Research Topics
| F R DeLeoSummaryAffiliation: National Institutes of Health Country: USA Publications
| Collaborators
|
Detail Information
Publications
An antidote for Staphylococcus aureus pneumonia?Frank R Deleo
Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
J Exp Med 205:271-4. 2008..aureus strains, protects mice against lethal pneumonia. This finding represents the first successful vaccine strategy for the treatment of staphylococcal pneumonia...- Sublytic concentrations of Staphylococcus aureus Panton-Valentine leukocidin alter human PMN gene expression and enhance bactericidal capacityShawna F Graves
Laboratory of Bacterial Pathogenesis, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA
J Leukoc Biol 92:361-74. 2012..We propose that PVL-mediated priming of PMNs enhances the host innate immune response... - Neutrophils in innate host defense against Staphylococcus aureus infectionsKevin M Rigby
Laboratory of Human Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 South 4th Street, Hamilton, MT 59840, USA
Semin Immunopathol 34:237-59. 2012..Here we provide an overview of the role of neutrophils in host defense against bacterial pathogens and discuss strategies employed by S. aureus to circumvent neutrophil function... 
Community-associated methicillin-resistant Staphylococcus aureus and athletesNatalia Malachowa
Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institute of Health, Hamilton, MT 59840, USA
Phys Sportsmed 40:13-21. 2012....- Mobile genetic elements of Staphylococcus aureusNatalia Malachowa
Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 South 4th Street, Hamilton, MT, 59840, USA
Cell Mol Life Sci 67:3057-71. 2010..Our understanding of S. aureus MGEs and the molecules they encode has played an important role toward these ends and has provided detailed insight into the evolution of antimicrobial resistance mechanisms and virulence... - Host defense and pathogenesis in Staphylococcus aureus infectionsFrank R Deleo
Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 South 4th Street, Hamilton, MT 59840, USA
Infect Dis Clin North Am 23:17-34. 2009..This article reviews human neutrophil function in the context of S aureus virulence mechanisms and provides an overview of community-associated methicillin-resistant S aureus pathogenicity... 
Modulation of phagocyte apoptosis by bacterial pathogensF R DeLeo
Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
Apoptosis 9:399-413. 2004..This review summarizes what is currently known about modulation of phagocyte apoptosis by bacteria and describes a paradigm whereby bacteria-induced neutrophil apoptosis plays a role in the resolution of infection...- Reemergence of antibiotic-resistant Staphylococcus aureus in the genomics eraFrank R Deleo
Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, NIH, Hamilton, Montana 59840, USA
J Clin Invest 119:2464-74. 2009..This Review focuses on progress made toward understanding the success of community-associated MRSA as a human pathogen, with an emphasis on genome-wide approaches and virulence determinants... - Molecular differentiation of historic phage-type 80/81 and contemporary epidemic Staphylococcus aureusFrank R Deleo
Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
Proc Natl Acad Sci U S A 108:18091-6. 2011..aureus, whereas key SNPs in contemporary CC30 clones restrict these pathogens to hospital settings in which the host is typically compromised... - Community-associated meticillin-resistant Staphylococcus aureusFrank R Deleo
Laboratory of Human Bacterial Pathogenesis, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
Lancet 375:1557-68. 2010..Here we review the most up-to-date knowledge and provide a perspective for the future prophylaxis or new treatments for CA-MRSA infections... - Is Panton-Valentine leukocidin the major virulence determinant in community-associated methicillin-resistant Staphylococcus aureus disease?Jovanka M Voyich
Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
J Infect Dis 194:1761-70. 2006..Although the toxin may be a highly linked epidemiological marker for CA-MRSA strains, we conclude that PVL is not the major virulence determinant of CA-MRSA... - Neutrophil microbicides induce a pathogen survival response in community-associated methicillin-resistant Staphylococcus aureusAmy M Palazzolo-Ballance
Laboratory of Human Bacterial Pathogenesis, Research Technologies Section, Genomics Unit, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
J Immunol 180:500-9. 2008..Collectively, the data provide an enhanced view of the mechanisms used by S. aureus to circumvent destruction by the innate immune system... - A point mutation in the agr locus rather than expression of the Panton-Valentine leukocidin caused previously reported phenotypes in Staphylococcus aureus pneumonia and gene regulationAmer E Villaruz
Laboratory of Human Bacterial Pathogenesis, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
J Infect Dis 200:724-34. 2009..Finally, our work emphasizes the need to frequently evaluate the integrity of the S. aureus agr locus... - An update on community-associated MRSA virulenceScott D Kobayashi
Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
Curr Opin Pharmacol 9:545-51. 2009..This review focuses on current progress toward understanding the enhanced virulence properties of CA-MRSA, with an emphasis on Panton-Valentine leukocidin, alpha-hemolysin, and the recently discovered alpha-type phenol-soluble modulins... 
