Howard Doong

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi What's in the 'BAG'?--A functional domain analysis of the BAG-family proteins
    Howard Doong
    Molecular Signaling Section, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Cancer Lett 188:25-32. 2002
  2. ncbi CAIR-1/BAG-3 modulates cell adhesion and migration by downregulating activity of focal adhesion proteins
    Jareer N Kassis
    Molecular Signaling Section, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, 10 Center Drive, MSC 1500, Bethesda, MD 20892 1500, USA
    Exp Cell Res 312:2962-71. 2006
  3. ncbi CAIR-1/BAG-3 abrogates heat shock protein-70 chaperone complex-mediated protein degradation: accumulation of poly-ubiquitinated Hsp90 client proteins
    Howard Doong
    Molecular Signaling Section, Laboratory of Pathology and Regulation of Protein Function Laboratory, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 278:28490-500. 2003
  4. ncbi Overexpression of ubiquilin decreases ubiquitination and degradation of presenilin proteins
    Leann K Massey
    MCB Graduate Program, 725 West Lombard Street, Baltimore, Maryland 21201, USA
    J Alzheimers Dis 6:79-92. 2004
  5. ncbi Characterization of erasin (UBXD2): a new ER protein that promotes ER-associated protein degradation
    Jing Liang
    Graduate Program in Molecular Medicine, and Institute for Neurodegenerative Diseases, University of Maryland Biotechnology Institute, 725 West Lombard Street, Baltimore, MD 21201, USA
    J Cell Sci 119:4011-24. 2006
  6. ncbi ER stress differentially regulates the stabilities of ERAD ubiquitin ligases and their substrates
    Yuxian Shen
    Institute of Clinical Pharmacology, Anhui Medical University, Hefei 230032, PR China
    Biochem Biophys Res Commun 352:919-24. 2007

Collaborators

Detail Information

Publications6

  1. ncbi What's in the 'BAG'?--A functional domain analysis of the BAG-family proteins
    Howard Doong
    Molecular Signaling Section, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Cancer Lett 188:25-32. 2002
    ..BAG-family proteins participate in a wide variety of cellular processes including cell survival (stress response), proliferation, migration and apoptosis...
  2. ncbi CAIR-1/BAG-3 modulates cell adhesion and migration by downregulating activity of focal adhesion proteins
    Jareer N Kassis
    Molecular Signaling Section, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, 10 Center Drive, MSC 1500, Bethesda, MD 20892 1500, USA
    Exp Cell Res 312:2962-71. 2006
    ..These results collectively indicate that CAIR-1 may negatively regulate adhesion, focal adhesion assembly, signaling, and migration via its PXXP domain...
  3. ncbi CAIR-1/BAG-3 abrogates heat shock protein-70 chaperone complex-mediated protein degradation: accumulation of poly-ubiquitinated Hsp90 client proteins
    Howard Doong
    Molecular Signaling Section, Laboratory of Pathology and Regulation of Protein Function Laboratory, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 278:28490-500. 2003
    ..Furthermore, poly-ubiquitination is not sufficient for efficient proteasomal targeting of Hsp client proteins...
  4. ncbi Overexpression of ubiquilin decreases ubiquitination and degradation of presenilin proteins
    Leann K Massey
    MCB Graduate Program, 725 West Lombard Street, Baltimore, Maryland 21201, USA
    J Alzheimers Dis 6:79-92. 2004
    ..Our results suggest that ubiquilin proteins play an important role in regulating PS protein levels in cells...
  5. ncbi Characterization of erasin (UBXD2): a new ER protein that promotes ER-associated protein degradation
    Jing Liang
    Graduate Program in Molecular Medicine, and Institute for Neurodegenerative Diseases, University of Maryland Biotechnology Institute, 725 West Lombard Street, Baltimore, MD 21201, USA
    J Cell Sci 119:4011-24. 2006
    ..These results suggest that erasin may be involved in ERAD and in Alzheimer's disease...
  6. ncbi ER stress differentially regulates the stabilities of ERAD ubiquitin ligases and their substrates
    Yuxian Shen
    Institute of Clinical Pharmacology, Anhui Medical University, Hefei 230032, PR China
    Biochem Biophys Res Commun 352:919-24. 2007
    ..Our data suggest that ER stress differentially regulates the stabilities of ERAD E3s and their substrates, which may represent a novel mechanism by which ER stress increases ERAD...