Marilyn Diaz

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. doi request reprint The role of activation-induced deaminase in lupus nephritis
    Marilyn Diaz
    Somatic Hypermutation Group, Laboratory of Molecular Genetics, NIEHS, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Autoimmunity 46:115-20. 2013
  2. ncbi request reprint Mutagenesis by AID, a molecule critical to immunoglobulin hypermutation, is not caused by an alteration of the precursor nucleotide pool
    Marilyn Diaz
    Laboratory of Molecular Genetics, Department of Health and Human Services, National Institute of Environmental Health Sciences, National Institutes of Health, 111 TW Alexander Drive, Research Triangle Park, NC 27709, USA
    Mol Immunol 40:261-8. 2003
  3. ncbi request reprint An update on the role of translesion synthesis DNA polymerases in Ig hypermutation
    Marilyn Diaz
    Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, 111 TW Alexander Drive, Research Triangle Park, NC 27709, USA
    Trends Immunol 26:215-20. 2005
  4. pmc Altered pattern of immunoglobulin hypermutation in mice deficient in Slip-GC protein
    Kathleen Richter
    Somatic Hypermutation Group, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 287:31856-65. 2012
  5. pmc Activation-induced deaminase heterozygous MRL/lpr mice are delayed in the production of high-affinity pathogenic antibodies and in the development of lupus nephritis
    Chuancang Jiang
    Laboratory of Molecular Genetics, D3 01 National Institute of Environmental Health Sciences National Institutes of Health, Research Triangle Park, NC 27709, USA
    Immunology 126:102-13. 2009
  6. pmc Activation-induced deaminase contributes to the antibody-independent role of B cells in the development of autoimmunity
    Chuancang Jiang
    Somatic Hypermutation Group, Laboratory of Molecular Genetics, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Autoimmunity 45:440-8. 2012
  7. pmc Activation-induced deaminase-deficient MRL/lpr mice secrete high levels of protective antibodies against lupus nephritis
    Chuancang Jiang
    National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA
    Arthritis Rheum 63:1086-96. 2011
  8. pmc Altered Ig hypermutation pattern and frequency in complementary mouse models of DNA polymerase ζ activity
    Janssen Daly
    Somatic Hypermutation Group, Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
    J Immunol 188:5528-37. 2012
  9. pmc Speckled-like pattern in the germinal center (SLIP-GC), a nuclear GTPase expressed in activation-induced deaminase-expressing lymphomas and germinal center B cells
    Kathleen Richter
    Laboratory of Molecular Genetics, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 284:30652-61. 2009
  10. pmc Abrogation of lupus nephritis in activation-induced deaminase-deficient MRL/lpr mice
    Chuancang Jiang
    Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences National Institutes of Health, Research Triangle Park, NC 27709, USA
    J Immunol 178:7422-31. 2007

Collaborators

  • Laurent Verkoczy
  • I Rogozin
  • Ingrid Tessmer
  • Christopher Lawrence
  • Silvia Bolland
  • T A Kunkel
  • Paolo Casali
  • Chuancang Jiang
  • Ming Lang Zhao
  • Kathleen Richter
  • Janssen Daly
  • Sukhdev S Brar
  • Madhumita Ray
  • Richard M Scearce
  • Grace Kissling
  • Zheng Xiao
  • W Glenn McGregor
  • Katherine M Waters
  • Lauranell Burch
  • David Henke
  • Katarzyna Bebenek
  • Danielle L Watt
  • Frank Chao
  • Prapaporn Pisitkun
  • Sukhdev Brar
  • Dorothy A Erie
  • Deborah L Croteau
  • Elizabeth J Sacho
  • Alan B Clark
  • Micheal Jokinen
  • Natasha Clayton
  • Ronald Herbert
  • Julie Foley
  • Mary Watson

