Miral Dizdaroglu

Summary

Affiliation: National Institute of Standards and Technology
Country: USA

Publications

  1. doi request reprint Oxidatively induced DNA damage: Mechanisms, repair and disease
    Miral Dizdaroglu
    Biochemical Science Division, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA Electronic address
    Cancer Lett 327:26-47. 2012
  2. doi request reprint Mechanisms of free radical-induced damage to DNA
    Miral Dizdaroglu
    Biochemical Science Division, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA
    Free Radic Res 46:382-419. 2012
  3. ncbi request reprint Novel substrates of Escherichia coli nth protein and its kinetics for excision of modified bases from DNA damaged by free radicals
    M Dizdaroglu
    Chemical Science and Technology Laboratory, National Institute of Standards and Technology, Gaithersburg, Maryland 20899 8311, USA
    Biochemistry 39:5586-92. 2000
  4. doi request reprint Identification and quantification of DNA repair proteins by liquid chromatography/isotope-dilution tandem mass spectrometry using their fully 15N-labeled analogues as internal standards
    Miral Dizdaroglu
    Biochemical Science Division, National Institute of Standards and Technology, Gaithersburg, Maryland 20899 8311, USA
    J Proteome Res 10:3802-13. 2011
  5. ncbi request reprint Free radical-induced damage to DNA: mechanisms and measurement
    Miral Dizdaroglu
    Chemical Science and Technology Laboratory, National Institute of Standards and Technology, Gaithersburg, MD 20899 8311, USA
    Free Radic Biol Med 32:1102-15. 2002
  6. ncbi request reprint Substrate specificities and excision kinetics of DNA glycosylases involved in base-excision repair of oxidative DNA damage
    Miral Dizdaroglu
    Chemical Science and Technology Laboratory, National Institute of Standards and Technology, Gaithersburg, MD 20899 8311, USA
    Mutat Res 531:109-26. 2003
  7. doi request reprint Formamidopyrimidines in DNA: mechanisms of formation, repair, and biological effects
    Miral Dizdaroglu
    Chemical Science and Technology Laboratory, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA
    Free Radic Biol Med 45:1610-21. 2008
  8. ncbi request reprint Base-excision repair of oxidative DNA damage by DNA glycosylases
    Miral Dizdaroglu
    Chemical Science and Technology Laboratory, National Institute of Standards and Technology, Gaithersburg, MD 20899 8311, USA
    Mutat Res 591:45-59. 2005
  9. ncbi request reprint Substrate specificity and excision kinetics of Escherichia coli endonuclease VIII (Nei) for modified bases in DNA damaged by free radicals
    M Dizdaroglu
    Chemical Science and Technology Laboratory, National Institute of Standards and Technology, Gaithersburg, Maryland 20899 8311, USA
    Biochemistry 40:12150-6. 2001
  10. ncbi request reprint Identification and quantification of 8,5'-cyclo-2'-deoxy-adenosine in DNA by liquid chromatography/ mass spectrometry
    M Dizdaroglu
    Chemical Science and Technology Laboratory, National Institute of Standards and Technology, Gaithersburg, MD 20899 8311, USA
    Free Radic Biol Med 30:774-84. 2001

Collaborators

Detail Information

Publications55

  1. doi request reprint Oxidatively induced DNA damage: Mechanisms, repair and disease
    Miral Dizdaroglu
    Biochemical Science Division, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA Electronic address
    Cancer Lett 327:26-47. 2012
    ..Thus this field deserves more research to contribute to the development of cancer biomarkers, DNA repair inhibitors and treatment approaches to better understand and fight cancer...
  2. doi request reprint Mechanisms of free radical-induced damage to DNA
    Miral Dizdaroglu
    Biochemical Science Division, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA
    Free Radic Res 46:382-419. 2012
    ..Further understanding of mechanisms of free radical-induced DNA damage, and cellular repair and biological consequences of DNA damage products will be of outmost importance for disease prevention and treatment...
