Ben Davidson

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. doi request reprint Expression and clinical role of antiapoptotic proteins of the bag, heat shock, and Bcl-2 families in effusions, primary tumors, and solid metastases in ovarian carcinoma
    Mari Bunkholt Elstrand
    Section for Gynecologic Oncology, Division of Obstetrics and Gynecology, Norwegian Radium Hospital, Oslo, Norway
    Int J Gynecol Pathol 28:211-21. 2009
  2. ncbi request reprint The clinical role of the PEA3 transcription factor in ovarian and breast carcinoma in effusions
    Ben Davidson
    Department of Pathology, The Norwegian Radium Hospital, Montebello, University of Oslo, Oslo, Norway
    Clin Exp Metastasis 21:191-9. 2004
  3. ncbi request reprint Granulin-epithelin precursor is a novel prognostic marker in epithelial ovarian carcinoma
    Ben Davidson
    Molecular Signaling Section, Laboratory of Pathology, Center for Cancer Research, The National Cancer Institute, Bethesda, Maryland 20892, USA
    Cancer 100:2139-47. 2004
  4. ncbi request reprint Altered expression of metastasis-associated and regulatory molecules in effusions from breast cancer patients: a novel model for tumor progression
    Ben Davidson
    Department of Pathology, The Norwegian Radium Hospital, Montebello, University of Oslo, Oslo, Norway
    Clin Cancer Res 10:7335-46. 2004
  5. ncbi request reprint Expression of HLA-G in malignant mesothelioma and clinically aggressive breast carcinoma
    Lilach Kleinberg
    Department of Pathology, Norwegian Radium Hospital, University of Oslo, Montebello, 0310 Oslo, Norway
    Virchows Arch 449:31-9. 2006
  6. ncbi request reprint The clinical role of phospholipase A2 isoforms in advanced-stage ovarian carcinoma
    Michal Gorovetz
    Department of Pharmacology and Experimental Therapeutics, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Israel, and Department of Gynecologic Oncology, National Hospital Norwegian Radium Hospital, Oslo, Norway
    Gynecol Oncol 103:831-40. 2006
  7. doi request reprint Expression of the folate receptor genes FOLR1 and FOLR3 differentiates ovarian carcinoma from breast carcinoma and malignant mesothelioma in serous effusions
    Yuan Yuan
    National Resource Center for Women s Health, Rikshospitalet University Hospital, Oslo, Norway
    Hum Pathol 40:1453-60. 2009
  8. pmc Activation of NF-kappaB signaling by inhibitor of NF-kappaB kinase beta increases aggressiveness of ovarian cancer
    Lidia Hernandez
    Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892 1906, USA
    Cancer Res 70:4005-14. 2010
  9. doi request reprint The chemokine receptor CXCR4 is more frequently expressed in breast compared to other metastatic adenocarcinomas in effusions
    Ben Davidson
    Pathology Clinic, Rikshospitalet Medical Center, Montebello, Oslo, Norway
    Breast J 14:476-82. 2008
  10. ncbi request reprint Coordinated expression of integrin subunits, matrix metalloproteinases (MMP), angiogenic genes and Ets transcription factors in advanced-stage ovarian carcinoma: a possible activation pathway?
    Ben Davidson
    Department of Pathology, The Norwegian Radium Hospital, Montebello N 0310 Oslo, affiliated with the University of Oslo, Norway
    Cancer Metastasis Rev 22:103-15. 2003

Collaborators

Detail Information

Publications96

  1. doi request reprint Expression and clinical role of antiapoptotic proteins of the bag, heat shock, and Bcl-2 families in effusions, primary tumors, and solid metastases in ovarian carcinoma
    Mari Bunkholt Elstrand
    Section for Gynecologic Oncology, Division of Obstetrics and Gynecology, Norwegian Radium Hospital, Oslo, Norway
    Int J Gynecol Pathol 28:211-21. 2009
    ..HSP70 expression in effusions may be a prognostic marker of poor survival, with a similar role for Bcl-2 in primary carcinomas...
  2. ncbi request reprint The clinical role of the PEA3 transcription factor in ovarian and breast carcinoma in effusions
    Ben Davidson
    Department of Pathology, The Norwegian Radium Hospital, Montebello, University of Oslo, Oslo, Norway
    Clin Exp Metastasis 21:191-9. 2004
    ..These findings support a biological role for Ets transcription factors in these malignancies and suggests that they may be targets for therapeutic intervention...
  3. ncbi request reprint Granulin-epithelin precursor is a novel prognostic marker in epithelial ovarian carcinoma
    Ben Davidson
    Molecular Signaling Section, Laboratory of Pathology, Center for Cancer Research, The National Cancer Institute, Bethesda, Maryland 20892, USA
    Cancer 100:2139-47. 2004
    ..The objective of the current study was to evaluate the anatomic site-related and cellular expression of GEP and its association with clinicopathologic parameters and survival in patients with advanced-stage ovarian carcinoma...
  4. ncbi request reprint Altered expression of metastasis-associated and regulatory molecules in effusions from breast cancer patients: a novel model for tumor progression
    Ben Davidson
    Department of Pathology, The Norwegian Radium Hospital, Montebello, University of Oslo, Oslo, Norway
    Clin Cancer Res 10:7335-46. 2004
    ....
  5. ncbi request reprint Expression of HLA-G in malignant mesothelioma and clinically aggressive breast carcinoma
    Lilach Kleinberg
    Department of Pathology, Norwegian Radium Hospital, University of Oslo, Montebello, 0310 Oslo, Norway
    Virchows Arch 449:31-9. 2006
    ..However, the up-regulated expression of HLA-G in MM effusions and its possible association with shorter disease-free survival in advanced stage of breast carcinoma suggest a possible role in immune response evasion in some tumors...
