Cindy D Davis

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. doi request reprint Selenoproteins and cancer prevention
    Cindy D Davis
    Nutritional Science Research Group, National Cancer Institute, Rockville, Maryland 20892, USA
    Annu Rev Nutr 32:73-95. 2012
  2. ncbi request reprint Nutritional interactions: credentialing of molecular targets for cancer prevention
    Cindy D Davis
    Nutritional Science Research Group, Division of Cancer Prevention, National Cancer Institute, 6130 Executive Boulevard, Suite 3159, Rockville, MD 20892 7328, USA
    Exp Biol Med (Maywood) 232:176-83. 2007
  3. ncbi request reprint Dietary components impact histone modifications and cancer risk
    Cindy D Davis
    Nutritional Science Research Group, Division of Cancer Prevention, National Cancer Institute, 6130 Executive Boulevard, Suite 3159, Rockville, MD 20892 7328, USA
    Nutr Rev 65:88-94. 2007
  4. ncbi request reprint Molecular targets for nutritional preemption of cancer
    Cindy D Davis
    Nutritional Science Research Group, National Cancer Institute, Rockville, MD 20892, USA
    Curr Cancer Drug Targets 7:410-5. 2007
  5. ncbi request reprint Biomarkers for diet and cancer prevention research: potentials and challenges
    Cindy D Davis
    Nutritional Science Research Group, National Cancer Institute, Rockville, MD 20892, USA
    Acta Pharmacol Sin 28:1262-73. 2007
  6. ncbi request reprint Vitamin D and cancer: current dilemmas and future needs
    Cindy D Davis
    Nutritional Science Research Group, Division of Cancer Prevention, National Cancer Institute, NIH, DHHS, 6130 Executive Boulevard, Suite 3159, Rockville, MD 20892, USA
    Nutr Rev 65:S71-4. 2007
  7. doi request reprint Evidence for dietary regulation of microRNA expression in cancer cells
    Cindy D Davis
    Nutritional Science Research Group, National Cancer Institute, 6130 Executive Blvd, Suite 3160, Rockville, MD 20892 7328, USA
    Nutr Rev 66:477-82. 2008
  8. ncbi request reprint Vitamin D and cancer: current dilemmas and future research needs
    Cindy D Davis
    Nutritional Sciences Research Group, National Cancer Institute, Rockville, MD, USA
    Am J Clin Nutr 88:565S-569S. 2008
  9. pmc Gastrointestinal microflora, food components and colon cancer prevention
    Cindy D Davis
    Nutritional Science Research Group, Division of Cancer Prevention, National Cancer Institute, Rockville, MD 20892 7328, USA
    J Nutr Biochem 20:743-52. 2009
  10. doi request reprint Cellular proliferation, apoptosis and angiogenesis: molecular targets for nutritional preemption of cancer
    Cindy D Davis
    Nutritional Science Research Group, Division of Cancer Prevention, National Cancer Institute, Rockville, MD 20892 7328, USA
    Semin Oncol 37:243-57. 2010

Detail Information

Publications38

  1. doi request reprint Selenoproteins and cancer prevention
    Cindy D Davis
    Nutritional Science Research Group, National Cancer Institute, Rockville, Maryland 20892, USA
    Annu Rev Nutr 32:73-95. 2012
    ....
  2. ncbi request reprint Nutritional interactions: credentialing of molecular targets for cancer prevention
    Cindy D Davis
    Nutritional Science Research Group, Division of Cancer Prevention, National Cancer Institute, 6130 Executive Boulevard, Suite 3159, Rockville, MD 20892 7328, USA
    Exp Biol Med (Maywood) 232:176-83. 2007
    ..Further research is also needed on the molecular targets for bioactive components and whether genetic and epigenetic events dictate the direction and magnitude of the response...
  3. ncbi request reprint Dietary components impact histone modifications and cancer risk
    Cindy D Davis
    Nutritional Science Research Group, Division of Cancer Prevention, National Cancer Institute, 6130 Executive Boulevard, Suite 3159, Rockville, MD 20892 7328, USA
    Nutr Rev 65:88-94. 2007
    ..This review focuses on several histone-modifying enzymes that are associated with cancer development and their modification by bioactive food components...
  4. ncbi request reprint Molecular targets for nutritional preemption of cancer
    Cindy D Davis
    Nutritional Science Research Group, National Cancer Institute, Rockville, MD 20892, USA
    Curr Cancer Drug Targets 7:410-5. 2007
    ....