Detail Information

Publications21

  1. doi request reprint The role of activation-induced deaminase in lupus nephritis
    Marilyn Diaz
    Somatic Hypermutation Group, Laboratory of Molecular Genetics, NIEHS, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Autoimmunity 46:115-20. 2013
    ..These results, likely the result of the immunodeficiency associated with AID deficiency, suggest caution in therapeutic approaches based in AID inhibition...
  2. ncbi request reprint Mutagenesis by AID, a molecule critical to immunoglobulin hypermutation, is not caused by an alteration of the precursor nucleotide pool
    Marilyn Diaz
    Laboratory of Molecular Genetics, Department of Health and Human Services, National Institute of Environmental Health Sciences, National Institutes of Health, 111 TW Alexander Drive, Research Triangle Park, NC 27709, USA
    Mol Immunol 40:261-8. 2003
    ....
  3. ncbi request reprint An update on the role of translesion synthesis DNA polymerases in Ig hypermutation
    Marilyn Diaz
    Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, 111 TW Alexander Drive, Research Triangle Park, NC 27709, USA
    Trends Immunol 26:215-20. 2005
    ....
  4. pmc Altered pattern of immunoglobulin hypermutation in mice deficient in Slip-GC protein
    Kathleen Richter
    Somatic Hypermutation Group, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 287:31856-65. 2012
    ..Given the intracellular localization of SLIP-GC to sites of replicating DNA, these results suggest that SLIP-GC protects replicating DNA from AID-mediated deamination of cytosines in both strands...
  5. pmc Activation-induced deaminase heterozygous MRL/lpr mice are delayed in the production of high-affinity pathogenic antibodies and in the development of lupus nephritis
    Chuancang Jiang
    Laboratory of Molecular Genetics, D3 01 National Institute of Environmental Health Sciences National Institutes of Health, Research Triangle Park, NC 27709, USA
    Immunology 126:102-13. 2009
    ..These results imply that AID levels impact the class switch recombination and somatic hypermutation mechanisms and directly implicate affinity maturation of autoantibodies in autoimmunity...
  6. pmc Activation-induced deaminase contributes to the antibody-independent role of B cells in the development of autoimmunity
    Chuancang Jiang
    Somatic Hypermutation Group, Laboratory of Molecular Genetics, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Autoimmunity 45:440-8. 2012
    ..These data establish AID as an important contributor to the antibody-independent role of B cells in autoimmunity...
  7. pmc Activation-induced deaminase-deficient MRL/lpr mice secrete high levels of protective antibodies against lupus nephritis
    Chuancang Jiang
    National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA
    Arthritis Rheum 63:1086-96. 2011
    ..The purpose of the present study was to test the hypothesis that high levels of germline autoreactive IgM in these mice confer protection against lupus nephritis...
  8. pmc Altered Ig hypermutation pattern and frequency in complementary mouse models of DNA polymerase ζ activity
    Janssen Daly
    Somatic Hypermutation Group, Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
    J Immunol 188:5528-37. 2012
    ..Combined, these data are best explained by a direct role for DNA polymerase ζ in Ig hypermutation...
  9. pmc Speckled-like pattern in the germinal center (SLIP-GC), a nuclear GTPase expressed in activation-induced deaminase-expressing lymphomas and germinal center B cells
    Kathleen Richter
    Laboratory of Molecular Genetics, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 284:30652-61. 2009
    ..These results strongly suggest that SLIP-GC is a replication-related protein in germinal center B cells whose reduction is toxic to cells through an AID-dependent mechanism...
  10. pmc Abrogation of lupus nephritis in activation-induced deaminase-deficient MRL/lpr mice
    Chuancang Jiang
    Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences National Institutes of Health, Research Triangle Park, NC 27709, USA
    J Immunol 178:7422-31. 2007
    ..This novel mouse model containing high levels of autoreactive, unmutated IgM Abs will help delineate the contribution of autoreactive IgM to autoimmunity...
  11. ncbi request reprint A novel cytidine deaminase AIDs in the delivery of error-prone polymerases to immunoglobulin genes
    Marilyn Diaz
