Sevilla D Detera-Wadleigh
Affiliation: National Institutes of Health
- G72/G30 in schizophrenia and bipolar disorder: review and meta-analysisSevilla D Detera-Wadleigh
National Institute of Mental Health Intramural Research Program, National Institutes of Health, U S Department of Health and Human Services, Bethesda, Maryland 20892 3719, USA
Biol Psychiatry 60:106-14. 2006..The association findings in the G72/G30 region, among the most compelling in psychiatry, may expose an important molecular pathway involved in susceptibility to schizophrenia and bipolar disorder...
- Meta-analysis of genome-wide association data identifies a risk locus for major mood disorders on 3p21.1Francis J McMahon
Unit on the Genetic Basis of Mood and Anxiety Disorders, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
Nat Genet 42:128-31. 2010..83-0.92), with supportive evidence for association observed in two out of three independent replication cohorts. These results provide an example of a shared genetic susceptibility locus for bipolar disorder and MDD...
- Loci on chromosomes 6q and 6p interact to increase susceptibility to bipolar affective disorder in the national institute of mental health genetics initiative pedigreesThomas G Schulze
Genetic Basis of Mood and Anxiety Disorders, Mood and Anxiety Program, Bethesda, USA
Biol Psychiatry 56:18-23. 2004....
- Linkage disequilibrium analysis in the LOC93081-KDELC1-BIVM region on 13q in bipolar disorderDilberto O Ferraren
Genetic Basis for Mood and Anxiety Disorders, Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, Maryland, USA
Am J Med Genet B Neuropsychiatr Genet 133:12-7. 2005....
- Genetic association studies in mood disorders: issues and promiseSevilla D Detera-Wadleigh
Mood and Anxiety Disorders Program, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 3719, USA
Int Rev Psychiatry 16:301-10. 2004..Relating associated variants to the phenotype represents the next critical step toward establishing the pathogenic role of gene variants in mood disorders...
- The International Consortium on Lithium Genetics (ConLiGen): an initiative by the NIMH and IGSLI to study the genetic basis of response to lithium treatmentThomas G Schulze
Genetic Basis of Mood and Anxiety Disorders, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 3719, USA
Neuropsychobiology 62:72-8. 2010..A stringent phenotype definition of response is one of the hallmarks of this collaboration. ConLiGen invites all lithium researchers to join its efforts...
- Sequence variation in DOCK9 and heterogeneity in bipolar disorderSevilla D Detera-Wadleigh
Genetic Basis of Mood and Anxiety Disorders, Mood and Anxiety Program, National Institute of Mental Health Intramural Research Program, National Institutes of Health U S DHHS, 35 Convent Drive, Bethesda, MD 20892, USA
Psychiatr Genet 17:274-86. 2007..Subsequent reports have shown that variations in the DAOA (G72) locus on 13q33 display association with bipolar disorder but these may not account for all of the linkage evidence in the region...
- Gene-based SNP mapping of a psychotic bipolar affective disorder linkage region on 22q12.3: association with HMG2L1 and TOM1James B Potash
Department of Psychiatry, Johns Hopkins University, Baltimore, Maryland 21287 7419, USA
Am J Med Genet B Neuropsychiatr Genet 147:59-67. 2008..Further work is needed to confirm these results and uncover the functional variation underlying the association signal...
- Association study between the Down syndrome cell adhesion molecule (DSCAM) gene and bipolar disorderKenji Amano
Laboratory for Neurogenetics, RIKEN Brain Science Institute, Wako Shi, Japan
Psychiatr Genet 18:1-10. 2008....
- A promoter haplotype of the inositol monophosphatase 2 gene (IMPA2) at 18p11.2 confers a possible risk for bipolar disorder by enhancing transcriptionTetsuo Ohnishi
Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama, Japan
Neuropsychopharmacology 32:1727-37. 2007..In conclusion, the present study suggests that a promoter haplotype of IMPA2 possibly contributes to risk for bipolar disorder by elevating IMPA2 levels in the brain, albeit the genetic effect varies among populations...
- Distinguishable haplotype blocks in the HTR3A and HTR3B region in the Japanese reveal evidence of association of HTR3B with female major depressionKazuo Yamada
Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako, Kawaguchi, Saitama, Japan
Biol Psychiatry 60:192-201. 2006..But the polymorphisms highlighted in these reports map to different locations in the two genes, therefore it is unclear which gene exerts a stronger effect on susceptibility...
- Polymorphisms at the G72/G30 gene locus, on 13q33, are associated with bipolar disorder in two independent pedigree seriesEiji Hattori
Department of Psychiatry, The University of Chicago, IL 60637, USA
Am J Hum Genet 72:1131-40. 2003..Taken together with the earlier report, this is the first demonstration of a novel gene(s), discovered through a positional approach, independently associated with both bipolar illness and schizophrenia...
- A mannosyltransferase gene at 11q23 is disrupted by a translocation breakpoint that co-segregates with bipolar affective disorder in a small familyBora E Baysal
Department of Psychiatry, The University of Pittsburgh Medical Center, Pennsylvania, USA
Neurogenetics 4:43-53. 2002..In conclusion, we found that a mannosyltransferase gene at 11q23 is disrupted by a translocation breakpoint co-segregating with BPAD in a family. However, its role in the disease susceptibility remains unconfirmed...
- Possible association between a haplotype of the GABA-A receptor alpha 1 subunit gene (GABRA1) and mood disordersYasue Horiuchi
Department of Medical Genetics, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
Biol Psychiatry 55:40-5. 2004..The GABRA1 gene encodes one of the subunits of GABA-A receptor and is located on human chromosome 5q34-q35, which is a region reportedly linked to mood disorders. We examined the GABRA1 gene as a candidate for mood disorders...
- Autistic-like phenotypes in Cadps2-knockout mice and aberrant CADPS2 splicing in autistic patientsTetsushi Sadakata
Laboratory for Molecular Neurogenesis and Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama, Japan
J Clin Invest 117:931-43. 2007..Exon 3 was shown to encode the dynactin 1-binding domain and affect axonal CADPS2 protein distribution. Our results suggest that a disturbance in CADPS2-mediated neurotrophin release contributes to autism susceptibility...
- Genome-wide scan and conditional analysis in bipolar disorder: evidence for genomic interaction in the National Institute of Mental Health genetics initiative bipolar pedigreesMelvin G McInnis
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, 21287-7463, USA
Biol Psychiatry 54:1265-73. 2003..Application of conditional analyses is potentially useful in larger sample collections to identify susceptibility genes of modest influence that may not be identified in a genome-wide scan aimed to identify single gene effects...
- Genome scan meta-analysis of schizophrenia and bipolar disorder, part III: Bipolar disorderRicardo Segurado
Neuropsychiatric Genetics Unit, Department of Genetics, Trinity College, Dublin 2, Ireland
Am J Hum Genet 73:49-62. 2003..We note that meta-analysis can sometimes provide support for linkage but cannot disprove linkage in any candidate region...
- Analysis of a cluster of polymorphisms in AKT1 gene in bipolar pedigrees: a family-based association studyTomoko Toyota
Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako, 351-0198, Saitama, Japan
Neurosci Lett 339:5-8. 2003..Seven polymorphic sites were clustered in a small segment spanning exon 14 and downstream intron. Transmission of haplotypes constructed from this cluster showed a weak evidence of association between the AKT1 and bipolar disorder...