S D Detera-Wadleigh

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Lithium-related genetics of bipolar disorder
    S D Detera-Wadleigh
    National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, MD 20892 4094, USA
    Ann Med 33:272-85. 2001
  2. pmc Affected-sib-pair analyses reveal support of prior evidence for a susceptibility locus for bipolar disorder, on 21q
    S D Detera-Wadleigh
    Clinical Neurogenetics Branch, National Institute of Mental Health, National Institute of Health, Bethesda, MD, USA
    Am J Hum Genet 58:1279-85. 1996
  3. pmc A high-density genome scan detects evidence for a bipolar-disorder susceptibility locus on 13q32 and other potential loci on 1q32 and 18p11.2
    S D Detera-Wadleigh
    Clinical Neurogenetics Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 96:5604-9. 1999
  4. ncbi request reprint The genomic structure of the human glucocorticoid receptor
    I J Encio
    Clinical Neurogenetics Branch, National Institute of Mental Health, Bethesda, Maryland 20892
    J Biol Chem 266:7182-8. 1991
  5. ncbi request reprint Serotonin transporter (5-HTT) gene and bipolar affective disorder
    L E Esterling
    Laboratory of Molecular Genetics, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland, USA
    Am J Med Genet 81:37-40. 1998
  6. ncbi request reprint An integrated physical map of 18p11.2: a susceptibility region for bipolar disorder
    L E Esterling
    Laboratory of Molecular Genetics, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Psychiatry 2:501-4. 1997
  7. ncbi request reprint New variants of the human and rat nuclear hormone receptor, TR4: expression and chromosomal localization of the human gene
    T Yoshikawa
    Unit on Gene Mapping and Expression, National Institute of Mental Health, Bethesda, Maryland, 20892, USA
    Genomics 35:361-6. 1996
  8. ncbi request reprint Isolation of chromosome 18-specific brain transcripts as positional candidates for bipolar disorder
    T Yoshikawa
    Clinical Neurogenetics Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    Am J Med Genet 74:140-9. 1997
  9. ncbi request reprint Lack of linkage between the corticotropin-releasing hormone (CRH) gene and bipolar affective disorder
    C A Stratakis
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Psychiatry 2:483-5. 1997
  10. ncbi request reprint A novel human myo-inositol monophosphatase gene, IMP.18p, maps to a susceptibility region for bipolar disorder
    T Yoshikawa
    Unit on Gene Mapping and Expression, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Psychiatry 2:393-7. 1997