  6. ncbi request reprint The clinical role of phospholipase A2 isoforms in advanced-stage ovarian carcinoma
    Michal Gorovetz
    Department of Pharmacology and Experimental Therapeutics, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Israel, and Department of Gynecologic Oncology, National Hospital Norwegian Radium Hospital, Oslo, Norway
    Gynecol Oncol 103:831-40. 2006
    ..To analyze the expression of phospholipase A2 (PLA2) isoforms and its relationship with matrix metalloproteinase (MMP) expression and clinical parameters in advanced-stage (FIGO III-IV) ovarian carcinoma...
  7. doi request reprint Expression of the folate receptor genes FOLR1 and FOLR3 differentiates ovarian carcinoma from breast carcinoma and malignant mesothelioma in serous effusions
    Yuan Yuan
    National Resource Center for Women s Health, Rikshospitalet University Hospital, Oslo, Norway
    Hum Pathol 40:1453-60. 2009
    ..The high expression of folate receptors in ovarian carcinoma supports their validity as molecular therapeutic targets in this disease...
  8. pmc Activation of NF-kappaB signaling by inhibitor of NF-kappaB kinase beta increases aggressiveness of ovarian cancer
    Lidia Hernandez
    Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892 1906, USA
    Cancer Res 70:4005-14. 2010
    ....
  9. doi request reprint The chemokine receptor CXCR4 is more frequently expressed in breast compared to other metastatic adenocarcinomas in effusions
    Ben Davidson
    Pathology Clinic, Rikshospitalet Medical Center, Montebello, Oslo, Norway
    Breast J 14:476-82. 2008
    ..The prognostic role of CCR7 expression in monocytes and CD8 counts in breast carcinoma effusions merits further research...
  10. ncbi request reprint Coordinated expression of integrin subunits, matrix metalloproteinases (MMP), angiogenic genes and Ets transcription factors in advanced-stage ovarian carcinoma: a possible activation pathway?
    Ben Davidson
    Department of Pathology, The Norwegian Radium Hospital, Montebello N 0310 Oslo, affiliated with the University of Oslo, Norway
    Cancer Metastasis Rev 22:103-15. 2003
    ..They also suggest the existence of a putative activation sequence of metastatic genes, involving the beta1 (and possibly alpha v) integrin subunits, IL-8, PEA3, Ets-1 and MMP in ovarian carcinoma...
  11. ncbi request reprint Interleukin-8 and vascular endothelial growth factor mRNA and protein levels are down-regulated in ovarian carcinoma cells in serous effusions
    Ben Davidson
    Department of Pathology, The Norwegian Radium Hospital, University of Oslo
    Clin Exp Metastasis 19:135-44. 2002
    ..Carcinoma cells in pleural and peritoneal effusions show a similar metastatic expression profile, in agreement with our previous findings, supporting the true metastatic nature of ovarian carcinoma cells in ascites...
  12. ncbi request reprint Matrix metalloproteinases (MMP), EMMPRIN (extracellular matrix metalloproteinase inducer) and mitogen-activated protein kinases (MAPK): co-expression in metastatic serous ovarian carcinoma
    Ben Davidson
    Department of Pathology, The Norwegian Radium Hospital, University of Oslo, Montebello Oslo, Norway
    Clin Exp Metastasis 20:621-31. 2003
    ..These data may expand our understanding regarding the mechanisms by which MMP synthesis is regulated in effusions and possibly affect treatment strategies for this form of malignancy...
  13. ncbi request reprint Heparanase and basic fibroblast growth factor are co-expressed in malignant mesothelioma
    Ben Davidson
    Department of Pathology, The Norwegian Radium Hospital, University of Oslo, Montebello, Oslo, Norway
    Clin Exp Metastasis 21:469-76. 2004
    ....
  14. ncbi request reprint Quantitative analysis of integrin expression in effusions using flow cytometric immunophenotyping
    Eva Sigstad
    Department of Pathology Section of Cytology, The Norwegian Radium Hospital, Oslo, Norway
    Diagn Cytopathol 33:325-31. 2005
    ..The frequent expression of the alphaV and beta1 subunits support attachment to fibronectin and vitronectin as the major ECM ligands in body cavities...
  15. ncbi request reprint Death receptor expression is associated with poor response to chemotherapy and shorter survival in metastatic ovarian carcinoma
    Hiep Phuc Dong
    Pathology Clinic, Rikshospitalet Radiumhospitalet Medical Center, Oslo, Norway
    Cancer 112:84-93. 2008
    ..Death receptors mediate both apoptosis and survival in cancer cells. The authors analyzed death receptor expression in metastatic ovarian carcinoma...
  16. ncbi request reprint Survivin, a member of the inhibitors of apoptosis family, is down-regulated in breast carcinoma effusions
    Lilach Kleinberg
    The Pathology Clinic, Rikshospitalet Radiumhospitalet Medical Center, Oslo, Norway
    Am J Clin Pathol 128:389-97. 2007
    ..Survivin expression may predict disease-free survival for patients with postchemotherapy effusions...
  17. ncbi request reprint Proteomic analysis of malignant ovarian cancer effusions as a tool for biologic and prognostic profiling
    Ben Davidson
    Molecular Signaling Section, Laboratory of Pathology, National Cancer Institute, Bethesda Maryland 20892, USA
    Clin Cancer Res 12:791-9. 2006
    ..Malignant epithelial ovarian cancer effusions are important in disease dissemination and clinical outcome. The identification of biochemical events active in effusions may improve our identification and application of targeted therapeutics...
