Research Topics
Genomes and Genes | Daniel C DouekSummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
Mapping of positive selection sites in the HIV-1 genome in the context of RNA and protein structural constraintsJoke Snoeck
Institute of Microbiology, University Hospital Center and University of Lausanne, Lausanne, Switzerland
Retrovirology 8:87. 2011....- Universal and specific quantitative detection of botulinum neurotoxin genesBrenna J Hill
Human Immunology Section, Vaccine Research Center, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
BMC Microbiol 10:267. 2010..botulinum regardless of the neurotoxin type. The second step uses quantitative PCR (qPCR) technology to determine the specific serotype of the neurotoxin... 
T cell dynamics in HIV-1 infectionDaniel C Douek
Human Immunology Section Vaccine Research Center, NIAID, NIH, Bethesda, Maryland 20892, USA
Annu Rev Immunol 21:265-304. 2003....- HIV preferentially infects HIV-specific CD4+ T cellsDaniel C Douek
Vaccine Research Center, NIAID, NIH, Maryland 20892, USA
Nature 417:95-8. 2002..Furthermore, the phenomenon of HIV specifically infecting the very cells that respond to it adds a cautionary note to the practice of structured therapy interruption... - Disrupting T-cell homeostasis: how HIV-1 infection causes diseaseDaniel C Douek
Human Immunology Section, Vaccine Research Center, NIAID, NIH, Room 3509, 40 Convent Drive, Bethesda, MD 20892, USA
AIDS Rev 5:172-7. 2003.... - A novel approach to the analysis of specificity, clonality, and frequency of HIV-specific T cell responses reveals a potential mechanism for control of viral escapeDaniel C Douek
Department of Experimental Transplantation and Immunology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 168:3099-104. 2002..Thus, CD8(+) T cells comprising multiple TCR clonotypes may expand in vivo in response to individual epitopes, and may increase the ability of the response to recognize virus escape mutants... - Acquisition of direct antiviral effector functions by CMV-specific CD4+ T lymphocytes with cellular maturationJoseph P Casazza
Immunology Laboratory, Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases (NIAID, National Institutes of Health (NIH, Bethesda, MD 20892, USA
J Exp Med 203:2865-77. 2006..Thus, mature CMV-specific CD4+ T cells exhibit distinct functional properties reminiscent of antiviral CD8+ T lymphocytes... - Graft-versus-leukemia effects associated with detectable Wilms tumor-1 specific T lymphocytes after allogeneic stem-cell transplantation for acute lymphoblastic leukemiaKatayoun Rezvani
Stem Cell Allotransplantation Section, Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1201, USA
Blood 110:1924-32. 2007..Our results support the immunogenicity of WT1 after SCT for ALL and highlight the potential for WT1 vaccines to boost GVL after SCT for ALL... - The functional profile of primary human antiviral CD8+ T cell effector activity is dictated by cognate peptide concentrationMichael R Betts
Immunology Laboratory, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 172:6407-17. 2004..The inherent ability of viruses to induce high or low Ag states may be the primary determinant of the cytokine vs cytolytic nature of the virus-specific CD8(+) T cell response... - The transfer of adaptive immunity to CMV during hematopoietic stem cell transplantation is dependent on the specificity and phenotype of CMV-specific T cells in the donorPhillip Scheinberg
Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA
Blood 114:5071-80. 2009.... - Public clonotype usage identifies protective Gag-specific CD8+ T cell responses in SIV infectionDavid A Price
Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Exp Med 206:923-36. 2009..Thus, the pattern of antigen-specific clonotype recruitment within a protective CD8(+) T cell population is a prognostic indicator of vaccine efficacy and biological outcome in an AIDS virus infection... - T-cell subsets that harbor human immunodeficiency virus (HIV) in vivo: implications for HIV pathogenesisJason M Brenchley
Human Immunology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
J Virol 78:1160-8. 2004..These data illuminate the underlying mechanisms that distort T-cell homeostasis in HIV infection... - Differential association of programmed death-1 and CD57 with ex vivo survival of CD8+ T cells in HIV infectionConstantinos Petrovas
Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20814, USA
J Immunol 183:1120-32. 2009..Thus, our data further support the role of PD-1 as a preapoptotic factor for CD8(+) T cells in HIV infection... - SIV-specific CD8+ T cells express high levels of PD1 and cytokines but have impaired proliferative capacity in acute and chronic SIVmac251 infectionConstantinos Petrovas
Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases NIH, 40 Convent Drive, Bethesda, MD 20892, USA
Blood 110:928-36. 2007..Manipulation of the interaction of PD-1 with its ligands could thus potentially restore the CD8+ T-cell responses in SIV infection... - Avidity for antigen shapes clonal dominance in CD8+ T cell populations specific for persistent DNA virusesDavid A Price
Human Immunology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Exp Med 202:1349-61. 2005..Vaccine strategies that reconstruct these biological processes could generate T cell populations that mediate optimal delivery of antiviral effector function... - In vitro induction of myeloid leukemia-specific CD4 and CD8 T cells by CD40 ligand-activated B cells gene modified to express primary granule proteinsHiroshi Fujiwara
Stem Cell Allotransplant Section, Hematology Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, Maryland 20892, USA
Clin Cancer Res 11:4495-503. 2005..This study emphasizes the clinical potential of PGP for expansion and adoptive transfer of polyclonal leukemia antigen-specific T cells to treat leukemia... - Autocrine production of beta-chemokines protects CMV-Specific CD4 T cells from HIV infectionJoseph P Casazza
Immunology Laboratory, Vaccine Research Center, NIAID, NIH, Bethesda, Maryland, USA
PLoS Pathog 5:e1000646. 2009..These data suggest that CD4+ T cells which produce MIP-1alpha and MIP-1beta bind these chemokines in an autocrine fashion which decreases the risk of in vivo HIV infection... 
Evaluation of the pathogenesis of decreasing CD4(+) T cell counts in human immunodeficiency virus type 1-infected patients receiving successfully suppressive antiretroviral therapyElizabeth Nies-Kraske
National Institute of Allergy and Infectious Diseases, National Institutes of Health, MD, USA
J Infect Dis 199:1648-56. 2009..All 4 patients had significant fibrosis of the T cell zone of lymphoid tissue, which appeared to be an important factor in the failure to reconstitute T cells...- Alloreactivity across HLA barriers is mediated by both naïve and antigen-experienced T cellsJ Joseph Melenhorst
Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1202, USA
Biol Blood Marrow Transplant 17:800-9. 2011.... - Systemic vaccination prevents the total destruction of mucosal CD4 T cells during acute SIV challengeJoseph J Mattapallil
Vaccine Research Center, NIAID, NIH, Bethesda, MD, USA
J Med Primatol 35:217-24. 2006..The primary objective of this study was to determine if systemic vaccination with DNA/rAd-5 encoding SIV-mac239-env, gag and pol could prevent the destruction of CD4 T cells in mucosal tissues... - High avidity myeloid leukemia-associated antigen-specific CD8+ T cells preferentially reside in the bone marrowJ Joseph Melenhorst
Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
Blood 113:2238-44. 2009..These data suggest that concomitant examination of bone marrow specimens in patients with myeloid leukemias might yield more definitive information in the search for immunologic prognosticators of clinical outcome... - Virological outcome after structured interruption of antiretroviral therapy for human immunodeficiency virus infection is associated with the functional profile of virus-specific CD8+ T cellsMarybeth Daucher
National Institute of Allergy and Infectious Diseases, Bldg 10 Rm 11B13, Bethesda, MD 20892, USA
J Virol 82:4102-14. 2008.... - Minor viral and host genetic polymorphisms can dramatically impact the biologic outcome of an epitope-specific CD8 T-cell responseChristof Geldmacher
Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA
Blood 114:1553-62. 2009..Thus, minor viral and host genetic polymorphisms can dramatically alter the immunologic and virologic outcome of an epitope-specific CD8 T-cell response... - CD4 T follicular helper cell dynamics during SIV infectionConstantinos Petrovas
Vaccine Research Center, NIAID, NIH, Bethesda, MD 20892, USA
J Clin Invest 122:3281-94. 2012..Therefore, chronic SIV does not disturb the ability of TFH cells to help B cell maturation and production of SIV-specific immunoglobulins... - Virus inhibition activity of effector memory CD8(+) T cells determines simian immunodeficiency virus load in vaccinated monkeys after vaccine breakthrough infectionTakuya Yamamoto
Vaccine Research Center, NIAID, NIH, Bethesda, Maryland, USA
J Virol 86:5877-84. 2012..The ability to elicit such virus-specific EM CD8(+) T cells might contribute substantially to an efficacious HIV/AIDS vaccine, even after breakthrough infection... - Characterization of functional and phenotypic changes in anti-Gag vaccine-induced T cell responses and their role in protection after HIV-1 infectionMichael R Betts
