Jennifer S Dickey

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi Intercellular communication of cellular stress monitored by gamma-H2AX induction
    Jennifer S Dickey
    Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20952, USA
    Carcinogenesis 30:1686-95. 2009
  2. ncbi H2AX: functional roles and potential applications
    Jennifer S Dickey
    Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Chromosoma 118:683-92. 2009
  3. ncbi Hypothermia postpones DNA damage repair in irradiated cells and protects against cell killing
    Brandon J Baird
    Laboratory of Molecular Pharmacology, CCR, NCI, Bethesda, MD 20892, USA
    Mutat Res 711:142-9. 2011
  4. ncbi Susceptibility to bystander DNA damage is influenced by replication and transcriptional activity
    Jennifer S Dickey
    Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20952, USA
    Nucleic Acids Res 40:10274-86. 2012
  5. ncbi Role of oxidatively induced DNA lesions in human pathogenesis
    Olga A Sedelnikova
    Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Mutat Res 704:152-9. 2010
  6. ncbi Systemic DNA damage related to cancer
    Olga A Martin
    Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA
    Cancer Res 71:3437-41. 2011
  7. ncbi GammaH2AX and cancer
    William M Bonner
    Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Rev Cancer 8:957-67. 2008
  8. ncbi Tumors induce complex DNA damage in distant proliferative tissues in vivo
    Christophe E Redon
    Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 107:17992-7. 2010
  9. ncbi H2AX phosphorylation in response to DNA double-strand break formation during bystander signalling: effect of microRNA knockdown
    Jennifer S Dickey
    Laboratory of Molecular Pharmacology, Center for Cancer Research, NCI, NIH, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Radiat Prot Dosimetry 143:264-9. 2011
  10. ncbi γ-H2AX detection in peripheral blood lymphocytes, splenocytes, bone marrow, xenografts, and skin
    Christophe E Redon
    Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA
    Methods Mol Biol 682:249-70. 2011

Detail Information

Publications14

  1. ncbi Intercellular communication of cellular stress monitored by gamma-H2AX induction
    Jennifer S Dickey
    Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20952, USA
    Carcinogenesis 30:1686-95. 2009
    ....
  2. ncbi H2AX: functional roles and potential applications
    Jennifer S Dickey
    Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Chromosoma 118:683-92. 2009
    ..Recent work indicates that gamma-H2AX detection may become a powerful tool for monitoring genotoxic events associated with cancer development and tumor progression...
  3. ncbi Hypothermia postpones DNA damage repair in irradiated cells and protects against cell killing
    Brandon J Baird
    Laboratory of Molecular Pharmacology, CCR, NCI, Bethesda, MD 20892, USA
    Mutat Res 711:142-9. 2011
    ....
  4. ncbi Susceptibility to bystander DNA damage is influenced by replication and transcriptional activity
    Jennifer S Dickey
    Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20952, USA
    Nucleic Acids Res 40:10274-86. 2012
    ..These results indicate that cell vulnerability to bystander DSB damage may result from transcription as well as replication. The findings offer insights into which tissues may be vulnerable to bystander genomic destabilization in vivo...
  5. ncbi Role of oxidatively induced DNA lesions in human pathogenesis
    Olga A Sedelnikova
    Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Mutat Res 704:152-9. 2010
    ..If unrepaired, these lesions can lead to the formation of mutations, DNA DSBs, and chromosome abnormalities. We discuss the roles of these lesions in human pathologies including aging and cancer, and in bystander effects...
  6. ncbi Systemic DNA damage related to cancer
    Olga A Martin
    Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA
    Cancer Res 71:3437-41. 2011
    ..Here, we discuss some of the implications of these observations...
  7. ncbi GammaH2AX and cancer
    William M Bonner
    Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Rev Cancer 8:957-67. 2008
    ..Using gammaH2AX detection to determine the extent of DSB induction may help to detect precancerous cells, to stage cancers, to monitor the effectiveness of cancer therapies and to develop novel anticancer drugs...
  8. ncbi Tumors induce complex DNA damage in distant proliferative tissues in vivo
    Christophe E Redon
    Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 107:17992-7. 2010
    ..Importantly, these findings suggest that tumors may have more profound effects on their hosts than heretofore expected...
  9. ncbi H2AX phosphorylation in response to DNA double-strand break formation during bystander signalling: effect of microRNA knockdown
    Jennifer S Dickey
    Laboratory of Molecular Pharmacology, Center for Cancer Research, NCI, NIH, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Radiat Prot Dosimetry 143:264-9. 2011
    ....
  10. ncbi γ-H2AX detection in peripheral blood lymphocytes, splenocytes, bone marrow, xenografts, and skin
    Christophe E Redon
    Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA
    Methods Mol Biol 682:249-70. 2011
    ..This chapter presents techniques for γ-H2AX detection in a variety of human and mouse samples...
  11. ncbi The role of miRNA in the direct and indirect effects of ionizing radiation
    Jennifer S Dickey
    Laboratory of Biochemistry, Division of Therapeutic Proteins, CDER, FDA, Bethesda, MD 20892, USA
    Radiat Environ Biophys 50:491-9. 2011
    ....
  12. ncbi The iron chelator Dp44mT inhibits the proliferation of cancer cells but fails to protect from doxorubicin-induced cardiotoxicity in spontaneously hypertensive rats
    V Ashutosh Rao
    Laboratory of Biochemistry, Center for Drug Evaluation and Research, Food and Drug Administration, 29 Lincoln Drive, Building 29A, Room 2A 11, Bethesda, MD 20892, USA
    Cancer Chemother Pharmacol 68:1125-34. 2011
    ..We tested the hypothesis that Dp44mT can improve clinical outcomes of treatment with Dox by alleviating cardiotoxicity...
  13. ncbi gamma-H2AX in bystander cells: not just a radiation-triggered event, a cellular response to stress mediated by intercellular communication
    Mykyta V Sokolov
    Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20895, USA
    Cell Cycle 6:2210-2. 2007
    ..This extra view points to some possibilities that might explain why DDR in human cells can be observed under bystander conditions...
  14. ncbi The antioxidant transcription factor Nrf2 negatively regulates autophagy and growth arrest induced by the anticancer redox agent mitoquinone
    V Ashutosh Rao
    Laboratory of Biochemistry, Center for Drug Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
    J Biol Chem 285:34447-59. 2010
    ..Keap1 and Nrf2 act as redox sensors for oxidative perturbations that lead to autophagy. MitoQ and similar compounds should be further evaluated for novel anticancer activity...