Nathalie Dautin

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Protein secretion in gram-negative bacteria via the autotransporter pathway
    Nathalie Dautin
    Genetics and Biochemistry Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 0538, USA
    Annu Rev Microbiol 61:89-112. 2007
  2. pmc Molecular basis for the activation of a catalytic asparagine residue in a self-cleaving bacterial autotransporter
    Travis J Barnard
    Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, US National Institutes of Health, Bethesda, MD 20892, USA
    J Mol Biol 415:128-42. 2012
  3. pmc Secretion of a bacterial virulence factor is driven by the folding of a C-terminal segment
    Janine H Peterson
    Genetics and Biochemistry Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 107:17739-44. 2010
  4. pmc Crystal structures of the outer membrane domain of intimin and invasin from enterohemorrhagic E. coli and enteropathogenic Y. pseudotuberculosis
    James W Fairman
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Structure 20:1233-43. 2012
  5. pmc Residues in a conserved α-helical segment are required for cleavage but not secretion of an Escherichia coli serine protease autotransporter passenger domain
    Nathalie Dautin
    Genetics and Biochemistry Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Bacteriol 193:3748-56. 2011
  6. pmc Autotransporter structure reveals intra-barrel cleavage followed by conformational changes
    Travis J Barnard
    Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, US National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Struct Mol Biol 14:1214-20. 2007
  7. pmc Cleavage of a bacterial autotransporter by an evolutionarily convergent autocatalytic mechanism
    Nathalie Dautin
    Genetics and Biochemistry Branch, National Institutes of Health, Bethesda, MD 20892, USA
    EMBO J 26:1942-52. 2007
  8. ncbi request reprint Essential role of methionine residues in calmodulin binding to Bordetella pertussis adenylate cyclase, as probed by selective oxidation and repair by the peptide methionine sulfoxide reductases
    Stéphanie Vougier
    Laboratoire de Biologie et Biochimie Cellulaire du Vieillissement, EA 3106, IFR 117, Universite Paris 7, Denis Diderot, 2 place Jussieu, Paris 75005, France
    J Biol Chem 279:30210-8. 2004

Collaborators

Detail Information

Publications8

  1. ncbi request reprint Protein secretion in gram-negative bacteria via the autotransporter pathway
    Nathalie Dautin
    Genetics and Biochemistry Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 0538, USA
    Annu Rev Microbiol 61:89-112. 2007
    ..We also discuss insights into each stage of autotransporter biogenesis that have emerged from recent structural, biochemical, and imaging studies...
  2. pmc Molecular basis for the activation of a catalytic asparagine residue in a self-cleaving bacterial autotransporter
    Travis J Barnard
    Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, US National Institutes of Health, Bethesda, MD 20892, USA
    J Mol Biol 415:128-42. 2012
    ..Together, these findings provide insight into factors important for asparagine cyclization, a mechanism broadly used for protein cleavage...
  3. pmc Secretion of a bacterial virulence factor is driven by the folding of a C-terminal segment
    Janine H Peterson
    Genetics and Biochemistry Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 107:17739-44. 2010
    ..Our results provide direct evidence that protein folding can drive translocation and help to clarify the mechanism of autotransporter secretion...
  4. pmc Crystal structures of the outer membrane domain of intimin and invasin from enterohemorrhagic E. coli and enteropathogenic Y. pseudotuberculosis
    James W Fairman
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Structure 20:1233-43. 2012
    ..We then use this set of sequences along with our structural data to find and map the evolutionarily constrained residues within the β domain...
  5. pmc Residues in a conserved α-helical segment are required for cleavage but not secretion of an Escherichia coli serine protease autotransporter passenger domain
    Nathalie Dautin
    Genetics and Biochemistry Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Bacteriol 193:3748-56. 2011
    ..Our results strongly suggest that the conserved residues are required to position the α-helical segment for the cleavage reaction and are not required to promote passenger domain secretion...
  6. pmc Autotransporter structure reveals intra-barrel cleavage followed by conformational changes
    Travis J Barnard
    Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, US National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Struct Mol Biol 14:1214-20. 2007
    ....
  7. pmc Cleavage of a bacterial autotransporter by an evolutionarily convergent autocatalytic mechanism
    Nathalie Dautin
    Genetics and Biochemistry Branch, National Institutes of Health, Bethesda, MD 20892, USA
    EMBO J 26:1942-52. 2007
    ..Remarkably, a very similar mechanism has been proposed for the maturation of eukaryotic viral capsids...
  8. ncbi request reprint Essential role of methionine residues in calmodulin binding to Bordetella pertussis adenylate cyclase, as probed by selective oxidation and repair by the peptide methionine sulfoxide reductases
    Stéphanie Vougier
    Laboratoire de Biologie et Biochimie Cellulaire du Vieillissement, EA 3106, IFR 117, Universite Paris 7, Denis Diderot, 2 place Jussieu, Paris 75005, France
    J Biol Chem 279:30210-8. 2004
    ..CaM complex to oxidation and the ability of AC to be efficiently activated by partially oxidized CaM molecules should allow the toxin to exert its cytotoxic effects on activated neutrophils and contribute to the host colonization...