  5. ncbi request reprint Biomarkers for diet and cancer prevention research: potentials and challenges
    Cindy D Davis
    Nutritional Science Research Group, National Cancer Institute, Rockville, MD 20892, USA
    Acta Pharmacol Sin 28:1262-73. 2007
    ..Thus, this threshold response to foods and their components will vary from individual to individual. The key to understanding a personalized response is a greater knowledge of nutrigenomics, proteomics and metabolomics...
  6. ncbi request reprint Vitamin D and cancer: current dilemmas and future needs
    Cindy D Davis
    Nutritional Science Research Group, Division of Cancer Prevention, National Cancer Institute, NIH, DHHS, 6130 Executive Boulevard, Suite 3159, Rockville, MD 20892, USA
    Nutr Rev 65:S71-4. 2007
  7. doi request reprint Evidence for dietary regulation of microRNA expression in cancer cells
    Cindy D Davis
    Nutritional Science Research Group, National Cancer Institute, 6130 Executive Blvd, Suite 3160, Rockville, MD 20892 7328, USA
    Nutr Rev 66:477-82. 2008
    ..miRNAs may be useful as biomarkers of cancer prevention or nutritional status, as well as serve as potential molecular targets that are influenced by dietary interventions...
  8. ncbi request reprint Vitamin D and cancer: current dilemmas and future research needs
    Cindy D Davis
    Nutritional Sciences Research Group, National Cancer Institute, Rockville, MD, USA
    Am J Clin Nutr 88:565S-569S. 2008
    ....
  9. pmc Gastrointestinal microflora, food components and colon cancer prevention
    Cindy D Davis
    Nutritional Science Research Group, Division of Cancer Prevention, National Cancer Institute, Rockville, MD 20892 7328, USA
    J Nutr Biochem 20:743-52. 2009
    ..Overall, a dynamic interrelationship exists between the intestinal microbiota and colon cancer risk, which can be modified by dietary components and eating behaviors...
  10. doi request reprint Cellular proliferation, apoptosis and angiogenesis: molecular targets for nutritional preemption of cancer
    Cindy D Davis
    Nutritional Science Research Group, Division of Cancer Prevention, National Cancer Institute, Rockville, MD 20892 7328, USA
    Semin Oncol 37:243-57. 2010
    ..Until more definite information surfaces, a balanced but varied diet is most prudent...
  11. doi request reprint Vitamin D and colon cancer
    Cindy D Davis
    Nutritional Sciences Research Group, Division of Cancer Prevention, National Cancer Institute, 6130 Executive Blvd, Suite 3159, MSC 7328, Rockville, MD 20892 7328, USA
    Expert Rev Gastroenterol Hepatol 5:67-81. 2011
    ..Scientists need to identify confounders and modifiers of the biological response to vitamin D, including dietary factors, lifestyle factors such as exercise, race or ethnicity, and genetic background...
  12. pmc Nutrigenomics, vitamin D and cancer prevention
    Cindy D Davis
    Nutritional Science Research Group, National Cancer Institute, Rockville, MD 20892 7328, USA
    J Nutrigenet Nutrigenomics 4:1-11. 2011
    ..Nutrigenomics should clarify who might benefit and be placed at risk because of vitamin D exposure...
  13. ncbi request reprint Nutritional "omics" technologies for elucidating the role(s) of bioactive food components in colon cancer prevention
    Cindy D Davis
    Nutritional Sciences Research Group, NCI National Institutes of Health, Rockville, MD 20892 7328, USA
    J Nutr 135:2694-7. 2005
    ....
  14. ncbi request reprint A research agenda for lycopene/tomato supplementation and cancer prevention
    Cindy D Davis
    Division of Cancer Prevention, National Cancer Institute, Rockville, MD 20852, USA
    J Nutr 135:2074S. 2005
  15. ncbi request reprint Executive summary report
    Cindy D Davis
    Division of Cancer Prevention, National Cancer Institute, Rockville, MD 20852, USA
    J Nutr 135:2014S-29S. 2005
  16. ncbi request reprint DNA methylation, cancer susceptibility, and nutrient interactions
    Cindy D Davis
    Nutritional Sciences Research Group, Division of Cancer Prevention, National Cancer Institute, 6130 Executive Boulevard, Suite 3159, Rockville, MD 20892 7328, USA
    Exp Biol Med (Maywood) 229:988-95. 2004
    ..Other dietary components such as vitamin B(12), alcohol, and selenium may modify the response to inadequate dietary folate...
