Roy G Cutler

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Evidence that accumulation of ceramides and cholesterol esters mediates oxidative stress-induced death of motor neurons in amyotrophic lateral sclerosis
    Roy G Cutler
    Laboratory of Neurosciences, National Institute on Aging Gerontology Research Center, Baltimore, MD, USA
    Ann Neurol 52:448-57. 2002
  2. ncbi request reprint The adversities of aging
    Roy G Cutler
    Laboratory of Neurosciences, National Institute on Aging, Intramural Research Program, Baltimore, MD 21224, USA
    Ageing Res Rev 5:221-38. 2006
  3. pmc Plumbagin, a novel Nrf2/ARE activator, protects against cerebral ischemia
    Tae Gen Son
    Laboratory of Neurosciences, National Institute on Aging, Intramural Research Program, Baltimore, MD 21224, USA
    J Neurochem 112:1316-26. 2010
  4. pmc Diet-induced elevations in serum cholesterol are associated with alterations in hippocampal lipid metabolism and increased oxidative stress
    Alexis M Stranahan
    Cellular and Molecular Neuroscience Section, Laboratory of Neurosciences, National Institute on Aging, Biomedical Research Center, Baltimore, Maryland, USA
    J Neurochem 118:611-5. 2011
  5. pmc Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's disease
    Roy G Cutler
    Laboratory of Neurosciences, National Institute on Aging Gerontology Research Center, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Proc Natl Acad Sci U S A 101:2070-5. 2004
  6. ncbi request reprint Intermittent fasting and caloric restriction ameliorate age-related behavioral deficits in the triple-transgenic mouse model of Alzheimer's disease
    Veerendra Kumar Madala Halagappa
    Laboratory of Neurosciences, National Institute on Aging, Intramural Research Program, Baltimore, MD 21224, USA
    Neurobiol Dis 26:212-20. 2007
  7. ncbi request reprint Soluble neuroprotective antioxidant uric acid analogs ameliorate ischemic brain injury in mice
    Frank Haberman
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, 5600 Nathan Shock Drive, Baltimore, MD, USA
    Neuromolecular Med 9:315-23. 2007
  8. pmc Hippocampal gene expression patterns underlying the enhancement of memory by running in aged mice
    Alexis M Stranahan
    Cellular and Molecular Neuroscience Section, Laboratory of Neurosciences, National Institute on Aging, Biomedical Research Center, 251 Bayview Boulevard, Baltimore, MD 21224 6825, United States
    Neurobiol Aging 31:1937-49. 2010
  9. pmc Knockdown of FABP5 mRNA decreases cellular cholesterol levels and results in decreased apoB100 secretion and triglyceride accumulation in ARPE-19 cells
    Tinghuai Wu
    Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Lab Invest 90:906-14. 2010
  10. ncbi request reprint Role of dietary iron restriction in a mouse model of Parkinson's disease
    Cathy W Levenson
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD 21224, USA
    Exp Neurol 190:506-14. 2004

Detail Information

Publications31

  1. ncbi request reprint Evidence that accumulation of ceramides and cholesterol esters mediates oxidative stress-induced death of motor neurons in amyotrophic lateral sclerosis
    Roy G Cutler
    Laboratory of Neurosciences, National Institute on Aging Gerontology Research Center, Baltimore, MD, USA
    Ann Neurol 52:448-57. 2002
    ..These findings suggest a pivotal role for altered sphingolipid metabolism in the pathogenesis of ALS...
  2. ncbi request reprint The adversities of aging
    Roy G Cutler
    Laboratory of Neurosciences, National Institute on Aging, Intramural Research Program, Baltimore, MD 21224, USA
    Ageing Res Rev 5:221-38. 2006
    ..A more productive approach would be to target the fundamental mechanisms of aging throughout adult life so as to extend healthspan. Caloric restriction and regular exercise are two such approaches...
  3. pmc Plumbagin, a novel Nrf2/ARE activator, protects against cerebral ischemia
    Tae Gen Son
    Laboratory of Neurosciences, National Institute on Aging, Intramural Research Program, Baltimore, MD 21224, USA
    J Neurochem 112:1316-26. 2010
    ..Our findings establish precedence for the identification and characterization of neuroprotective phytochemicals based upon their ability to activate adaptive cellular stress response pathways...