Global analysis of community-associated methicillin-resistant Staphylococcus aureus exoproteins reveals molecules produced in vitro and during infectionChristopher Burlak
Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
Cell Microbiol 9:1172-90. 2007..We conclude that the exoproteins identified herein likely account in part for the success of CA-MRSA as a human pathogen...- Epidemic community-associated methicillin-resistant Staphylococcus aureus: recent clonal expansion and diversificationAdam D Kennedy
Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
Proc Natl Acad Sci U S A 105:1327-32. 2008..aureus (known as phage-type 80/81 S. aureus) in the 1950s... - In vitro serial passage of Staphylococcus aureus: changes in physiology, virulence factor production, and agr nucleotide sequenceGreg A Somerville
Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases/NIH, 903 South 4th Street, Hamilton, Montana 59840, USA
J Bacteriol 184:1430-7. 2002..aureus undergoes significant phenotypic and genotypic changes during serial passage and suggest that vigilance should be used when extrapolating data obtained from the study of high-passage strains... - Genome-wide molecular dissection of serotype M3 group A Streptococcus strains causing two epidemics of invasive infectionsStephen B Beres
Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
Proc Natl Acad Sci U S A 101:11833-8. 2004..Genome-wide analysis of population-based strain samples cultured from clinically well defined patients is crucial for understanding the molecular events underlying bacterial epidemics... - FcepsilonRI- and Fcgamma receptor-mediated production of reactive oxygen species by mast cells is lipoxygenase- and cyclooxygenase-dependent and NADPH oxidase-independentEmily J Swindle
Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1881, USA
J Immunol 179:7059-71. 2007.... - STAT3 mutations in the hyper-IgE syndromeSteven M Holland
National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
N Engl J Med 357:1608-19. 2007..Inheritance is autosomal dominant; sporadic cases are also found... - Insights into mechanisms used by Staphylococcus aureus to avoid destruction by human neutrophilsJovanka M Voyich
Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, NIH, Hamilton, MT 59840, USA
J Immunol 175:3907-19. 2005..Our studies reveal a gene transcription program in a prominent human pathogen that likely contributes to evasion of innate host defense... - Identification of novel cytolytic peptides as key virulence determinants for community-associated MRSARong Wang
Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, US National Institutes of Health, 903 South 4th Street, Hamilton, Montana 59840, USA
Nat Med 13:1510-4. 2007..Our study reveals a previously uncharacterized set of S. aureus virulence factors that account at least in part for the enhanced virulence of CA-MRSA... - Engagement of the pathogen survival response used by group A Streptococcus to avert destruction by innate host defenseJovanka M Voyich
Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
J Immunol 173:1194-201. 2004..Importantly, our studies identify specific genes in the pathogen survival response as potential targets to control human infections... - Relapsing fever spirochaetes produce a serine protease that provides resistance to oxidative stress and killing by neutrophilsCyril Guyard
Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
Mol Microbiol 60:710-22. 2006..This periplasmic enzyme may prevent the accumulation of proteins damaged by the innate immune response and contribute to the ability of the relapsing fever spirochaetes to achieve high cell densities in blood... - Characterization of an extracellular virulence factor made by group A Streptococcus with homology to the Listeria monocytogenes internalin family of proteinsSean D Reid
Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
Infect Immun 71:7043-52. 2003..These studies characterize the first GAS LRR protein as an extracellular virulence factor that contributes to pathogenesis and may participate in evasion of the innate host defense... - Host-microbe interaction systems biology: lifecycle transcriptomics and comparative genomicsDaniel E Sturdevant