  3. ncbi request reprint Novel substrates of Escherichia coli nth protein and its kinetics for excision of modified bases from DNA damaged by free radicals
    M Dizdaroglu
    Chemical Science and Technology Laboratory, National Institute of Standards and Technology, Gaithersburg, Maryland 20899 8311, USA
    Biochemistry 39:5586-92. 2000
    ..This comparison shows that significant differences exist with respect to substrate specificity and kinetic parameters despite extensive structural conservation among the Nth homologues...
  4. doi request reprint Identification and quantification of DNA repair proteins by liquid chromatography/isotope-dilution tandem mass spectrometry using their fully 15N-labeled analogues as internal standards
    Miral Dizdaroglu
    Biochemical Science Division, National Institute of Standards and Technology, Gaithersburg, Maryland 20899 8311, USA
    J Proteome Res 10:3802-13. 2011
    ..The results obtained suggest that the methodology developed would be highly suitable for the positive identification and accurate quantification of DNA repair proteins in vivo as potential biomarkers for cancer and other diseases...
  5. ncbi request reprint Free radical-induced damage to DNA: mechanisms and measurement
    Miral Dizdaroglu
    Chemical Science and Technology Laboratory, National Institute of Standards and Technology, Gaithersburg, MD 20899 8311, USA
    Free Radic Biol Med 32:1102-15. 2002
    ..This article reviews mechanistic aspects of oxidative damage to DNA and recent developments in the measurement of this type of damage using chromatographic and mass spectrometric techniques...
  6. ncbi request reprint Substrate specificities and excision kinetics of DNA glycosylases involved in base-excision repair of oxidative DNA damage
    Miral Dizdaroglu
    Chemical Science and Technology Laboratory, National Institute of Standards and Technology, Gaithersburg, MD 20899 8311, USA
    Mutat Res 531:109-26. 2003
    ..This paper reviews the substrate specificities and excision kinetics of DNA glycosylases that have been investigated with the use of gas chromatography/mass spectrometry and DNA substrates with multiple lesions...
  7. doi request reprint Formamidopyrimidines in DNA: mechanisms of formation, repair, and biological effects
    Miral Dizdaroglu
    Chemical Science and Technology Laboratory, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA
    Free Radic Biol Med 45:1610-21. 2008
    ..Our goal is to emphasize the importance of these neglected lesions in many biological and disease processes...
  8. ncbi request reprint Base-excision repair of oxidative DNA damage by DNA glycosylases
    Miral Dizdaroglu
    Chemical Science and Technology Laboratory, National Institute of Standards and Technology, Gaithersburg, MD 20899 8311, USA
    Mutat Res 591:45-59. 2005
    ..This paper reviews substrate specificities and excision kinetics of DNA glycosylases for removal of pyrimidine- and purine-derived lesions in high-molecular weight DNA...
  9. ncbi request reprint Substrate specificity and excision kinetics of Escherichia coli endonuclease VIII (Nei) for modified bases in DNA damaged by free radicals
    M Dizdaroglu
    Chemical Science and Technology Laboratory, National Institute of Standards and Technology, Gaithersburg, Maryland 20899 8311, USA
    Biochemistry 40:12150-6. 2001
    ..The present work extends the substrate specificity of Nei and shows the effect of a single mutation in the nei gene on the specificity of Nei...
  10. ncbi request reprint Identification and quantification of 8,5'-cyclo-2'-deoxy-adenosine in DNA by liquid chromatography/ mass spectrometry
    M Dizdaroglu
    Chemical Science and Technology Laboratory, National Institute of Standards and Technology, Gaithersburg, MD 20899 8311, USA
    Free Radic Biol Med 30:774-84. 2001
    ..The measurement of 8,5'-cyclo-2'-deoxyadenosine by liquid chromatography/mass spectrometry may contribute to the understanding of its biological properties and its role in diseases with defective nucleotide-excision repair...
  11. pmc Measurement of 8-hydroxy-2'-deoxyguanosine in DNA by high-performance liquid chromatography-mass spectrometry: comparison with measurement by gas chromatography-mass spectrometry
    M Dizdaroglu
    Chemical Science and Technology Laboratory, National Institute of Standards and Technology, Gaithersburg, MD 20899 8311, USA
    Nucleic Acids Res 29:E12. 2001
    ..Taken together, the results unequivocally show that LC/IDMS-SIM is well suited for sensitive and accurate measurement of 8-OH-dGuo in DNA and that both LC/IDMS-SIM and GC/IDMS-SIM can provide similar results...