  4. pmc Diet-induced elevations in serum cholesterol are associated with alterations in hippocampal lipid metabolism and increased oxidative stress
    Alexis M Stranahan
    Cellular and Molecular Neuroscience Section, Laboratory of Neurosciences, National Institute on Aging, Biomedical Research Center, Baltimore, Maryland, USA
    J Neurochem 118:611-5. 2011
    ..Taken together, these observations support the existence of a potentially pathogenic relationship between dietary fat intake, peripheral cholesterol and triglyceride levels, brain cell sphingolipid metabolism, and oxidative stress...
  5. pmc Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's disease
    Roy G Cutler
    Laboratory of Neurosciences, National Institute on Aging Gerontology Research Center, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Proc Natl Acad Sci U S A 101:2070-5. 2004
    ....
  6. ncbi request reprint Intermittent fasting and caloric restriction ameliorate age-related behavioral deficits in the triple-transgenic mouse model of Alzheimer's disease
    Veerendra Kumar Madala Halagappa
    Laboratory of Neurosciences, National Institute on Aging, Intramural Research Program, Baltimore, MD 21224, USA
    Neurobiol Dis 26:212-20. 2007
    ..We conclude that CR and IF dietary regimens can ameliorate age-related deficits in cognitive function by mechanisms that may or may not be related to Abeta and tau pathologies...
  7. ncbi request reprint Soluble neuroprotective antioxidant uric acid analogs ameliorate ischemic brain injury in mice
    Frank Haberman
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, 5600 Nathan Shock Drive, Baltimore, MD, USA
    Neuromolecular Med 9:315-23. 2007
    ..These findings suggest a therapeutic potential for soluble analogs of uric acid in the treatment of stroke and related neurodegenerative conditions...
  8. pmc Hippocampal gene expression patterns underlying the enhancement of memory by running in aged mice
    Alexis M Stranahan
    Cellular and Molecular Neuroscience Section, Laboratory of Neurosciences, National Institute on Aging, Biomedical Research Center, 251 Bayview Boulevard, Baltimore, MD 21224 6825, United States
    Neurobiol Aging 31:1937-49. 2010
    ..These results suggest that the enhancement of cognitive function by lifelong exercise is associated with an altered transcriptional profile following learning...
  9. pmc Knockdown of FABP5 mRNA decreases cellular cholesterol levels and results in decreased apoB100 secretion and triglyceride accumulation in ARPE-19 cells
    Tinghuai Wu
    Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Lab Invest 90:906-14. 2010
    ..These observations indicated that FABP5 plays a critical role in lipid metabolism in RPE cells, suggesting that FABP5 downregulation in the RPE/choroid complex in vivo might contribute to aging and early age-related macular degeneration...
  10. ncbi request reprint Role of dietary iron restriction in a mouse model of Parkinson's disease
    Cathy W Levenson
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD 21224, USA
    Exp Neurol 190:506-14. 2004
    ....
  11. pmc Decline in daily running distance presages disease onset in a mouse model of ALS
    Daniel A Bruestle
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD 21224, USA
    Neuromolecular Med 11:58-62. 2009
    ..The monitoring of voluntary running distance may provide a valuable biomarker to evaluate the efficacy of potential therapeutic interventions for ALS in preclinical studies...
  12. ncbi request reprint Folic acid deficiency and homocysteine impair DNA repair in hippocampal neurons and sensitize them to amyloid toxicity in experimental models of Alzheimer's disease
    Inna I Kruman
    Laboratory of Neurosciences, National Institute on Aging Gerontology Research Center, Baltimore, Maryland 21224, USA
    J Neurosci 22:1752-62. 2002
    ..Levels of Abeta were unchanged in the brains of folate-deficient APP mutant mice. Our data suggest that folic acid deficiency and homocysteine impair DNA repair in neurons, which sensitizes them to oxidative damage induced by Abeta...