  17. ncbi request reprint Low dietary copper increases fecal free radical production, fecal water alkaline phosphatase activity and cytotoxicity in healthy men
    Cindy D Davis
    U S Department of Agriculture, Grand Forks Human Nutrition Research Center, Grand Forks, ND 58202 9034, USA
    J Nutr 133:522-7. 2003
    ..These results suggest that low dietary copper adversely affects fecal free radical production and fecal water alkaline phosphatase activity, which are putative risk factors for colon cancer...
  18. ncbi request reprint Frontiers in nutrigenomics, proteomics, metabolomics and cancer prevention
    Cindy D Davis
    NIH NCI, Nutritional Sciences Research Group, 6130 Executive Blvd, MSC 7328, Rockville, MD 20892 7328, USA
    Mutat Res 551:51-64. 2004
    ..Deciphering the importance of each of these potential sites of regulation will be particularly challenging but does hold promise in explaining many of the inconsistencies in the literature...
  19. ncbi request reprint Dietary folate and selenium affect dimethylhydrazine-induced aberrant crypt formation, global DNA methylation and one-carbon metabolism in rats
    Cindy D Davis
    US Department of Agriculture, Grand Forks Human Nutrition Research Center, Grand Forks, ND 58202 9034, USA
    J Nutr 133:2907-14. 2003
    ..These results suggest that selenium deprivation ameliorates some of the effects of folate deficiency, probably by shunting the buildup of homocysteine (as a result of folate deficiency) to glutathione...
  20. ncbi request reprint Use of exfoliated cells from target tissues to predict responses to bioactive food components
    Cindy D Davis
    Nutritional Sciences Research Group, National Institutes of Health NCI, Rockville, MD 20892 7328, USA
    J Nutr 133:1769-72. 2003
    ..Although there are limitations on the collection of exfoliated cells, the inaccessibility of tissues they can represent raises intriguing possibilities for their ability to predict the outcome of nutritional intervention studies...
  21. doi request reprint Differential responses to selenomethionine supplementation by sex and genotype in healthy adults
    Gerald F Combs
    Grand Forks Human Nutrition Research Center, USDA ARS, 2420 2nd Avenue North, Stop 9034, Grand Forks, ND 58202 9034, USA
    Br J Nutr 107:1514-25. 2012
    ..In a cohort of relatively high Se status, the Se intake (as SeMet) required to support plasma Se concentration at a target level (Se(pl-target)) is: Se(in) = [(Se(pl - target) - Se(pl))/(18.2ng d kg⁰.⁷⁵/ml per mu g)] ...
  22. ncbi request reprint Differential effects of dietary selenium (se) and folate on methyl metabolism in liver and colon of rats
    Eric O Uthus
    USDA ARS Grand Forks Human Nutrition Research Center, P O Box 9034, Grand Forks, ND 58202 9034, USA
    Biol Trace Elem Res 109:201-14. 2006
    ..This suggests that selenium deficiency appears to be a more important modifier of methyl metabolism than either adequate or supplemental selenium...
  23. doi request reprint High dietary intake of sodium selenite does not affect gene mutation frequency in rat colon and liver
    Huawei Zeng
    United States Department of Agriculture, Agricultural Research Service, Grand Forks Human Nutrition Research Center, Grand Forks, ND 58202 9034, USA
    Biol Trace Elem Res 131:71-80. 2009
    ....
  24. ncbi request reprint Effect of selenium-enriched broccoli diet on differential gene expression in min mouse liver(1,2)
    Huawei Zeng
    United States Department of Agriculture, Grand Forks Human Nutrition Research Center, Grand Forks, North Dakota 58202 9034, USA
    J Nutr Biochem 14:227-31. 2003
    ..Collectively, these results suggest for the first time that selenium-enriched broccoli activates certain pro-apoptotic genes linked to p53, NFkappaB and stress signal pathways in response to "danger signals" such as tumorigenesis...
  25. ncbi request reprint Dietary copper affects azoxymethane-induced intestinal tumor formation and protein kinase C isozyme protein and mRNA expression in colon of rats
    Cindy D Davis
    Agricultural Research Service, Grand Forks Human Nutrition Research Center, U S Department of Agriculture, Grand Forks, ND 58202 9034, USA
    J Nutr 132:1018-25. 2002
    ..These results along with previous observations suggest that dietary copper-mediated changes in PKC alpha, delta and zeta protein expression are not as important for colon tumor promotion/progression as they are for tumor initiation...
  26. pmc Deficiency in the 15-kDa selenoprotein inhibits tumorigenicity and metastasis of colon cancer cells
    Robert Irons
    Nutritional Science Research Group, Molecular Biology of Selenium Section, Laboratory of Cancer Prevention, National Cancer Institute, Rockville, MD 20892 7328, USA
    Cancer Prev Res (Phila) 3:630-9. 2010
    ..These data suggest tissue specificity in the cancer-protective effects of Sep15 downregulation, which are mediated, at least in part, by influencing the cell cycle...