Laboratory of Immunology, Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 40 Convent Drive, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 102:4512-7. 2005..These data suggest that control of HIV by vaccine-elicited HIV-specific T cell responses may be difficult, even when the T cell response has those characteristics predicted to provide optimal protection... - Differential Th17 CD4 T-cell depletion in pathogenic and nonpathogenic lentiviral infectionsJason M Brenchley
Human Immunology Section, Vaccine Research Center VRC, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, Bethesda, MD, USA
Blood 112:2826-35. 2008..Finally, these data may help account for the nonprogressive nature of nonpathogenic SIV infection in sooty mangabeys... - T cell receptor recognition motifs govern immune escape patterns in acute SIV infectionDavid A Price
Human Immunology Section, Vaccine Research Center, NIAID/NIH, Bethesda, MD 20892, USA
Immunity 21:793-803. 2004..These findings have profound implications for the development of vaccines that elicit T cell immunity to combat pathogens with unstable genomes... - Interleukin-15 but not interleukin-7 abrogates vaccine-induced decrease in virus level in simian immunodeficiency virus mac251-infected macaquesAnna Hryniewicz
Animal Models and Retroviral Vaccines Section, National Cancer Institute, Building 41, Bethesda, MD 20892, USA
J Immunol 178:3492-504. 2007..These results underscore the importance of testing immunomodulatory approaches in vivo to assess potential risks and benefits for HIV-1-infected individuals... - The clonal composition of human CD4+CD25+Foxp3+ cells determined by a comprehensive DNA-based multiplex PCR for TCRB gene rearrangementsPhillip Scheinberg
Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol Methods 321:107-20. 2007..Clonotypes shared between the CD4+CD25+Foxp3+ and CD4+CD25+Foxp3- subsets were observed in all 3 UCB and in one adult PBMCs, suggesting that naïve and memory CD4+ T(R) can share the same clonotypes as CD4+ non-T(R) in humans... - In vitro culture during retroviral transduction improves thymic repopulation and output after total body irradiation and autologous peripheral blood progenitor cell transplantation in rhesus macaquesKarin Lore
Immunology Laboratory, Research Center, National Institute of Allergy and Infectious Diseases, NIH, Department of Health and Human Services, Bethesda, Maryland 20892 1202, USA
Stem Cells 24:1539-48. 2006..These results have implications for the design of gene therapy trials, as well as for the use of expanded PBPCs for improved T-cell immune reconstitution after transplantation... - Vaccination preserves CD4 memory T cells during acute simian immunodeficiency virus challengeJoseph J Mattapallil
Vaccine Research Center, National Institute of Allergy and Infectious Disease (NIAID, National Institutes of Health (NIH, Bethesda, MD 20892, USA
J Exp Med 203:1533-41. 2006.... - Microbial translocation is a cause of systemic immune activation in chronic HIV infectionJason M Brenchley
Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Nat Med 12:1365-71. 2006..These data establish a mechanism for chronic immune activation in the context of a compromised gastrointestinal mucosal surface and provide new directions for therapeutic interventions that modify the consequences of acute HIV infection... - Imatinib inhibits T-cell receptor-mediated T-cell proliferation and activation in a dose-dependent mannerRuth Seggewiss
Hematology Branch, National Heart, Lung, and Blood Institute (NHLBI, the Immunology Laboratory, NIH/DHHS, Bldg 10, CRC, Rm 4-5140, 10 Center Dr, MSC 1202, Bethesda, MD 20892, USA
Blood 105:2473-9. 2005.... - T-cell responses directed against multiple HLA-A*0201-restricted epitopes derived from Wilms' tumor 1 protein in patients with leukemia and healthy donors: identification, quantification, and characterizationKatayoun Rezvani
Stem Cell Allotransplantation Section, Hematology Branch, National Heart Lung Blood Institute and Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20892, USA
Clin Cancer Res 11:8799-807. 2005..Four HLA-A*0201-restricted WT1-derived epitopes have been identified: WT37, WT126, WT187, and WT235. We determined the natural immunogenecity of these antigens in patients with hematologic malignancies and healthy donor... - Preferential infection shortens the life span of human immunodeficiency virus-specific CD4+ T cells in vivoJason M Brenchley
Human Virology Section, Vaccine Research Center, NIAID, NIH, Bethesda, MD 20892, USA
J Virol 80:6801-9. 2006.... - Characterization of subsets of CD4+ memory T cells reveals early branched pathways of T cell differentiation in humansKaimei Song