  13. ncbi request reprint p53 inhibitors preserve dopamine neurons and motor function in experimental parkinsonism
    Wenzhen Duan
    Laboratory of Neurosciences, Gerontology Research Center 4F01, National Institute on Aging NIH, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Ann Neurol 52:597-606. 2002
    ..Our findings demonstrate a pivotal role for p53 in experimental parkinsonism and identify a novel class of synthetic p53 inhibitors with clinical potential...
  14. ncbi request reprint Energy intake and amyotrophic lateral sclerosis
    Mark P Mattson
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Neuromolecular Med 9:17-20. 2007
    ..One reason that motor neurons might be selectively vulnerable to low-energy diets is that they are unable to engage neuroprotective responses to energetic stress response involving the protein chaperones, such as, heat-shock protein-70...
  15. ncbi request reprint Novel p53 inactivators with neuroprotective action: syntheses and pharmacological evaluation of 2-imino-2,3,4,5,6,7-hexahydrobenzothiazole and 2-imino-2,3,4,5,6,7-hexahydrobenzoxazole derivatives
    Xiaoxiang Zhu
    Laboratory of Neurosciences, Gerontology Research Center, National Institute on Aging, Intramural Research Program, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, Maryland 21224, USA
    J Med Chem 45:5090-7. 2002
    ....
  16. pmc The KATP channel activator diazoxide ameliorates amyloid-β and tau pathologies and improves memory in the 3xTgAD mouse model of Alzheimer's disease
    Dong Liu
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD 21224, USA
    J Alzheimers Dis 22:443-57. 2010
    ..Our findings show that diazoxide can ameliorate molecular, cytopathological, and behavioral alterations in a mouse model of AD suggesting a therapeutic potential for drugs that activate KATP channels in the treatment of AD...
  17. ncbi request reprint Suppression of calcium release from inositol 1,4,5-trisphosphate-sensitive stores mediates the anti-apoptotic function of nuclear factor-kappaB
    Simonetta Camandola
    Laboratory of Neurosciences, National Institute on Aging NIH, Gerontology Research Center, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    J Biol Chem 280:22287-96. 2005
    ..Overexpression of Bcl-2 normalizes ER calcium homeostasis and prevents calcium-mediated apoptosis in RelA-deficient cells. These findings establish an ER calcium channel as a pivotal target for NF-kappaB-mediated cell survival signaling...
  18. ncbi request reprint Neuroprotective actions of a histidine analogue in models of ischemic stroke
    Sung Chun Tang
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, Maryland 21224, USA
    J Neurochem 101:729-36. 2007
    ..These findings suggest a therapeutic potential for HNE-scavenging histidine analogues in the treatment of stroke and related neurodegenerative conditions...
  19. pmc Iron-deficiency anaemia enhances red blood cell oxidative stress
    Enika Nagababu
    Molecular Dynamics Section, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Free Radic Res 42:824-9. 2008
    ..Increased haemoglobin autoxidation and subsequent generation of ROS can account for the shorter RBC lifespan and other pathological changes associated with iron-deficiency anaemia...
  20. pmc Plasma membrane sphingomyelin hydrolysis increases hippocampal neuron excitability by sphingosine-1-phosphate mediated mechanisms
    ERIC NORMAN
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, NIH Biomedical Research Center, Baltimore, Maryland 21224, USA
    J Neurochem 114:430-9. 2010
    ..Moreover, direct intracellular application of S1P to CA1 neurons increased action potential firing. Our findings suggest roles for sphingomyelin metabolism and S1P in the positive regulation of the excitability of hippocampal neurons...
  21. pmc Diet-induced insulin resistance impairs hippocampal synaptic plasticity and cognition in middle-aged rats
    Alexis M Stranahan
    Cellular and Molecular Neurosciences Section, Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, Maryland, USA
    Hippocampus 18:1085-8. 2008
    ..We conclude that a high-calorie diet reduces hippocampal synaptic plasticity and impairs cognitive function, possibly through BDNF-mediated effects on dendritic spines...
  22. ncbi request reprint Perturbation of sphingolipid metabolism and ceramide production in HIV-dementia
    Norman J Haughey
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Ann Neurol 55:257-67. 2004
    ..These results suggest that HIV-1 infection may promote a lipid imbalance in neural cells, resulting in an overproduction of ceramide and consequent cellular dysfunction and death...