  18. ncbi request reprint AlphaV- and beta1-integrin subunits are commonly expressed in malignant effusions from ovarian carcinoma patients
    Ben Davidson
    Department of Pathology, The Norwegian Radium Hospital, Montebello N 0310 Oslo, University of Oslo, Norway
    Gynecol Oncol 90:248-57. 2003
    ....
  19. doi request reprint Genomic aberration patterns and expression profiles of squamous cell carcinomas of the vulva
    Francesca Micci
    Section for Cancer Cytogenetics, Institute for Medical Informatics, The Norwegian Radium Hospital, Centre for Cancer Biomedicine, University of Oslo, Oslo, Norway
    Genes Chromosomes Cancer 52:551-63. 2013
    ..Notable among the downregulated genes were MAL (in 2q11), KRT4 (in 12q13), and OLFM4 (in 13q14), whereas upregulated genes included SPRR2G (in 1q21.3) and S100A7A (in 1q21.3)...
  20. ncbi request reprint Expression of the chromatin remodeling factor Rsf-1 is upregulated in ovarian carcinoma effusions and predicts poor survival
    Ben Davidson
    Department of Pathology, National Hospital Norwegian Radium Hospital, University of Oslo, Montebello N 0310 Oslo, Norway
    Gynecol Oncol 103:814-9. 2006
    ..However, its clinical role in ovarian cancer effusions is not clear. In the present study, we assessed the clinical significance of Rsf-1 overexpression in ovarian carcinoma effusions...
  21. ncbi request reprint MUC4 is upregulated in ovarian carcinoma effusions and differentiates carcinoma cells from mesothelial cells
    Ben Davidson
    Department of Pathology, Radiumhospitalet Rikshospitalet Medical Center, University of Oslo, Montebello N 0310 Oslo, Norway
    Diagn Cytopathol 35:756-60. 2007
    ..The data in the present study, together with our earlier report, show that MUC4 is an excellent marker for differentiating OC/PPC from both benign and malignant mesothelial cells...
  22. ncbi request reprint The mitogen-activated protein kinases (MAPK) p38 and JNK are markers of tumor progression in breast carcinoma
    Ben Davidson
    Department of Pathology, The National Hospital Norwegian Radium Hospital, University of Oslo, Montebello N 0310 Oslo, Norway
    Gynecol Oncol 102:453-61. 2006
    ..To investigate the activation of mitogen-activated protein kinases (MAPK) in breast carcinoma effusions and to analyze its relationship to anatomic site and clinical parameters...
  23. ncbi request reprint Flow cytometric immunphenotyping of epithelial cancer cells in effusions--technical considerations and pitfalls
    Hiep P Dong
    Pathology Clinic, Radiumhospitalet Rikshospitalet Medical Center, University of Oslo, Montebello, N 0310 Oslo, Norway
    Cytometry B Clin Cytom 72:332-43. 2007
    ..In the present study, we optimized the conditions for FCM immunphenotyping of effusions using a four-color analysis and investigated aspects related to the advantages and limitations of this method in this setting...
  24. ncbi request reprint The activated nerve growth factor receptor p-TrkA is selectively expressed in advanced-stage ovarian carcinoma
    Elin Ødegaard
    Department of Gynecology, Ulleval University Hospital, University of Oslo, N 0407 Oslo, Norway
    Hum Pathol 38:140-6. 2007
    ..These data provide further evidence regarding the clinical role of p-TrkA in ovarian carcinoma. NGF receptors probably signal via MAPK-independent pathways in ovarian carcinoma...
  25. ncbi request reprint Site-related expression of metastasis-associated and signaling molecules in malignant mesothelioma--a new model for the study of tumor biology and disease progression
    Ben Davidson
    Department of Pathology, The Norwegian Radium Hospital, University of Oslo, Montebello, N 0310 Oslo, Norway
    Lung Cancer 49:S89-93. 2005
  26. doi request reprint Cleaved caspase-3 and nuclear factor-kappaB p65 are prognostic factors in metastatic serous ovarian carcinoma
    Lilach Kleinberg
    Norwegian Radium Hospital, Rikshospitalet Medical Center, Oslo, Norway
    Hum Pathol 40:795-806. 2009
    ..Nuclear factor-kappaB p65 is frequently expressed in advanced-stage serous ovarian carcinoma, and its nuclear localization is associated with poor progression-free survival...
  27. doi request reprint Expression and clinical role of growth differentiation factor-15 in ovarian carcinoma effusions
    Annika J Bock
    Division of Pathology, Oslo University Hospital, Norwegian Radium Hospital, Oslo, Norway
    Int J Gynecol Cancer 20:1448-55. 2010
    ..Growth differentiation factor-15 (GDF-15) is a member of the transforming growth factor-β family. We analyzed the expression and clinical role of GDF-15 in ovarian carcinoma effusions...
  28. ncbi request reprint EMMPRIN (extracellular matrix metalloproteinase inducer) is a novel marker of poor outcome in serous ovarian carcinoma
    Ben Davidson
    Department of Pathology, The Norwegian Radium Hospital, University of Oslo, Oslo, Norway
    Clin Exp Metastasis 20:161-9. 2003
    ..The identical phenotype of carcinoma cells in pleural and peritoneal effusions provides further evidence to our theory that cells at these sites share similar genotypic and phenotypic profiles...
  29. doi request reprint Different expression and clinical role of S100A4 in serous ovarian carcinoma at different anatomic sites
    Gunhild M Maelandsmo
    Department of Tumor Biology and Surgery, Norwegian Radium Hospital, Rikshospitalet University Hospital, Oslo, Norway
    Tumour Biol 30:15-25. 2009
    ....