Inflammation Biology Section, Laboratory of Molecular Immunology and Sections of Human Immunology and ImmunoTechnology, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 102:7916-21. 2005..Rather, developmental pathways branch early on to yield effector/memory populations that are highly heterogeneous and multifunctional and have the potential to become stable resting cells... - Massive infection and loss of memory CD4+ T cells in multiple tissues during acute SIV infectionJoseph J Mattapallil
Immunotechnology Section, Vaccine Research Center, NIAID, NIH, Bethesda, Maryland 20892, USA
Nature 434:1093-7. 2005..Our findings point to the importance of reducing the cell-associated viral load during acute infection through therapeutic or vaccination strategies... - Immunologic pressure within class I-restricted cognate human immunodeficiency virus epitopes during highly active antiretroviral therapyJoseph P Casazza
Immunology Laboratory, National Institutes of Health, Bethesda, MD 20892, USA
J Virol 79:3653-63. 2005.... - Flow cytometric analysis of human antigen-specific T-cell proliferationJason M Brenchley
Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland 20874, USA
Methods Cell Biol 75:481-96. 2004 - Identification and in vitro expansion of CD4+ and CD8+ T cells specific for human neutrophil elastaseHiroshi Fujiwara
Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
Blood 103:3076-83. 2004..HNE could, therefore, be used in an HLA-unrestricted manner to induce leukemia-reactive CTLs for adoptive immunotherapy... - HIV-infected Langerhans cells preferentially transmit virus to proliferating autologous CD4+ memory T cells located within Langerhans cell-T cell clustersMakoto Sugaya
Dermatology Branch, Center for Cancer Research, National Cancer Institute, and Vaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
J Immunol 172:2219-24. 2004..Disrupting cluster formation between LC and memory CD4(+) T cells may be a novel strategy to interfere with sexual transmission of HIV... - Surface expression patterns of negative regulatory molecules identify determinants of virus-specific CD8+ T-cell exhaustion in HIV infectionTakuya Yamamoto
National Institutes of Health, Bethesda, MD, USA
Blood 117:4805-15. 2011..Thus, multiple coinhibitory receptors can affect the development of HIV-specific CD8(+) T-cell responses and, by extension, represent potential targets for new immune-based interventions in HIV-infected persons... - Immunization with vaccinia virus induces polyfunctional and phenotypically distinctive CD8(+) T cell responsesMelissa L Precopio
Immunology Laboratory, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Exp Med 204:1405-16. 2007..This quality of the CD8(+) T cell response may be at least partially responsible for the profound efficacy of these vaccines in protection against smallpox and serves as a benchmark against which other vaccines can be evaluated... - Alloreactive T cell clonotype recruitment in a mixed lymphocyte reaction: implications for graft engineeringPhillip Scheinberg
Hematology Branch, National Heart, Lung, and Blood Institute, Bethesda, MD 20892 1202, USA
Exp Hematol 34:788-95. 2006..To better understand the alloresponse between HLA-identical related pairs, we characterized the alloreactive T cells generated in a mixed lymphocyte reaction (MLR) assay system... - Evolution of the donor T-cell repertoire in recipients in the second decade after allogeneic stem cell transplantationRobert Quan Le
Stem Cell Allotransplantation Section, Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA
Blood 117:5250-6. 2011..This study is registered at http://www.clinicaltrials.gov as NCT00106925... - Expression of CD57 defines replicative senescence and antigen-induced apoptotic death of CD8+ T cellsJason M Brenchley
Vaccine Research Center and the Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Blood 101:2711-20. 2003..Thus, our studies define a phenotype associated with replicative senescence in HIV-specific CD8(+) T cells, which may have broad implications to other conditions associated with chronic antigenic stimulation... - Keratinocyte growth factor augments immune reconstitution after autologous hematopoietic progenitor cell transplantation in rhesus macaquesRuth Seggewiss
Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
Blood 110:441-9. 2007..Thus, our findings suggest that KGF may be a useful adjuvant therapy to augment T-cell reconstitution after human PBPC transplantation... - PD-1 is a regulator of virus-specific CD8+ T cell survival in HIV infectionConstantinos Petrovas
Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Exp Med 203:2281-92. 2006.... - IL-7 therapy dramatically alters peripheral T-cell homeostasis in normal and SIV-infected nonhuman primatesTerry J Fry
Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
