Research Topics
Species | Brian DaySummaryAffiliation: National Jewish Medical and Research Center Country: USA Publications
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Publications
Long-term administration of a small molecular weight catalytic metalloporphyrin antioxidant, AEOL 10150, protects lungs from radiation-induced injuryZahid N Rabbani
Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
Int J Radiat Oncol Biol Phys 67:573-80. 2007....- A role for CFTR in the elevation of glutathione levels in the lung by oral glutathione administrationChirag Kariya
Department of Medicine, National Jewish Medical and Research Center, University of Colorado Health Sciences Center, Denver, Colorado, USA
Am J Physiol Lung Cell Mol Physiol 292:L1590-7. 2007..No change in GSH levels was observed in the uncorrected Cftr KO mice. These studies suggest that CFTR plays an important role in GSH uptake from the diet and transport processes in the lung... - Manganic porphyrins possess catalase activity and protect endothelial cells against hydrogen peroxide-mediated injuryB J Day
Department of Biochemistry, Duke University, Durham, North Carolina 27710, USA
Arch Biochem Biophys 347:256-62. 1997..These data suggest that manganic porphyrins may be useful therapeutics against disease states associated with the overproduction of reactive oxygen species... - Role for cystic fibrosis transmembrane conductance regulator protein in a glutathione response to bronchopulmonary pseudomonas infectionBrian J Day
Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
Infect Immun 72:2045-51. 2004..Individuals with lung diseases associated with altered antioxidant transport, such as cystic fibrosis, might lack the ability to adapt to the infection and present with a more severe inflammatory response... - Catalytic antioxidants: a radical approach to new therapeuticsBrian J Day
National Jewish Medical and Research Center, K715, 1400 Jackson Street, Denver, CO 80206, USA
Drug Discov Today 9:557-66. 2004..Cardiovascular, neurodegenerative and inflammatory lung disorders are all potentially important targets for catalytic antioxidant therapy... - Oxidative stress in NRTI-induced toxicity: evidence from clinical experience and experiments in vitro and in vivoBrian J Day
Department of Medicine, National Jewish Medical and ResearchCenter, Denver, CO 80206, USA
Cardiovasc Toxicol 4:207-16. 2004..The impact of oxidative stress on cardiovascular disease is likely to increase because patients with HIV infection are living longer as a result of effective antiretroviral therapy... - A novel class of cytochrome P450 reductase redox cyclers: cationic manganoporphyrinsBrian J Day
Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
Toxicol Sci 85:713-9. 2005..It is possible that interactions between manganoporphyrins and flavin-dependent oxidoreductases can account for both adverse and beneficial effects of the compounds... - Antioxidants as potential therapeutics for lung fibrosisBrian J Day
Division of Environmental and Occupational Health Sciences, Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
Antioxid Redox Signal 10:355-70. 2008..Numerous studies have shown oxidative stress to be associated with many interstitial lung diseases and that these agents are effective in attenuating fibroproliferative responses in the lung of animals and humans... - Catalase and glutathione peroxidase mimicsBrian J Day
Department of Medicine, National Jewish Health, Departments of Medicine, Immunology and Pharmaceutical Sciences, University of Colorado Health Sciences Center, Denver, CO 80206, USA
Biochem Pharmacol 77:285-96. 2009..This review will focus on recent development of catalytic scavengers of peroxides and their potential use as therapeutic agents for pulmonary, cardiovascular, neurodegenerative and inflammatory disorders... - A mechanism of paraquat toxicity involving nitric oxide synthaseB J Day
Department of Medicine, National Jewish Medical and Research Center, School of Pharmacy, University of Colorado Health Sciences Center, Denver, CO 80206, USA
Proc Natl Acad Sci U S A 96:12760-5. 1999..These data indicate that NOS is a PQ diaphorase and that toxicity of such redox-active compounds involves a loss of NO-related activity... - Metalloporphyrins are potent inhibitors of lipid peroxidationB J Day
Department of Medicine, National Jewish Medical and Research Center, Denver, CO 80206, USA
Free Radic Biol Med 26:730-6. 1999..The broad array of antioxidant activities possessed by metalloporphyrins make them attractive therapeutic agents in disease states that involve the overproduction of reactive oxygen species... - Mitochondrial oxidative stress in the lungs of cystic fibrosis transmembrane conductance regulator protein mutant miceLeonard W Velsor