  23. doi request reprint Oxidized low density lipoproteins induce a pathologic response by retinal pigmented epithelial cells
    Yuko Yamada
    Wilmer Eye Institute, Johns Hopkins Medical Institutes, Baltimore, Maryland 21287, USA
    J Neurochem 105:1187-97. 2008
    ..Addition of an inhibitor of sphingomyelin synthase inhibited this apoptosis by 41%. These data support the hypothesis that oxidized lipoproteins are one trigger for initiating early events in the pathogenesis of AMD...
  24. pmc Elongation factor 2 diphthamide is critical for translation of two IRES-dependent protein targets, XIAP and FGF2, under oxidative stress conditions
    Sandro Arguelles
    Laboratory of Neurosciences, National Institute on Aging, Intramural Research Program, Baltimore, MD 21224, USA Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, University of Seville, 41012 Seville, Spain
    Free Radic Biol Med 67:131-8. 2014
    ..Our findings therefore suggest that eEF2 diphthamide controls the selective translation of IRES-dependent protein targets XIAP and FGF2, critical for cell survival under conditions of oxidative stress. ..
  25. pmc TLR4-dependent metabolic changes are associated with cognitive impairment in an animal model of type 1 diabetes
    Elisa M Kawamoto
    Laboratory of Neurosciences, National Institute on Aging, Intramural Research Program, National Institutes of Health, Baltimore, MD, USA
    Biochem Biophys Res Commun 443:731-7. 2014
    ..Our data show that TLR4 contributes to the negative impact of T1D on anxiety and cognition. ..
  26. pmc Impulsivity is associated with uric acid: evidence from humans and mice
    Angelina R Sutin
    Department of Medical Humanities and Social Sciences, Florida State University College of Medicine, Tallahassee, Florida Laboratory of Behavioral Neuroscience, National Institute on Aging, National Institute of Health, Bethesda, Maryland Laboratory of Neuroscience, National Institute on Aging, National Institute of Health, Bethesda, Maryland Electronic address
    Biol Psychiatry 75:31-7. 2014
    ..The present research tests the hypothesis that impulsivity is associated with higher uric acid in humans and mice...
  27. ncbi request reprint Dietary folate deficiency and elevated homocysteine levels endanger dopaminergic neurons in models of Parkinson's disease
    Wenzhen Duan
    Laboratory of Neurosciences, National Institute on Aging Gerontology Research Center, Baltimore, Maryland 21224, USA
    J Neurochem 80:101-10. 2002
    ..The ability of folate deficiency and elevated homocysteine levels to sensitize dopaminergic neurons to environmental toxins suggests a mechanism whereby dietary folate may influence risk for PD...
  28. pmc Diabetes impairs hippocampal function through glucocorticoid-mediated effects on new and mature neurons
    Alexis M Stranahan
    Psychology Department, Princeton University, Green Hall Washington Road, Princeton, New Jersey 08544, USA
    Nat Neurosci 11:309-17. 2008
    ....
  29. pmc Alternate day calorie restriction improves clinical findings and reduces markers of oxidative stress and inflammation in overweight adults with moderate asthma
    James B Johnson
    Department of Surgery, Louisiana State University Medical Center, New Orleans, LA 70006, USA
    Free Radic Biol Med 42:665-74. 2007
    ..These findings demonstrate rapid and sustained beneficial effects of ADCR on the underlying disease process in subjects with asthma, suggesting a novel approach for therapeutic intervention in this disorder...
  30. ncbi request reprint Mutant SPTLC1 dominantly inhibits serine palmitoyltransferase activity in vivo and confers an age-dependent neuropathy
    Alexander McCampbell
    Day Laboratory for Neuromuscular Research, Massachusetts General Hospital and Harvard Medical School, Charlestown, 02129, USA
    Hum Mol Genet 14:3507-21. 2005
    ..These mice represent a novel mouse model of peripheral neuropathy and confirm the link between mutant SPT and neuronal dysfunction...
  31. ncbi request reprint Suppression of uracil-DNA glycosylase induces neuronal apoptosis
    Inna I Kruman
    Sun Health Research Institute, Sun City, Arizona 85351, USA
    J Biol Chem 279:43952-60. 2004
    ....