J G Donaldson

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Constitutive internalization of G protein-coupled receptors and G proteins via clathrin-independent endocytosis
    Marco Scarselli
    Laboratory of Cell Biology, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 284:3577-85. 2009
  2. pmc Targeting of Arf-1 to the early Golgi by membrin, an ER-Golgi SNARE
    Akira Honda
    Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Biol 168:1039-51. 2005
  3. pmc Phosphatidylinositol 4,5-bisphosphate and Arf6-regulated membrane traffic
    F D Brown
    Laboratory of Cell Biology, National Heart Lung and Blood Institute, National Institute of Health, Bethesda, MD 20892, USA
    J Cell Biol 154:1007-17. 2001
  4. pmc Releasable SNAP-tag probes for studying endocytosis and recycling
    Nelson B Cole
    Laboratory of Cell Biology, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, United States
    ACS Chem Biol 7:464-9. 2012
  5. pmc Arf6 recruits the Rac GEF Kalirin to the plasma membrane facilitating Rac activation
    Tae Hyeon Koo
    Laboratory of Cell Biology, NHLBI, NIH, Bethesda, MD 20892, USA
    BMC Cell Biol 8:29. 2007
  6. pmc Phospholipase D in endocytosis and endosomal recycling pathways
    Julie G Donaldson
    Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Building 50, Room 2503, Bethesda, MD 20892, USA
    Biochim Biophys Acta 1791:845-9. 2009
  7. doi request reprint Arfs and membrane lipids: sensing, generating and responding to membrane curvature
    Julie G Donaldson
    Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bld 50, Rm 2503, Bethesda, MD 20892, USA
    Biochem J 414:e1-2. 2008
  8. pmc Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling
    Julie G Donaldson
    Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Cell Signal 21:1-6. 2009
  9. pmc ARF family G proteins and their regulators: roles in membrane transport, development and disease
    Julie G Donaldson
    Laboratory of Cell Biology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Rev Mol Cell Biol 12:362-75. 2011
  10. ncbi request reprint Arfs, phosphoinositides and membrane traffic
    J G Donaldson
    Laboratory of Cell Biology, National Heart, Lung and Blood Institute, National Institutes of Health, Building 50, Rm 2503, Bethesda, MD 20892, USA
    Biochem Soc Trans 33:1276-8. 2005

Collaborators

Detail Information

Publications36

  1. pmc Constitutive internalization of G protein-coupled receptors and G proteins via clathrin-independent endocytosis
    Marco Scarselli
    Laboratory of Cell Biology, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 284:3577-85. 2009
    ..These findings demonstrate that GPCRs are versatile PM proteins that can utilize different mechanisms of internalization depending upon ligand activation...
  2. pmc Targeting of Arf-1 to the early Golgi by membrin, an ER-Golgi SNARE
    Akira Honda
    Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Biol 168:1039-51. 2005
    ..These studies suggest that membrin recruits Arf-1 to the early Golgi and reveal distinct kinetic cycles for Arf-1 at early and late Golgi determined by different sets of Arf regulators and effectors...
  3. pmc Phosphatidylinositol 4,5-bisphosphate and Arf6-regulated membrane traffic
    F D Brown
    Laboratory of Cell Biology, National Heart Lung and Blood Institute, National Institute of Health, Bethesda, MD 20892, USA
    J Cell Biol 154:1007-17. 2001
    ..These results demonstrate that PIP 5-kinase activity and PIP2 turnover controlled by activation and inactivation of Arf6 is critical for trafficking through the Arf6 PM-endosomal recycling pathway...
  4. pmc Releasable SNAP-tag probes for studying endocytosis and recycling
    Nelson B Cole
    Laboratory of Cell Biology, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, United States
    ACS Chem Biol 7:464-9. 2012
    ..This simple yet effective approach allows quantitative measurements of endocytosis and recycling in both imaging and biochemical assays and is especially useful when studying endosomal dynamics in live cells...