    Laboratory of Molecular Genetics, NIEHS, Research Triangle Park, NC, USA
    DNA Repair (Amst) 2:623-7. 2003
    ..The authors review the implications of this work and argue that deamination of deoxy-cytidine to deoxy-uracil seems to initiate several pathways in which error-prone polymerases are postulated to create mutations...
  12. ncbi request reprint Activation-induced cytosine deaminase (AID) is actively exported out of the nucleus but retained by the induction of DNA breaks
    Sukhdev S Brar
    Laboratory of Molecular Genetics, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709 2233, USA
    J Biol Chem 279:26395-401. 2004
    ..Finally, we found that agents that induce DNA breaks caused retention of AID in the nucleus, suggesting that DNA breaks or the repair patches initiated as a result are a substrate for AID binding...
  13. ncbi request reprint Cutting edge: DGYW/WRCH is a better predictor of mutability at G:C bases in Ig hypermutation than the widely accepted RGYW/WRCY motif and probably reflects a two-step activation-induced cytidine deaminase-triggered process
    Igor B Rogozin
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA
    J Immunol 172:3382-4. 2004
    ..We also found evidence that a DNA repair enzyme may play a role in modifying the sequence of hypermutation hotspots...
  14. ncbi request reprint Enzymatic cytosine deamination: friend and foe
    Thomas A Kunkel
    Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Mol Cell 10:962-3. 2002
  15. pmc Known components of the immunoglobulin A:T mutational machinery are intact in Burkitt lymphoma cell lines with G:C bias
    Zheng Xiao
    Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, D3 01, 111 T W Alexander Drive, Research Triangle Park, NC 27709, USA
    Mol Immunol 44:2659-66. 2007
    ..Either scenario suggests that cytosine deamination by AID is not enough to trigger A:T mutation, and that additional unidentified factors are required for full spectrum hypermutation in vivo...
  16. ncbi request reprint Decreased frequency and highly aberrant spectrum of ultraviolet-induced mutations in the hprt gene of mouse fibroblasts expressing antisense RNA to DNA polymerase zeta
    Marilyn Diaz
    Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC, USA
    Mol Cancer Res 1:836-47. 2003
    ..The antisense Rev3 mice should be a useful model to study mutagenic lesion bypass by pol zeta in mammalian cells and to investigate the role this polymerase plays in carcinogenesis...
  17. ncbi request reprint Activation-induced deaminase-deficient MRL/lpr mice secrete high levels of protective antibodies against lupus nephritis
    Chuancang Jiang
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina
    Arthritis Rheum 63:1086-96. 2011
    ..The purpose of the present study was to test the hypothesis that high levels of germline autoreactive IgM in these mice confer protection against lupus nephritis...
  18. pmc Activation-induced deaminase, AID, is catalytically active as a monomer on single-stranded DNA
    Sukhdev S Brar
    Laboratory of Molecular Genetics, D3 01, National Institute of Environmental Health Sciences National Institutes of Health, 111 TW Alexander Drive, Research Triangle Park, NC 27709, USA
    DNA Repair (Amst) 7:77-87. 2008
    ....
  19. ncbi request reprint Autoreactivity in HIV-1 broadly neutralizing antibodies: implications for their function and induction by vaccination
    Laurent Verkoczy
    aDuke Human Vaccine Institute, Duke University Medical Center, Durham bNational Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
    Curr Opin HIV AIDS 9:224-34. 2014
    ..This review discusses progress in understanding the impact of immune tolerance on inducing broadly neutralizing antibodies (bnAbs), and how such knowledge can be incorporated into novel immunization approaches...
  20. ncbi request reprint Structural analysis, selection, and ontogeny of the shark new antigen receptor (IgNAR): identification of a new locus preferentially expressed in early development
    Marilyn Diaz
    Department of Immunology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Immunogenetics 54:501-12. 2002
    ....
  21. ncbi request reprint Somatic immunoglobulin hypermutation
    Marilyn Diaz
    Department of Immunology, Imm16, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Curr Opin Immunol 14:235-40. 2002
    ..The nature of the targeting mechanism and the trans-factors effecting such breaks and their repair remain to be determined...