Brian Day

Summary

Affiliation: National Jewish Medical and Research Center
Country: USA

Publications

  1. pmc Long-term administration of a small molecular weight catalytic metalloporphyrin antioxidant, AEOL 10150, protects lungs from radiation-induced injury
    Zahid N Rabbani
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Int J Radiat Oncol Biol Phys 67:573-80. 2007
  2. ncbi A role for CFTR in the elevation of glutathione levels in the lung by oral glutathione administration
    Chirag Kariya
    Department of Medicine, National Jewish Medical and Research Center, University of Colorado Health Sciences Center, Denver, Colorado, USA
    Am J Physiol Lung Cell Mol Physiol 292:L1590-7. 2007
  3. ncbi Manganic porphyrins possess catalase activity and protect endothelial cells against hydrogen peroxide-mediated injury
    B J Day
    Department of Biochemistry, Duke University, Durham, North Carolina 27710, USA
    Arch Biochem Biophys 347:256-62. 1997
  4. pmc Role for cystic fibrosis transmembrane conductance regulator protein in a glutathione response to bronchopulmonary pseudomonas infection
    Brian J Day
    Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Infect Immun 72:2045-51. 2004
  5. ncbi Oxidative stress in NRTI-induced toxicity: evidence from clinical experience and experiments in vitro and in vivo
    Brian J Day
    Department of Medicine, National Jewish Medical and ResearchCenter, Denver, CO 80206, USA
    Cardiovasc Toxicol 4:207-16. 2004
  6. ncbi A novel class of cytochrome P450 reductase redox cyclers: cationic manganoporphyrins
    Brian J Day
    Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Toxicol Sci 85:713-9. 2005
  7. ncbi Catalytic antioxidants: a radical approach to new therapeutics
    Brian J Day
    National Jewish Medical and Research Center, K715, 1400 Jackson Street, Denver, CO 80206, USA
    Drug Discov Today 9:557-66. 2004
  8. pmc Antioxidants as potential therapeutics for lung fibrosis
    Brian J Day
    Division of Environmental and Occupational Health Sciences, Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Antioxid Redox Signal 10:355-70. 2008
  9. pmc Catalase and glutathione peroxidase mimics
    Brian J Day
    Department of Medicine, National Jewish Health, Departments of Medicine, Immunology and Pharmaceutical Sciences, University of Colorado Health Sciences Center, Denver, CO 80206, USA
    Biochem Pharmacol 77:285-96. 2009
  10. ncbi Metalloporphyrins are potent inhibitors of lipid peroxidation
    B J Day
    Department of Medicine, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Free Radic Biol Med 26:730-6. 1999

Collaborators

Detail Information

Publications56

  1. pmc Long-term administration of a small molecular weight catalytic metalloporphyrin antioxidant, AEOL 10150, protects lungs from radiation-induced injury
    Zahid N Rabbani
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Int J Radiat Oncol Biol Phys 67:573-80. 2007
    ....
  2. ncbi A role for CFTR in the elevation of glutathione levels in the lung by oral glutathione administration
    Chirag Kariya
    Department of Medicine, National Jewish Medical and Research Center, University of Colorado Health Sciences Center, Denver, Colorado, USA
    Am J Physiol Lung Cell Mol Physiol 292:L1590-7. 2007
    ..No change in GSH levels was observed in the uncorrected Cftr KO mice. These studies suggest that CFTR plays an important role in GSH uptake from the diet and transport processes in the lung...
  3. ncbi Manganic porphyrins possess catalase activity and protect endothelial cells against hydrogen peroxide-mediated injury
    B J Day
    Department of Biochemistry, Duke University, Durham, North Carolina 27710, USA
    Arch Biochem Biophys 347:256-62. 1997
    ..These data suggest that manganic porphyrins may be useful therapeutics against disease states associated with the overproduction of reactive oxygen species...
  4. pmc Role for cystic fibrosis transmembrane conductance regulator protein in a glutathione response to bronchopulmonary pseudomonas infection
    Brian J Day
    Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Infect Immun 72:2045-51. 2004
    ..Individuals with lung diseases associated with altered antioxidant transport, such as cystic fibrosis, might lack the ability to adapt to the infection and present with a more severe inflammatory response...
  5. ncbi Oxidative stress in NRTI-induced toxicity: evidence from clinical experience and experiments in vitro and in vivo
    Brian J Day
    Department of Medicine, National Jewish Medical and ResearchCenter, Denver, CO 80206, USA
    Cardiovasc Toxicol 4:207-16. 2004
    ..The impact of oxidative stress on cardiovascular disease is likely to increase because patients with HIV infection are living longer as a result of effective antiretroviral therapy...