Department of Medicine, National Jewish Medical and Research Center, University of Colorado Health Science Center, Denver, Colorado, USA
Am J Respir Cell Mol Biol 35:579-86. 2006..Further studies are needed to determine how CFTR deficiency contributes to mitochondrial oxidative stress and the role this plays in CFTR-mediated lung pathophysiology... - Aging adversely affects the cigarette smoke-induced glutathione adaptive response in the lungNeal S Gould
Department of Medicine, National Jewish Health, Denver, Colorado 80206, USA
Am J Respir Crit Care Med 182:1114-22. 2010..A prominent defense against the oxidant burden caused by CS is the glutathione (GSH) adaptive response in the lung epithelial lining fluid (ELF) and tissue. However, as one ages the ability to maintain GSH levels declines... - Interaction among nitric oxide, reactive oxygen species, and antioxidants during endotoxemia-related acute renal failureWei Wang
Department of Medicine, University of Colorado Health Sciences Center, Denver 80262, USA
Am J Physiol Renal Physiol 284:F532-7. 2003..Antioxidant therapy preserved GFR and RBF during endotoxemia. The reversal of this protective effect by inhibition of iNOS suggests the importance of the bioavailability of NO for preservation of renal function during early endotoxemia... - An orally active catalytic metalloporphyrin protects against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity in vivoLi Ping Liang
Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
J Neurosci 27:4326-33. 2007..This is the first demonstration of neuroprotection by an orally active catalytic antioxidant in the MPTP mouse model and suggests its potential clinical utility for the treatment of chronic neurodegenerative diseases such as PD... - Sulfasalazine and mesalamine modulate beryllium-specific lymphocyte proliferation and inflammatory cytokine productionDave R Dobis
Department of Medicine, Robert H Hollis Laboratory of Environmental and Occupational Health Sciences, National Jewish Health, Denver, CO 80206, USA
Am J Respir Cell Mol Biol 43:458-64. 2010.... - Casiopeína IIgly-induced oxidative stress and mitochondrial dysfunction in human lung cancer A549 and H157 cellsRemy Kachadourian
Department of Medicine, National Jewish Health, Denver, CO 80206, USA
Toxicology 268:176-83. 2010..These results suggest that Cas IIgly initiates multiple possible sources of ROS over-production leading to mitochondrial dysfunction and cell death... - Flavin-dependent antioxidant properties of a new series of meso-N,N'-dialkyl-imidazolium substituted manganese(III) porphyrinsRemy Kachadourian
Department of Medicine, National Jewish Medical and Research Center, Denver, CO, USA
Biochem Pharmacol 67:77-85. 2004..These data suggest that metalloporphyrins may have differential antioxidant effects in tissues due to the presence or absence of flavin-dependent oxidoreductases... - Treatment with the catalytic metalloporphyrin AEOL 10150 reduces inflammation and oxidative stress due to inhalation of the sulfur mustard analog 2-chloroethyl ethyl sulfideHeidi C O'Neill
Department of Pharmaceutical Sciences, University of Colorado at Denver Health Sciences Center, Denver, CO 80217, USA
Free Radic Biol Med 48:1188-96. 2010..Further investigation utilizing catalytic antioxidants as treatment for SM inhalation injury is warranted... - Synthesis and in vitro antioxidant properties of manganese(III) beta-octabromo-meso-tetrakis(4-carboxyphenyl)porphyrinRemy Kachadourian
Department of Medicine, National Jewish Medical and Research Center, Denver, CO 80206, USA
J Inorg Biochem 95:240-8. 2003..In these in vitro models, in which cationic Mn-porphyrins exhibit very low activity, MnBr(8)TBAP appears to be at least eightfold more active than the non-brominated analog MnTBAP... - Mycoplasma pneumoniae infection and environmental tobacco smoke inhibit lung glutathione adaptive responses and increase oxidative stressChirag Kariya
University of Colorado Health Sciences Center, Denver, Colorado 80206, USA
Infect Immun 76:4455-62. 2008..These studies suggest that M. pneumoniae infection synergizes with ETS and suppresses the lung's ability to respond appropriately to environmental challenges leading to enhanced oxidative stress... - Modulation of lymphocyte proliferation by antioxidants in chronic beryllium diseaseDave R Dobis
Department of Medicine, Robert H Hollis Laboratory of Environmental and Occupational Health Sciences, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
