Knut Tomas Dalen

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint LSDP5 is a PAT protein specifically expressed in fatty acid oxidizing tissues
    Knut Tomas Dalen
    Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, P O Box 1046 Blindern, N 0316 Oslo, Norway
    Biochim Biophys Acta 1771:210-27. 2007
  2. ncbi request reprint Tissue-specific autoregulation of the LXRalpha gene facilitates induction of apoE in mouse adipose tissue
    Stine Marie Ulven
    Department of Nutrition, University of Oslo, N 0316 Oslo, Norway
    J Lipid Res 45:2052-62. 2004
  3. doi request reprint Regulation of hepatic fatty acid elongase 5 by LXRalpha-SREBP-1c
    Yan Qin
    Department of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, PO Box 1046 Blindern, N 0316 Oslo, Norway
    Biochim Biophys Acta 1791:140-7. 2009
  4. ncbi request reprint PPARalpha activators and fasting induce the expression of adipose differentiation-related protein in liver
    Knut Tomas Dalen
    Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Norway
    J Lipid Res 47:931-43. 2006
  5. pmc Activation of LXR increases acyl-CoA synthetase activity through direct regulation of ACSL3 in human placental trophoblast cells
    M Susanne Weedon-Fekjaer
    Faculty of Medicine, University of Oslo, and Department of Endocrinology, Oslo University Hospital, Oslo, Norway
    J Lipid Res 51:1886-96. 2010
  6. ncbi request reprint Adipose tissue expression of the lipid droplet-associating proteins S3-12 and perilipin is controlled by peroxisome proliferator-activated receptor-gamma
    Knut Tomas Dalen
    Institute for Nutrition Research, University of Oslo, Blindern, N 0316 Oslo, Norway
    Diabetes 53:1243-52. 2004
  7. ncbi request reprint LXR is crucial in lipid metabolism
    Stine Marie Ulven
    Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, P O Box 1046 Blindern, N 0316 Oslo, Norway
    Prostaglandins Leukot Essent Fatty Acids 73:59-63. 2005
  8. pmc Fatty acids regulate perilipin5 in muscle by activating PPARδ
    Christian Bindesbøll
    Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
    J Lipid Res 54:1949-63. 2013
  9. ncbi request reprint Regulation of ADRP expression by long-chain polyunsaturated fatty acids in BeWo cells, a human placental choriocarcinoma cell line
    Kari Anne Risan Tobin
    Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
    J Lipid Res 47:815-23. 2006
  10. ncbi request reprint Expression of the insulin-responsive glucose transporter GLUT4 in adipocytes is dependent on liver X receptor alpha
    Knut Tomas Dalen
    Institute for Nutrition Research, University of Oslo, N 0316 Oslo, Norway
    J Biol Chem 278:48283-91. 2003

Collaborators

Detail Information

Publications11

  1. ncbi request reprint LSDP5 is a PAT protein specifically expressed in fatty acid oxidizing tissues
    Knut Tomas Dalen
    Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, P O Box 1046 Blindern, N 0316 Oslo, Norway
    Biochim Biophys Acta 1771:210-27. 2007
    ..PPARalpha is generally required for regulation of fatty acid metabolism during fasting, but fasting induces LSDP5 mRNA in liver even in the absence of PPARalpha...
  2. ncbi request reprint Tissue-specific autoregulation of the LXRalpha gene facilitates induction of apoE in mouse adipose tissue
    Stine Marie Ulven
    Department of Nutrition, University of Oslo, N 0316 Oslo, Norway
    J Lipid Res 45:2052-62. 2004
    ..We suggest that an important aspect of LXRalpha autoregulation in adipose tissue may be to increase the level of LXRalpha over a threshold level necessary to induce the expression of certain target genes...
  3. doi request reprint Regulation of hepatic fatty acid elongase 5 by LXRalpha-SREBP-1c
    Yan Qin
    Department of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, PO Box 1046 Blindern, N 0316 Oslo, Norway
    Biochim Biophys Acta 1791:140-7. 2009
    ..The stimulatory role of LXRalpha-SREBP-1c in the production of PUFAs enables the possibility for a feedback regulation of hepatic lipogenesis through PUFA mediated repression of SREBP-1c expression...
  4. ncbi request reprint PPARalpha activators and fasting induce the expression of adipose differentiation-related protein in liver
    Knut Tomas Dalen
    Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Norway
    J Lipid Res 47:931-43. 2006
    ..These observations suggest that ADFP is primarily a fasting-induced protein in liver that coats the newly synthesized triacylglycerol-containing LDs formed during fasting...
  5. pmc Activation of LXR increases acyl-CoA synthetase activity through direct regulation of ACSL3 in human placental trophoblast cells
    M Susanne Weedon-Fekjaer
    Faculty of Medicine, University of Oslo, and Department of Endocrinology, Oslo University Hospital, Oslo, Norway
    J Lipid Res 51:1886-96. 2010
    ..Our results suggest that LXR plays a regulatory role in fatty acid metabolism by direct regulation of ACSL3 in human placental trophoblast cells...
  6. ncbi request reprint Adipose tissue expression of the lipid droplet-associating proteins S3-12 and perilipin is controlled by peroxisome proliferator-activated receptor-gamma
    Knut Tomas Dalen
    Institute for Nutrition Research, University of Oslo, Blindern, N 0316 Oslo, Norway
    Diabetes 53:1243-52. 2004
    ....
  7. ncbi request reprint LXR is crucial in lipid metabolism
    Stine Marie Ulven
    Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, P O Box 1046 Blindern, N 0316 Oslo, Norway
    Prostaglandins Leukot Essent Fatty Acids 73:59-63. 2005
    ..Here, we review recent studies that provide new insights into the mechanisms by which LXRs act to influence fatty acid synthesis in liver and adipose tissue...
  8. pmc Fatty acids regulate perilipin5 in muscle by activating PPARδ
    Christian Bindesbøll
    Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
    J Lipid Res 54:1949-63. 2013
    ..Our study reveals that muscle cells respond to elevated FAs by increasing transcription of several perilipin LD-coating proteins. This induction renders the muscle better equipped to sequester incoming FAs into cytosolic LDs...
  9. ncbi request reprint Regulation of ADRP expression by long-chain polyunsaturated fatty acids in BeWo cells, a human placental choriocarcinoma cell line
    Kari Anne Risan Tobin
    Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
    J Lipid Res 47:815-23. 2006
    ..These studies provide new information on the regulation of ADRP in placental trophoblasts and suggest that LCPUFA-dependent regulation of ADRP could be involved in the metabolism of lipids in the placenta...
  10. ncbi request reprint Expression of the insulin-responsive glucose transporter GLUT4 in adipocytes is dependent on liver X receptor alpha
    Knut Tomas Dalen
    Institute for Nutrition Research, University of Oslo, N 0316 Oslo, Norway
    J Biol Chem 278:48283-91. 2003
    ....
  11. ncbi request reprint On the role of liver X receptors in lipid accumulation in adipocytes
    Lene K Juvet
    Institute for Nutrition Research, University of Oslo, N 0316 Oslo, Norway
    Mol Endocrinol 17:172-82. 2003
    ..These findings imply a role for LXR in controlling lipid storage capacity in mature adipocytes and point to an intriguing physiological interplay between LXR and PPARgamma in controlling pathways in lipid handling...