Genomics Unit, Research Technologies Section, Research Technologies Branch, Rocky Mountain Laboratories, NIH, 904 South 4th Street, Hamilton, MT 59840, USA
Future Microbiol 5:205-19. 2010..Together, microarray and comparative genomic technologies will continue to advance our understanding of pathogen evolution and assist in combating human infectious disease... - Relative contribution of Panton-Valentine leukocidin to PMN plasma membrane permeability and lysis caused by USA300 and USA400 culture supernatantsShawna F Graves
Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 South 4th Street, Hamilton, MT 59840, USA
Microbes Infect 12:446-56. 2010..aureus culture supernatants have limited ability to estimate the relative contribution of PVL to pathogenesis (or cytolysis in vitro or in vivo), especially when assayed using culture media that promote selective high production of PVL... - Evasion of human innate and acquired immunity by a bacterial homolog of CD11b that inhibits opsonophagocytosisB Lei
Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana, USA
Nat Med 7:1298-305. 2001.... - Community-associated methicillin-resistant Staphylococcus aureus immune evasion and virulenceShawna F Graves
Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, 59840, USA
J Mol Med (Berl) 88:109-14. 2010..In this review, we discuss the role of neutrophils in host defense against S. aureus and highlight progress made toward understanding mechanisms of CA-MRSA virulence and pathogenesis... - Progress toward characterization of the group A Streptococcus metagenome: complete genome sequence of a macrolide-resistant serotype M6 strainDavid J Banks
Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA
J Infect Dis 190:727-38. 2004..Our studies add to the theme that GAS prophage-encoded extracellular proteins contribute to host-pathogen interactions in a strain-specific fashion... - Identification of a novel Staphylococcus aureus two-component leukotoxin using cell surface proteomicsChristy L Ventura
Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America
PLoS ONE 5:e11634. 2010..We conclude LukGH is a novel two-component leukotoxin with cytolytic activity toward neutrophils, and thus potentially contributes to S. aureus virulence... - Genome-wide protective response used by group A Streptococcus to evade destruction by human polymorphonuclear leukocytesJovanka M Voyich
Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
Proc Natl Acad Sci U S A 100:1996-2001. 2003..The gene regulatory program revealed by our studies identifies previously undescribed potential vaccine antigens and targets for therapeutic interventions designed to control GAS infections... - Opsonophagocytosis-inhibiting mac protein of group a streptococcus: identification and characteristics of two genetic complexesBenfang Lei
Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
Infect Immun 70:6880-90. 2002..Taken together, the data add to the emerging theme in GAS pathogenesis that allelic variation in virulence genes contributes to fundamental differences in host-pathogen interactions among strains... - An apoptosis differentiation programme in human polymorphonuclear leucocytesS D Kobayashi
Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 South 4th Street, Hamilton, MT 59840, USA
Biochem Soc Trans 32:474-6. 2004..Collectively, these studies establish a global model of host cell-pathogen interaction, which provides fundamental insight into the resolution of infection in humans... - A crucial role for exopolysaccharide modification in bacterial biofilm formation, immune evasion, and virulenceCuong Vuong
Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, NIAID, National Institutes of Health, Hamilton, Montana 59840, USA
J Biol Chem 279:54881-6. 2004..Notably, this general virulence mechanism is likely similar for other pathogenic bacteria and constitutes an excellent target for therapeutic maneuvers aimed at combating biofilm-associated infection... - Gene expression profiling provides insight into the pathophysiology of chronic granulomatous diseaseScott D Kobayashi
Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 South 4th Street, Hamilton, MT 59840, USA