Am J Respir Crit Care Med 177:1002-11. 2008..Studies show that oxidative stress plays a role in the pathogenesis of chronic inflammatory disorders... - Beryllium-stimulated reactive oxygen species and macrophage apoptosisRichard T Sawyer
Department of Medicine, Robert H Hollis Laboratory of Environmental and Occupational Health Sciences, National Jewish Medical and Research Center, Denver, 1400 Jackson Street, CO 80206, USA
Free Radic Biol Med 38:928-37. 2005..Our data are the first to demonstrate that Be stimulates macrophage ROS formation which plays an important role in Be-induced macrophage apoptosis... - Beryllium-ferritin: lymphocyte proliferation and macrophage apoptosis in chronic beryllium diseaseRichard T Sawyer
Department of Medicine, Robert H Hollis Laboratory of Environmental and Occupational Health Sciences, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
Am J Respir Cell Mol Biol 31:470-7. 2004.... - Interaction between cigarette smoke and mycoplasma infection: a murine modelRichard J Martin
National Jewish Medical and Research Center, Denver, Colorado 80206, USA
COPD 3:3-8. 2006.... - Hemodynamic effects of metalloporphyrin catalytic antioxidants: structure-activity relationships and species specificityAron D Ross
Department of Medicine, National Jewish Medical and Research Center, Denver, CO 80209, USA
Free Radic Biol Med 33:1657-69. 2002..Chlorpheniramine attenuated the effect, suggesting that the blood pressure response in rats is related to histamine release rather than the protection of nitric oxide... - A catalytic antioxidant attenuates alveolar structural remodeling in bronchopulmonary dysplasiaLing Yi L Chang
Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado, USA
Am J Respir Crit Care Med 167:57-64. 2003..These results suggest that AEOL 10113 might reduce the risk of pulmonary oxygen toxicity in prematurely born infants... - Multiple and additive functions of ALDH3A1 and ALDH1A1: cataract phenotype and ocular oxidative damage in Aldh3a1(-/-)/Aldh1a1(-/-) knock-out miceNatalie Lassen
Molecular Toxicology and Environmental Health Sciences Program, Department of Pharmaceutical Sciences, Rocky Mountain Lions Eye Institute, The Children s Hospital, University of Colorado, Denver, Colorado 80262, USA
J Biol Chem 282:25668-76. 2007..In conclusion, these findings support the hypothesis that corneal ALDH3A1 and lens ALDH1A1 protect the eye against cataract formation via nonenzymatic (light filtering) and enzymatic (detoxification) functions... - A role for mitochondrial oxidative stress in sulfur mustard analog 2-chloroethyl ethyl sulfide-induced lung cell injury and antioxidant protectionNeal S Gould
Department of Pharmaceutical Sciences, University ofColorado Health Sciences Center, Denver, Colorado, USA
J Pharmacol Exp Ther 328:732-9. 2009..These findings suggest a role for oxidative stress in CEES toxicity and provide a rationale to investigate antioxidants as rescue agents in SM exposures... - Effects of metalloporphyrin catalytic antioxidants in experimental brain ischemiaHuaxin Sheng
Department of Anesthesiology, Multidisciplinary Neuroprotection Laboratories, Duke University Medical Center, Durham, NC 27710, USA
Free Radic Biol Med 33:947-61. 2002..AEOL 10150 is an effective neuroprotective compound offering a wide therapeutic window with a large margin of safety against adverse behavioral side effects... - Glutathione transport is a unique function of the ATP-binding cassette protein ABCG2Heather M Brechbuhl
Departments of Medicine, University of Colorado Denver Health Sciences Center, Aurora, Colorado 80045, USA
J Biol Chem 285:16582-7. 2010..In addition, suppression of ABCG2 with short hairpin RNA or ABCG2 overexpression in human epithelial cells decreased or increased extracellular GSH levels, respectively. Our data indicate that ABCG2 is a novel GSH transporter... - Inhibition of mitochondrial hydrogen peroxide production by lipophilic metalloporphyrinsPablo R Castello
Department of Pharmaceutical Sciences, 4200 East Ninth Ave, School of Pharmacy, C238, Denver, CO 80262, USA
J Pharmacol Exp Ther 324:970-6. 2008..These results provide a simplified in vitro model system to detect physiologically generated mitochondrial H(2)O(2) as a screening tool to predict the biological efficacy of potential therapeutic entities... - Pulmonary edema fluid antioxidants are depressed in acute lung injuryRussell P Bowler
Department of Medicine, National Jewish Medical and Research Center, Denver, CO, USA
Crit Care Med 31:2309-15. 2003..In acute lung injury, the distal airspace antioxidants ascorbate, urate, and glutathione may play a role in attenuating lung injury... - Antioxidant function of corneal ALDH3A1 in cultured stromal fibroblastsNatalie Lassen