  6. ncbi A novel class of cytochrome P450 reductase redox cyclers: cationic manganoporphyrins
    Brian J Day
    Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Toxicol Sci 85:713-9. 2005
    ..It is possible that interactions between manganoporphyrins and flavin-dependent oxidoreductases can account for both adverse and beneficial effects of the compounds...
  7. ncbi Catalytic antioxidants: a radical approach to new therapeutics
    Brian J Day
    National Jewish Medical and Research Center, K715, 1400 Jackson Street, Denver, CO 80206, USA
    Drug Discov Today 9:557-66. 2004
    ..Cardiovascular, neurodegenerative and inflammatory lung disorders are all potentially important targets for catalytic antioxidant therapy...
  8. pmc Antioxidants as potential therapeutics for lung fibrosis
    Brian J Day
    Division of Environmental and Occupational Health Sciences, Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Antioxid Redox Signal 10:355-70. 2008
    ..Numerous studies have shown oxidative stress to be associated with many interstitial lung diseases and that these agents are effective in attenuating fibroproliferative responses in the lung of animals and humans...
  9. pmc Catalase and glutathione peroxidase mimics
    Brian J Day
    Department of Medicine, National Jewish Health, Departments of Medicine, Immunology and Pharmaceutical Sciences, University of Colorado Health Sciences Center, Denver, CO 80206, USA
    Biochem Pharmacol 77:285-96. 2009
    ..This review will focus on recent development of catalytic scavengers of peroxides and their potential use as therapeutic agents for pulmonary, cardiovascular, neurodegenerative and inflammatory disorders...
  10. ncbi Metalloporphyrins are potent inhibitors of lipid peroxidation
    B J Day
    Department of Medicine, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Free Radic Biol Med 26:730-6. 1999
    ..The broad array of antioxidant activities possessed by metalloporphyrins make them attractive therapeutic agents in disease states that involve the overproduction of reactive oxygen species...
  11. pmc A mechanism of paraquat toxicity involving nitric oxide synthase
    B J Day
    Department of Medicine, National Jewish Medical and Research Center, School of Pharmacy, University of Colorado Health Sciences Center, Denver, CO 80206, USA
    Proc Natl Acad Sci U S A 96:12760-5. 1999
    ..These data indicate that NOS is a PQ diaphorase and that toxicity of such redox-active compounds involves a loss of NO-related activity...
  12. pmc Mitochondrial oxidative stress in the lungs of cystic fibrosis transmembrane conductance regulator protein mutant mice
    Leonard W Velsor
    Department of Medicine, National Jewish Medical and Research Center, University of Colorado Health Science Center, Denver, Colorado, USA
    Am J Respir Cell Mol Biol 35:579-86. 2006
    ..Further studies are needed to determine how CFTR deficiency contributes to mitochondrial oxidative stress and the role this plays in CFTR-mediated lung pathophysiology...
  13. ncbi Interaction among nitric oxide, reactive oxygen species, and antioxidants during endotoxemia-related acute renal failure
    Wei Wang
    Department of Medicine, University of Colorado Health Sciences Center, Denver 80262, USA
    Am J Physiol Renal Physiol 284:F532-7. 2003
    ..Antioxidant therapy preserved GFR and RBF during endotoxemia. The reversal of this protective effect by inhibition of iNOS suggests the importance of the bioavailability of NO for preservation of renal function during early endotoxemia...
  14. pmc Aging adversely affects the cigarette smoke-induced glutathione adaptive response in the lung
    Neal S Gould
    Department of Medicine, National Jewish Health, Denver, Colorado 80206, USA
    Am J Respir Crit Care Med 182:1114-22. 2010
    ..A prominent defense against the oxidant burden caused by CS is the glutathione (GSH) adaptive response in the lung epithelial lining fluid (ELF) and tissue. However, as one ages the ability to maintain GSH levels declines...
  15. ncbi Flavin-dependent antioxidant properties of a new series of meso-N,N'-dialkyl-imidazolium substituted manganese(III) porphyrins
    Remy Kachadourian
    Department of Medicine, National Jewish Medical and Research Center, Denver, CO, USA
    Biochem Pharmacol 67:77-85. 2004
    ..These data suggest that metalloporphyrins may have differential antioxidant effects in tissues due to the presence or absence of flavin-dependent oxidoreductases...