J Immunol 172:636-43. 2004.... - Host-pathogen interactions: leukocyte phagocytosis and associated sequelaeJovanka M Voyich
Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
Methods Cell Sci 24:79-90. 2002..Taken together, these assays provide rapid and accurate assessment of critical PMN processes... - Neutrophil apoptosis and the resolution of infectionAdam D Kennedy
Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 South 4th Street, Hamilton, MT 59840, USA
Immunol Res 43:25-61. 2009..However, some bacterial pathogens alter PMN apoptosis to survive and thereby cause disease. Herein, we review PMN apoptosis and the ability of microorganisms to alter this important process... - Mobile genetic element-encoded cytolysin connects virulence to methicillin resistance in MRSAShu Y Queck
Laboratory of Human Bacterial Pathogenesis, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA
PLoS Pathog 5:e1000533. 2009..Thus, our study reveals a previously unknown role of methicillin resistance clusters in staphylococcal pathogenesis and shows that important virulence and antibiotic resistance determinants may be combined in staphylococcal MGEs... - Evolution of virulence in epidemic community-associated methicillin-resistant Staphylococcus aureusMin Li
National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 South 4th Street, Hamilton, MT 59840, MD 20892, USA
Proc Natl Acad Sci U S A 106:5883-8. 2009..This finding calls for a profound revision of our notion about CA-MRSA pathogenesis at the molecular level and has important implications for design of therapeutics directed against CA-MRSA... - Down-regulation of proinflammatory capacity during apoptosis in human polymorphonuclear leukocytesScott D Kobayashi
Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
J Immunol 170:3357-68. 2003..These findings provide new insight into the molecular events that resolve inflammation following PMN activation in humans... - Transmission of Yersinia pestis from an infectious biofilm in the flea vectorClayton O Jarrett
Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
J Infect Dis 190:783-92. 2004..pestis. Enabling arthropod-borne transmission represents a novel function of a bacterial biofilm... - An apoptosis-differentiation program in human polymorphonuclear leukocytes facilitates resolution of inflammationScott D Kobayashi
Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 South 4th Street, Hamilton, MT 59840, USA
J Leukoc Biol 73:315-22. 2003..These findings provide new insight into the molecular events that contribute to the resolution of inflammation in humans... - Targeting of alpha-hemolysin by active or passive immunization decreases severity of USA300 skin infection in a mouse modelAdam D Kennedy
Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
J Infect Dis 202:1050-8. 2010..We conclude that Hla is a potential target for therapeutics or vaccines designed to moderate severe S. aureus skin infections... - Postgenomic analysis of four novel antigens of group a streptococcus: growth phase-dependent gene transcription and human serologic responseSean D Reid
Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
J Bacteriol 184:6316-24. 2002..These results are additional evidence that postgenomic strategies provide new ways to identify and investigate novel bacterial proteins that may participate in host-pathogen interactions or serve as targets for therapeutics research... - Global changes in gene expression by human polymorphonuclear leukocytes during receptor-mediated phagocytosis: cell fate is regulated at the level of gene expressionScott D Kobayashi
Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
Proc Natl Acad Sci U S A 99:6901-6. 2002..Most significantly, we discovered that programmed cell death is regulated at the level of gene expression. Thus, we hypothesize that gene regulation in PMNs facilitates resolution of inflammatory responses... - Dectin-1 promotes fungicidal activity of human neutrophilsAdam D Kennedy
Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
Eur J Immunol 37:467-78. 2007..8% for beta-glucan and 36.2% for GE2, p<0.01). Our results reveal a mechanism whereby PMN dectin-1 plays a key role in the recognition and killing of fungal pathogens by the innate immune system... - Spontaneous neutrophil apoptosis and regulation of cell survival by granulocyte macrophage-colony stimulating factorScott D Kobayashi
Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 South 4th Street, Hamilton, MT 59840, USA
J Leukoc Biol 78:1408-18. 2005..These studies provide a global view of the molecular events that regulate neutrophil survival and apoptosis... - Complete nucleotide sequence analysis of plasmids in strains of Staphylococcus aureus clone USA300 reveals a high level of identity among isolates with closely related core genome sequencesAdam D Kennedy
Laboratory of Human Bacterial Pathogenesis, Genomics Unit, Rocky Mountain Laboratories, Hamilton, MT 59840, USA
J Clin Microbiol 48:4504-11. 2010..The high level of plasmid sequence identity among the majority of closely related USA300 isolates is consistent with the recent clonal emergence hypothesis for USA300... - Key role of poly-gamma-DL-glutamic acid in immune evasion and virulence of Staphylococcus epidermidisStanislava Kocianova
Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases (NIAID, NIH, Hamilton, Montana 59840, USA
J Clin Invest 115:688-94. 2005..Our study presents important novel biological functions for PGA and indicates that PGA represents an excellent target for therapeutic maneuvers aimed at treating disease caused by S. epidermidis and related staphylococci... - Regulation of the neutrophil-mediated inflammatory response to infectionScott D Kobayashi
Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 S. 4th Street, Hamilton, MT 59840, USA
Microbes Infect 5:1337-44. 2003.... - Identification and characterization of HtsA, a second heme-binding protein made by Streptococcus pyogenesBenfang Lei
Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
Infect Immun 71:5962-9. 2003..Our results suggest that HtsABC is an ABC transporter that may participate in heme acquisition in GAS... - Bacterial pathogens modulate an apoptosis differentiation program in human neutrophilsScott D Kobayashi
Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
Proc Natl Acad Sci U S A 100:10948-53. 2003..pyogenes alters the apoptosis differentiation program in neutrophils, resulting in pathogen survival and disease... - Apoptosis in human polymorphonuclear leukocytes: searching for a genetic roadmapScott D Kobayashi
Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
Arch Immunol Ther Exp (Warsz) 51:1-8. 2003..Further characterization of the apoptosis-differentiation program and associated biochemical pathways in mature PMNs will likely yield important insights into the resolution of inflammation and infection... - Maturation of human neutrophil phagosomes includes incorporation of molecular chaperones and endoplasmic reticulum quality control machineryChristopher Burlak
Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
Mol Cell Proteomics 5:620-34. 2006..We conclude that neutrophil phagosomes have heretofore unrecognized complexity and function, which includes potential for antigen processing events... - Neutrophils in the innate immune responseScott D Kobayashi
Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
Arch Immunol Ther Exp (Warsz) 53:505-17. 2005..This review provides a general overview of the role of human neutrophils in the innate host response to infection and summarizes some of the recent advances in neutrophil biology... - Autosomal dominant and sporadic monocytopenia with susceptibility to mycobacteria, fungi, papillomaviruses, and myelodysplasiaDonald C Vinh
Immunopathogenesis Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Blood 115:1519-29. 2010..This novel clinical syndrome links susceptibility to mycobacterial, viral, and fungal infections with malignancy and can be transmitted in an autosomal dominant pattern... - Insight into the molecular basis of pathogen abundance: group A Streptococcus inhibitor of complement inhibits bacterial adherence and internalization into human cellsNancy P Hoe
Laboratory of Human Bacterial Pathogenesis, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 South 4th Street, Hamilton, MT 59840, USA