  30. ncbi request reprint Low-molecular weight forms of cyclin E differentiate ovarian carcinoma from cells of mesothelial origin and are associated with poor survival in ovarian carcinoma
    Ben Davidson
    Pathology Clinic, Radiumhospitalet Rikshospitalet Medical Center, Oslo, Norway
    Cancer 110:1264-71. 2007
    ..In the current study, they analyzed the expression of low-molecular weight (LMW) forms of cyclin E in ovarian carcinoma, malignant mesothelioma, and benign reactive effusions...
  31. ncbi request reprint The diagnostic role of claudins in serous effusions
    Lilach Kleinberg
    Pathology Clinic, Rikshospitalet Radiumhospitalet Medical Center, University of Oslo, Oslo, Norway
    Am J Clin Pathol 127:928-37. 2007
    ..Claudins may, therefore, be of diagnostic value in effusion cytology...
  32. ncbi request reprint Expression and clinical role of the bric-a-brac tramtrack broad complex/poxvirus and zinc protein NAC-1 in ovarian carcinoma effusions
    Ben Davidson
    Pathology Clinic, Rikshospitalet Radiumhospitalet Medical Center, University of Oslo, Montebello Oslo, Norway
    Hum Pathol 38:1030-6. 2007
    ..NAC-1 is up-regulated in tumor cells after chemotherapy, suggesting a role for this protein in tumor progression and in the development of chemotherapy resistance in ovarian cancer...
  33. pmc DNA ploidy may be a prognostic marker in stage I and II serous adenocarcinoma of the endometrium
    Manohar Pradhan
    Institute for Medical Informatics, Oslo University Hospital, Oslo, Norway
    Virchows Arch 461:291-8. 2012
    ..A DNA ploidy parameter, 5c exceeding rate, may be a prognostic marker in this patient group and should be further validated in larger series...
  34. ncbi request reprint Activation of c-jun N-terminal kinase is associated with cell proliferation and shorter relapse-free period in superficial spreading malignant melanoma
    Kjersti Jørgensen
    Department of Pathology, The Norwegian Radium Hospital HF, University of Oslo, Oslo, Norway
    Mod Pathol 19:1446-55. 2006
    ..In contrast, activation of p38 seems to play a less important role in development and progression of malignant melanomas...
  35. doi request reprint Nucleoside transporters are widely expressed in ovarian carcinoma effusions
    Annika J Bock
    Department of Pathology, Oslo University Hospital, Norwegian Radium Hospital, Montebello, 0424 Oslo, Norway
    Cancer Chemother Pharmacol 69:467-75. 2012
    ..Equilibrative and concentrative nucleoside transporters (ENTs and CNTs) mediate the cellular uptake of anticancer nucleosides and sensitivity to such compounds. We studied the expression of ENTs and CNTs in ovarian carcinoma effusions...
  36. ncbi request reprint Heparanase expression correlates with poor survival in metastatic ovarian carcinoma
    Ben Davidson
    Department of Pathology, National Hospital Norwegian Radium Hospital, Montebello N 0310 Oslo, University of Oslo, Norway
    Gynecol Oncol 104:311-9. 2007
    ..To analyze the expression of Heparanase, an enzyme involved in cancer metastasis and angiogenesis, in ovarian and breast carcinoma cells in effusions...
  37. ncbi request reprint Expression of Snail, Slug and Sip1 in malignant mesothelioma effusions is associated with matrix metalloproteinase, but not with cadherin expression
    Stine Sivertsen
    Department of Pathology, Radiumhospitalet Rikshospitalet Medical Center, University of Oslo, Montebello, N 0310 Oslo, Norway
    Lung Cancer 54:309-17. 2006
    ..The increased E-cadherin expression in effusions may be related to lack of negative regulation at the epigenetic level. The relationship between Snail and MMP in MM is uncertain at present...
  38. ncbi request reprint Kallikrein 4 expression is up-regulated in epithelial ovarian carcinoma cells in effusions
    Ben Davidson
    Department of Pathology, The Norwegian Radium Hospital, Oslo, Norway
    Am J Clin Pathol 123:360-8. 2005
    ..hK4 expression in carcinoma cells of effusions or solid tumors does not predict survival...
  39. ncbi request reprint NK- and B-cell infiltration correlates with worse outcome in metastatic ovarian carcinoma
    Hiep Phuc Dong
    Department of Pathology, Norwegian Radium Hospital, University of Oslo, Norway
    Am J Clin Pathol 125:451-8. 2006
    ..Immune response parameters in ovarian cancer effusions are weak predictors of outcome...
  40. ncbi request reprint Expression of the nerve growth factor receptors TrkA and p75 in malignant mesothelioma
    Ben Davidson
    Department of Pathology, The Norwegian Radium Hospital, Montebello N 0310 Oslo, University of Oslo, Oslo, Norway
    Lung Cancer 44:159-65. 2004
    ....
  41. ncbi request reprint Expression and clinical role of DJ-1, a negative regulator of PTEN, in ovarian carcinoma
    Ben Davidson
    Pathology Clinic, Rikshospitalet Radiumhospitalet Medical Center, Montebello, N 0310 Oslo, Norway
    Hum Pathol 39:87-95. 2008
    ..In contrast, PTEN expression is infrequent in this disease. These findings may provide one of the molecular mechanisms that mediate cancer cell survival and aggressiveness in this tumor...
