Research Topics
| Roy G CutlerSummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
Evidence that accumulation of ceramides and cholesterol esters mediates oxidative stress-induced death of motor neurons in amyotrophic lateral sclerosisRoy G Cutler
Laboratory of Neurosciences, National Institute on Aging Gerontology Research Center, Baltimore, MD, USA
Ann Neurol 52:448-57. 2002..These findings suggest a pivotal role for altered sphingolipid metabolism in the pathogenesis of ALS...- The adversities of agingRoy G Cutler
Laboratory of Neurosciences, National Institute on Aging, Intramural Research Program, Baltimore, MD 21224, USA
Ageing Res Rev 5:221-38. 2006..A more productive approach would be to target the fundamental mechanisms of aging throughout adult life so as to extend healthspan. Caloric restriction and regular exercise are two such approaches... 
Plumbagin, a novel Nrf2/ARE activator, protects against cerebral ischemiaTae Gen Son
Laboratory of Neurosciences, National Institute on Aging, Intramural Research Program, Baltimore, MD 21224, USA
J Neurochem 112:1316-26. 2010..Our findings establish precedence for the identification and characterization of neuroprotective phytochemicals based upon their ability to activate adaptive cellular stress response pathways...- Diet-induced elevations in serum cholesterol are associated with alterations in hippocampal lipid metabolism and increased oxidative stressAlexis M Stranahan
Cellular and Molecular Neuroscience Section, Laboratory of Neurosciences, National Institute on Aging, Biomedical Research Center, Baltimore, Maryland, USA
J Neurochem 118:611-5. 2011..Taken together, these observations support the existence of a potentially pathogenic relationship between dietary fat intake, peripheral cholesterol and triglyceride levels, brain cell sphingolipid metabolism, and oxidative stress... - Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's diseaseRoy G Cutler
Laboratory of Neurosciences, National Institute on Aging Gerontology Research Center, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
Proc Natl Acad Sci U S A 101:2070-5. 2004.... - Intermittent fasting and caloric restriction ameliorate age-related behavioral deficits in the triple-transgenic mouse model of Alzheimer's diseaseVeerendra Kumar Madala Halagappa
Laboratory of Neurosciences, National Institute on Aging, Intramural Research Program, Baltimore, MD 21224, USA
Neurobiol Dis 26:212-20. 2007..We conclude that CR and IF dietary regimens can ameliorate age-related deficits in cognitive function by mechanisms that may or may not be related to Abeta and tau pathologies... - Hippocampal gene expression patterns underlying the enhancement of memory by running in aged miceAlexis M Stranahan
Cellular and Molecular Neuroscience Section, Laboratory of Neurosciences, National Institute on Aging, Biomedical Research Center, 251 Bayview Boulevard, Baltimore, MD 21224 6825, United States
Neurobiol Aging 31:1937-49. 2010..These results suggest that the enhancement of cognitive function by lifelong exercise is associated with an altered transcriptional profile following learning... - Knockdown of FABP5 mRNA decreases cellular cholesterol levels and results in decreased apoB100 secretion and triglyceride accumulation in ARPE-19 cellsTinghuai Wu
Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Lab Invest 90:906-14. 2010..These observations indicated that FABP5 plays a critical role in lipid metabolism in RPE cells, suggesting that FABP5 downregulation in the RPE/choroid complex in vivo might contribute to aging and early age-related macular degeneration... - p53 inhibitors preserve dopamine neurons and motor function in experimental parkinsonismWenzhen Duan
Laboratory of Neurosciences, Gerontology Research Center 4F01, National Institute on Aging/NIH, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
Ann Neurol 52:597-606. 2002..Our findings demonstrate a pivotal role for p53 in experimental parkinsonism and identify a novel class of synthetic p53 inhibitors with clinical potential... - Folic acid deficiency and homocysteine impair DNA repair in hippocampal neurons and sensitize them to amyloid toxicity in experimental models of Alzheimer's diseaseInna I Kruman
Laboratory of Neurosciences, National Institute on Aging Gerontology Research Center, Baltimore, Maryland 21224, USA
J Neurosci 22:1752-62. 2002..Levels of Abeta were unchanged in the brains of folate-deficient APP mutant mice. Our data suggest that folic acid deficiency and homocysteine impair DNA repair in neurons, which sensitizes them to oxidative damage induced by Abeta... - Decline in daily running distance presages disease onset in a mouse model of ALSDaniel A Bruestle
Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD 21224, USA
Neuromolecular Med 11:58-62. 2009..The monitoring of voluntary running distance may provide a valuable biomarker to evaluate the efficacy of potential therapeutic interventions for ALS in preclinical studies... - Energy intake and amyotrophic lateral sclerosisMark P Mattson
Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
Neuromolecular Med 9:17-20. 2007..One reason that motor neurons might be selectively vulnerable to low-energy diets is that they are unable to engage neuroprotective responses to energetic stress response involving the protein chaperones, such as, heat-shock protein-70... - Role of dietary iron restriction in a mouse model of Parkinson's diseaseCathy W Levenson
Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD 21224, USA
Exp Neurol 190:506-14. 2004.... - Novel p53 inactivators with neuroprotective action: syntheses and pharmacological evaluation of 2-imino-2,3,4,5,6,7-hexahydrobenzothiazole and 2-imino-2,3,4,5,6,7-hexahydrobenzoxazole derivativesXiaoxiang Zhu
Laboratory of Neurosciences, Gerontology Research Center, National Institute on Aging, Intramural Research Program, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, Maryland 21224, USA
