A Danilkovitch

Summary

Affiliation: National Cancer Institute
Country: USA

Publications

  1. ncbi request reprint Kinases involved in MSP/RON signaling
    A Danilkovitch
    Laboratory of Immunobiology, National Cancer Institute, Frederick Cancer Research and Development Center, Maryland 21702, USA
    J Leukoc Biol 65:345-8. 1999
  2. ncbi request reprint Macrophage stimulating protein-induced epithelial cell adhesion is mediated by a PI3-K-dependent, but FAK-independent mechanism
    A Danilkovitch
    Laboratory of Immunobiology, National Cancer Institute, Frederick, Maryland, 21702, USA
    Exp Cell Res 248:575-82. 1999
  3. ncbi request reprint Interaction of macrophage-stimulating protein with its receptor. Residues critical for beta chain binding and evidence for independent alpha chain binding
    A Danilkovitch
    Laboratory of Immunobiology, NCI Frederick Cancer Research and Development Center, ABL Basic Research Program, Frederick, Maryland 21702, USA
    J Biol Chem 274:29937-43. 1999
  4. pmc Two independent signaling pathways mediate the antiapoptotic action of macrophage-stimulating protein on epithelial cells
    A Danilkovitch
    Immunopathology Section, Laboratory of Immunobiology, National Cancer Institute, Frederick, Maryland, USA
    Mol Cell Biol 20:2218-27. 2000
  5. ncbi request reprint Integrin-mediated RON growth factor receptor phosphorylation requires tyrosine kinase activity of both the receptor and c-Src
    A Danilkovitch-Miagkova
    Laboratory of Immunobiology, NCI Frederick Cancer Research and Development Center, Frederick, Maryland 21702, USA
    J Biol Chem 275:14783-6. 2000
  6. ncbi request reprint Cross-talk between RON receptor tyrosine kinase and other transmembrane receptors
    A Danilkovitch-Miagkova
    Laboratory of Immunobiology, National Cancer Institute, Frederick Cancer Research and Development Center, 21702, USA
    Histol Histopathol 16:623-31. 2001
  7. ncbi request reprint Anti-apoptotic action of macrophage stimulating protein (MSP)
    A Danilkovitch-Miagkova
    Section of Immunopathology, Laboratory of Immunobiology, National Cancer Institute, Frederick, Maryland 21702, USA
    Apoptosis 6:183-90. 2001
  8. pmc Oncogenic mutants of RON and MET receptor tyrosine kinases cause activation of the beta-catenin pathway
    A Danilkovitch-Miagkova
    Laboratory of Immunobiology, National Cancer Institute, Frederick Cancer Research and Development Center, Fort Detrick, Frederick, MD 21702, USA
    Mol Cell Biol 21:5857-68. 2001

Collaborators

  • M Miller
  • A Danilkovitch-Miagkova
  • E J Leonard
  • A Skeel
  • N Nakaigawa
  • A Miagkov
  • B Zbar
  • D Angeloni
  • M Lerman
  • S Donley

Detail Information

Publications8

  1. ncbi request reprint Kinases involved in MSP/RON signaling
    A Danilkovitch
    Laboratory of Immunobiology, National Cancer Institute, Frederick Cancer Research and Development Center, Maryland 21702, USA
    J Leukoc Biol 65:345-8. 1999
    ..PI3-K regulates MSP-induced adhesion and motility but via downstream components different from AKT. Thus, occupancy of the RON receptor by MSP activates distinct signal transduction pathways that mediate several cellular responses...
  2. ncbi request reprint Macrophage stimulating protein-induced epithelial cell adhesion is mediated by a PI3-K-dependent, but FAK-independent mechanism
    A Danilkovitch
    Laboratory of Immunobiology, National Cancer Institute, Frederick, Maryland, 21702, USA
    Exp Cell Res 248:575-82. 1999
    ..Also, we found ligand-independent association between RON and beta1 integrin, which is additional evidence for a relationship between these two receptor systems...
  3. ncbi request reprint Interaction of macrophage-stimulating protein with its receptor. Residues critical for beta chain binding and evidence for independent alpha chain binding
    A Danilkovitch
    Laboratory of Immunobiology, NCI Frederick Cancer Research and Development Center, ABL Basic Research Program, Frederick, Maryland 21702, USA
    J Biol Chem 274:29937-43. 1999
    ..The data suggest that MSP has two independent binding sites with high and low affinities located in beta and alpha chain, respectively, and that the two sites together mediate receptor dimerization and subsequent activation...
  4. pmc Two independent signaling pathways mediate the antiapoptotic action of macrophage-stimulating protein on epithelial cells
    A Danilkovitch
    Immunopathology Section, Laboratory of Immunobiology, National Cancer Institute, Frederick, Maryland, USA
    Mol Cell Biol 20:2218-27. 2000
    ..Growth factors induce MAPK activation, and adhesion mediates MAPK translocation from the cytoplasm into the nucleus...
  5. ncbi request reprint Integrin-mediated RON growth factor receptor phosphorylation requires tyrosine kinase activity of both the receptor and c-Src
    A Danilkovitch-Miagkova
    Laboratory of Immunobiology, NCI Frederick Cancer Research and Development Center, Frederick, Maryland 21702, USA
    J Biol Chem 275:14783-6. 2000
    ..Integrin-induced epidermal growth factor receptor (EGFR) phosphorylation also depended on both EGFR and c-Src kinase activities. This sequence appears to be a general pathway for integrin-dependent growth factor RTK activation...
  6. ncbi request reprint Cross-talk between RON receptor tyrosine kinase and other transmembrane receptors
    A Danilkovitch-Miagkova
    Laboratory of Immunobiology, National Cancer Institute, Frederick Cancer Research and Development Center, 21702, USA
    Histol Histopathol 16:623-31. 2001
    ..The purpose of this review is to summarize data and to discuss a role of cross-talk between RON and other transmembrane receptors...
  7. ncbi request reprint Anti-apoptotic action of macrophage stimulating protein (MSP)
    A Danilkovitch-Miagkova
    Section of Immunopathology, Laboratory of Immunobiology, National Cancer Institute, Frederick, Maryland 21702, USA
    Apoptosis 6:183-90. 2001
    ..A hypothesis that Stat3 might represent a key component of the adhesion-induced anti-apoptotic pathway is presented in this review...
  8. pmc Oncogenic mutants of RON and MET receptor tyrosine kinases cause activation of the beta-catenin pathway
    A Danilkovitch-Miagkova
    Laboratory of Immunobiology, National Cancer Institute, Frederick Cancer Research and Development Center, Fort Detrick, Frederick, MD 21702, USA
    Mol Cell Biol 21:5857-68. 2001
    ..Activation of beta-catenin by oncogenic RON and MET constitutes a new pathway, which might lead to cell transformation by these and other mutant growth factor RTKs...