  12. doi request reprint Identification and quantification of human DNA repair protein NEIL1 by liquid chromatography/isotope-dilution tandem mass spectrometry
    Prasad T Reddy
    Biochemical Science Division, National Institute of Standards and Technology, Gaithersburg, Maryland 20899, USA
    J Proteome Res 12:1049-61. 2013
    ..These results suggest that the developed assays would be highly suitable for the in vivo positive identification and accurate quantification of hNEIL1 in tissues...
  13. pmc Evidence for the involvement of DNA repair enzyme NEIL1 in nucleotide excision repair of (5'R)- and (5'S)-8,5'-cyclo-2'-deoxyadenosines
    Pawel Jaruga
    Chemical Science and Technology Laboratory, National Institute of Standards and Technology, Gaithersburg, Maryland 20899, USA
    Biochemistry 49:1053-5. 2010
    ..Further studies aimed at elucidating the mechanism of action of NEIL1 in NER are warranted...
  14. ncbi request reprint Overexpression and rapid purification of Escherichia coli formamidopyrimidine-DNA glycosylase
    Prasad Reddy
    Chemical Science and Technology Laboratory, National Institute of Standards and Technology, Gaithersburg, MD, USA
    Protein Expr Purif 34:126-33. 2004
    ..Therefore, this method should prove useful for a large number of laboratories and further research on oxidative DNA damage...
  15. ncbi request reprint Lymphoblasts of women with BRCA1 mutations are deficient in cellular repair of 8,5'-Cyclopurine-2'-deoxynucleosides and 8-hydroxy-2'-deoxyguanosine
    Henry Rodriguez
    Chemical Science and Technology Laboratory, and Statistical Engineering Division, National Institute of Standards and Technology, Gaithersburg, Maryland 20899 8311, USA
    Biochemistry 46:2488-96. 2007
    ..This work suggest that accumulation of these lesions may lead to a high rate of mutations and to deleterious changes in gene expression, increasing breast cancer risk and contributing to breast carcinogenesis...
  16. doi request reprint Stable isotope-labeling of DNA repair proteins, and their purification and characterization
    Prasad T Reddy
    Biochemical Science Division, National Institute of Standards and Technology, Gaithersburg, MD, USA
    Protein Expr Purif 78:94-101. 2011
    ..The procedures described in this work may be used for obtaining stable isotope-labeled analogs of other DNA repair proteins for mass spectrometric measurements of these proteins as disease biomarkers...
  17. doi request reprint Measurement of formamidopyrimidines in DNA
    Pawel Jaruga
    Chemical Science and Technology Laboratory, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA
    Free Radic Biol Med 45:1601-9. 2008
    ..This paper reports on the details of this GC/MS methodology...
  18. doi request reprint 8,5'-Cyclopurine-2'-deoxynucleosides in DNA: mechanisms of formation, measurement, repair and biological effects
    Pawel Jaruga
    Chemical Science and Technology Laboratory, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA
    DNA Repair (Amst) 7:1413-25. 2008
    ..Accumulation of cdA and cdG was observed in tissues in vivo in connection to disease and environmental conditions, suggesting an important role for these lesions in disease processes including carcinogenesis and neuronal death...
  19. ncbi request reprint Mouse NEIL1 protein is specific for excision of 2,6-diamino-4-hydroxy-5-formamidopyrimidine and 4,6-diamino-5-formamidopyrimidine from oxidatively damaged DNA
    Pawel Jaruga
    Chemical Science and Technology Laboratory, National Institute of Standards and Technology, Gaithersburg, Maryland 20899 8311, USA
    Biochemistry 43:15909-14. 2004
    ..A comparison of the specificity and excision kinetics of mNEIL1 with other DNA glycosylases shows that this enzyme is as efficient as those DNA glycosylases, which specifically remove the formamidopyrimidines from DNA...