Proc Natl Acad Sci U S A 99:7646-51. 2002..Sic enhances bacterial survival by enabling the pathogen to avoid the intracellular environment. This process contributes to the abundance of M1 GAS in human infections and their ability to cause epidemics... - Polysaccharide intercellular adhesin (PIA) protects Staphylococcus epidermidis against major components of the human innate immune systemCuong Vuong
Laboratories of Human Bacterial Pathogenesis, National Institute of Allergy and Infectious Diseases, National Institute of Health, Hamilton, MT 59840, USA
Cell Microbiol 6:269-75. 2004..PIA represents the first defined factor of the staphylococcal biofilm matrix that protects against major components of human innate host defence... - Streptococcus pyogenes and human neutrophils: a paradigm for evasion of innate host defense by bacterial pathogensJovanka M Voyich
Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 S. 4th Street, Hamilton, MT 59840, USA
Microbes Infect 6:1117-23. 2004..This review focuses on the interaction of human PMNs with Streptococcus pyogenes as a paradigm for successful pathogen evasion mechanisms... - The arginine catabolic mobile element and staphylococcal chromosomal cassette mec linkage: convergence of virulence and resistance in the USA300 clone of methicillin-resistant Staphylococcus aureusBinh An Diep
Division of Infectious Diseases, Department of Medicine, San Francisco General Hospital, University of California, San Francisco 94110, USA
J Infect Dis 197:1523-30. 2008..These data are consistent with a model in which ACME enhances growth and survival of USA300, allowing for genetic "hitchhiking" of SCCmec. SCCmec in turn protects against exposure to beta-lactams... - Poring over pores: alpha-hemolysin and Panton-Valentine leukocidin in Staphylococcus aureus pneumoniaJuliane Bubeck Wardenburg
Nat Med 13:1405-6. 2007 - Central role of a bacterial two-component gene regulatory system of previously unknown function in pathogen persistence in human salivaSamuel A Shelburne
Department of Medicine, Center for Human Bacterial Pathogenesis, Baylor College of Medicine, Houston, TX 77030, USA
Proc Natl Acad Sci U S A 102:16037-42. 2005..The discovery of a genetic program that significantly increased persistence of a major human pathogen in saliva enhances understanding of how bacteria survive in the host and suggests new therapeutic strategies... - Insights into pathogen immune evasion mechanisms: Anaplasma phagocytophilum fails to induce an apoptosis differentiation program in human neutrophilsDori L Borjesson
Department of Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, St Paul, MN 55108, USA
J Immunol 174:6364-72. 2005..phagocytophilum fails to trigger the apoptosis differentiation program usually induced by bacteria, and 2) a protein or molecule on the pathogen surface can mediate an early delay in spontaneous neutrophil apoptosis... - A chemokine-degrading extracellular protease made by group A Streptococcus alters pathogenesis by enhancing evasion of the innate immune responsePaul Sumby
Center for Molecular and Translational Human Infectious Diseases Research, The Methodist Hospital Research Institute, 6565 Fannin Street, Houston, TX 77030, USA
Infect Immun 76:978-85. 2008..The data indicate that SpyCEP contributes to GAS virulence in a strain- and disease-dependent manner... - Analysis of Staphylococcus aureus gene expression during PMN phagocytosisJovanka M Voyich
Department of Veterinary Molecular Biology, Montana State University, Bozeman, MT, USA
Methods Mol Biol 431:109-22. 2008..aureus pathogenesis. This chapter describes methods to analyze gene expression in S. aureus during interaction with human neutrophils... - Community-associated methicillin-resistant Staphylococcus aureus skin infections: advances toward identifying the key virulence factorsTyler K Nygaard
Department of Veterinary Molecular Biology, Montana State University, Bozeman, MT 59718, USA
Curr Opin Infect Dis 21:147-52. 2008..The purpose of this review is to provide a critical analysis of our current knowledge of virulence factors contributing to skin and soft-tissue infections caused by CA-MRSA... - Differential distribution and expression of Panton-Valentine leucocidin among community-acquired methicillin-resistant Staphylococcus aureus strainsBattouli Said-Salim