  16. ncbi Synthesis and in vitro antioxidant properties of manganese(III) beta-octabromo-meso-tetrakis(4-carboxyphenyl)porphyrin
    Remy Kachadourian
    Department of Medicine, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Inorg Biochem 95:240-8. 2003
    ..In these in vitro models, in which cationic Mn-porphyrins exhibit very low activity, MnBr(8)TBAP appears to be at least eightfold more active than the non-brominated analog MnTBAP...
  17. pmc Sulfasalazine and mesalamine modulate beryllium-specific lymphocyte proliferation and inflammatory cytokine production
    Dave R Dobis
    Department of Medicine, Robert H Hollis Laboratory of Environmental and Occupational Health Sciences, National Jewish Health, Denver, CO 80206, USA
    Am J Respir Cell Mol Biol 43:458-64. 2010
    ....
  18. pmc Treatment with the catalytic metalloporphyrin AEOL 10150 reduces inflammation and oxidative stress due to inhalation of the sulfur mustard analog 2-chloroethyl ethyl sulfide
    Heidi C O'Neill
    Department of Pharmaceutical Sciences, University of Colorado at Denver Health Sciences Center, Denver, CO 80217, USA
    Free Radic Biol Med 48:1188-96. 2010
    ..Further investigation utilizing catalytic antioxidants as treatment for SM inhalation injury is warranted...
  19. pmc CasiopeĆ­na IIgly-induced oxidative stress and mitochondrial dysfunction in human lung cancer A549 and H157 cells
    Remy Kachadourian
    Department of Medicine, National Jewish Health, Denver, CO 80206, USA
    Toxicology 268:176-83. 2010
    ..These results suggest that Cas IIgly initiates multiple possible sources of ROS over-production leading to mitochondrial dysfunction and cell death...
  20. pmc Modulation of lymphocyte proliferation by antioxidants in chronic beryllium disease
    Dave R Dobis
    Department of Medicine, Robert H Hollis Laboratory of Environmental and Occupational Health Sciences, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Am J Respir Crit Care Med 177:1002-11. 2008
    ..Studies show that oxidative stress plays a role in the pathogenesis of chronic inflammatory disorders...
  21. pmc Mycoplasma pneumoniae infection and environmental tobacco smoke inhibit lung glutathione adaptive responses and increase oxidative stress
    Chirag Kariya
    University of Colorado Health Sciences Center, Denver, Colorado 80206, USA
    Infect Immun 76:4455-62. 2008
    ..These studies suggest that M. pneumoniae infection synergizes with ETS and suppresses the lung's ability to respond appropriately to environmental challenges leading to enhanced oxidative stress...
  22. ncbi An orally active catalytic metalloporphyrin protects against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity in vivo
    Li Ping Liang
    Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Neurosci 27:4326-33. 2007
    ..This is the first demonstration of neuroprotection by an orally active catalytic antioxidant in the MPTP mouse model and suggests its potential clinical utility for the treatment of chronic neurodegenerative diseases such as PD...
  23. ncbi Beryllium-stimulated reactive oxygen species and macrophage apoptosis
    Richard T Sawyer
    Department of Medicine, Robert H Hollis Laboratory of Environmental and Occupational Health Sciences, National Jewish Medical and Research Center, Denver, 1400 Jackson Street, CO 80206, USA
    Free Radic Biol Med 38:928-37. 2005
    ..Our data are the first to demonstrate that Be stimulates macrophage ROS formation which plays an important role in Be-induced macrophage apoptosis...
  24. ncbi Interaction between cigarette smoke and mycoplasma infection: a murine model
    Richard J Martin
    National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    COPD 3:3-8. 2006
    ....
  25. ncbi Beryllium-ferritin: lymphocyte proliferation and macrophage apoptosis in chronic beryllium disease
    Richard T Sawyer
    Department of Medicine, Robert H Hollis Laboratory of Environmental and Occupational Health Sciences, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    Am J Respir Cell Mol Biol 31:470-7. 2004
    ....
  26. ncbi Hemodynamic effects of metalloporphyrin catalytic antioxidants: structure-activity relationships and species specificity
    Aron D Ross
    Department of Medicine, National Jewish Medical and Research Center, Denver, CO 80209, USA
    Free Radic Biol Med 33:1657-69. 2002
    ..Chlorpheniramine attenuated the effect, suggesting that the blood pressure response in rats is related to histamine release rather than the protection of nitric oxide...
