Brian P Dolan

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. doi request reprint Quantitating MHC class I ligand production and presentation using TCR-like antibodies
    Brian P Dolan
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Methods Mol Biol 960:169-77. 2013
  2. pmc RNA polymerase II inhibitors dissociate antigenic peptide generation from normal viral protein synthesis: a role for nuclear translation in defective ribosomal product synthesis?
    Brian P Dolan
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    J Immunol 185:6728-33. 2010
  3. pmc Endogenous viral antigen processing generates peptide-specific MHC class I cell-surface clusters
    Xiuju Lu
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 109:15407-12. 2012
  4. pmc MHC class I antigen processing distinguishes endogenous antigens based on their translation from cellular vs. viral mRNA
    Brian P Dolan
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 109:7025-30. 2012
  5. pmc Distinct pathways generate peptides from defective ribosomal products for CD8+ T cell immunosurveillance
    Brian P Dolan
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 186:2065-72. 2011
  6. pmc Nuclear translation visualized by ribosome-bound nascent chain puromycylation
    Alexandre David
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Biol 197:45-57. 2012
  7. pmc Translating DRiPs: progress in understanding viral and cellular sources of MHC class I peptide ligands
    Brian P Dolan
    Laboratory of Viral Diseases, NIAID, Bethesda, MD 20892, USA
    Cell Mol Life Sci 68:1481-9. 2011
  8. pmc Compartmentalized MHC class I antigen processing enhances immunosurveillance by circumventing the law of mass action
    Avital Lev
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 107:6964-9. 2010
  9. pmc Unexpected role for the immunoproteasome subunit LMP2 in antiviral humoral and innate immune responses
    Scott E Hensley
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 184:4115-22. 2010
  10. pmc Defective ribosomal products are the major source of antigenic peptides endogenously generated from influenza A virus neuraminidase
    Brian P Dolan
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 184:1419-24. 2010

Collaborators

  • Jonathan W Yewdell
  • Jack R Bennink
  • Philippe Pierre
  • Rajat Varma
  • Peter van Endert
  • Alexandre David
  • Heather D Hickman
  • Xiuju Lu
  • James S Gibbs
  • Avital Lev
  • Scott E Hensley
  • Weisan Chen
  • Giovanna Clavarino
  • David M Kranz
  • Jonathan J Knowlton
  • Yetao Jin
  • Damien Zanker
  • Anne Burgevin
  • Cara N Skon
  • Elizabeth Waffarn
  • Thomas A Griffin
  • Alan C Embry
  • Damian Zanker
  • Chiharu Kumagai
  • Kristie M Grebe
  • Michael F Princiotta
  • Kazuyo Takeda

Detail Information

Publications10

  1. doi request reprint Quantitating MHC class I ligand production and presentation using TCR-like antibodies
    Brian P Dolan
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Methods Mol Biol 960:169-77. 2013
    ....
  2. pmc RNA polymerase II inhibitors dissociate antigenic peptide generation from normal viral protein synthesis: a role for nuclear translation in defective ribosomal product synthesis?
    Brian P Dolan
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    J Immunol 185:6728-33. 2010
    ..These data support the idea that Ag processing uses compartmentalized translation, perhaps even in the nucleus itself, to increase the efficiency of the generation of class I peptide ligands...
  3. pmc Endogenous viral antigen processing generates peptide-specific MHC class I cell-surface clusters
    Xiuju Lu
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 109:15407-12. 2012
    ..We propose that endogenous processing generates peptide-specific clusters of class I molecules to maximize the sensitivity and speed of T-cell immunosurveillance...
  4. pmc MHC class I antigen processing distinguishes endogenous antigens based on their translation from cellular vs. viral mRNA
    Brian P Dolan
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 109:7025-30. 2012
    ..virus-encoded mRNA. Thus, class I antigen-processing machinery can distinguish folded proteins based on the precise details of their synthesis to modulate antigen presentation efficiency...
  5. pmc Distinct pathways generate peptides from defective ribosomal products for CD8+ T cell immunosurveillance
    Brian P Dolan
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 186:2065-72. 2011
    ....
  6. pmc Nuclear translation visualized by ribosome-bound nascent chain puromycylation
    Alexandre David
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Biol 197:45-57. 2012
    ..In this paper, we use the RPM to provide evidence for translation in the nucleoplasm and nucleolus, which is regulated by infectious and chemical stress...
  7. pmc Translating DRiPs: progress in understanding viral and cellular sources of MHC class I peptide ligands
    Brian P Dolan
    Laboratory of Viral Diseases, NIAID, Bethesda, MD 20892, USA
    Cell Mol Life Sci 68:1481-9. 2011
    ....
  8. pmc Compartmentalized MHC class I antigen processing enhances immunosurveillance by circumventing the law of mass action
    Avital Lev
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 107:6964-9. 2010
    ..This provides an explanation for the exquisite ability of T cells to recognize peptides generated from otherwise undetected gene products...
  9. pmc Unexpected role for the immunoproteasome subunit LMP2 in antiviral humoral and innate immune responses
    Scott E Hensley
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 184:4115-22. 2010
    ..These findings demonstrate an important role for immunoproteasomes in immune cell function beyond their contribution to Ag processing...
  10. pmc Defective ribosomal products are the major source of antigenic peptides endogenously generated from influenza A virus neuraminidase
    Brian P Dolan
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 184:1419-24. 2010
    ..These observations extend the relevance of the DRiP hypothesis to viral proteins generated in their natural context...