J Med Chem 45:5090-7. 2002.... - The KATP channel activator diazoxide ameliorates amyloid-β and tau pathologies and improves memory in the 3xTgAD mouse model of Alzheimer's diseaseDong Liu
Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD 21224, USA
J Alzheimers Dis 22:443-57. 2010..Our findings show that diazoxide can ameliorate molecular, cytopathological, and behavioral alterations in a mouse model of AD suggesting a therapeutic potential for drugs that activate KATP channels in the treatment of AD... - Soluble neuroprotective antioxidant uric acid analogs ameliorate ischemic brain injury in miceFrank Haberman
Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, 5600 Nathan Shock Drive, Baltimore, MD, USA
Neuromolecular Med 9:315-23. 2007..These findings suggest a therapeutic potential for soluble analogs of uric acid in the treatment of stroke and related neurodegenerative conditions... - Suppression of calcium release from inositol 1,4,5-trisphosphate-sensitive stores mediates the anti-apoptotic function of nuclear factor-kappaBSimonetta Camandola
Laboratory of Neurosciences, National Institute on Aging NIH, Gerontology Research Center, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
J Biol Chem 280:22287-96. 2005..Overexpression of Bcl-2 normalizes ER calcium homeostasis and prevents calcium-mediated apoptosis in RelA-deficient cells. These findings establish an ER calcium channel as a pivotal target for NF-kappaB-mediated cell survival signaling... - Iron-deficiency anaemia enhances red blood cell oxidative stressEnika Nagababu
Molecular Dynamics Section, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
Free Radic Res 42:824-9. 2008..Increased haemoglobin autoxidation and subsequent generation of ROS can account for the shorter RBC lifespan and other pathological changes associated with iron-deficiency anaemia... - Neuroprotective actions of a histidine analogue in models of ischemic strokeSung Chun Tang
Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, Maryland 21224, USA
J Neurochem 101:729-36. 2007..These findings suggest a therapeutic potential for HNE-scavenging histidine analogues in the treatment of stroke and related neurodegenerative conditions... - Diet-induced insulin resistance impairs hippocampal synaptic plasticity and cognition in middle-aged ratsAlexis M Stranahan
Cellular and Molecular Neurosciences Section, Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, Maryland, USA
Hippocampus 18:1085-8. 2008..We conclude that a high-calorie diet reduces hippocampal synaptic plasticity and impairs cognitive function, possibly through BDNF-mediated effects on dendritic spines... - Plasma membrane sphingomyelin hydrolysis increases hippocampal neuron excitability by sphingosine-1-phosphate mediated mechanismsERIC NORMAN
Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, NIH Biomedical Research Center, Baltimore, Maryland 21224, USA
J Neurochem 114:430-9. 2010..Moreover, direct intracellular application of S1P to CA1 neurons increased action potential firing. Our findings suggest roles for sphingomyelin metabolism and S1P in the positive regulation of the excitability of hippocampal neurons... - Perturbation of sphingolipid metabolism and ceramide production in HIV-dementiaNorman J Haughey
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Ann Neurol 55:257-67. 2004..These results suggest that HIV-1 infection may promote a lipid imbalance in neural cells, resulting in an overproduction of ceramide and consequent cellular dysfunction and death... 
Oxidized low density lipoproteins induce a pathologic response by retinal pigmented epithelial cellsYuko Yamada
Wilmer Eye Institute, Johns Hopkins Medical Institutes, Baltimore, Maryland 21287, USA
J Neurochem 105:1187-97. 2008..Addition of an inhibitor of sphingomyelin synthase inhibited this apoptosis by 41%. These data support the hypothesis that oxidized lipoproteins are one trigger for initiating early events in the pathogenesis of AMD...- Dietary folate deficiency and elevated homocysteine levels endanger dopaminergic neurons in models of Parkinson's diseaseWenzhen Duan
Laboratory of Neurosciences, National Institute on Aging Gerontology Research Center, Baltimore, Maryland 21224, USA
J Neurochem 80:101-10. 2002..The ability of folate deficiency and elevated homocysteine levels to sensitize dopaminergic neurons to environmental toxins suggests a mechanism whereby dietary folate may influence risk for PD... - Diabetes impairs hippocampal function through glucocorticoid-mediated effects on new and mature neuronsAlexis M Stranahan
Psychology Department, Princeton University, Green Hall Washington Road, Princeton, New Jersey 08544, USA
Nat Neurosci 11:309-17. 2008.... - Mutant SPTLC1 dominantly inhibits serine palmitoyltransferase activity in vivo and confers an age-dependent neuropathyAlexander McCampbell
Day Laboratory for Neuromuscular Research, Massachusetts General Hospital and Harvard Medical School, Charlestown, 02129, USA
Hum Mol Genet 14:3507-21. 2005..These mice represent a novel mouse model of peripheral neuropathy and confirm the link between mutant SPT and neuronal dysfunction... - Suppression of uracil-DNA glycosylase induces neuronal apoptosisInna I Kruman
Sun Health Research Institute, Sun City, Arizona 85351, USA
J Biol Chem 279:43952-60. 2004.... - Alternate day calorie restriction improves clinical findings and reduces markers of oxidative stress and inflammation in overweight adults with moderate asthmaJames B Johnson
Department of Surgery, Louisiana State University Medical Center, New Orleans, LA 70006, USA
Free Radic Biol Med 42:665-74. 2007..These findings demonstrate rapid and sustained beneficial effects of ADCR on the underlying disease process in subjects with asthma, suggesting a novel approach for therapeutic intervention in this disorder...