  5. pmc Arf6 recruits the Rac GEF Kalirin to the plasma membrane facilitating Rac activation
    Tae Hyeon Koo
    Laboratory of Cell Biology, NHLBI, NIH, Bethesda, MD 20892, USA
    BMC Cell Biol 8:29. 2007
    ..Although Arf6 facilitates the trafficking of Rac1 to the plasma membrane and in many cases Arf6 activation leads to the activation of Rac1, the details of how Arf6 influences Rac function remain to be elucidated...
  6. pmc Phospholipase D in endocytosis and endosomal recycling pathways
    Julie G Donaldson
    Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Building 50, Room 2503, Bethesda, MD 20892, USA
    Biochim Biophys Acta 1791:845-9. 2009
    ..This review examines studies that have reported a role for PLD in endocytosis and membrane recycling from endocytic pathways...
  7. doi request reprint Arfs and membrane lipids: sensing, generating and responding to membrane curvature
    Julie G Donaldson
    Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bld 50, Rm 2503, Bethesda, MD 20892, USA
    Biochem J 414:e1-2. 2008
    ..These findings suggest that Arf protein activation and membrane interaction may initiate membrane curvature that will be enhanced further by coat proteins during vesicle formation...
  8. pmc Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling
    Julie G Donaldson
    Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Cell Signal 21:1-6. 2009
    ..Furthermore, activation of some of these signaling molecules (H-Ras, Rac and Arf6) can switch the constitutive form of clathrin-independent endocytosis into a stimulated one, associated with PM ruffling and macropinocytosis...
  9. pmc ARF family G proteins and their regulators: roles in membrane transport, development and disease
    Julie G Donaldson
    Laboratory of Cell Biology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Rev Mol Cell Biol 12:362-75. 2011
    ..Important advances are being gained in our understanding of the functional networks that are formed not only by the GEFs and GAPs themselves but also by the inactive forms of the ARF proteins...
  10. ncbi request reprint Arfs, phosphoinositides and membrane traffic
    J G Donaldson
    Laboratory of Cell Biology, National Heart, Lung and Blood Institute, National Institutes of Health, Building 50, Rm 2503, Bethesda, MD 20892, USA
    Biochem Soc Trans 33:1276-8. 2005
    ..Arf1 can also stimulate the activity of phosphatidylinositol kinases and recruit coat proteins and actin cytoskeletal elements to the Golgi complex...
  11. ncbi request reprint Localization and function of Arf family GTPases
    J G Donaldson
    Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Biochem Soc Trans 33:639-42. 2005
    ..Whereas Arf6 is targeted to the plasma membrane through multiple regions along the protein, we have found a Golgi-targeting region in Arf1 that is sufficient to target Arf6 to the Golgi complex...
  12. ncbi request reprint Multiple activities for Arf1 at the Golgi complex
    Julie G Donaldson
    Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Building 50, Room 2503, Bethesda, MD 20892, USA
    Biochim Biophys Acta 1744:364-73. 2005
    ..This spatial distribution of Arf regulators may facilitate the recruitment of the coat proteins and other Arf effectors to different regions of the Golgi complex...
  13. ncbi request reprint Regulators and effectors of the ARF GTPases
    J G Donaldson
    Laboratory of Cell Biology, NHLBI, NIH, Bethesda, 20892, USA
    Curr Opin Cell Biol 12:475-82. 2000
    ..In addition, two new classes of effectors, the PIP kinases and a novel family of monomeric coat-like proteins have been discovered...