  42. ncbi request reprint Methods for simultaneous measurement of apoptosis and cell surface phenotype of epithelial cells in effusions by flow cytometry
    Hiep Phuc Dong
    Division of Pathology, Norwegian Radium Hospital, Rikshospitalet Medical Center, Ullernchaussen 70, Montebello, N 0310 Oslo, Norway
    Nat Protoc 3:955-64. 2008
    ..The culturing of cell lines requires 2-3 days and induction of apoptosis requires 16 h...
  43. ncbi request reprint Anatomic site-related expression of cancer-associated molecules in ovarian carcinoma
    Ben Davidson
    Pathology Clinic, National Hospital Norwegian Radium Hospital, University of Oslo, Montebello N 0310 Oslo, Norway
    Curr Cancer Drug Targets 7:109-20. 2007
    ..This review will present the current knowledge in this area...
  44. ncbi request reprint Altered expression and activation of the nerve growth factor receptors TrkA and p75 provide the first evidence of tumor progression to effusion in breast carcinoma
    Ben Davidson
    Department of Pathology, The Norwegian Radium Hospital, University of Oslo, Montebello, Oslo, Norway
    Breast Cancer Res Treat 83:119-28. 2004
    ..Furthermore, the rapid progression to effusion in cases showing NGF expression in tumor cells underscores the aggressive clinical behavior of tumors that are able to utilize this pathway in an autocrine manner...
  45. pmc Nuclear factor kappaB transcription factors are coexpressed and convey a poor outcome in ovarian cancer
    Christina M Annunziata
    Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 1906, USA
    Cancer 116:3276-84. 2010
    ..The authors hypothesized that the NF-kappaB pathway is over activated in aggressive ovarian cancers...
  46. pmc A BTB/POZ protein, NAC-1, is related to tumor recurrence and is essential for tumor growth and survival
    Kentaro Nakayama
    Department of Pathology, Johns Hopkins Medical Institutions, 1550 Orleans Street, Baltimore, MD 21231, USA
    Proc Natl Acad Sci U S A 103:18739-44. 2006
    ....
  47. ncbi request reprint Gene expression signatures differentiate ovarian/peritoneal serous carcinoma from diffuse malignant peritoneal mesothelioma
    Ben Davidson
    Department of Pathology, Radiumhospitalet Rikshospitalet Medical Center, University of Oslo, Oslo, Norway
    Clin Cancer Res 12:5944-50. 2006
    ..It remains unclear whether both tumors are molecularly distinct neoplasms. The current study compared global gene expression patterns in OC/PPC and DMPM...
  48. doi request reprint The diagnostic and research applications of flow cytometry in cytopathology
    Ben Davidson
    Faculty of Medicine, University of Oslo, N 0316 Oslo, Norway
    Diagn Cytopathol 40:525-35. 2012
    ..This article reviews the currently available data in this area of cytopathology...
  49. doi request reprint Gene expression signatures differentiate adenocarcinoma of lung and breast origin in effusions
    Ben Davidson
    Division of Pathology, Norwegian Radium Hospital, Oslo University Hospital, N 0310 Oslo, Norway
    Hum Pathol 43:684-94. 2012
    ..The molecular signatures unique to these cancers may facilitate their differential diagnosis and may provide a molecular basis for therapeutic target discovery...
  50. doi request reprint Rab25 is overexpressed in Müllerian serous carcinoma compared to malignant mesothelioma
    Kjersti Brusegard
    Department of Pathology, Norwegian Radium Hospital, Oslo University Hospital, 0424 Oslo, Norway
    Virchows Arch 460:193-202. 2012
    ..Our data confirm that Rab25 effectively differentiates Müllerian carcinomas from malignant mesothelioma at the mRNA and protein level, suggesting a role in the diagnostic work-up of serosal cancers...
  51. ncbi request reprint Expression of xeroderma pigmentosum A protein predicts improved outcome in metastatic ovarian carcinoma
    Ellen V Stevens
    Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA
    Cancer 103:2313-9. 2005
    ..The authors hypothesized that expression of the NER protein xeroderma pigmentosum A (XPA) would be reduced in a clinically significant fashion in metastatic ovarian carcinoma...
  52. doi request reprint Biological effects induced by insulin-like growth factor binding protein 3 (IGFBP-3) in malignant melanoma
    Geir Frode Oy
    Department of Tumor Biology, Institute for Cancer Research, Oslo, Norway
    Int J Cancer 126:350-61. 2010
    ..Development of resistance to the antiproliferative effects of IGFBP-3 may be an important step in progression of malignant melanomas...
  53. pmc Tenascin-X is a novel diagnostic marker of malignant mesothelioma
    Yuan Yuan
    Department of Pathology, Norwegian Radium Hospital, Norway
    Am J Surg Pathol 33:1673-82. 2009
    ....
  54. ncbi request reprint PEA3 is the second Ets family transcription factor involved in tumor progression in ovarian carcinoma
    Ben Davidson
    Department of Pathology, The Norwegian Radium Hospital, Montebello, N 0310 Oslo, University of Oslo, Norway
    Clin Cancer Res 9:1412-9. 2003
    ..The purpose of this study was to analyze the possible correlation between PEA3 mRNA expression and survival in advanced-stage ovarian carcinomas, studying two patient groups with extremely different disease outcome...
  55. ncbi request reprint Nuclear expression of survivin is associated with improved survival in metastatic ovarian carcinoma
    Lilach Kleinberg
    Pathology Clinic, Rikshospitalet Radiumhospitalet Medical Center, Oslo, Norway
    Cancer 109:228-38. 2007
    ..Inhibitor of apoptosis proteins (IAPs) mediate cancer cell survival and chemoresistance. The expression of XIAP, Survivin, and Livin in ovarian carcinoma was analyzed...