  20. ncbi request reprint Chlorella virus pyrimidine dimer glycosylase excises ultraviolet radiation- and hydroxyl radical-induced products 4,6-diamino-5-formamidopyrimidine and 2,6-diamino-4-hydroxy-5-formamidopyrimidine from DNA
    Pawel Jaruga
    Chemical Science and Technology Laboratory, National Institute of Standards and Technology, Gaithersburg, MD, USA
    Photochem Photobiol 75:85-91. 2002
    ..On the other hand, cv-pdg possesses a greater efficiency for the extension of FapyAde than T4-pdg. These two enzymes exhibit different substrate specificities despite substantial structural similarities...
  21. ncbi request reprint Mass spectrometric assays for the tandem lesion 8,5'-cyclo-2'-deoxyguanosine in mammalian DNA
    Pawel Jaruga
    Chemical Science and Technology Laboratory, National Institute of Standards and Technology, Gaithersburg, Maryland 20899 8311, USA
    Biochemistry 41:3703-11. 2002
    ..The results showed that both LC/IDMS and GC/IDMS are well suited for the sensitive detection and precise quantification of both (5'R)-8,5'-cdGuo and (5'S)-8,5'-cdGuo in DNA...
  22. ncbi request reprint DNA base damage by the antitumor agent 3-amino-1,2,4-benzotriazine 1,4-dioxide (tirapazamine)
    Mustafa Birincioglu
    Chemical Science and Technology Laboratory, National Institute of Standards and Technology, Gaithersburg, Maryland 20899 8311, USA
    J Am Chem Soc 125:11607-15. 2003
    ..Overall, the results indicate that DNA base damage may contribute to the biological effects of tirapazamine in vivo...
  23. doi request reprint Measurement of (5'R)- and (5'S)-8,5'-cyclo-2'-deoxyadenosines in DNA in vivo by liquid chromatography/isotope-dilution tandem mass spectrometry
    Pawel Jaruga
    Chemical Science and Technology Laboratory, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA
    Biochem Biophys Res Commun 386:656-60. 2009
    ....
  24. doi request reprint Identification and quantification of (5'R)- and (5'S)-8,5'-cyclo-2'-deoxyadenosines in human urine as putative biomarkers of oxidatively induced damage to DNA
    Pawel Jaruga
    Biochemical Science Division, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA
    Biochem Biophys Res Commun 397:48-52. 2010
    ..This study shows, for the first time, that R-cdA and S-cdA exist in human urine and can be identified and quantified by LC-MS/MS. We propose that R-cdA and S-cdA may be well-suited biomarkers for disease processes such as carcinogenesis...
  25. pmc Accumulation of (5'S)-8,5'-cyclo-2'-deoxyadenosine in organs of Cockayne syndrome complementation group B gene knockout mice
    Guldal Kirkali
    Chemical Science and Technology Laboratory, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA
    DNA Repair (Amst) 8:274-8. 2009
    ..Thus, this study provides, for the first time, the evidence that CSB plays a role in the repair of the DNA helix-distorting tandem lesion S-cdA. Accumulation of unrepaired S-cdA in vivo may contribute to the pathology associated with CS...
  26. doi request reprint DNA damage products (5'R)- and (5'S)-8,5'-cyclo-2'-deoxyadenosines as potential biomarkers in human urine for atherosclerosis
    Pawel Jaruga
    Biochemical Science Division, National Institute of Standards and Technology, Gaithersburg, Maryland 20899, United States
    Biochemistry 51:1822-4. 2012
    ..Our data suggest that R-cdA and S-cdA can be accurately and reproducibly measured in human urine as potential biomarkers of risk and diagnosis for atherosclerosis...
  27. ncbi request reprint Oxidative DNA damage in polymorphonuclear leukocytes of patients with familial Mediterranean fever
    Guldal Kirkali
    Chemical Science and Technology Laboratory, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA
    Free Radic Biol Med 44:386-93. 2008
    ..Future research should deal with prevention of oxidative DNA damage and apoptosis in FMF patients, and also the elucidation of a possible role of DNA repair in this disease...
  28. pmc Identification and Quantification of DNA Repair Protein Apurinic/Apyrimidinic Endonuclease 1 (APE1) in Human Cells by Liquid Chromatography/Isotope-Dilution Tandem Mass Spectrometry
    Guldal Kirkali
    Biomolecular Measurement Division, National Institute of Standards and Technology, Gaithersburg, Maryland, United States of America
    PLoS ONE 8:e69894. 2013
    ..The results describe a novel approach for the accurate measurement of wild-type and variant forms of hAPE1 in vivo, and ultimately for defining the role of this protein in disease development and treatment responses. ..