  14. ncbi request reprint Multiple roles for Arf6: sorting, structuring, and signaling at the plasma membrane
    Julie G Donaldson
    Laboratory of Cell Biology, NHLBI, National Institutes of Health, Building 50 Room 2503, Bethesda, MD 20892, USA
    J Biol Chem 278:41573-6. 2003
  15. pmc ACAPs are arf6 GTPase-activating proteins that function in the cell periphery
    T R Jackson
    Laboratory of Cellular Oncology, Division of Basic Sciences, National Cancer Institute, Bethesda, Maryland 20892 4255, USA
    J Cell Biol 151:627-38. 2000
    ..The additional effects of ASAP1 on PDGF-induced ruffling in fibroblasts suggest that multiple Arf GAPs function coordinately in the cell periphery...
  16. ncbi request reprint ARF6 requirement for Rac ruffling suggests a role for membrane trafficking in cortical actin rearrangements
    H Radhakrishna
    Laboratory of Cell Biology, NHLBI, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Sci 112:855-66. 1999
    ..These observations suggest that ARF6, a non-Rho family GTPase, can, by itself, alter cortical actin and can influence the ability of Rac1 to form lamellipodia, in part, by regulating its trafficking to the plasma membrane...
  17. pmc Guanine nucleotides modulate the effects of brefeldin A in semipermeable cells: regulation of the association of a 110-kD peripheral membrane protein with the Golgi apparatus
    J G Donaldson
    Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892
    J Cell Biol 112:579-88. 1991
    ....
  18. pmc Separation of membrane trafficking and actin remodeling functions of ARF6 with an effector domain mutant
    O Al-Awar
    Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Cell Biol 20:5998-6007. 2000
    ..Thus, we have uncoupled two functions of ARF6, one involved in membrane trafficking, which is necessary for Rac ruffling, and another involved in protrusion formation...
  19. ncbi request reprint Building a secretory apparatus: role of ARF1/COPI in Golgi biogenesis and maintenance
    J Lippincott-Schwartz
    Cell Biology and Metabolism Branch, NICHD, NIH, Bethesda, MD 20892 5430, USA
    Histochem Cell Biol 109:449-62. 1998
    ....
  20. pmc Active Arf6 recruits ARNO/cytohesin GEFs to the PM by binding their PH domains
    Lee Ann Cohen
    Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, and Endocrinology and Reproduction Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Biol Cell 18:2244-53. 2007
    ..This interaction was direct and required both inositol phospholipids and GTP. We propose a model of sequential Arf activation at the PM whereby Arf6-GTP recruits ARNO family GEFs for further activation of other Arf isoforms...
  21. pmc Convergence of non-clathrin- and clathrin-derived endosomes involves Arf6 inactivation and changes in phosphoinositides
    Naava Naslavsky
    Laboratory of Cell Biology, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Biol Cell 14:417-31. 2003
    ..A similar block in transport of MHCI and Tac was reversibly induced by a PI3-kinase inhibitor, implying that inactivation of Arf6 and acquisition of PI3P are required for convergence of endosomes arising from these two pathways...
  22. pmc A unique platform for H-Ras signaling involving clathrin-independent endocytosis
    Natalie Porat-Shliom
    Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Biol Cell 19:765-75. 2008
    ..Arf6 stimulation of macropinocytosis also involves passage through the distinct lipid phases, but recruitment of Akt is not observed...
  23. pmc Discovery of new cargo proteins that enter cells through clathrin-independent endocytosis
    Craig A Eyster
    Laboratory of Cell Biology, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    Traffic 10:590-9. 2009
    ..This divergent itinerary suggests that sorting may occur along this CIE pathway. Furthermore, the identification of new cargo proteins will assist others studying CIE in different cell types and tissues...
  24. pmc Characterization of a nonclathrin endocytic pathway: membrane cargo and lipid requirements
    Naava Naslavsky
    Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Biol Cell 15:3542-52. 2004
    ..Endocytosis of transferrin was not affected by any of these treatments. These observations suggest common mechanisms for endocytosis without clathrin...
  25. pmc Recycling of Raft-associated prohormone sorting receptor carboxypeptidase E requires interaction with ARF6
    Irina Arnaoutova
    Section of Cellular Neurobiology, Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Biol Cell 14:4448-57. 2003
    ..Thus, CPE recycles back to the TGN by a novel mechanism requiring ARF6 interaction and activity...
