 3:374-80. 2011
    ..While mutations in these three genes can be identified in less than 10% of cases of familial stuttering, this knowledge allows a variety of new studies that can help identify the neuropathology that underlies this disorder...
  4. ncbi Absolute pitch: a special group of ears
    Dennis T Drayna
    National Institute on Deafness and Other Communication Disorders, National Institutes of Health, 5 Research Court, Rockville, MD 20850, USA
    Proc Natl Acad Sci U S A 104:14549-50. 2007
  5. ncbi Human taste genetics
    Dennis Drayna
    National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Rockville, Maryland 20850, USA
    Annu Rev Genomics Hum Genet 6:217-35. 2005
    ..More general studies of linkage and association between genetic markers and taste phenotypes may reveal genes encoding proteins that were previously unsuspected to be involved in this sensory process...
  6. ncbi Positional cloning of the human quantitative trait locus underlying taste sensitivity to phenylthiocarbamide
    Un Kyung Kim
    National Institute on Deafness and Other Communication Disorders, National Institutes of Health, 5 Research Court, Rockville, MD 20850, USA
    Science 299:1221-5. 2003
    ....
  7. ncbi Tune deafness: processing melodic errors outside of conscious awareness as reflected by components of the auditory ERP
    Allen Braun
    Language Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 3:e2349. 2008
    ..Given the high heritability of TD, these patients may make it possible to use genetic methods to study cellular and molecular mechanisms underlying conscious awareness...
  8. ncbi A twin study of auditory processing indicates that dichotic listening ability is a strongly heritable trait
    Robert J Morell
    Laboratory of Molecular Genetics, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, 5 Research Court, Rockville, MD 20850, USA
    Hum Genet 122:103-11. 2007
    ..These findings should help illuminate the etiology of APDs, and help to clarify the relationships between auditory processing abilities and learning/language disorders associated with APDs...
  9. ncbi Mutant dynactin in motor neuron disease
    Imke Puls
    Neurogenetics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Genet 33:455-6. 2003
    ..Binding assays show decreased binding of the mutant protein to microtubules. Our results show that dysfunction of dynactin-mediated transport can lead to human motor neuron disease...
  10. ncbi Variation in the human TAS1R taste receptor genes
    Un-Kyung Kim
    National Institute on Deafness and Other Communication Disorders, National Institutes of Health, 5 Research Court, Rockville, MD 20850, USA
    Chem Senses 31:599-611. 2006
    ....
  11. ncbi Allelic polymorphism within the TAS1R3 promoter is associated with human taste sensitivity to sucrose
    Alexey A Fushan
    National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20850, USA
    Curr Biol 19:1288-93. 2009
    ..We propose that inherited differences in TAS1R3 transcription account for a substantial fraction of worldwide differences in human sweet taste perception...
  12. ncbi Genetic analysis of a complex trait in the Utah Genetic Reference Project: a major locus for PTC taste ability on chromosome 7q and a secondary locus on chromosome 16p
    Dennis Drayna
    National Institute on Deafness and Other Communication Disorders, NIH, Rockville, MD 20850, USA
    Hum Genet 112:567-72. 2003
    ..31 at 344 cM) and 16 (lod=2.01 at 14 cM). A subsequent two-locus whole-genome scan conditional on the chromosome 7 quantitative trait locus identified the chromosome 16 locus (two-locus lod=3.33 at 14 cM)...
  13. ncbi Genetics of speech and language disorders
    Changsoo Kang
    National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892, USA
    Annu Rev Genomics Hum Genet 12:145-64. 2011
    ....
  14. ncbi Association between common variation in genes encoding sweet taste signaling components and human sucrose perception
    Alexey A Fushan
    National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Rockville, MD 20850, USA
    Chem Senses 35:579-92. 2010
    ..Collectively, GNAT3 polymorphisms explain 13% of the variation in sucrose perception. Our findings underscore the importance of common genetic variants influencing human taste perception...
  15. ncbi Phonological processing in adults with deficits in musical pitch recognition
    Jennifer L Jones
    National Institute on Deafness and Other Communication Disorders, NIH, Bethesda, MD 20892, USA
    J Commun Disord 42:226-34. 2009
    ....
  16. ncbi Associations between phenylthiocarbamide gene polymorphisms and cigarette smoking
    Dale S Cannon
    Department of Psychiatry, University of Utah, Salt Lake City, UT, USA
    Nicotine Tob Res 7:853-8. 2005
    ..392, p = .001. The predicted relationship between PAV and AVI and taste motivation was found, F(2, 348) = 3.303, p = .038. The results encourage further exploration of the role of taste/sensory processes in tobacco dependence...