  29. doi request reprint Copper oxide nanoparticle mediated DNA damage in terrestrial plant models
    Donald H Atha
    Material Measurement Laboratory, National Institute of Standards and Technology, 100 Bureau Drive, Gaithersburg, Maryland 20899, United States
    Environ Sci Technol 46:1819-27. 2012
    ..To our knowledge, this is the first evidence of multiple DNA lesion formation and accumulation in plants. These findings provide impetus for future investigations on nanoparticle-mediated DNA damage and repair mechanisms in plants...
  30. ncbi request reprint Measurement of DNA biomarkers for the safety of tissue-engineered medical products, using artificial skin as a model
    Henry Rodriguez
    Chemical Science and Technology Laboratory, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA
    Tissue Eng 10:1332-45. 2004
    ..More importantly, this exploratory work addresses technological considerations that need to be addressed in order to expedite accurate and useful international reference standards for the emerging tissue-engineering industry...
  31. pmc Complete release of (5'S)-8,5'-cyclo-2'-deoxyadenosine from dinucleotides, oligodeoxynucleotides and DNA, and direct comparison of its levels in cellular DNA with other oxidatively induced DNA lesions
    Pawel Jaruga
    Department of Chemical and Biochemical Engineering, University of Maryland Baltimore County, MD 22777, USA
    Nucleic Acids Res 32:e87. 2004
    ..We conclude that (5'S)-cdA can be completely released from DNA by enzymic hydrolysis, and the level of (5'S)-cdA in tissue DNA is comparable to those of other oxidatively induced DNA lesions...
  32. doi request reprint Protective roles of single-wall carbon nanotubes in ultrasonication-induced DNA base damage
    Elijah J Petersen
    Biochemical Science Division, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA
    Small 9:205-8. 2013
    ..The protective role of SWCNTs observed in this work suggests a contrary view to the general idea that carbon nanotubes have damaging effects on biomolecules...
  33. ncbi request reprint Cellular repair of oxidatively induced DNA base lesions is defective in prostate cancer cell lines, PC-3 and DU-145
    Andrzej R Trzeciak
    Laboratory of Cellular and Molecular Biology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224 6825, USA
    Carcinogenesis 25:1359-70. 2004
    ..These data suggest that the malignant phenotype in PC-3 and DU-145 cell lines may be associated with defects in base excision repair and alterations in expression of antioxidant enzymes...
  34. ncbi request reprint Oxidative DNA damage: mechanisms, mutation, and disease
    Marcus S Cooke
    Oxidative Stress Group, Department of Clinical Biochemistry, University of Leicester, Leicester Royal Infirmary, University Hospitals of Leicester NHS Trust, Leicester, LE2 7LX, UK
    FASEB J 17:1195-214. 2003
    ....
  35. ncbi request reprint Stoichiometric preference in copper-promoted oxidative DNA damage by ochratoxin A
    Richard A Manderville
    Department of Chemistry, Wake Forest University, Winston Salem, NC 27109 7486, USA
    J Inorg Biochem 95:87-96. 2003
    ..The implications of these findings with regard to the mutagenicity of OTA are discussed...
  36. ncbi request reprint Primary fibroblasts of Cockayne syndrome patients are defective in cellular repair of 8-hydroxyguanine and 8-hydroxyadenine resulting from oxidative stress
    Jingsheng Tuo
    Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    FASEB J 17:668-74. 2003
    ..A deficiency in cellular repair of oxidative DNA damage might contribute to developmental defects in CS patients...
  37. pmc Linking uracil base excision repair and 5-fluorouracil toxicity in yeast
    Lauren Seiple
    Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Nucleic Acids Res 34:140-51. 2006
    ..These findings suggest that new strategies for chemical intervention targeting BER could enhance the effectiveness of this widely used anticancer drug...