Blood 101:2294-9. 2003..These results also raise the possibility that IL-7 therapy could be used to temporarily modulate T-cell cycling in vivo in the context of immunotherapies such as vaccination... - Sensitive and viable identification of antigen-specific CD8+ T cells by a flow cytometric assay for degranulationMichael R Betts
Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 40 Convent Drive, Bethesda, MD 20892, USA
J Immunol Methods 281:65-78. 2003.... - Reduction of immune activation with chloroquine therapy during chronic HIV infectionShannon M Murray
Human Immunology Section, NIH Vaccine Research Center, Bethesda, MD 20892 3005, USA
J Virol 84:12082-6. 2010..Our data indicate that treatment with CQ reduces systemic T-cell immune activation and, thus, that its use may be beneficial for certain groups of HIV-infected individuals... - Detection of low avidity CD8(+) T cell populations with coreceptor-enhanced peptide-major histocompatibility complex class I tetramersJ Joseph Melenhorst
Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol Methods 338:31-9. 2008.... - Cytopenia and leukocyte recovery shape cytokine fluctuations after myeloablative allogeneic hematopoietic stem cell transplantationJan Joseph Melenhorst
Hematology Branch, National Heart, Lung, and Blood Institute, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
Haematologica 97:867-73. 2012..The aim of this study was to examine the contributions of the conditioning regimen, donor engraftment, infections, and graft-versus-host disease to fluctuations in cytokines involved in homeostasis and inflammation... - CCR2 identifies a stable population of human effector memory CD4+ T cells equipped for rapid recall responseHongwei H Zhang
Inflammation Biology Section, Laboratory of Molecular Immunology, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 185:6646-63. 2010.... - Host response to translocated microbial products predicts outcomes of patients with HBV or HCV infectionNetanya G Sandler
Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Gastroenterology 141:1220-30, 1230.e1-3. 2011..We investigated whether the extent and progression of liver disease in patients with chronic HBV or HCV infection are associated with microbial translocation and subsequent activation of monocytes... - Convergent recombination shapes the clonotypic landscape of the naive T-cell repertoireMaire F Quigley
Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 107:19414-9. 2010..These findings provide a framework for understanding the early mobilization of public CD8(+) T-cell clonotypes, which can exert profound biological effects during acute infectious processes... - Emerging concepts in the immunopathogenesis of AIDSDaniel C Douek
Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Annu Rev Med 60:471-84. 2009.... - IFN-gamma mediates the death of Th1 cells in a paracrine mannerKathryn E Foulds
Cellular Immunology Section, Human Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 180:842-9. 2008..Collectively, these data show the multiple mechanisms by which Th1 effector cells are efficiently eliminated in vivo... - Longitudinal assessment of de novo T cell production in relation to HIV-associated T cell homeostasis failurePratip K Chattopadhyay
Vaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA
AIDS Res Hum Retroviruses 22:501-7. 2006..These results suggest that deficits in de novo T cell production, either through the decline of thymic function or the destruction of naive T cells, are likely to play an important role in TCH failure and progression of HIV-1 disease... - Early reconstitution of the T-cell repertoire after non-myeloablative peripheral blood stem cell transplantation is from post-thymic T-cell expansion and is unaffected by graft-versus-host disease or mixed chimaerismErkut Bahceci
Bone Marrow Transplant Unit, Hematology Branch, National Heart, Lung, and Blood Institute, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
Br J Haematol 122:934-43. 2003..These results define important qualitative differences in the T-cell repertoire according to the type of transplant schedule used... - Vaccine design for CD8 T lymphocyte responsesRichard A Koup
Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Cold Spring Harb Perspect Med 1:a007252. 2011.... - HLA B*5701-positive long-term nonprogressors/elite controllers are not distinguished from progressors by the clonal composition of HIV-specific CD8+ T cellsDaniel Mendoza
HIV Specific Immunity Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
