Affiliation: National Institutes of Health
- What's in the 'BAG'?--A functional domain analysis of the BAG-family proteinsHoward Doong
Molecular Signaling Section, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Cancer Lett 188:25-32. 2002..BAG-family proteins participate in a wide variety of cellular processes including cell survival (stress response), proliferation, migration and apoptosis...
- CAIR-1/BAG-3 modulates cell adhesion and migration by downregulating activity of focal adhesion proteinsJareer N Kassis
Molecular Signaling Section, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, 10 Center Drive, MSC 1500, Bethesda, MD 20892 1500, USA
Exp Cell Res 312:2962-71. 2006..These results collectively indicate that CAIR-1 may negatively regulate adhesion, focal adhesion assembly, signaling, and migration via its PXXP domain...
- CAIR-1/BAG-3 abrogates heat shock protein-70 chaperone complex-mediated protein degradation: accumulation of poly-ubiquitinated Hsp90 client proteinsHoward Doong
Molecular Signaling Section, Laboratory of Pathology and Regulation of Protein Function Laboratory, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 278:28490-500. 2003..Furthermore, poly-ubiquitination is not sufficient for efficient proteasomal targeting of Hsp client proteins...
- Overexpression of ubiquilin decreases ubiquitination and degradation of presenilin proteinsLeann K Massey
MCB Graduate Program, 725 West Lombard Street, Baltimore, Maryland 21201, USA
J Alzheimers Dis 6:79-92. 2004..Our results suggest that ubiquilin proteins play an important role in regulating PS protein levels in cells...
- Characterization of erasin (UBXD2): a new ER protein that promotes ER-associated protein degradationJing Liang
Graduate Program in Molecular Medicine, and Institute for Neurodegenerative Diseases, University of Maryland Biotechnology Institute, 725 West Lombard Street, Baltimore, MD 21201, USA
J Cell Sci 119:4011-24. 2006..These results suggest that erasin may be involved in ERAD and in Alzheimer's disease...
- ER stress differentially regulates the stabilities of ERAD ubiquitin ligases and their substratesYuxian Shen
Institute of Clinical Pharmacology, Anhui Medical University, Hefei 230032, PR China
Biochem Biophys Res Commun 352:919-24. 2007..Our data suggest that ER stress differentially regulates the stabilities of ERAD E3s and their substrates, which may represent a novel mechanism by which ER stress increases ERAD...