Molecular Toxicology and Environmental Health Sciences Program, Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Free Radic Biol Med 41:1459-69. 2006..g., 4-HNE), maintaining cellular GSH levels and redox balance, and operating as an antioxidant... - Mitochondrial oxidative stress in human hepatoma cells exposed to stavudineLeonard W Velsor
Department of Medicine, National Jewish Medical and Research Center, Denver, CO 80206, USA
Toxicol Appl Pharmacol 199:10-9. 2004..These deleterious events may be potentiated in acquired immunodeficiency syndrome (AIDS) by human immunodeficiency virus (HIV) infection itself, coinfection (e.g., viral hepatitis), aging, substance, and alcohol use... - Basal and stimulated protein S-nitrosylation in multiple cell types and tissuesAndrew J Gow
Department of Medicine and Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina 27710, USA
J Biol Chem 277:9637-40. 2002.... - Rapid mtDNA deletion by oxidants in rat liver mitochondria after hemin exposureHagir B Suliman
Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
Free Radic Biol Med 32:246-56. 2002..This mtDNA damage is associated with altered expression of mitochondrial cell death proteins, thereby suggesting a novel mechanism for systemic or environmental pro-oxidants to influence apoptosis... - Harnessing drug resistance: using ABC transporter proteins to target cancer cellsHeather M Leitner
Department of Pharmaceutical Sciences, University of Colorado, Health Sciences Center, Denver, CO, USA
Biochem Pharmacol 74:1677-85. 2007..This review will emphasize MRP-mediated modulation of intracellular GSH levels as a potential alternative and adjunctive approach for cancer therapy... - Select cyclopentenone prostaglandins trigger glutathione efflux and the role of ABCG2 transportHeather M Brechbuhl
Department of Pharmaceutical Sciences, University of Colorado at Denver Health Sciences Center, Denver, CO 80262, USA
Free Radic Biol Med 47:722-30. 2009..We report for the first time that ABCG2 may play a role in GSH efflux in response to cyPG treatment and may link inflammatory signaling with antioxidant adaptive responses... - Oxidant-mediated mitochondrial injury in eosinophil apoptosis: enhancement by glucocorticoids and inhibition by granulocyte-macrophage colony-stimulating factorShyra J Gardai
Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
J Immunol 170:556-66. 2003..These data demonstrate that oxidant-induced mitochondrial injury is pivotal in eosinophil apoptosis, and is enhanced by GC-induced prolonged JNK activation that is in turn inhibited by GM-CSF... - Selected flavonoids potentiate the toxicity of cisplatin in human lung adenocarcinoma cells: a role for glutathione depletionRemy Kachadourian
Department of Medicine, National Jewish Medical and Research Center, Denver, CO 80206, USA
Int J Oncol 31:161-8. 2007.... - Flavonoid-induced glutathione depletion: potential implications for cancer treatmentRemy Kachadourian
Department of Medicine, National Jewish Medical and Research Center, Denver, CO 80206, USA
Free Radic Biol Med 41:65-76. 2006..Assessments of mitochondrial GSH levels mitochondrial membrane potential and cytochrome c release showed that the potentiation effects induced by 2',5'-DHC and chrysin involve mitochondrial dysfunction... - Sulfur mustard analog induces oxidative stress and activates signaling cascades in the skin of SKH-1 hairless miceArttatrana Pal
Department of Pharmaceutical Sciences, School of Pharmacy, University of Colorado at Denver, Aurora, CO 80045, USA
Free Radic Biol Med 47:1640-51. 2009..These novel molecular targets could be supportive in the development of prophylactic and therapeutic interventions against HD-related skin injury... - High-performance liquid chromatography with spectrophotometric and electrochemical detection of a series of manganese(III) cationic porphyrinsRemy Kachadourian
Department of Medicine, National Jewish Medical and Research Center, Denver, CO 80206, USA
J Chromatogr B Analyt Technol Biomed Life Sci 767:61-7. 2002..Both methods of detection were quantitative, but electrochemical detection, although less specific for in vivo applications, appears to be considerably more sensitive than spectrophotometric detection... - Decreased hepatic ischemia-reperfusion injury by manganese-porphyrin complexesTzong Jin Wu
Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Free Radic Res 41:127-34. 2007..These results demonstrate that MnP complexes can attenuate hepatic I/R injury and may have therapeutic implications in disease states involving oxidants... - Life extension through neurofibromin mitochondrial regulation and antioxidant therapy for neurofibromatosis-1 in Drosophila melanogasterJames Jiayuan Tong