  56. ncbi request reprint Cadherin expression in ovarian carcinoma and malignant mesothelioma cell effusions
    Stine Sivertsen
    Department of Pathology, National Hospital Norwegian Radium Hospital, University of Oslo, Oslo, Norway
    Acta Cytol 50:603-7. 2006
    ..To analyze potential differences in cadherin expression between ovarian carcinoma/primary peritoneal carcinoma (OC/PPC) and malignant mesothelioma (MM) at this anatomic site...
  57. doi request reprint Expression of the peroxisome proliferator-activated receptors-alpha, -beta, and -gamma in ovarian carcinoma effusions is associated with poor chemoresponse and shorter survival
    Ben Davidson
    Division of Pathology, Norwegian Radium Hospital, Rikshospitalet Medical Center, Montebello N 0310, Oslo, Norway
    Hum Pathol 40:705-13. 2009
    ..Peroxisome proliferator-activated receptor expression in effusions is associated with poor response to chemotherapy at disease recurrence and poor survival, suggesting a role in tumor biology at this unique microenvironment...
  58. doi request reprint Gene expression signatures differentiate ovarian/peritoneal serous carcinoma from breast carcinoma in effusions
    Ben Davidson
    Division of Pathology, Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
    J Cell Mol Med 15:535-44. 2011
    ..The molecular signatures unique to these cancers may facilitate their differential diagnosis and may provide a molecular basis for therapeutic target discovery...
  59. pmc Jagged-1 and Notch3 juxtacrine loop regulates ovarian tumor growth and adhesion
    Jung Hye Choi
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Cancer Res 68:5716-23. 2008
    ....
  60. ncbi request reprint Expression of activated Akt and PTEN in malignant melanomas: relationship with clinical outcome
    Ana Slipicevic
    Department of Pathology, The Norwegian Radium Hospital, University of Oslo, Oslo, Norway
    Am J Clin Pathol 124:528-36. 2005
    ..025) for patients with superficial spreading melanoma...
  61. pmc Clinical relevance of multidrug resistance gene expression in ovarian serous carcinoma effusions
    Jean Pierre Gillet
    Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    Mol Pharm 8:2080-8. 2011
    ..This pilot study highlights two new gene signatures that may help in optimizing the treatment for ovarian carcinoma patients with effusions...
  62. doi request reprint Assessment of endoglin and calprotectin as potential biomarkers in ovarian carcinoma and borderline tumors of the ovary
    Elin Ødegaard
    Department of Obstetrics, Ulleval University Hospital, Oslo, Norway
    Am J Obstet Gynecol 199:533.e1-8. 2008
    ..The objective of the study was to analyze circulating endoglin concentration in ovarian carcinoma and evaluate a prognostic role for calprotectin and endoglin in effusions in advanced-stage disease...
  63. ncbi request reprint HLA-G expression in effusions is a possible marker of tumor susceptibility to chemotherapy in ovarian carcinoma
    Ben Davidson
    Department of Pathology, The Norwegian Radium Hospital, University of Oslo, Montebello N 0310 Oslo, Norway
    Gynecol Oncol 96:42-7. 2005
    ..The objective of this study was to evaluate the expression and clinical role of HLA-G in effusions and corresponding solid tumors from patients diagnosed with advanced-stage ovarian carcinoma...
  64. doi request reprint Ovarian carcinoma cells in effusions show increased S-phase fraction compared to corresponding primary tumors
    Lilach Kleinberg
    Division of Pathology, The Norwegian Radium Hospital, Rikshospitalet Medical Center, Oslo, Norway
    Diagn Cytopathol 36:637-44. 2008
    ....
  65. ncbi request reprint Expression of inhibitor-of-apoptosis protein family members in malignant mesothelioma
    Lilach Kleinberg
    Pathology Clinic, Rikshospitalet Radiumhospitalet Medical Center, Oslo, Norway
    Hum Pathol 38:986-94. 2007
    ..XIAP is upregulated in mesothelioma effusions and peritoneal mesotheliomas, suggesting a prosurvival role in malignant mesothelioma cells, particularly at these anatomic sites...
  66. ncbi request reprint Chemokine receptors are infrequently expressed in malignant and benign mesothelial cells
    Ben Davidson
    Pathology Clinic, Rikshospitalet Radiumhospitalet Medical Center, University of Oslo, Oslo, Norway
    Am J Clin Pathol 127:752-9. 2007
    ..The increased monocyte infiltration and their higher chemokine receptor expression in MM effusions may have a tumor-promoting rather than tumor-inhibiting effect...
  67. ncbi request reprint Homozygous deletion of MKK4 in ovarian serous carcinoma
    Kentaro Nakayama
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
    Cancer Biol Ther 5:630-4. 2006
    ..These findings suggest that homozygous deletion or reduced expression of MKK4 may contribute to the development of ovarian serous carcinoma...
  68. doi request reprint DNA ploidy heterogeneity in endometrial carcinoma: comparison between curettage and hysterectomy specimens
    Manohar Pradhan
    Department of Pathology, Oslo University Hospital, University of Oslo, Oslo, Norway
    Int J Gynecol Pathol 29:572-8. 2010
    ..The difference observed, which we believe reflects the intratumoral heterogeneity, should be taken into account when applying DNA ploidy to endometrial carcinoma specimens...
  69. ncbi request reprint Kallikrein 4 is expressed in malignant mesothelioma--further evidence for the histogenetic link between mesothelial and epithelial cells
    Ben Davidson
    Pathology Clinic, Rikshospitalet Radiumhospitalet Medical Center, Montebello, N 0310 Oslo, Norway
    Diagn Cytopathol 35:80-4. 2007
    ..The presence of hK4 in MM, a non-hormonally regulated tumor, provides further support to the histogenetic link between mesothelial and epithelial cells...