Collaborators

Detail Information

Publications33

  1. ncbi request reprint Lithium-related genetics of bipolar disorder
    S D Detera-Wadleigh
    National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, MD 20892 4094, USA
    Ann Med 33:272-85. 2001
    ..Similarly, lithium-sensitive gene products could provide a new generation of pharmacological targets...
  2. pmc Affected-sib-pair analyses reveal support of prior evidence for a susceptibility locus for bipolar disorder, on 21q
    S D Detera-Wadleigh
    Clinical Neurogenetics Branch, National Institute of Mental Health, National Institute of Health, Bethesda, MD, USA
    Am J Hum Genet 58:1279-85. 1996
    ..03-.0003). These findings support prior evidence that a susceptibility locus for bipolar disorder is on 21q...
  3. pmc A high-density genome scan detects evidence for a bipolar-disorder susceptibility locus on 13q32 and other potential loci on 1q32 and 18p11.2
    S D Detera-Wadleigh
    Clinical Neurogenetics Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 96:5604-9. 1999
    ..By comprehensive screening of the entire genome, we detected unreported loci for bipolar disorder, found support for proposed linkages, and gained evidence for the overlap of susceptibility regions for bipolar disorder and schizophrenia...
  4. ncbi request reprint The genomic structure of the human glucocorticoid receptor
    I J Encio
    Clinical Neurogenetics Branch, National Institute of Mental Health, Bethesda, Maryland 20892
    J Biol Chem 266:7182-8. 1991
    ..This comparison also permitted the prediction of the positions of the splice sites and the sizes of the putative exons in the human mineralocorticoid receptor...
  5. ncbi request reprint Serotonin transporter (5-HTT) gene and bipolar affective disorder
    L E Esterling
    Laboratory of Molecular Genetics, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland, USA
    Am J Med Genet 81:37-40. 1998
    ..We also refined the location of 5-HTT by radiation hybrid mapping, placing the locus between D17S1294 and SHGC11022 on 17q11.2...
  6. ncbi request reprint An integrated physical map of 18p11.2: a susceptibility region for bipolar disorder
    L E Esterling
    Laboratory of Molecular Genetics, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Psychiatry 2:501-4. 1997
    ..This high resolution integrated map will be an important tool in providing loci for contig construction, and positional candidates for mutation screening...
  7. ncbi request reprint New variants of the human and rat nuclear hormone receptor, TR4: expression and chromosomal localization of the human gene
    T Yoshikawa
    Unit on Gene Mapping and Expression, National Institute of Mental Health, Bethesda, Maryland, 20892, USA
    Genomics 35:361-6. 1996
    ..In contrast, the human ovarian cancer cell line, PA1, failed to express hTR4alpha1. By fluorescence in situ hybridization, we have mapped the hTR4 gene to 3p25, a region deleted in some forms of cancer...
  8. ncbi request reprint Isolation of chromosome 18-specific brain transcripts as positional candidates for bipolar disorder
    T Yoshikawa
    Clinical Neurogenetics Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    Am J Med Genet 74:140-9. 1997
    ..The majority of the transcripts were found to cluster to discrete locations on 18p and 18q, previously hypothesized as susceptibility regions for bipolar disorder, identifying them as positional candidate genes...
  9. ncbi request reprint Lack of linkage between the corticotropin-releasing hormone (CRH) gene and bipolar affective disorder
    C A Stratakis
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Psychiatry 2:483-5. 1997
    ....
  10. ncbi request reprint A novel human myo-inositol monophosphatase gene, IMP.18p, maps to a susceptibility region for bipolar disorder
    T Yoshikawa
    Unit on Gene Mapping and Expression, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Psychiatry 2:393-7. 1997
    ..2 region. We, therefore, designated this novel gene as IMP.18p. The physical position and possible function suggest that IMP.18p is an important candidate gene for bipolar disorder...
  11. ncbi request reprint Molecular analysis of microtubule-associated protein-2 kinase cDNA from mouse and rat brain
    C de Miguel
    Clinical Neurogenetics Branch, National Institute of Mental Health, Bethesda, MD 20892
    DNA Cell Biol 10:505-14. 1991
    ....
  12. ncbi request reprint Splice variants of rat TR4 orphan receptor: differential expression of novel sequences in the 5'-untranslated region and C-terminal domain
    T Yoshikawa
    Unit on Gene Mapping and Expression, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    Endocrinology 137:1562-71. 1996
    ..N-Methyl-D-aspartate treatment triggered a marked increase in TR4 expression. These results suggest a possible role for TR4 in neuronal differentiation...
  13. ncbi request reprint Genomic structure and novel variants of myo-inositol monophosphatase 2 (IMPA2)
    T Yoshikawa
    Unit on Gene Mapping and Expression, Clinical Neurogenetics Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Psychiatry 5:165-71. 2000
    ..By Fisher's exact test the silent mutation showed a trend for association (P = 0.051) with bipolar disorder suggesting that further scrutiny of this gene is warranted...
  14. ncbi request reprint Multiple transcriptional variants and RNA editing in C18orf1, a novel gene with LDLRA and transmembrane domains on 18p11.2
    T Yoshikawa
    Unit on Gene Mapping and Expression, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genomics 47:246-57. 1998
    ..We also present evidence of RNA editing in the 5'-UTR of beta 2, the first demonstration of this phenomenon in 5'-UTR...
  15. pmc Interaction networks of lithium and valproate molecular targets reveal a striking enrichment of apoptosis functional clusters and neurotrophin signaling
    A Gupta
    Human Genetics Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Pharmacogenomics J 12:328-41. 2012
    ..The convergence of biological responses unveils a functional signature for lithium and valproate that could be key modulators of their therapeutic efficacy...
  16. pmc A genome-wide association study implicates diacylglycerol kinase eta (DGKH) and several other genes in the etiology of bipolar disorder
    A E Baum
    Unit on the Genetic Basis of Mood and Anxiety Disorders, Mood and Anxiety Disorders Program, US Department of Health and Human Services, National Institute of Mental Health, NIH, Bethesda, MD 20892, USA
    Mol Psychiatry 13:197-207. 2008