  38. ncbi request reprint Arabidopsis thaliana Ogg1 protein excises 8-hydroxyguanine and 2,6-diamino-4-hydroxy-5-formamidopyrimidine from oxidatively damaged DNA containing multiple lesions
    Teresa Morales-Ruiz
    Departamento de Genetica, Facultad de Ciencias, Universidad de Cordoba, Cordoba, Spain
    Biochemistry 42:3089-95. 2003
    ..The results unequivocally show that AtOgg1 possesses common substrates with other eukaryotic Ogg1 proteins albeit significant differences between their excision kinetics...
  39. ncbi request reprint The cockayne syndrome group B gene product is involved in cellular repair of 8-hydroxyadenine in DNA
    Jingsheng Tuo
    Laboratory of Molecular Gerontology, National Institute on Aging NIH, Baltimore, MD 21224, USA
    J Biol Chem 277:30832-7. 2002
    ..These results suggest that the CSB protein contributes to cellular repair of 8-OH-Ade and that the motif VI of the putative helicase domain of CSB is required for this activity...
  40. pmc Identification and characterization of a human DNA glycosylase for repair of modified bases in oxidatively damaged DNA
    Tapas K Hazra
    Sealy Center for Molecular Science and Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, TX 77555, USA
    Proc Natl Acad Sci U S A 99:3523-8. 2002
    ..The tissue-specific levels of NEH1 and OGG1 mRNAs are distinct, and S phase-specific increase in NEH1 at both RNA and protein levels suggests that NEH1 is involved in replication-associated repair of oxidized bases...
  41. ncbi request reprint Determination of active site residues in Escherichia coli endonuclease VIII
    Sarah Burgess
    Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, Texas 77555 1071, USA
    J Biol Chem 277:2938-44. 2002
    ..These studies provide detailed predictions concerning the active site of endoVIII...
  42. pmc Biomarkers signal contaminant effects on the organs of English sole (Parophrys vetulus) from Puget Sound
    Donald C Malins
    Biochemical Oncology Program, Pacific Northwest Research Institute, Seattle, Washington 98122, USA
    Environ Health Perspect 114:823-9. 2006
    ..The biomarkers described are highly promising for identifying contaminant-induced stresses in fish populations from polluted and reference sites and, in addition, for monitoring the progress of remedial actions...
  43. ncbi request reprint Oxidative DNA damage and disease: induction, repair and significance
    Mark D Evans
    Oxidative Stress Group, Department of Clinical Biochemistry, University of Leicester, Leicester Royal Infirmary, University Hospitals of Leicester NHS Trust, LE2 7LX, UK
    Mutat Res 567:1-61. 2004
    ..However, exact roles remain to be elucidated...
  44. ncbi request reprint Human polymorphic variants of the NEIL1 DNA glycosylase
    Laura M Roy
    Center for Research on Occupational and Environmental Toxicology, Department of Molecular and Medical Genetics, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    J Biol Chem 282:15790-8. 2007
    ..Extrapolation of these data suggests that individuals who are heterozygous for these inactive variant neil1 alleles may be at increased risk for metabolic syndrome...
  45. ncbi request reprint Oxidized guanine lesions and hOgg1 activity in lung cancer
    Elizabeth Mambo
    Department of Otolaryngology Head and Neck Surgery, Head and Neck Cancer Research Division, The Johns Hopkins University School of Medicine, Baltimore, MD 21205 2196, USA
    Oncogene 24:4496-508. 2005
    ..These results provide evidence for defective incision of 8-oxoG in both nuclear and mitochondria of H1650 and H226 lung cancer cell lines. These results may implicate 8-oxoG repair defects in certain lung cancers...
  46. pmc New functions of XPC in the protection of human skin cells from oxidative damage
    Mariarosaria D'Errico
    Department of Environment and Primary Prevention, Istituto Superiore di Sanita, Rome, Italy
    EMBO J 25:4305-15. 2006
    ..The accumulation of endogenous oxidative DNA damage might contribute to increased skin cancer risk and account for internal cancers reported for XP-C patients...