TB Center, Public Health Research Institute, 225 Warren Street, Newark, NJ, 07103, USA
J Clin Microbiol 43:3373-9. 2005..Unexpectedly, there was no correlation between PVL expression and PMN lysis, suggesting that additional virulence factors underlie leukotoxicity and, thus, the pathogenesis of CA-MRSA... - Panton-Valentine leukocidin is not a virulence determinant in murine models of community-associated methicillin-resistant Staphylococcus aureus diseaseJuliane Bubeck Wardenburg
Department of Microbiology, University of Chicago, Chicago, Illinois, USA
J Infect Dis 198:1166-70. 2008..The data presented in this report support the observation that PVL does not contribute to the pathogenesis of staphylococcal infection of mice... - The expanding role of NADPH oxidases in health and disease: no longer just agents of death and destructionMark T Quinn
Department of Veterinary Molecular Biology, Montana State University, Bozeman, MT 59717, USA
Clin Sci (Lond) 111:1-20. 2006..Herein, we summarize our current understanding of NADPH oxidases and provide an overview of how they contribute to specific human diseases... - Genome-scale transcript analyses in human neutrophilsScott D Kobayashi
Department of Microbiology, Molecular Biology, and Biochemistry, University of Idaho, Moscow, ID, USA
Methods Mol Biol 412:441-53. 2007..Notably, the procedures utilize commercially available reagents and materials and thus represent a standardized approach for evaluating PMN transcript levels... - Molecular genetic anatomy of inter- and intraserotype variation in the human bacterial pathogen group A StreptococcusStephen B Beres
Center for Molecular and Translational Human Infectious Diseases Research, The Methodist Hospital Research Institute, Houston, TX 77030, USA
Proc Natl Acad Sci U S A 103:7059-64. 2006..Our analysis provided unprecedented detail about the molecular anatomy of bacterial strain genotype-patient phenotype relationships... - ADAM17 activity during human neutrophil activation and apoptosisBruce Walcheck
Department of Veterinary and Biomedical Sciences, University of Minnesota, St Paul, MN 55108, USA
Eur J Immunol 36:968-76. 2006..Our data thus indicate prolonged ADAM17 expression during neutrophil effector functions. The implications of this may be a role by ADAM17 in both the induction and down-regulation of neutrophil activity... - Neutrophil methods and protocols. PrefaceMark T Quinn
Department of Veterinary Molecular Biology, Montana State University, Bozeman, USA
Methods Mol Biol 412:vii-viii. 2007 - Toward a genome-wide systems biology analysis of host-pathogen interactions in group A StreptococcusJames M Musser
Center for Molecular and Translational Human Infectious Diseases Research, The Methodist Hospital Research Institute, and Department of Pathology, The Methodist Hospital, Houston, TX 77030, USA
Am J Pathol 167:1461-72. 2005..In addition, we hope the review will stimulate investigators to consider using analogous approaches for analysis of the molecular pathogenesis of other microbes... - Role of NF-kappaB in transcriptional regulation of the phagocyte NADPH oxidase by tumor necrosis factor-alphaKatherine A Gauss
Department of Veterinary Molecular Biology, Montana State University, Bozeman, MT 59717, USA
J Leukoc Biol 82:729-41. 2007.... - Variants of the 5'-untranslated region of human NCF2: expression and translational efficiencyKatherine A Gauss
Department of Veterinary Molecular Biology, Montana State University, Bozeman, MT 59717, USA
Gene 366:169-79. 2006..These studies suggest that expression of p67(phox) is regulated through mechanisms that include modulation of transcription and translation... - Methods molecular biology. PrefaceMichael Otto
Methods Mol Biol 431:V-VI. 2008 - A plague upon the phagocytesFrank R Deleo
Nat Med 11:927-8. 2005 - Maltodextrin utilization plays a key role in the ability of group A Streptococcus to colonize the oropharynxSamuel A Shelburne
Section of Infectious Diseases, Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
Infect Immun 74:4605-14. 2006..Further investigation into carbohydrate transport and metabolism pathways may yield novel insights into GAS pathogenesis...