  70. ncbi request reprint Caveolin-1 expression in ovarian carcinoma is MDR1 independent
    Ben Davidson
    Department of Pathology, Norwegian Radium Hospital, Oslo
    Am J Clin Pathol 117:225-34. 2002
    ..Expression seems MDR1 independent...
  71. ncbi request reprint Malignant effusions: from diagnosis to biology
    Ben Davidson
    Department of Pathology, The Norwegian Radium Hospital, University of Oslo, Montebello N 0310 Oslo, Norway
    Diagn Cytopathol 31:246-54. 2004
    ..The case also is made for potential applications of this rapidly evolving body of knowledge in the diagnosis, classification, and prediction of biological behavior of processes resulting in cryptic effusions at the clinical level...
  72. ncbi request reprint Adenomatous polyposis coli (APC) protein expression in primary and metastatic serous ovarian carcinoma
    Eleonora Karbova
    Department of Pathology, The Norwegian Radium Hospital, University of Oslo, Oslo, Norway
    Int J Surg Pathol 10:175-80. 2002
    ..The mechanism behind the down-regulated expression of APC in serous ovarian carcinoma and its significance has yet to be elucidated...
  73. pmc The anti-apoptotic activity of BAG3 is restricted by caspases and the proteasome
    Victoria M Virador
    Molecular Signaling Section, Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America
    PLoS ONE 4:e5136. 2009
    ..We previously reported BAG3 overexpression protected ubiquitinated clients, such as AKT, from proteasomal degradation and conferred cytoprotection against heat shock. We hypothesized that the BAG3 protein is regulated by proteolysis...
  74. ncbi request reprint BAG-4/SODD and associated antiapoptotic proteins are linked to aggressiveness of epithelial ovarian cancer
    Christina M Annunziata
    Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    Clin Cancer Res 13:6585-92. 2007
    ..We hypothesized that elevated expression in ovarian cancer of the BAG family of prosurvival proteins and associated partners would be associated with clinical features of aggressiveness in ovarian cancer...
  75. pmc Amplification of a chromatin remodeling gene, Rsf-1/HBXAP, in ovarian carcinoma
    Ie Ming Shih
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Proc Natl Acad Sci U S A 102:14004-9. 2005
    ..Furthermore, Rsf-1 gene knockdown inhibited cell growth in OVCAR3 cells, which harbor Rsf-1 amplification. Taken together, these findings indicate an important role of Rsf-1 amplification in ovarian cancer...
  76. doi request reprint Different clinical roles for p21-activated kinase-1 in primary and recurrent ovarian carcinoma
    Ben Davidson
    Department of Pathology, Norwegian Radium Hospital, Rikshospitalet University Hospital, Montebello, Oslo, Norway
    Hum Pathol 39:1630-6. 2008
    ..This suggests altered cellular function for this kinase along disease progression, possibly chemotherapy mediated...
  77. ncbi request reprint Detection of malignant epithelial cells in effusions using flow cytometric immunophenotyping: an analysis of 92 cases
    Ben Davidson
    Department of Pathology, Division of Cytology, Norwegian Radium Hospital, Oslo
    Am J Clin Pathol 118:85-92. 2002
    ..By using established cellular markers coupled with biological markers, FCM also has great promise for experimental purposes...
  78. doi request reprint New diagnostic and molecular characteristics of malignant mesothelioma
    Ben Davidson
    Division of Pathology, Norwegian Radium Hospital, Rikshospitalet University Hospital, Oslo, Norway
    Ultrastruct Pathol 32:227-40. 2008
    ..This review presents current data regarding the diagnostic and biological aspects of malignant mesothelioma...
  79. ncbi request reprint The biological differences between ovarian serous carcinoma and diffuse peritoneal malignant mesothelioma
    Ben Davidson
    Department of Pathology, Norwegian Radium Hospital National Hospital, University of Oslo, Oslo, Norway
    Semin Diagn Pathol 23:35-43. 2006
    ....
  80. ncbi request reprint Measurement of cyclin E genomic copy number and strand length in cell-free DNA distinguish malignant versus benign effusions
    Ritu Salani
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
    Clin Cancer Res 13:5805-9. 2007
    ..We hypothesized that analysis of both DNA copy number and strand length of cell-free DNA from an amplified chromosomal region could improve the diagnosis of malignant diseases in body fluids...
  81. doi request reprint Gross genomic alterations differ between serous borderline tumors and serous adenocarcinomas--an image cytometric DNA ploidy analysis of 307 cases with histogenetic implications
    Manohar Pradhan
    Division of Pathology, Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
    Virchows Arch 454:677-83. 2009
    ....
  82. ncbi request reprint Proteomics and ovarian cancer: implications for diagnosis and treatment: a critical review of the recent literature
    Edwin M Posadas
    Laboratory of Pathology, National Cancer Institute and NCI FDA Clinical Proteomics Program Bethesda, Maryland, USA
    Curr Opin Oncol 16:478-84. 2004
    ..Emerging proteomic technologies have promise for early diagnosis and in advancing treatment directions. Application of these technologies has produced new biomarkers, diagnostic approaches, and understanding of disease biology...
  83. ncbi request reprint The AP-2gamma transcription factor is upregulated in advanced-stage ovarian carcinoma
    Elin Ødegaard
    Department of Gynecology, Ulleval University Hospital, N 0407 Oslo, Norway
    Gynecol Oncol 100:462-8. 2006
    ..To analyze the expression of the AP-2gamma transcription factor in ovarian borderline tumors, early-stage ovarian carcinoma and advanced-stage ovarian carcinoma, and to evaluate its prognostic role in advanced-stage tumors...