  47. ncbi request reprint Regulation of reactive oxygen species, DNA damage, and c-Myc function by peroxiredoxin 1
    Rachel A Egler
    Department of Pediatrics, Section of Hematology Oncology, Children s Hospital of Pittsburgh, Rangos Research Center, 3460 Fifth Ave, USA
    Oncogene 24:8038-50. 2005
    ..prdx1-/- mice should be useful in studying the role of oxidative DNA damage in the causation of cancer and its prevention by antioxidants. They should also help in studying the relationship between oncogenes such as c-Myc and DNA damage...
  48. pmc The oxidatively induced DNA lesions 8,5'-cyclo-2'-deoxyadenosine and 8-hydroxy-2'-deoxyadenosine are strongly resistant to acid-induced hydrolysis of the glycosidic bond
    Jacob A Theruvathu
    Section on Molecular Neurobiology, Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, 5625 Fishers Lane, Room 3S 32, MSC 9412, Bethesda, MD 20952 9412, USA
    Mech Ageing Dev 128:494-502. 2007
    ....
  49. ncbi request reprint Accumulation of oxidatively induced DNA damage in human breast cancer cell lines following treatment with hydrogen peroxide
    Simon G Nyaga
    Laboratory of Cellular and Molecular Biology, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
    Cell Cycle 6:1472-8. 2007
    ..Furthermore, MCF-7 and HCC1937 cell lines were deficient in the excision repair of all the four lesions studied. These results suggest that oxidatively induced DNA damage and its repair may be critical in the etiology of breast cancer...
  50. pmc Molecular analysis of base damage clustering associated with a site-specific radiation-induced DNA double-strand break
    Kamal Datta
    Department of Nuclear Medicine, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA
    Radiat Res 166:767-81. 2006
    ..These base lesions were 8-hydroxyguanine, 8-hydroxyadenine and 5-hydroxycytosine. Finally, evidence is presented for base damage >24 bp upstream from the (125)I-decay site that may form via a charge migration mechanism...
  51. ncbi request reprint Repair of formamidopyrimidines in DNA involves different glycosylases: role of the OGG1, NTH1, and NEIL1 enzymes
    Jingping Hu
    Laboratory of Molecular Gerontology, NIA, National Institutes of Health, Baltimore, Maryland 21224, USA
    J Biol Chem 280:40544-51. 2005
    ..FapyG and FapyA levels were significantly elevated in DNA from the knock-out mice, underscoring the biological role of OGG1 and NTH1 in the repair of these lesions...
  52. pmc Reduced repair of 8-hydroxyguanine in the human breast cancer cell line, HCC1937
    Simon G Nyaga
    Laboratory of Cellular and Molecular Biology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    BMC Cancer 6:297. 2006
    ..The aim of this study was to investigate the ability of HCC1937 and MCF-7 breast cancer cell lines to repair 8-OH-Gua relative to a nonmalignant human mammary epithelial cell line, AG11134...
  53. ncbi request reprint Structural alterations in breast stromal and epithelial DNA: the influence of 8,5'-cyclo-2'-deoxyadenosine
    Katie M Anderson
    Biochemical Oncology Program, Pacific Northwest Research Institute, Seattle, Washington, USA
    Cell Cycle 5:1240-4. 2006
    ..Initial insight is provided on changes in DNA structure that potentially affect gene expression and increase breast cancer risk...
  54. pmc Polyamines stimulate the formation of mutagenic 1,N2-propanodeoxyguanosine adducts from acetaldehyde
    Jacob A Theruvathu
    Section on Molecular Neurobiology, Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, NIH 5625 Fishers Lane, Room 3S32, MSC 9412, Bethesda, MD 20952 9412, USA
    Nucleic Acids Res 33:3513-20. 2005
    ..We propose that AA derived from ethanol metabolism is converted to CrA by polyamines in dividing cells, forming Cr-PdG adducts, which may be responsible for the carcinogenicity of alcoholic beverage consumption...
  55. ncbi request reprint Oxidative changes in the DNA of stroma and epithelium from the female breast: potential implications for breast cancer
    Donald C Malins
    Biochemical Oncology Program, Pacific Northwest Research Institute, Seattle, Washington 98122, USA
    Cell Cycle 5:1629-32. 2006
    ..Collectively, the findings imply that the structural changes in DNA described may potentially disrupt normal reciprocal interactions between the cell types, thus increasing breast cancer risk...