  26. pmc An effector domain mutant of Arf6 implicates phospholipase D in endosomal membrane recycling
    Olivera A Jovanovic
    Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Biol Cell 17:327-35. 2006
    ..Together, these observations provide compelling evidence that Arf6 stimulation of PLD is required for endosomal membrane recycling and GAP recruitment...
  27. pmc Rab22a regulates the recycling of membrane proteins internalized independently of clathrin
    Roberto Weigert
    Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892 8017, USA
    Mol Biol Cell 15:3758-70. 2004
    ..Dominant negative mutant of Rab11a also inhibited recycling of MHCI but not the formation of recycling tubules, suggesting that Rab22a and Rab11a might coordinate different steps of MHCI recycling...
  28. pmc A tubular EHD1-containing compartment involved in the recycling of major histocompatibility complex class I molecules to the plasma membrane
    Steve Caplan
    Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    EMBO J 21:2557-67. 2002
    ..These observations suggest an additional function of EHD1 as a tubule-inducing factor in the Arf6 pathway for recycling of plasma membrane proteins internalized by clathrin-independent endocytosis...
  29. ncbi request reprint Immunofluorescence staining
    J G Donaldson
    National Heart, Lung, and Blood Institute/NIH, Bethesda, Maryland, USA
    Curr Protoc Cell Biol . 2001
    ..This provides both a visible signal and amplification of the signal and the results are observed with a fluorescent microscope...
  30. pmc Brefeldin A-inhibited guanine nucleotide-exchange activity of Sec7 domain from yeast Sec7 with yeast and mammalian ADP ribosylation factors
    M Sata
    Pulmonary Critical Care Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 95:4204-8. 1998
    ..These results are consistent with the conclusion that the yeast Sec7 domain itself contains the elements necessary for ARF GEP activity and its inhibition by BFA...
  31. pmc Intracellular assembly and trafficking of MHC class I molecules
    Julie G Donaldson
    Laboratory of Cell Biology, National Heart, Lung and Blood Institute, NIH, Bethesda, MD 20892, USA
    Traffic 10:1745-52. 2009
    ..We review recent progress in our understanding of class I assembly, anterograde transport and endocytosis and highlight some of the events targeted by viruses as a means to evade detection by cytotoxic T cells and natural killer cells...
  32. ncbi request reprint Arf6 and its role in cytoskeletal modulation
    Julie G Donaldson
    Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA
    Methods Mol Biol 189:191-8. 2002
  33. ncbi request reprint Myoblasts fuse when loner meets ARF6
    Julie G Donaldson
    Laboratory of Cell Biology, NHLBI, NIH, Building 50, Room 2503, Bethesda, MD 20892, USA
    Dev Cell 5:527-8. 2003
    ..A paper by Chen et al. published in the September 19 issue of Cell adds ARF6, a GTPase, and one of its guanine nucleotide exchange factors to this set of players...
  34. ncbi request reprint Fluorescent microscopy-based assays to study the role of Rab22a in clathrin-independent endocytosis
    Roberto Weigert
    Methods Enzymol 403:243-53. 2005
    ..Here we describe cell-based flourescence assays to examine the effects of expression and depletion of Rab22 on endosomal morphology and endocytic recycling...
  35. ncbi request reprint Somatostatin receptors signal through EFA6A-ARF6 to activate phospholipase D in clonal beta-cells
    Justin A Grodnitzky
    Department of Biomedical Sciences, Iowa State University, Ames, Iowa 50011, USA
    J Biol Chem 282:13410-8. 2007
    ..In addition, overexpression of dn-ARNO mutant, ARNO(E156K), another GEF of Arf6, had no effect on SS-induced activation of PLD. Taken together, these results suggest that SS signals through EFA6A to activate Arf6-PLD cascade...