  84. ncbi request reprint Differential expression of the 67 kilodalton laminin receptor in epithelioid malignant mesothelioma and carcinomas that spread to serosal cavities
    Reuven Reich
    Department of Pharmacology and Experimental Therapeutics, Faculty of Medicine, Hebrew University, Jerusalem, Israel
    Diagn Cytopathol 33:332-7. 2005
    ....
  85. ncbi request reprint D2-40 is not a specific marker for cells of mesothelial origin in serous effusions
    Assia V Bassarova
    Pathology Clinic, The National Hospital The Norwegian Radium Hospital, University of Oslo, Montebello 0310 Oslo, Norway
    Am J Surg Pathol 30:878-82. 2006
    ....
  86. ncbi request reprint Expression of E-cadherin transcriptional regulators in ovarian carcinoma
    Sivan Elloul
    Department of Pharmacology and Experimental Therapeutics, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 91120, Israel
    Virchows Arch 449:520-8. 2006
    ..In solid tumors, E-cadherin is negatively regulated by Snail and Slug. In effusions, SIP1 may be the main regulator of E-cadherin, but with a lesser level of suppression compared with primary tumors and solid metastases...
  87. pmc Expression of the chromatin remodeling factor Rsf-1 is down-regulated in breast carcinoma effusions
    Ben Davidson
    Pathology Clinic, Rikshospitalet Radiumhospitalet Medical Center, N 0310 Oslo, Norway
    Hum Pathol 39:616-22. 2008
    ..In conclusion, in contrast to ovarian carcinoma, Rsf-1 expression is down-regulated in breast carcinoma cells in effusions compared with the solid counterparts and has no prognostic role at this anatomic site...
  88. ncbi request reprint Expression of the 67 kDa laminin receptor and the alpha6 integrin subunit in serous ovarian carcinoma
    Vered Givant-Horwitz
    Department of Pharmacology and Experimental Therapeutics, Faculty of Medicine, Hebrew University, Jerusalem, Israel
    Clin Exp Metastasis 20:599-609. 2003
    ..LBP mRNA and protein expression is independent of that of the alpha6 integrin subunit in both solid tumors and effusions of serous ovarian carcinoma...
  89. ncbi request reprint The PAC-1 dual specificity phosphatase predicts poor outcome in serous ovarian carcinoma
    Vered Givant-Horwitz
    Department of Pharmacology and Experimental Therapeutics, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 91120, Israel
    Gynecol Oncol 93:517-23. 2004
    ..The objective of the present study was to investigate the expression and clinical role of dual-specificity phosphatases (DUSP), inhibitors of MAPK signaling, in ovarian cancer cells at this site...
  90. ncbi request reprint Angiogenic molecule expression is downregulated in effusions from breast cancer patients
    Sophya Konstantinovsky
    Department of Pharmacology and Experimental Therapeutics, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel
    Breast Cancer Res Treat 94:71-80. 2005
    ..The poor disease-free survival for patients with bFGF-positive effusions suggests a role for this growth factor in mediating tumor survival rather than angiogenesis at this site...
  91. ncbi request reprint Laminin-induced signaling in tumor cells: the role of the M(r) 67,000 laminin receptor
    Vered Givant-Horwitz
    Department of Pharmacology, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel
    Cancer Res 64:3572-9. 2004
    ....
  92. ncbi request reprint Snail, Slug, and Smad-interacting protein 1 as novel parameters of disease aggressiveness in metastatic ovarian and breast carcinoma
    Sivan Elloul
    Department of Pharmacology and Experimental Therapeutics, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel
    Cancer 103:1631-43. 2005
    ..For the current study, the authors analyzed the relation between the expression of Snail, Slug, and Sip1; the expression of MMP-2 and E-cadherin; and clinical parameters in patients with metastatic ovarian and breast carcinoma...
  93. ncbi request reprint Identification and characterization of membralin, a novel tumor-associated gene, in ovarian carcinoma
    Yu Chi Chen
    Department of Pathology and Oncology, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Biochim Biophys Acta 1730:96-102. 2005
    ..001). In conclusion, these findings represent the first characterization of human membralin and suggest that membralin is a novel tumor-associated marker in ovarian serous carcinomas...
  94. pmc The fatty acid binding protein 7 (FABP7) is involved in proliferation and invasion of melanoma cells
    Ana Slipicevic
    Pathology Clinic, Rikshospitalet Radiumhospitalet Medical Center, Montebello N 0310 Oslo, Norway
    BMC Cancer 8:276. 2008
    ..One of the new candidates that emerged from a recent gene expression profiling study is fatty acid-binding protein 7 (FABP7), involved in lipid metabolism, gene regulation, cell growth and differentiation...
  95. ncbi request reprint Mitogen-activated protein kinases (MAPK) as predictors of clinical outcome in serous ovarian carcinoma in effusions
    Vered Givant-Horwitz
    Department of Pharmacology and Experimental Therapeutics, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 91120, Israel
    Gynecol Oncol 91:160-72. 2003
    ....
  96. pmc MicroRNA expression and identification of putative miRNA targets in ovarian cancer
    Neetu Dahiya
    Laboratory of Cellular and Molecular Biology, Hopkins Medical Institutions, Baltimore, Maryland, United States of America
    PLoS ONE 3:e2436. 2008
    ..Emerging evidence suggests the potential involvement of altered regulation of miRNA in the pathogenesis of cancers, and these genes are thought to function as both tumor suppressors and oncogenes...