  27. ncbi A catalytic antioxidant attenuates alveolar structural remodeling in bronchopulmonary dysplasia
    Ling Yi L Chang
    Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado, USA
    Am J Respir Crit Care Med 167:57-64. 2003
    ..These results suggest that AEOL 10113 might reduce the risk of pulmonary oxygen toxicity in prematurely born infants...
  28. doi Obesity impairs apoptotic cell clearance in asthma
    Ruby Fernandez-Boyanapalli
    Department of Pediatrics, National Jewish Health, University of Colorado School of Medicine, Denver, CO 80206, USA
    J Allergy Clin Immunol 131:1041-7, 1047.e1-3. 2013
    ..Asthma in obese adults is typically more severe and less responsive to glucocorticoids than asthma in nonobese adults...
  29. pmc Multiple and additive functions of ALDH3A1 and ALDH1A1: cataract phenotype and ocular oxidative damage in Aldh3a1(-/-)/Aldh1a1(-/-) knock-out mice
    Natalie Lassen
    Molecular Toxicology and Environmental Health Sciences Program, Department of Pharmaceutical Sciences, Rocky Mountain Lions Eye Institute, The Children s Hospital, University of Colorado, Denver, Colorado 80262, USA
    J Biol Chem 282:25668-76. 2007
    ..In conclusion, these findings support the hypothesis that corneal ALDH3A1 and lens ALDH1A1 protect the eye against cataract formation via nonenzymatic (light filtering) and enzymatic (detoxification) functions...
  30. ncbi Effects of metalloporphyrin catalytic antioxidants in experimental brain ischemia
    Huaxin Sheng
    Department of Anesthesiology, Multidisciplinary Neuroprotection Laboratories, Duke University Medical Center, Durham, NC 27710, USA
    Free Radic Biol Med 33:947-61. 2002
    ..AEOL 10150 is an effective neuroprotective compound offering a wide therapeutic window with a large margin of safety against adverse behavioral side effects...
  31. pmc A role for mitochondrial oxidative stress in sulfur mustard analog 2-chloroethyl ethyl sulfide-induced lung cell injury and antioxidant protection
    Neal S Gould
    Department of Pharmaceutical Sciences, University ofColorado Health Sciences Center, Denver, Colorado, USA
    J Pharmacol Exp Ther 328:732-9. 2009
    ..These findings suggest a role for oxidative stress in CEES toxicity and provide a rationale to investigate antioxidants as rescue agents in SM exposures...
  32. ncbi Inhibition of mitochondrial hydrogen peroxide production by lipophilic metalloporphyrins
    Pablo R Castello
    Department of Pharmaceutical Sciences, 4200 East Ninth Ave, School of Pharmacy, C238, Denver, CO 80262, USA
    J Pharmacol Exp Ther 324:970-6. 2008
    ..These results provide a simplified in vitro model system to detect physiologically generated mitochondrial H(2)O(2) as a screening tool to predict the biological efficacy of potential therapeutic entities...
  33. ncbi Mitochondrial oxidative stress in human hepatoma cells exposed to stavudine
    Leonard W Velsor
    Department of Medicine, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Toxicol Appl Pharmacol 199:10-9. 2004
    ..These deleterious events may be potentiated in acquired immunodeficiency syndrome (AIDS) by human immunodeficiency virus (HIV) infection itself, coinfection (e.g., viral hepatitis), aging, substance, and alcohol use...
  34. pmc Glutathione transport is a unique function of the ATP-binding cassette protein ABCG2
    Heather M Brechbuhl
    Departments of Medicine, University of Colorado Denver Health Sciences Center, Aurora, Colorado 80045, USA
    J Biol Chem 285:16582-7. 2010
    ..In addition, suppression of ABCG2 with short hairpin RNA or ABCG2 overexpression in human epithelial cells decreased or increased extracellular GSH levels, respectively. Our data indicate that ABCG2 is a novel GSH transporter...
  35. ncbi Pulmonary edema fluid antioxidants are depressed in acute lung injury
    Russell P Bowler
    Department of Medicine, National Jewish Medical and Research Center, Denver, CO, USA
    Crit Care Med 31:2309-15. 2003
    ..To test the hypothesis that low concentrations of distal airspace water-soluble antioxidants are associated with acute lung injury...
  36. ncbi Antioxidant function of corneal ALDH3A1 in cultured stromal fibroblasts
    Natalie Lassen
    Molecular Toxicology and Environmental Health Sciences Program, Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Free Radic Biol Med 41:1459-69. 2006
    ..g., 4-HNE), maintaining cellular GSH levels and redox balance, and operating as an antioxidant...