Center for Molecular and Mitochondrial Medicine and Genetics with Department of Biological Chemistry, Ecology and Evolutionary Biology, University of California, Irvine, California 92697, USA
Nat Genet 39:476-85. 2007..Thus, neurofibromin regulates longevity and stress resistance through cAMP regulation of mitochondrial respiration and ROS production, and NF1 may be treatable using catalytic antioxidants... - Superoxide dismutase mimetics: synthesis and structure-activity relationship study of MnTBAP analoguesPolivina Jolicia F Gauuan
Albany Molecular Research, Inc, 21 Corporate Circle, PO Box 15098, Albany, NY 12212 5098, USA
Bioorg Med Chem 10:3013-21. 2002.... - Superoxide dismutase mimetics. Part 2: synthesis and structure-activity relationship of glyoxylate- and glyoxamide-derived metalloporphyrinsMichael P Trova
Albany Molecular Research, Inc, 21 Corporate Circle, PO Box 15098, Albany, NY 12212-5098, USA
Bioorg Med Chem 11:2695-707. 2003.... - Regulation of postischemic liver injury following different durations of ischemiaIan N Hines
Department of Molecular and Cellular Physiology, LSU Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130, USA
Am J Physiol Gastrointest Liver Physiol 284:G536-45. 2003..We conclude that the sources for O(2)(-) formation and the relative importance of TNF-alpha in the pathophysiology of I/R-induced hepatocellular injury differ depending on the duration of ischemia... - Mitochondrial toxicity of NRTI antiviral drugs: an integrated cellular perspectiveWilliam Lewis
Emory University, Department of Pathology, 1639 Pierce Drive, Room 7117, Atlanta, Georgia 30322, USA
Nat Rev Drug Discov 2:812-22. 2003..This review characterizes the pharmacological mechanisms and pathways that are involved in mitochondrial dysfunction caused by NRTIs, and suggests opportunities for future pharmacological research... - The mitochondrial DNA polymerase as a target of oxidative damageMaria A Graziewicz
Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, PO Box 12233, 111 TW Alexander Drive, Research Triangle Park, NC 27709, USA
Nucleic Acids Res 30:2817-24. 2002..These results suggest pol gamma as a target of oxidative damage, which may result in a reduction in mitochondrial DNA replication and repair capacities... - Decreased mtDNA, oxidative stress, cardiomyopathy, and death from transgenic cardiac targeted human mutant polymerase gammaWilliam Lewis
Department of Pathology, Emory University School of Medicine, Atlanta, GA 30322, USA
Lab Invest 87:326-35. 2007..The transgenic model pathophysiologically links human mutant Pol gamma, mtDNA depletion, and mitochondrial oxidative stress to the mtDNA replication apparatus and to CM... - In vitro pro- and antioxidant properties of estrogensPaul A Thibodeau
Department of Nuclear Medicine and Radiobiology, Faculty of Medicine, , Que, Canada
J Steroid Biochem Mol Biol 81:227-36. 2002..The 2-methoxyestrogens were both potent electron donors and inhibitors of lipid peroxidation. Although 2-methoxyestrogens cannot generate superoxide in vitro, they may also be considered pro-oxidants in vivo... - Glutathione: a radical treatment for cystic fibrosis lung disease?Brian J Day
Chest 127:12-4. 2005 - Targeted myocardial transgenic expression of HIV Tat causes cardiomyopathy and mitochondrial damageScott M Raidel
Emory University School of Medicine, Atlanta, Georgia 30322, USA
Am J Physiol Heart Circ Physiol 282:H1672-8. 2002..Tat caused cardiac dysfunction in this TG and may impact on cardiomyopathy in acquired immunodeficiency syndrome...
Research Grants
- Adaptive glutathione responses to cigarette smoke in COPDBrian Day; Fiscal Year: 2009..These studies will elucidate the role of antioxidant adaptive pathways as a protective mechanism in cigarette smoke-induced lung oxidation and injury and provides unique avenues for therapeutic intervention in the progression of COPD. ..
- Glutathione transport, oxidative stress and lung injuryBrian Day; Fiscal Year: 2007..oxidative stress from oxidant air pollutants in sensitive populations with pre-existing lung disease, since a large number of pulmonary diseases (including COPD, ARDS, asthma and pulmonary fibrosis) also have deficits pulmonary ELF GSH ..
- Role of Oxidatve Stress in Chronic Beryllium DiseaseBrian Day; Fiscal Year: 2006..These studies have the potential to further define the etiology of CBD, risk factors, and suggest novel approaches to prevent and treat this disease. ..
- Targeting Oxidative Stress in Chronic Beryllium DiseaseBrian Day; Fiscal Year: 2009..The studies will mechanistically target these changes with a novel therapeutic approach using 5 aminosalicylic acid in CBD subjects. ..