    ..This first genome-wide association study of bipolar disorder shows that several genes, each of modest effect, reproducibly influence disease risk. Bipolar disorder may be a polygenic disease...
  17. ncbi request reprint Detection, simultaneous display and direct sequencing of multiple nuclear hormone receptor genes using bilaterally targeted RNA fingerprinting
    T Yoshikawa
    Unit on Gene Mapping and Expression, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Biochim Biophys Acta 1264:63-71. 1995
    ..We believe that this approach provides a convenient and rapid screening method for detecting and characterizing members of a gene family...
  18. ncbi request reprint Familial glucocorticoid resistance caused by a splice site deletion in the human glucocorticoid receptor gene
    M Karl
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892
    J Clin Endocrinol Metab 76:683-9. 1993
    ..The presence of the null allele was apparently compensated for by increased cortisol production at the expense of concurrent hyperandrogenism...
  19. pmc Linkage of Niemann-Pick disease type C to human chromosome 18
    E D Carstea
    Developmental and Metabolic Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892
    Proc Natl Acad Sci U S A 90:2002-4. 1993
    ..84. Analysis of meiotic chromosomal breakpoint patterns among the affected individuals indicated that the NPC gene is pericentromerically localized on human chromosome 18...
  20. doi request reprint A systems approach to the biology of mood disorders through network analysis of candidate genes
    S D Detera-Wadleigh
    Human Genetics Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 3719, USA
    Pharmacopsychiatry 44:S35-42. 2011
    ..Network analysis of meta analysis- generated candidate genes that exhibited differential expression in mood disorder brains identified signaling pathways and functional clusters that may be involved in genetic risk for mood disorders...
  21. ncbi request reprint Molecular analysis of human and rat calmodulin complementary DNA clones. Evidence for additional active genes in these species
    B Sengupta
    Division of Intramural Research Programs, National Institute of Mental Health, Bethesda, Maryland 20892
    J Biol Chem 262:16663-70. 1987
    ..Transcripts of lambda rCB1 and lambda hCE1 were observed in all tissues examined indicating the absence of tissue-specific expression. Calmodulin gene polymorphisms were detected using TaqI, HindIII, and MspI...
  22. ncbi request reprint Characterization of the human glucocorticoid receptor promoter
    Y Nobukuni
    Clinical Neurogenetics Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biochemistry 34:8207-14. 1995
    ..Our studies demonstrate that several transcription factors are involved in regulating GR expression and that AP2 could function as an important positive regulator of GR promoter activity...
  23. pmc Two variants in Ankyrin 3 (ANK3) are independent genetic risk factors for bipolar disorder
    T G Schulze
    Unit on the Genetic Basis of Mood and Anxiety Disorders, National Institute of Mental Health, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892 3719, USA
    Mol Psychiatry 14:487-91. 2009
    ..Further analysis suggested that each marker contributed independently to BD, with no significant marker x marker interaction. Our findings strongly support ANK3 as a BD susceptibility gene and suggest true allelic heterogeneity...
  24. ncbi request reprint Multipoint genetic linkage analysis of the m2 human muscarinic receptor gene
    J A Badner
    Clinical Neurogenetics Branch, National Institute of Mental Health, Bethesda, Maryland 20892, USA
    Mamm Genome 6:489-90. 1995
  25. ncbi request reprint Assignment of the human nuclear hormone receptor, NUC1 (PPARD), to chromosome 6p21.1-p21.2
    T Yoshikawa
    Clinical Neurogenetics Branch, National Institute of Mental Health, Bethesda, Maryland 20892, USA
    Genomics 35:637-8. 1996
  26. ncbi request reprint Radiation hybrid mapping of genes in the lithium-sensitive wnt signaling pathway
    A R Rhoads
    Department of Biochemistry and Molecular Biology, Howard University, Washington, DC 20059, USA
    Mol Psychiatry 4:437-42. 1999
    ....
  27. ncbi request reprint Assignment of the human gene for smoothelin (SMTN) to chromosome 22q12 by fluorescence in situ hybridization and radiation hybrid mapping
    J J Engelen
    Department of Molecular Cell Biology and Genetics, University of Maastricht, The Netherlands
    Genomics 43:245-7. 1997
  28. ncbi request reprint Association analysis of adenylate cyclase type 9 gene using pedigree disequilibrium test in bipolar disorder
    T Toyota
    Mol Psychiatry 7:450-2. 2002
  29. ncbi request reprint Findings in an independent sample support an association between bipolar affective disorder and the G72/G30 locus on chromosome 13q33
    Y S Chen
    Department of Human Genetics, The University of Chicago, Chicago, IL, USA
    Mol Psychiatry 9:87-92; image 5. 2004
    ....
  30. ncbi request reprint Fine mapping of a susceptibility locus for bipolar and genetically related unipolar affective disorders, to a region containing the C21ORF29 and TRPM2 genes on chromosome 21q22.3
    A McQuillin
    Molecular Psychiatry Laboratory, Department of Mental Health Sciences, Royal Free and University College London Medical School, Windeyer Institute of Medical Sciences, and Royal London Hospital, London, UK
    Mol Psychiatry 11:134-42. 2006
    ..A third nonconservative change from histidine to glutamic acid was found in exon 8 of TSPEAR. These changes need further investigation to establish any aetiological role in bipolar disorder...
  31. ncbi request reprint Map of candidate genes and STSs on 18p11.2, a bipolar disorder and schizophrenia susceptibility region
    G D Reyes
    Mol Psychiatry 7:337-9. 2002
  32. ncbi request reprint Evidence for association of the myo-inositol monophosphatase 2 (IMPA2) gene with schizophrenia in Japanese samples
    T Yoshikawa
    Laboratory for Molecular Psychiatry, Brain Science Institute, RIKEN, Wako, Saitama 351 0198, Japan
    Mol Psychiatry 6:202-10. 2001
    ..Our findings suggest that IMPA2 or a gene nearby may contribute to the overall genetic risk for schizophrenia among Japanese...
  33. ncbi request reprint Association between serotonin 4 receptor gene polymorphisms and bipolar disorder in Japanese case-control samples and the NIMH Genetics Initiative Bipolar Pedigrees
    T Ohtsuki
    Department of Medical Genetics, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Mol Psychiatry 7:954-61. 2002
    ..These findings suggest that genomic variations in the HTR4 gene may confer susceptibility to mood disorder...