  37. pmc Select cyclopentenone prostaglandins trigger glutathione efflux and the role of ABCG2 transport
    Heather M Brechbuhl
    Department of Pharmaceutical Sciences, University of Colorado at Denver Health Sciences Center, Denver, CO 80262, USA
    Free Radic Biol Med 47:722-30. 2009
    ..We report for the first time that ABCG2 may play a role in GSH efflux in response to cyPG treatment and may link inflammatory signaling with antioxidant adaptive responses...
  38. pmc Sulfur mustard analog induces oxidative stress and activates signaling cascades in the skin of SKH-1 hairless mice
    Arttatrana Pal
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Colorado at Denver, Aurora, CO 80045, USA
    Free Radic Biol Med 47:1640-51. 2009
    ..These novel molecular targets could be supportive in the development of prophylactic and therapeutic interventions against HD-related skin injury...
  39. ncbi Flavonoid-induced glutathione depletion: potential implications for cancer treatment
    Remy Kachadourian
    Department of Medicine, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Free Radic Biol Med 41:65-76. 2006
    ..Assessments of mitochondrial GSH levels mitochondrial membrane potential and cytochrome c release showed that the potentiation effects induced by 2',5'-DHC and chrysin involve mitochondrial dysfunction...
  40. ncbi Selected flavonoids potentiate the toxicity of cisplatin in human lung adenocarcinoma cells: a role for glutathione depletion
    Remy Kachadourian
    Department of Medicine, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Int J Oncol 31:161-8. 2007
    ....
  41. ncbi High-performance liquid chromatography with spectrophotometric and electrochemical detection of a series of manganese(III) cationic porphyrins
    Remy Kachadourian
    Department of Medicine, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 767:61-7. 2002
    ..Both methods of detection were quantitative, but electrochemical detection, although less specific for in vivo applications, appears to be considerably more sensitive than spectrophotometric detection...
  42. ncbi Rapid mtDNA deletion by oxidants in rat liver mitochondria after hemin exposure
    Hagir B Suliman
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Free Radic Biol Med 32:246-56. 2002
    ..This mtDNA damage is associated with altered expression of mitochondrial cell death proteins, thereby suggesting a novel mechanism for systemic or environmental pro-oxidants to influence apoptosis...
  43. ncbi Oxidant-mediated mitochondrial injury in eosinophil apoptosis: enhancement by glucocorticoids and inhibition by granulocyte-macrophage colony-stimulating factor
    Shyra J Gardai
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 170:556-66. 2003
    ..These data demonstrate that oxidant-induced mitochondrial injury is pivotal in eosinophil apoptosis, and is enhanced by GC-induced prolonged JNK activation that is in turn inhibited by GM-CSF...
  44. ncbi Basal and stimulated protein S-nitrosylation in multiple cell types and tissues
    Andrew J Gow
    Department of Medicine and Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 277:9637-40. 2002
    ....
  45. pmc Harnessing drug resistance: using ABC transporter proteins to target cancer cells
    Heather M Leitner
    Department of Pharmaceutical Sciences, University of Colorado, Health Sciences Center, Denver, CO, USA
    Biochem Pharmacol 74:1677-85. 2007
    ..This review will emphasize MRP-mediated modulation of intracellular GSH levels as a potential alternative and adjunctive approach for cancer therapy...
  46. ncbi Superoxide dismutase mimetics: synthesis and structure-activity relationship study of MnTBAP analogues
    Polivina Jolicia F Gauuan
    Albany Molecular Research, Inc, 21 Corporate Circle, PO Box 15098, Albany, NY 12212 5098, USA
    Bioorg Med Chem 10:3013-21. 2002
    ....
  47. ncbi Regulation of postischemic liver injury following different durations of ischemia
    Ian N Hines
    Department of Molecular and Cellular Physiology, LSU Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130, USA
    Am J Physiol Gastrointest Liver Physiol 284:G536-45. 2003
    ..We conclude that the sources for O(2)(-) formation and the relative importance of TNF-alpha in the pathophysiology of I/R-induced hepatocellular injury differ depending on the duration of ischemia...
  48. ncbi Decreased hepatic ischemia-reperfusion injury by manganese-porphyrin complexes
    Tzong Jin Wu
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Free Radic Res 41:127-34. 2007
    ..These results demonstrate that MnP complexes can attenuate hepatic I/R injury and may have therapeutic implications in disease states involving oxidants...