J Virol 86:4014-8. 2012..Thus, HIV-specific CD8(+) T-cell responses in LTNP/EC are not differentiated from those of progressors on the basis of clonal diversity or TCR sharing... - Functional leukemia-associated antigen-specific memory CD8+ T cells exist in healthy individuals and in patients with chronic myelogenous leukemia before and after stem cell transplantationKatayoun Rezvani
National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
Blood 102:2892-900. 2003..The increased response in patients after SCT suggests a quantitative explanation for the greater effect of allogeneic SCT... - Lymphopenia and interleukin-2 therapy alter homeostasis of CD4+CD25+ regulatory T cellsHua Zhang
Pediatric Oncology Branch, National Institutes of Health, 10 Center Drive, Bethesda, Maryland 20892, USA
Nat Med 11:1238-43. 2005..These studies suggest that IL-2 and lymphopenia are primary modulators of CD4(+)CD25(+) T(reg) cell homeostasis... - Downregulation of robust acute type I interferon responses distinguishes nonpathogenic simian immunodeficiency virus (SIV) infection of natural hosts from pathogenic SIV infection of rhesus macaquesLevelle D Harris
Laboratory of Molecular Microbiology, NIAID, NIH, Bethesda, Maryland, USA
J Virol 84:7886-91. 2010..In contrast, persistently high type I IFN responses are observed during pathogenic SIV infection of rhesus macaques... - HIV disease: fallout from a mucosal catastrophe?Jason M Brenchley
Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Nat Immunol 7:235-9. 2006.... - Cellular immunity elicited by human immunodeficiency virus type 1/ simian immunodeficiency virus DNA vaccination does not augment the sterile protection afforded by passive infusion of neutralizing antibodiesJohn R Mascola
Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
J Virol 77:10348-56. 2003..These data suggest that although effector T cells can limit viral replication, they are not able to assist humoral immunity to prevent the establishment of initial infection... - T-cell immune responses to Wilms tumor 1 protein in myelodysplasia responsive to immunosuppressive therapyElaine M Sloand
Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
Blood 117:2691-9. 2011..Thus, our results suggest that WT1 is one of the antigens that triggers T cell-mediated myelosuppression in MDS... - Damaged intestinal epithelial integrity linked to microbial translocation in pathogenic simian immunodeficiency virus infectionsJacob D Estes
AIDS and Cancer Virus Program, SAIC Frederick, Inc, NCI Frederick, Frederick, Maryland, USA
PLoS Pathog 6:e1001052. 2010..Novel therapeutic approaches to inhibit microbial translocation and/or attenuate chronic immune activation in HIV-infected individuals may complement treatments aimed at direct suppression of viral replication... - Evidence for translocation of microbial products in patients with idiopathic CD4 lymphocytopeniaPhilip I Lee
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
J Infect Dis 199:1664-70. 2009..These findings suggest a potential association of translocation of microbial products with perturbed CD4 T cell homeostasis in individuals with CD4 lymphopenic states other than HIV infection... - Thymic output generates a new and diverse TCR repertoire after autologous stem cell transplantation in multiple sclerosis patientsPaolo A Muraro
Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
J Exp Med 201:805-16. 2005.... - CD4+ T cell depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tractJason M Brenchley
Human Immunology Section, Vaccine Research Center, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, 40 Convent Dr, Room 3509, Bethesda, MD 20892, USA
J Exp Med 200:749-59. 2004.... - Renewing the T cell repertoire to arrest autoimmune aggressionPaolo A Muraro
Neuroimmunology Branch, NINDS NIH, Bldg 10, Room 5B16, 10 Center Drive, MSC1400, Bethesda, MD 20892 1400, USA
Trends Immunol 27:61-7. 2006..We propose a model envisioning a coordinated sequence of events, rebuilding an immune system that is competent against infection but that is substantially reconfigured in a way that is less likely to redevelop autoimmunity... - Nonprogressive and progressive primate immunodeficiency lentivirus infectionsJason M Brenchley
Immunopathogenesis Unit, Lab of Molecular Microbiology, NIAID, NIH, Bethesda, MD 20892, USA
Immunity 32:737-42. 2010.... - Human immunodeficiency virus type 1 neutralization measured by flow cytometric quantitation of single-round infection of primary human T cellsJohn R Mascola
Vaccine Research Center, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
J Virol 76:4810-21. 2002..The precision and reproducibility of this assay will facilitate the measurement of HIV-1 neutralization, particularly incrementally improved neutralizing antibody responses generated by new candidate vaccines... - Hypomorphic Rag mutations can cause destructive midline granulomatous diseaseSuk See De Ravin
Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Blood 116:1263-71. 2010..This study was registered at www.clinicaltrials.gov as #NCT00128973... - The rational design of an AIDS vaccineDaniel C Douek
Vaccine Research Center, NIAID, National Institutes of Health, Room 4502, Building 40, MSC-3005, 40 Convent Drive, Bethesda, MD 20892, USA
Cell 124:677-81. 2006..AIDS vaccine design requires a scientifically driven, rational approach that encompasses the latest advances in viral molecular genetics, structural biology, and immunology... - Induction and evolution of cytomegalovirus-specific CD4+ T cell clonotypes in rhesus macaquesDavid A Price
Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
J Immunol 180:269-80. 2008.... - Effects of exogenous interleukin-7 on human thymus functionYukari Okamoto
Vaccine Research Center, National Institute of Allergy and Infectious Diseases and Department of Experimental Transplantation and Immunology, Medicine Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
Blood 99:2851-8. 2002..Our results provide compelling evidence that IL-7 has a direct effect on increasing TCR-alphabeta rearrangement and indicate the potential use of IL-7 for enhancing de novo naïve T-cell generation in immunocompromised patients... - Impaired T(H)17 cell differentiation in subjects with autosomal dominant hyper-IgE syndromeJoshua D Milner
Laboratory of Immunology, National Institutes of Health, Bethesda, Maryland 20892, USA
Nature 452:773-6. 2008..Thus, our data suggest that the inability to produce T(H)17 cells is a mechanism underlying the susceptibility to the recurrent infections commonly seen in HIES... - Contribution of TCR-beta locus and HLA to the shape of the mature human Vbeta repertoireJ Joseph Melenhorst
Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 180:6484-9. 2008..We therefore conclude that the correlation in Vbeta expression patterns between CD4(+) and CD8(+) T cells can be explained predominantly by germline TCR-beta locus factors and not TCR-beta allelic or HLA effects... - High prevalence of autoreactive, neuroantigen-specific CD8+ T cells in multiple sclerosis revealed by novel flow cytometric assayMichael P Crawford
Department of Pathology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390-9072, USA
Blood 103:4222-31. 2004..The results emphasize the need to evaluate both CD4(+) and CD8(+) T-cell responses in MS and to make both subsets a consideration in the development of novel therapeutic strategies... - Immunisation with BCG and recombinant MVA85A induces long-lasting, polyfunctional Mycobacterium tuberculosis-specific CD4+ memory T lymphocyte populationsNatalie E R Beveridge
Centre for Clinical Vaccinology and Tropical Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, UK
Eur J Immunol 37:3089-100. 2007..Overall, these data strongly support the use of MVA85A in humans as a boosting agent to expand polyfunctional M.tb-specific CD4(+) T cells capable of significant secondary responses... - Increased thymic output during acute measles virus infectionSallie R Permar
W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe Street, Baltimore, MD 21205-2179, USA
J Virol 77:7872-9. 2003..These findings suggest that a decrease in thymic output is not the cause of the lymphopenia and depressed cellular immunity associated with measles... - Progressive CD4+ central memory T cell decline results in CD4+ effector memory insufficiency and overt disease in chronic SIV infectionAfam Okoye
Vaccine and Gene Therapy Institute, Department of Pathology, and the Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006, USA
J Exp Med 204:2171-85. 2007.... - T cells containing T cell receptor excision circles are inversely related to HIV replication and are selectively and rapidly released into circulation with antiretroviral treatmentMireya Diaz
Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio 44106, USA
AIDS 17:1145-9. 2003..CONCLUSIONS: These findings suggest that recent thymic emigrants are sequestered in lymphoid tissue during uncontrolled HIV replication and are selectively released into circulation rapidly after initiation of antiretroviral therapies... - Comparison of plasma viremia and antibody responses in macaques inoculated with envelope variants of single-cycle simian immunodeficiency virus differing in infectivity and cellular tropismM Quinn DeGottardi
Department of Microbiology and Molecular Genetics, Harvard Medical School, New England Primate Research Center, One Pine Hill Drive, Southborough, MA 01772 9102, USA
J Virol 82:321-34. 2008..These studies reveal differences in the peaks and durations of a single round of productive infection that reflect envelope-specific differences in infectivity, chemokine receptor specificity, and cellular tropism... - Validation of RNA-based molecular clonotype analysis for virus-specific CD8+ T-cells in formaldehyde-fixed specimens isolated from peripheral bloodDavid van Bockel
