L D'ADAMIO

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Participation of presenilin 2 in apoptosis: enhanced basal activity conferred by an Alzheimer mutation
    B Wolozin
    Unit on Alzheimer Biology, Laboratory of Clinical Science, National Institute of Mental Health, Building 10, Room 3D41, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Science 274:1710-3. 1996
  2. ncbi request reprint Requirement of the familial Alzheimer's disease gene PS2 for apoptosis. Opposing effect of ALG-3
    P Vito
    T Cell Molecular Biology Unit, Laboratory of Cellular and Molecular Immunology, NIAID, National Institutes of Health, Maryland 20892, USA
    J Biol Chem 271:31025-8. 1996
  3. ncbi request reprint Interaction of Alzheimer's presenilin-1 and presenilin-2 with Bcl-X(L). A potential role in modulating the threshold of cell death
    B J Passer
    T Cell Apoptosis Unit, Laboratory of Cellular and Molecular Immunology, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 274:24007-13. 1999
  4. ncbi request reprint Cloning of AIP1, a novel protein that associates with the apoptosis-linked gene ALG-2 in a Ca2+-dependent reaction
    P Vito
    T Cell Molecular Biology Unit, Laboratory of Cellular and Molecular Immunology, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 274:1533-40. 1999
  5. ncbi request reprint Regulation of Fas ligand expression and cell death by apoptosis-linked gene 4
    E Lacana
    T Cell Apoptosis Unit, Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Med 5:542-7. 1999
  6. ncbi request reprint Alternative, non-secretase processing of Alzheimer's beta-amyloid precursor protein during apoptosis by caspase-6 and -8
    L Pellegrini
    T Cell Apoptosis Unit, Laboratory of Cellular and Molecular Immunology, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 274:21011-6. 1999
  7. ncbi request reprint Interfering with apoptosis: Ca(2+)-binding protein ALG-2 and Alzheimer's disease gene ALG-3
    P Vito
    T Cell Molecular Biology Unit, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Science 271:521-5. 1996
  8. ncbi request reprint Generation of anti-apoptotic presenilin-2 polypeptides by alternative transcription, proteolysis, and caspase-3 cleavage
    P Vito
    T Cell Molecular Biology Unit, Laboratory of Cellular and Molecular Immunology, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 272:28315-20. 1997

Collaborators

Detail Information

Publications8

  1. ncbi request reprint Participation of presenilin 2 in apoptosis: enhanced basal activity conferred by an Alzheimer mutation
    B Wolozin
    Unit on Alzheimer Biology, Laboratory of Clinical Science, National Institute of Mental Health, Building 10, Room 3D41, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Science 274:1710-3. 1996
    ..This gain of function might accelerate the process of neurodegeneration that occurs in Alzheimer's disease, leading to the earlier age of onset characteristic of familial Alzheimer's disease...
  2. ncbi request reprint Requirement of the familial Alzheimer's disease gene PS2 for apoptosis. Opposing effect of ALG-3
    P Vito
    T Cell Molecular Biology Unit, Laboratory of Cellular and Molecular Immunology, NIAID, National Institutes of Health, Maryland 20892, USA
    J Biol Chem 271:31025-8. 1996
    ..Thus, the PS2 gene is required for some forms of cell death in diverse cell types, and its function is opposed by ALG-3...
  3. ncbi request reprint Interaction of Alzheimer's presenilin-1 and presenilin-2 with Bcl-X(L). A potential role in modulating the threshold of cell death
    B J Passer
    T Cell Apoptosis Unit, Laboratory of Cellular and Molecular Immunology, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 274:24007-13. 1999
    ..Together, these data support a possible role of the Alzheimer's presenilins in modulating the anti-apoptotic effects of Bcl-X(L)...
  4. ncbi request reprint Cloning of AIP1, a novel protein that associates with the apoptosis-linked gene ALG-2 in a Ca2+-dependent reaction
    P Vito
    T Cell Molecular Biology Unit, Laboratory of Cellular and Molecular Immunology, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 274:1533-40. 1999
    ....
  5. ncbi request reprint Regulation of Fas ligand expression and cell death by apoptosis-linked gene 4
    E Lacana
    T Cell Apoptosis Unit, Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Med 5:542-7. 1999
    ..Understanding the molecular mechanisms of FasL regulation could be very useful in elucidating how these diseases develop and in identifying potential therapeutic targets...
  6. ncbi request reprint Alternative, non-secretase processing of Alzheimer's beta-amyloid precursor protein during apoptosis by caspase-6 and -8
    L Pellegrini
    T Cell Apoptosis Unit, Laboratory of Cellular and Molecular Immunology, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 274:21011-6. 1999
    ..Moreover, it represents a general effect of apoptosis, because it occurs during cell death induced by several stimuli both in T cells and in neuronal cells...
  7. ncbi request reprint Interfering with apoptosis: Ca(2+)-binding protein ALG-2 and Alzheimer's disease gene ALG-3
    P Vito
    T Cell Molecular Biology Unit, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Science 271:521-5. 1996
    ..These findings suggest that ALG-2 may mediate Ca(2+)-regulated signals along the death pathway and that cell death may play a role in Alzheimer's disease...
  8. ncbi request reprint Generation of anti-apoptotic presenilin-2 polypeptides by alternative transcription, proteolysis, and caspase-3 cleavage
    P Vito
    T Cell Molecular Biology Unit, Laboratory of Cellular and Molecular Immunology, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 272:28315-20. 1997
    ..Thus, whereas PS2 is required for apoptosis, PS2s and PS2Ccas oppose this process, and the balance between PS2 and these COOH-terminal fragments may dictate the cell fate...