  49. ncbi Superoxide dismutase mimetics. Part 2: synthesis and structure-activity relationship of glyoxylate- and glyoxamide-derived metalloporphyrins
    Michael P Trova
    Albany Molecular Research, Inc, 21 Corporate Circle, PO Box 15098, Albany, NY 12212 5098, USA
    Bioorg Med Chem 11:2695-707. 2003
    ....
  50. ncbi Life extension through neurofibromin mitochondrial regulation and antioxidant therapy for neurofibromatosis-1 in Drosophila melanogaster
    James Jiayuan Tong
    Center for Molecular and Mitochondrial Medicine and Genetics with Department of Biological Chemistry, Ecology and Evolutionary Biology, University of California, Irvine, California 92697, USA
    Nat Genet 39:476-85. 2007
    ..Thus, neurofibromin regulates longevity and stress resistance through cAMP regulation of mitochondrial respiration and ROS production, and NF1 may be treatable using catalytic antioxidants...
  51. ncbi Mitochondrial toxicity of NRTI antiviral drugs: an integrated cellular perspective
    William Lewis
    Emory University, Department of Pathology, 1639 Pierce Drive, Room 7117, Atlanta, Georgia 30322, USA
    Nat Rev Drug Discov 2:812-22. 2003
    ..This review characterizes the pharmacological mechanisms and pathways that are involved in mitochondrial dysfunction caused by NRTIs, and suggests opportunities for future pharmacological research...
  52. ncbi In vitro pro- and antioxidant properties of estrogens
    Paul A Thibodeau
    Department of Nuclear Medicine and Radiobiology, Faculty of Medicine, Universite de Sherbrooke, Que, Canada
    J Steroid Biochem Mol Biol 81:227-36. 2002
    ..The 2-methoxyestrogens were both potent electron donors and inhibitors of lipid peroxidation. Although 2-methoxyestrogens cannot generate superoxide in vitro, they may also be considered pro-oxidants in vivo...
  53. ncbi Targeted myocardial transgenic expression of HIV Tat causes cardiomyopathy and mitochondrial damage
    Scott M Raidel
    Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Am J Physiol Heart Circ Physiol 282:H1672-8. 2002
    ..Tat caused cardiac dysfunction in this TG and may impact on cardiomyopathy in acquired immunodeficiency syndrome...
  54. pmc The mitochondrial DNA polymerase as a target of oxidative damage
    Maria A Graziewicz
    Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, PO Box 12233, 111 TW Alexander Drive, Research Triangle Park, NC 27709, USA
    Nucleic Acids Res 30:2817-24. 2002
    ..These results suggest pol gamma as a target of oxidative damage, which may result in a reduction in mitochondrial DNA replication and repair capacities...
  55. ncbi Glutathione: a radical treatment for cystic fibrosis lung disease?
    Brian J Day
    Chest 127:12-4. 2005
  56. pmc Decreased mtDNA, oxidative stress, cardiomyopathy, and death from transgenic cardiac targeted human mutant polymerase gamma
    William Lewis
    Department of Pathology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Lab Invest 87:326-35. 2007
    ..The transgenic model pathophysiologically links human mutant Pol gamma, mtDNA depletion, and mitochondrial oxidative stress to the mtDNA replication apparatus and to CM...

Research Grants12

  1. Adaptive glutathione responses to cigarette smoke in COPD
    Brian Day; Fiscal Year: 2009
    ..These studies will elucidate the role of antioxidant adaptive pathways as a protective mechanism in cigarette smoke-induced lung oxidation and injury and provides unique avenues for therapeutic intervention in the progression of COPD. ..
  2. Glutathione transport, oxidative stress and lung injury
    Brian Day; Fiscal Year: 2007
    ..oxidative stress from oxidant air pollutants in sensitive populations with pre-existing lung disease, since a large number of pulmonary diseases (including COPD, ARDS, asthma and pulmonary fibrosis) also have deficits pulmonary ELF GSH ..
  3. Role of Oxidatve Stress in Chronic Beryllium Disease
    Brian Day; Fiscal Year: 2006
    ..These studies have the potential to further define the etiology of CBD, risk factors, and suggest novel approaches to prevent and treat this disease. ..
  4. Targeting Oxidative Stress in Chronic Beryllium Disease
    Brian Day; Fiscal Year: 2009
    ..The studies will mechanistically target these changes with a novel therapeutic approach using 5 aminosalicylic acid in CBD subjects. ..