Centre for Immunology, St Vincent s Hospital, Sydney, NSW, Australia
J Immunol Methods 326:127-38. 2007.... - Acute loss of intestinal CD4+ T cells is not predictive of simian immunodeficiency virus virulenceIvona V Pandrea
Divisions of Comparative Pathology and Microbiology, Tulane National Primate Research Center, 18703 Three Rivers Road, Covington, LA 70433, USA
J Immunol 179:3035-46. 2007.... - Factors influencing T-lymphopoiesis after allogeneic hematopoietic cell transplantationJan Storek
Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
Transplantation 73:1154-8. 2002..without irradiation), acute graft-versus-host disease (aGVHD), or chronic graft-versus-host disease (cGVHD) in multivariate analysis. We conclude that patient age is the primary determinant of CD4 T-lymphopoiesis after allogeneic HCT... - Where does HIV live?Justin Stebbing
Department of Immunology, Division of Investigative Science, Faculty of Medicine, Imperial College of Science, Technology and Medicine, Chelsea and Westminster Hospital, London
N Engl J Med 350:1872-80. 2004 - T cell responses to whole SARS coronavirus in humansChris Ka fai Li
MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK
J Immunol 181:5490-500. 2008..Our study provides a roadmap for the immunogenicity of SARS-CoV and types of immune responses that may be responsible for the virus clearance, and should serve as a benchmark for SARS-CoV vaccine design and evaluation... - The role of production frequency in the sharing of simian immunodeficiency virus-specific CD8+ TCRs between macaquesVanessa Venturi
Complex Systems in Biology Group, Centre for Vascular Research, University of New South Wales, Kensington, Australia
J Immunol 181:2597-609. 2008..Thus, convergent recombination is a major determinant of the extent of TCRbeta sharing... - Interaction between the CD8 coreceptor and major histocompatibility complex class I stabilizes T cell receptor-antigen complexes at the cell surfaceLinda Wooldridge
T Cell Modulation Group, Nuffield Department of Medicine, Peter Medawar Building for Pathogen Research, University of Oxford, South Parks Road, Oxford OX1 3SY, United Kingdom
J Biol Chem 280:27491-501. 2005.... - Degeneracy and repertoire of the human HIV-1 Gag p17(77-85) CTL responseJune Kan-Mitchell
Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
J Immunol 176:6690-701. 2006..This study suggests that agonist sequences can replace aberrantly immunogenic native epitopes for the rational design of vaccines targeting HIV-1... - Maintenance of HIV-specific CD4+ T cell help distinguishes HIV-2 from HIV-1 infectionMelody G Duvall
Medical Research Council (MRC) Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
J Immunol 176:6973-81. 2006..This study demonstrates that HIV-2-infected donors have a well-preserved and functionally heterogeneous HIV-specific memory CD4+ T cell response that is associated with delayed disease progression in the majority of infected people... - Glatiramer acetate (Copaxone) therapy induces CD8(+) T cell responses in patients with multiple sclerosisNitin J Karandikar
Department of Pathology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9072, USA
J Clin Invest 109:641-9. 2002.... - CD8+ T cell efficacy in vaccination and diseaseVictor Appay
Cellular Immunology Laboratory, Institut Nationale de la Santé et de la Recherche Médicale U543, Avenir Group, Hopital Pitie Salpetriere, Universite Pierre et Marie Curie Paris 06, 91 Boulevard de l Hopital, 75013 Paris, France
Nat Med 14:623-8. 2008..This new knowledge paves the way to the design of more effective T cell vaccines and highlights the importance of comprehensive immunomonitoring... - Unusual immunophenotype of CD8+ T cells in familial hemophagocytic lymphohistiocytosisNitin J Karandikar
Department of Pathology, The University of Texas Southwestern Medical Center at Dallas, 75390 9072, USA
Blood 104:2007-9. 2004..This case provides an instructive example of uncontrolled reactive proliferation of CD8+ T cells in FHL, resulting in atypical morphology and unusual immunophenotypic features that might suggest malignancy in other clinical settings... - CD127 and CD25 expression defines CD4+ T cell subsets that are differentially depleted during HIV infectionRichard M Dunham
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
J Immunol 180:5582-92. 2008..Further studies will determine whether monitoring the three subsets of CD4(+) T cells defined based on the expression of CD25 and CD127 should be used in the clinical management of HIV-infected individuals...