  27. pmc Deficiency in the 15 kDa selenoprotein inhibits human colon cancer cell growth
    Petra A Tsuji
    Cancer Prevention Fellowship Program, National Cancer Institute, Rockville, MD 20892, USA
    Nutrients 3:805-17. 2011
    ..The potential mechanism by which human colon cancer cells lacking Sep15 revert their cancer phenotype will need to be explored further...
  28. ncbi request reprint Dietary selenite and azadeoxycytidine treatments affect dimethylhydrazine-induced aberrant crypt formation in rat colon and DNA methylation in HT-29 cells
    Cindy D Davis
    U S Department of Agriculture, Grand Forks Human Nutrition Research Center, Grand Forks, ND 58202 9034, USA
    J Nutr 132:292-7. 2002
    ..These results suggest that aza-dC treatment may protect selenium-deficient rats against carcinogen-induced aberrant crypt formation...
  29. pmc Determinants of selenium status in healthy adults
    Gerald F Combs
    Grand Forks Human Nutrition Research Center, USDA ARS, Grand Forks, ND, USA
    Nutr J 10:75. 2011
    ..A more informative means of characterizing Se status in non-deficient individuals is needed...
  30. ncbi request reprint Down-regulation of proliferating cell nuclear antigen gene expression occurs during cell cycle arrest induced by human fecal water in colonic HT-29 cells
    Huawei Zeng
    U S Department of Agriculture, Grand Forks Human Nutrition Research Center, Grand Forks, ND 58202 9034, USA
    J Nutr 133:2682-7. 2003
    ..Collectively, these results suggest that human fecal water and selenite can differentially induce growth arrest genes, and that PCNA gene expression is uniquely and highly sensitive to human fecal water...
  31. ncbi request reprint Both selenoproteins and low molecular weight selenocompounds reduce colon cancer risk in mice with genetically impaired selenoprotein expression
    Robert Irons
    Nutritional Science Research Group, National Cancer Institute, Rockville, MD 20852, USA
    J Nutr 136:1311-7. 2006
    ..These results are, to our knowledge, the first to provide evidence that both selenoproteins and low molecular weight selenocompounds are important for the cancer-protective effects of selenium...
  32. pmc MicroRNA, nutrition, and cancer prevention
    Sharon A Ross
    Nutritional Science Research Group, National Cancer Institute, Bethesda, MD 20892, USA
    Adv Nutr 2:472-85. 2011
    ..Understanding the affect of dietary factors on miRNA expression and function may provide insight on prevention strategies to reduce the burden of cancer...
  33. doi request reprint The vitamin D and cancer conundrum: aiming at a moving target
    Cheryl D Toner
    Nutritional Science Research Group, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD 20892, USA
    J Am Diet Assoc 110:1492-500. 2010
    ..Continued investigation is necessary to ensure that vitamin D recommendations are appropriately targeted to individuals who stand to benefit most, while protecting vulnerable subgroups from risk of overexposure...
  34. ncbi request reprint Selenium-enriched broccoli decreases intestinal tumorigenesis in multiple intestinal neoplasia mice
    Cindy D Davis
    U S Department of Agriculture, Grand Forks Human Nutrition Research Center, Grand Forks, ND 58202 9034, USA
    J Nutr 132:307-9. 2002
    ..These results extend previous observations that selenium-enriched broccoli is protective against chemically induced mammary and colon cancer in rats...
  35. ncbi request reprint Dietary manganese intake and type of lipid do not affect clinical or neuropsychological measures in healthy young women
    John W Finley
    US Department of Agriculture, Agricultural Research Service, Grand Forks Human Nutrition Research Center, Grand Forks, ND, USA
    J Nutr 133:2849-56. 2003
    ..Thus, dietary intakes of Mn from 0.8 to 20 mg for 8 wk likely do not result in Mn deficiency or toxicity signs in healthy adults...
  36. ncbi request reprint Does dietary selenium affect plasma homocysteine concentrations in humans?
    Cindy D Davis
    J Nutr 133:2392; author reply 2393. 2003
  37. ncbi request reprint The "sunshine vitamin": benefits beyond bone?
    Cindy D Davis
    J Natl Cancer Inst 99:1563-5. 2007
  38. ncbi request reprint Nutrigenomics and the prevention of colon cancer
    Cindy D Davis
    Pharmacogenomics 8:121-4. 2007